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cellular & Molecular Immunology 2021年第6期18卷 1571-1574页

作者： Yuan Song Yonghao Liu Huey Yee Teo Zuhairah Binte Hanafi Yu Mei Ying Zhu Yen Leong Chua Mengze Lv Zhengfan Jiang Haiyan Liu Immunology Programme Life Sciences Institute and Department of Microbiology and ImmunologyYong Loo Lin School of MedicineNational University of SingaporeSingapore117456Singapore Jill Roberts Institute for Research in Inflammatory Bowel Disease(JRI) Weill Cornell MedicineCornell UniversityNew YorkNYUSA Key laboratory of Cell Proliferation and Differentiation of the Ministry of Education School of Life SciencesPeking UniversityBeijing100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing100871China

The presence of cytosolic DNA at tumor sites and the activation of the cGAS-STING pathway have been implicated in the activation of antitumor immune responses.1,2,3 Manganese (Mn) is a necessary trace element for intracellular activities. It plays important roles in development, digestion, reproduction, antioxidant defense, energy production, immunity, and neuronal activity regulation.4 Mn was reported to enhance cGAS-STING activation through increased sensitivity to dsDNA during viral infections.5 However, it is unclear whether Mn can enhance antitumor immune functions. Here, we revealed that Mn2+ could inhibit the development of murine hepatocellular carcinoma (HCC) through immune modulations. It upregulated IFN-γ and TNF-α production in splenic and tumor-infiltrating CD8+ T cells. Moreover, Mn2+ significantly increased type I interferon (IFN) production and type I IFN-stimulated gene (ISG) expression in tumor-bearing mice. Further analysis revealed that myeloid cells could upregulate type I IFN production and increase costimulatory molecule expression upon Mn2+ stimulation. In vivo depletion of CD8+ T cells or treatment of IFNAR KO mice diminished the antitumor activity of Mn2+, suggesting that the antitumor function of Mn2+ is dependent on both CD8+ T cells and type I IFN signaling. Our results provide evidence to support Mn2+ as a novel agent that can be incorporated into cancer immunotherapy.

关键词： immunity interferon function

Correction to: Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants

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Protein & Cell 2019年第9期10卷 700-700页

作者： Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine Shanghai Key Laboratory of Regulatory BiologySchool of Life SciencesEast China Normal UniversityShanghai 200241 China Fengxian Hospital Affiliated to Southern Medical University Shanghai 201499China Xinhua Hospital Shanghai Jiao Tong University School of MedicineShanghai 200092China School of Life Sciences Hunan Normal UniversityChangsha 410081China Bioray Laboratories Inc. Shanghai 200241China Departme nt of Molecular and cellular Medici ne The In stitute of Bioscie nces and Tech no logyTexas AM Un iversity Health Science CenterHoustonTX 77030USA

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://***/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

关键词： Commons licenses unrestricted

神经胶质细胞与神经突触的相互作用——从星形胶质细胞到小胶质细胞和少突胶质细胞谱系细胞

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神经损伤与功能重建 2023年第9期18卷 F0003-F0003页

作者： Yao Liu Xi Shen Yuhan Zhang Xiaoli Zheng Carlos Cepeda YaoWang Shumin Duan Xiaoping Tong 杜一星(编译) Songjiang Institute and Songjiang Hospital Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Anatomy and Physiology Shanghai Jiao Tong University School of MedicineShanghaiChina College of Basic Medical Science Shanghai Jiao Tong University School of MedicineShanghaiChina Intellectual and Developmental Disabilities Research Center David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCaliforniaUSA Department of Assisted reproduction The Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Liangzhu laboratory MOE Frontier Science Center for Brain Science and Brain-Machine IntegrationState Key Laboratory of Brain-Machine IntelligenceZhejiang UniversityHangzhouChina Shanghai Research Center for Brain Science and Brain-Inspired Intelligence ShanghaiChina. 不详

哺乳动物的大脑是一个由神经元、神经胶质细胞和超过1×1014个突触组成的复杂的器官。神经元是一组异质的电活性细胞,形成大脑复杂电回路的框架。然而,神经胶质细胞约占哺乳动物中枢神经系统(CNS)所有神经细胞的一半,主要分为星形胶质... 详细信息

哺乳动物的大脑是一个由神经元、神经胶质细胞和超过1×1014个突触组成的复杂的器官。神经元是一组异质的电活性细胞,形成大脑复杂电回路的框架。然而,神经胶质细胞约占哺乳动物中枢神经系统(CNS)所有神经细胞的一半,主要分为星形胶质细胞、小胶质细胞、少突胶质细胞(OL)和少突胶质细胞前体细胞(OPC);神经胶质细胞主要为大脑中的神经元提供营养支持。近二十年来,“三联突触”的概念引起了广泛关注,该概念强调星形胶质细胞是突触的组成部分,并在接受神经元信号后以反馈方式调节神经元活动。自此,神经胶质细胞的突触调节得到了广泛的研究和实质性的修改。本综述总结了关于神经胶质细胞(特别是小胶质细胞和OL谱系细胞)如何影响和重塑大脑突触结构和功能的最新重要发现。我们的综述强调了神经元-神经胶质细胞串扰的细胞和分子方面,并提供了有关神经元和神经胶质细胞之间的异常突触通讯如何导致神经病理学的额外信息。

关键词：星形胶质细胞小胶质细胞少突胶质细胞前体细胞少突胶质细胞突触传递

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PNAS:科学家发现新的精子运动调节器

现代生物医学进展 2017年第27期17卷 I0001-I0002页

作者： Castaneda, Julio M. Hua, Rong Miyata, Haruhiko Oji, Asami Guo, Yueshuai Cheng, Yiwei Zhou, Tao Guo, Xuejiang Cui, Yiqiang Shen, Bin Wang, Zibin Hu, Zhibin Zhou, Zuomin Sha, Jiahao Prunskaite-Hyyrylainen, Renata Yu, Zhifeng Ramirez-Solis, Ramiro Ikawa, Masahito Matzuk, Martin M. Liu, Mingxi Baylor Coll Med Dept Pathol & Immunol Houston TX 77030 USA Osaka Univ Res Inst Microbial Dis Suita Osaka 5650871 Japan Nanjing Med Univ State Key Lab Reprod Med Nanjing 210029 Jiangsu Peoples R China Nanjing Med Univ Dept Histol & Embryol Nanjing 210029 Jiangsu Peoples R China Osaka Univ Grad Sch Pharmaceut Sci Suita Osaka 5650871 Japan Nanjing Med Univ Anim Core Facil Nanjing 210029 Jiangsu Peoples R China Baylor Coll Med Ctr Reprod Med Houston TX 77030 USA Univ Oulu Fac Biochem & Mol Med FI-90014 Oulu Finland Baylor Coll Med Ctr Drug Discovery Houston TX 77030 USA Wellcome Trust Sanger Inst Hinxton CB10 1SA England Univ Tokyo Inst Med Sci Minato Ku Tokyo 1088639 Japan Baylor Coll Med Dept Mol & Cellular Biol Houston TX 77030 USA Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Baylor Coll Med Dept Pharmacol Houston TX 77030 USA

南京医科大学生殖医学国家重点实验室、基础医学院组织胚胎学系刘明兮课题组与贝勒医学院***课题组、大阪大学MasahitoIkawa课题组等共同解析了一个精子运动调节基因TCTE1，结果发表于《美国科学院院刊》（PNAs）。

关键词：精子运动调节器科学家国家重点实验室组织胚胎学课题组生殖医学医科大学