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Clove(Syzygium aromaticum):a precious spice

Asian Pacific Journal of Tropical Biomedicine 2014年第2期4卷 90-96页

作者： diego Francisco Cortés-rojas Claudia regina Fernandes de Souza Wanderley Pereira Oliveira laboratory of r&d on pharmaceutical processes-laprofar-faruldade de ciencias farmaceuticas de ribeirao preto/usp Av.do Cafe s/nBloco Q.14040-903Ribeirao PretoSPBrazil

Clove(Syzygium aromaticum) is one of the most valuable spices that has been used for centuries as food preservative and Tor many medicinal *** is native of Indonesia but nowadays is cultured in several parts of the world including Brazil in the slate of *** plant represents one of the richest source of phenolic compounds such as eugenol,eugenol acetate and gallic acid and posses great potential for pharmaceutical,cosmetic,food and agricultural *** review includes the main studies reporting the biological activities of clove and *** antioxidant and antimicrobial activity of clove is higher than many fruits,vegetables and other spices and should deserve special attention.A new application of clove as larvicidal agent is an interesting strategy to combat dengue which is a serious health problem in Brazil and other tropical *** and lexicological studies were also *** different studies reviewed in this work confirm the traditional use of clove as food preservative and medicinal plant standing out the importance of this plant for different applications.

关键词： Spice Clove Aromatic plant Volatile Antioxidant dengue fever Larvicidal

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pharmaceutical applications of spouted beds: A review on solid dosage forms

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Particuology 2019年第1期17卷 126-136页

作者： Luis Alexandre Pedro de Freitas Faculdade de ciencias farmaceuticas de ribeirao preto University of Sao PauloVia do Cafe s/n. Campus USPRibeirao Preto14040-903Sao Paulo. Brazil

Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological characteristics of pharmaceutical solid forms. Particle properties like morphology, size, porosity, flowability, and dissolution rate can be improved by managing geometric and operational conditions for spouting. drying is probably the most disseminated operation for pharmaceutical processing in SBs, and many studies have investigated drying of medicinal plant extracts such as achiote (Bixa orellana sp.), guarana (Paullinia cupana sp.), passion flower (Passiflora alata d.), and rosemary (rosmarinus officinalis L.) with excellent pharmacotechnical and stability results. Another important application is coating of tablets and gelatin capsules, and previous studies have shown that SBs and spout–fluid beds may be advantageous over traditional pan coating, especially for polymeric film coating. recently, an alternative process for improving drug bioavailability has involved preparation of β-cyclodextrin inclusion complexes in SBs. The first study to propose SBs for this pharmaceutical application explored the advantage of obtaining solid forms of inclusion complexes in just one step, and obtained expressive increases in drug solubility. The technique has been applied in subsequent studies on inclusion complexes of the medication carvedilol and uxi (Endopleura uchi L.) extracts.

关键词： Coating drying Granulation Inclusion Microencapsulation

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