检索结果-南通市图书馆

Potential Medicinal Value of Rhein for Diabetic Kidney Disease

在线全文

学校读者我要写书评

暂无评论

chinese Journal of Integrative medicine 2023年第10期29卷 951-960页

作者： MAO Xi XU Ding-qiao YUE Shi-jun FU Rui-jia ZHANG Sai TANG Yu-ping Key laboratory of shaanxi administration of traditional chinese medicine for tcm compatibility Shaanxi University of Chinese MedicineXi’an712046China

Diabetic kidney disease(DKD)is the primary cause of mortality among diabetic *** the increasing prevalence of diabetes,it has become a major concern around the *** therapeutic effect of clinical use of drugs is far from expected,and therapy choices to slow the progression of DKD remain ***,research on new drugs and treatments for DKD has been a hot topic in the medical *** has been found that rhein has the potential to target the pathogenesis of DKD and has a wide range of pharmacological effects on DKD,such as anti-nephritis,decreasing blood glucose,controlling blood lipids and renal *** recent years,the medical value of rhein in the treatment of diabetes,DKD and renal disease has gradually attracted worldwide attention,especially its potential in the treatment of ***,DKD can only be treated with medications from a single symptom and are accompanied by adverse effects,while rhein improves DKD with a multi-pathway and multi-target ***,this paper reviews the therapeutic effects of rhein on DKD,and proposes solutions to the limitations of rhein itself,in order to provide valuable references for the clinical application of rhein in DKD and the development of new drugs.

关键词： rhein diabetic kidney disease rhein derivatives toxicity bioavailability

Modern research thoughts and methods on bio-active components of tcm formulae

在线全文

学校读者我要写书评

暂无评论

chinese Journal of Natural medicines 2022年第7期20卷 481-493页

作者： TANG Yu-Ping XU Ding-Qiao YUE Shi-Jun CHEN Yan-Yan FU Rui-Jia BAI Xue Key laboratory of shaanxi administration of traditional chinese medicine for tcm compatibility State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drug ResearchShaanxi Collaborative Innovation Center of Chinese Medicinal Resource IndustrializationShaanxi University of Chinese MedicineXi’an 712046China

tcm formulae are the important guidances for clinical application of traditional chinese medicines,which follow the principles of diagnosis and treatment in *** the bio-active components of tcm formulae is the key to the modernization and internationalization of traditional chinese *** the rapid development of modern instruments and technology,many new theories,methods and strategies are emerging,which upgrade the research of tcm formulae into a higher *** when the medicinal efficacy,bio-active components,function mechanism of tcm formulae are understood,we can guarantee tcm safety and quality *** this paper,we summarized the latest modern research thoughts and methods on bio-active components of tcm formulae including formula decomposition study,serum pharmacology and serum pharmacochemistry,association analysis,biochro-matography,network pharmacology,metabolomics and proteomics,so as to provide reference for the research and development of tcm in the future.

关键词： chinese medicine tcm formulae Bio-active component Morden research methods

Methodology of network pharmacology for research on chinese herbal medicine against COVID-19:A review

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative medicine 2022年第6期20卷 477-487页

作者： Yi-xuan Wang Zhen Yang Wen-xiao Wang Yu-xi Huang Qiao Zhang Jia-jia Li Yu-ping Tang Shi-jun Yue Key laboratory of shaanxi administration of traditional chinese medicine for tcm compatibility State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationShaanxi University of Chinese MedicineXi’an 712046Shaanxi ProvinceChina Department of Scientific Research Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina

traditional chinese medicine,as a complementary and alternative medicine,has been practiced for thousands of years in China and possesses remarkable clinical ***,systematic analysis and examination of the mechanistic links between chinese herbal medicine(CHM)and the complex human body can benefit contemporary understandings by carrying out qualitative and quantitative *** increasing attention,the approach of network pharmacology has begun to unveil the mystery of CHM by constructing the heterogeneous network relationship of“herb-compound-target-pathway,”which corresponds to the holistic mechanisms of *** integrating computational techniques into network pharmacology,the efficiency and accuracy of active compound screening and target fishing have been improved at an unprecedented *** review dissects the core innovations to the network pharmacology approach that were developed in the years since 2015 and highlights how this tool has been applied to understanding the coronavirus disease 2019 and refining the clinical use of CHM to combat it.

关键词： chinese traditional medicine Herbal medicine Network pharmacology Compound identification COVID-19

Efficacy and safety of Tuomin Zhiti decoction(脱敏止嚏汤) on patients with seasonal allergic rhinitis: A randomized， double-blind， placebo-controlled trial

在线全文

学校读者我要写书评

暂无评论

Journal of traditional chinese medicine 2025年

作者： ZHAO Weibo WANG Yaqi KONG Lingyao WANG Tianyi ZHAO Haihong ZHANG Ying LUO Bin WANG Ji WANG Qi National Institute of tcm Constitution and Preventive medicine， Beijing University of chinese medicine College of Basic Medical Sciences， Zhejiang chinese Medical University Centre for Evidence-Based chinese medicine， Beijing University of chinese medicine Beijing University of chinese medicine International School

Objective: To evaluate the clinical efficacy and safety of Tuomin Zhiti decoction (TZD) in the short-term treatment of seasonal allergic rhinitis (SAR). Methods: This study is a randomized， double-blind placebo-controlled， and single-center clinical trial. In April 2021， during the spring pollen season in Beijing， 94 SAR patients aged 19-60 years were randomized (1:1 ratio) to receive two weeks of TZD or placebo. The primary outcome was the change of Total Nasal Symptom Score (TNSS) and Total Ocular Symptom Score (TOSS) from baseline to the end of treatment. Secondary outcomes were the changed score of the mini Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ)， Rescue Medication Score (RMS)， and Patient Global Impression of Change (PGIC). All adverse events were recorded and evaluated by two senior physicians. Results: TZD significantly reduced both the total nasal symptom scores and total ocular symptom scores compared to scores at baseline， while the placebo group showed an increasing trajectory in both symptom scores. Compared to the placebo group， the TZD group also showed a greater improvement in the quality of life， scores of RMS， nasal and eye symptoms scores after TZD treatment (P < 0.001). Most notably， at the end of treatment， the proportion of remission measured by PGIC was significantly higher in the TZD group (82.97%) compared with the placebo group (47.72%， P < 0.001). Conclusion: This study suggested that two weeks of TZD is an effective and safe treatment for SAR patients and spring pollen allergy， TZD could significantly improve the nasal and eye symptoms and improve the quality of life of patients.

关键词：

A review of Behcet's disease from the perspectives of both Western and chinese medicine

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of traditional chinese medicine 2019年第1期39卷 139-148页

作者： Zhang Jing Tang Yuping Liu Pei Zhou Guisheng Kang An Yue Shijun Chen Yanyan Duan Jinao Key laboratory of shaanxi administration of traditional chinese medicine for tcm compatibility and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Researchand Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationShaanxi University of Chinese MedicineXi'an 712046China Jiangsu Collaborative Innovation Center of chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM Formulaeand National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative MedicineNanjing University of Chinese MedicineNanjing 210023China

Behcet's disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet's disease can affect every tissue and organ in the body,and is characterized by recurrent oral and genital ulcers, ocular inflammation, skin lesions, and other manifestations. The incidence of Behcet's disease has a distinct regional specificity, and is most prevalent along the Silk Road, a route that stretched between the Mediterranean, Middle East and Far *** article reviews the recent literature to evaluate the prevalence, clinical manifestations, pathogenesis and mechanism, and current treatments of Behcet's disease. Furthermore, the etiology of Behcet's disease will be evaluated from the aspect of traditional chinese medicine(tcm) syndrome differentiation. As Behcet's disease is complex and intractable, its treatment warrants further ***, Behcet's disease is treated with Western medicine(WM) via medications that act locally and systemically; this WM treatment protocol usually has a good effect, but relapse can occur after reducing the dosage. Thus, it may be ideal to treat Behcet's disease via a combination of WM and *** studies have indicated that such a combination of chinese and Western treatments has a better effect than either treatment alone. The aim of the present review is to describe the clinical features of Behcet's disease, and to outline its possible pathogenesis in terms of both tcm and WM. Based on these findings, the present review proposes a Behcet's disease treatment protocol composed of a combination of chinese and WM that can effectively improve the occurrence of relapse caused by the reduction of the dosage of Western medication.

关键词： Behcet syndrome Syndrome differentiation treatment Virulence Recurrence Therapeutics Review

Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu Guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical laboratory medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

Comparative pharmacodynamic, pharmacokinetic and tissue distribution of Dahuang-Gancao decoction in normal and experimental constipation mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Journal of Natural medicines 2019年第11期17卷 871-880页

作者： CHEN Yan-Yan CAO Yu-Jie TANG Yu-Ping YUE Shi-Jun DUAN Jin-Ao Key laboratory of shaanxi administration of traditional chinese medicine for tcm compatibility and State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Researchand Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationShaanxi University of Chinese MedicineXi’an 712046China Jiangsu Collaborative Innovation Center of chinese Medicinal Resources Industrialization and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicineand Jiangsu Key Laboratory for High Technology Research of TCM FormulaeNanjing University of Chinese MedicineNanjing 210023China

Dahuang-Gancao decoction(DGD)is a classical formula,which is commonly used for reliving constipation in chinese *** aim of this study was to investigate the pharmacodynamic,pharmacokinetic and tissue distribution alternations of DGD in normal and constipation *** exhibited stronger purgative effect in constipation mice by the increased fecal excretion and reduced first defection time compared with normal *** Cmax,AUC0-t and MRT0-t of rhein,aloe-emodin,rhein-8-O-β-D-glucoside,sennoside A,and glycyrrhizic acid as main bio-active components in DGD were markedly increased in constipation *** tissue distribution of the analytes in constipation mice were higher than those in normal mice with rhein>rhein-8-O-β-D-glucoside>aloe-emodin>glycyrrhizic acid>emodin in liver,and glycyrrhizic acid>rhein-8-O-β-D-glucoside>liquitin>sennoside A>rhein>aloe-emodin>emodin in *** kidney concentrations of the analytes showed a descending order of rhein>rhein-8-O-β-D-glucoside>sennoside A>glycyrrhizic acid>aloe-emodin>emodin,most of them were higher while rhein was lower in constipation mice than normal *** higher exposure of the anthraquinones in plasma,liver and colon may result in the stronger purgative effect in the constipation mice than normal *** is mainly excreted through the kidney,the decreased level of rhein in constipation mice may explain the alleviated side *** of glycyrrhizic acid in colon may related with the moderate property of *** results provided the experimental basis for understanding the therapeutic effects and metabolite profile of DGD.

关键词： Rhubarb Licorice Pharmacodynamic Pharmacokinetic Tissue distribution Constipation

Elucidating the interaction of kansui and licorice by comparative plasma/tissue metabolomics and a heatmap with relative fold change

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2019年第5期9卷 312-323页

作者： Yan-Yan Chen Juan Shen Yu-Ping Tang Jin-Gao Yu Jing Wang Shi-Jun Yue Jie Yang Jia-Qian Chen Li-Mei Feng Zhen-Hua Zhu Wei-Wei Tao Li Zhang Jin-Ao Duan Key laboratory of shaanxi administration of traditional chinese medicine for tcm compatibility State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Researchand Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationShaanxi University of Chinese MedicineXi’an 712046Shaanxi ProvinceChina Jiangsu Collaborative Innovation Center of chinese Medicinal Resources Industrialization National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicineand Jiangsu Key Laboratory for High Technology Research of TCM FormulaeNanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

Although compatibility is highly advocated in traditional chinese medicine (tcm), inappropriate combination of some herbs may reduce the therapeutic action and even produce toxic effects. Kansui and licorice, one of tcm “Eighteen Incompatible Medicaments”, are the most representative cases of improper herbal combination, which may still be applied simultaneously under given conditions. However, the potential mechanism of their compatibility and incompatibility is unclear. In the present study, two different ratios of kansui and licorice, representing their compatibility and incompatibility respectively, were designed to elucidate their interaction by comparative plasma/tissue metabolomics and a heatmap with relative fold change. As a result, glycocholic acid, prostaglandin F2a, dihydroceramide and sphinganine were screened out as the principal alternative biomarkers of compatibility group;sphinganine, dihydroceramide, arachidonic acid, leukotriene B4, acetoacetic acid and linoleic acid were those of incompatibility group. Based on the values of biomarkers in each tissue, the liver was identified as the compatible target organ, while the heart, liver, and kidney were the incompatible target organs. Furthermore, important pathways for compatibility and incompatibility were also constructed. These results help us to better understand and utilize the two herbs, and the study was the first to reveal some innate characters of herbs related to tcm “Eighteen Incompatible Medicaments”.

关键词： Comparative metabolomics Kansui Licorice Incompatibility Heatmap

A nitric oxide-triggered hydrolysis reaction to construct controlled self-assemblies with complex topologies

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第4期67卷 1289-1299页

作者： Wenzhuo Chen Yuping Tang Shuai Chen Zipei Chen Jia He Hongbin Huo Juan Zhang Jiajia Li Fei Yan Wei Tian laboratory of shaanxi administration of traditional chinese medicine for tcm compatibility Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs ResearchCollege of PharmacyShaanxi University of Chinese MedicineXianyang 712046China shaanxi Key laboratory of Macromolecular Science and Technology Xi’an Key Laboratory of Hybrid Luminescent Materials and Photonic DeviceMOE Key Laboratory of Material Physics and Chemistry under Extraordinary ConditionsSchool of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Polymeric Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China

Hydrolysis reactions are capable of directing the non-equilibrium assembly of biomolecular scaffolds to realize sophisticated structures and functions in natural ***,utilizing the proper hydrolysis reactions to construct controlled assemblies with complex topologies is still an arduous challenge in artificial systems and needs to be ***,we report a nitric oxide(NO)-triggered slow hydrolysis strategy for the controlled construction of biomimetic supramolecular toroids(STs),thus realizing their visualization of intermediate structures and regulation of geometry *** presented protocol harnesses hydrolysis reactions to control of non-equilibrium self-assembly processes for the construction of self-assemblies with complex topologies successfully,which sheds light on how the hydrolysis reaction rate can modulate the kinetic pathway of assembly,thus realizing the artificial establishment of bio-inspired hierarchical structures.

关键词： supramolecular toroids controlled self-assembly nitic oxide-triggered hydrolysis pathway regulation