检索结果-南通市图书馆

Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders

引用

Acta Pharmaceutica Sinica B 2023年第5期13卷 1866-1886页

作者： Rania Awad Avi Avital Alejandro Sosnik Laboratory of Pharmaceutical Nanomaterials Science Department of Materials Science and EngineeringTechnion-Israel Institute of TechnologyHaifa 3200003Israel Behavioral Neurobiology laboratory Department of Occupational TherapyFaculty of Social Welfare and Health SciencesUniversity of HaifaHaifa 3498838Israel

Neurodegenerative diseases are progressive conditions that affect the neurons of the central nervous system(CNS)and result in their damage and death.Neurodevelopmental disorders include intellectual disability,autism spectrum disorder,and attention-deficit/hyperactivity disorder and stem from the disruption of essential neurodevelopmental processes.The treatment of neurodegenerative and neurodevelopmental conditions,together affecting~120 million people worldwide,is challenged by the blood—brain barrier(BBB)and the blood—cerebrospinal fluid barrier that prevent the crossing of drugs from the systemic circulation into the CNS.The nose-to-brain pathway that bypasses the BBB and increases the brain bioavailability of intranasally administered drugs is promising to improve the treatment of CNS conditions.This pathway is more efficient for nanoparticles than for solutions,hence,the research on intranasal nano-drug delivery systems has grown exponentially over the last decade.Polymeric nanoparticles have become key players in the field owing to the high design and synthetic flexibility.This review describes the challenges faced for the treatment of neurodegenerative and neurodevelopmental conditions,the molecular and cellular features of the nasal mucosa and the contribution of intranasal nano-drug delivery to overcome them.Then,a comprehensive overview of polymeric nanocarriers investigated to increase drug bioavailability in the brain is introduced.

关键词： Neurodegenerative diseases Neurodevelopmental disorders Central nervous system Blood—brain barrier Nano-drug delivery systems Nose-to-brain pathway Intranasal administration Polymeric nanoparticles Polymeric micelles Dendrimers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Graphene oxide as a hole extraction layer loaded on BiVO_(4)photoanode for highly efficient photoelectrochemical water splitting

引用

Rare Metals 2022年第11期41卷 3795-3802页

作者： Min-Li Guo Shi-Peng Wan Cao-Long Li Kan Zhang Key laboratory of Biomedical Functional Materials School of ScienceChina Pharmaceutical UniversityNanjing211198China Institute of Optoelectronics and nanomaterials MIIT Key Laboratory of Advanced Display Material and DevicesCollege of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing210094China

The tailor-made oxygen evolution catalysts(OECs)paired with photoanodes offer a path to promote water oxidation kinetics;however,the unsatisfied interface between OECs and photoanode sets a barrier for efficient charge transfer.Herein,a graphene oxide(GO)layer to promote the charge transfer from BiVO_(4)(BVO)to NiOOH OEC is reported.It is found that GO layer inserted between BVO and NiOOH can not only serve as hole extraction layer due to its hole storage capability,but also improve the stability.Finally,the rationally designed NiOOH/GO/BVO photoanode achieves a photocurrent density of 3.81 mA·cm^(-2)at 1.23 V(vs.reversible hydrogen electrode(RHE)),which is 3.85 times as high as that of bare BVO.This work opens up low-cost auxiliary materials for enhancing photoelectrochemical water splitting.

关键词： BiVO_(4) Water splitting Charge extraction Oxygen evolution catalyst Graphene oxide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Editorial of Special Column on Delivery Nanotechnologies to Modulate the Immune System and Combat Inflammation and Infection

引用

药学学报:英文版 2023年第6期13卷 2296-2297页

作者： Wei He Alejandro Sosnik Chenjie Xu School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Laboratory of Pharmaceutical Nanomaterials Science Department of Materials Science and EngineeringTechnion-Israel Institute of TechnologyHaifa 3200003Israel Department of Biomedical Engineering City University of Hong KongHong Kong 999077China

Our immune system has a vital role,and any variation because of either heritable or non-heritable stimuli might cause health disorders such as cancer,diabetes,and cardiovascular diseases1.In addition,the complexity of the anatomical barriers,such as the blood brain barrier,challenges the therapy of central nervous system(CNS)diseases.The goal of nano-dimensional drugs(nanomedicines)is to improve the efficacy of treatments while minimizing systemic toxicity and side effects.

关键词： drugs cardiovascular Immune

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors

引用

Nano Research 2021年第3期14卷 667-673页

作者： Yinghua Zhang Huifang Liu Xinyue Dai Hang Li Xiaohan Zhou Shizhu Chen Jinchao Zhang Xing-Jie Liang Zhenhua Li College of Chemistry&Environmental science Analytical Chemistry Key Laboratory of Hebei ProvinceChemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding071002China Key laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Institute of Life Science and Green DevelopmentHebei UniversityBaoding071002China College of pharmaceutical science Key Laboratory of Pharmaceutical Quality Control of Hebei ProvinceHebei UniversityBaoding071002China Beijing pharmaceutical Group Company Limited Beijing100101China The National Institutes of pharmaceutical R&D Co. Ltd.China Resources Pharmaceutical Group LimitedBeijing102206China CAS Key laboratory for Biological Effects of nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing100190China

Tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy,as well as predisposing for increased tumor metastases.Therefore,strategies for the eradication of the hypoxic tumor are highly desirable.Photodynamic therapy(PDT)is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a photosensitizer.Compared to traditional radiotherapy and chemotherapy,photodynamic therapy has many advantages,such as good selectivity,low toxicity,and less trauma and resistance.However,PDT is oxygen-dependent,and the lack of oxygen in hypoxic tumors renders photodynamic therapy ineffective.Cyanobacteria,the earliest photosynthetic oxygen-generating organisms,can utilize water as an electron donor to reduce CO_(2) into organic carbon compounds along with continuously releasing oxygen under sunlight.Inspired by this,herein,cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles(UCNP)to construct a self-supplying oxygen PDT system.Improvement in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared(NIR)light using UCNP as a light harvesting antenna.A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms.

关键词： self-supplying oxygen cyanobacteria hypoxic tumor photodynamic therapy upconversion nanoparticles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The age of vanadium-based nanozymes: Synthesis, catalytic mechanisms, regulation and biomedical applications

引用

Chinese Chemical Letters 2024年第4期35卷 52-60页

作者： Shuaiwen Li Zihui Chen Feng Yang Wanqing Yue Department of Chemistry Key Laboratory of Biomedical Functional MaterialsSchool of ScienceChina Pharmaceutical UniversityNanjing 211198China Key laboratory of Drug Quality Control and Pharmacovigilance(China pharmaceutical University) Ministry of EducationNanjing 211198China

nanomaterials with enzyme-mimic(nanozyme) activity have garnered considerable attention as a potential alternative to natural enzymes, thanks to their low preparation cost, high activity, ease of preservation, and unique physicochemical properties. Vanadium(V) is a transition metal that integrates the benefits of valence-richness, low cost, and non-toxicity, making it a desirable candidate for developing a range of emerging nanozymes. In this review, we provide the first systematic summary of recent research progress on V-based nanozymes. First, we summarize the preparation of V-based nanozymes using both top-down and bottom-up synthesis methods. Next, we review the mechanism of V-based nanozymes that mimic the activity of various enzymes. We then discuss methods for regulating V-based nanozyme activity, including morphology, size, valence engineering, defect engineering, external triggering, and surface engineering. Afterward, we outline various biomedical applications, including therapeutic, anti-inflammatory, antibacterial, and biosensing. Finally, we prospect the challenges and countermeasures for V-based nanozymes based on their development. By summarizing recent research progress on V-based nanozymes, we hope to provide useful insights for researchers to further explore their potential applications and overcome their existing challenges.

关键词： Vanadium Nanozymes Catalytic mechanisms Biomedical applications Regulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

引用

Frontiers of Medicine 2018年第6期12卷 667-677页

作者： Yinlong Zhang Guangna Liu Jingyan Wei Guangjun Nie College of pharmaceutical science Jilin UniversityChangchun 130021China CAS Key laboratory for Biomedical Effects of nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of sciences Beijing 100049China

Platelets have long been known to play critical roles in hemostasis by clumping and clotting blood vessel injuries. Recent experimental evidence strongly indicates that platelets can also interact with tumor cells by direct binding or secreting cytokines. For example, platelets have been shown to protect circulating cancer cells in blood circulation and to promote tumor metastasis. In-depth understanding of the role of platelets in cancer progression and metastasis provides promising approaches for platelet biomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatment. This review highlights recent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associated platelets for cancer therapy. The paper also discusses future development opportunities and challenges encountered for clinical translation.

关键词： EPR effect cancer therapy platelet-mimicking delivery systems tumor-associated platelets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lipase-activated glycopeptide nano-assemblies as an antibiotic nano-adjuvant to inhibit Pseudomonas aeruginosa biofilm and enhance antibacterial activity

引用

science China Chemistry 2022年第12期65卷 2538-2547页

作者： Yifei Song Jingkai Zhang Yue Fei Zhangjian Huang Xiaoxuan Liu Li-Li Li CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing100190China College of Life science and Technology Beijing University of Chemical TechnologyBeijing100029China State Key laboratory of Natural Medicines and Jiangsu Key laboratory of Drug Discovery for Metabolic Diseases Center of Drug DiscoveryCenter of Advanced Pharmaceutics and BiomaterialsChina Pharmaceutical UniversityNanjing210009China

Bacterial infections,especially those caused by biofilms,pose a serious threat to public health.In this work,we propose a glycopeptide-based antibiotic nano-adjuvant(GalAc-2) that can synergistically enhance the antibacterial activity of antibiotics through its biofilm inhibition activity.Our glycopeptide nanoparticles can be specifically activated by bacterial infection overexpressed lipase and sequentially enlarged by glycosyl exposure on the surface.The stability and bonding affinity of the nanoparticles were enhanced through the increase in β-sheet conformation.The bacterial growth inhibition rate of the mixture of levofloxacin(LEV) and GalAc-2 at 0.54 μg/m L was over sevenfold higher than that of LEV alone because of the electrostatic and multivalence Lec A interactions that inhibited biofilm formation on the bacterial surface.Finally,the mixture of the antibiotic with GalAc-2 significantly inhibited the abscess exposed to skin infection and significantly reduced the infiltration of immune cells.We believe that GalAc-2 can be further used to enhance broad-spectrum antibiotic sensitization and prolong the lifetime of antibiotics.

关键词： glycopeptide self-assembly antibiotic nano-adjuvant bacteria biofilm

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gold-based nanomaterials for the treatment of brain cancer

引用

Cancer Biology & Medicine 2021年第2期18卷 372-387页

作者： Li Tu Zheng Luo Yun-Long Wu Shuaidong Huo Xing-Jie Liang Fujian Provincial Key laboratory of Innovative Drug Target Research School of Pharmaceutical SciencesXiamen UniversityXiamen 361102China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China

Brain cancer,also known as intracranial cancer,is one of the most invasive and fatal cancers affecting people of all ages.Despite the great advances in medical technology,improvements in transporting drugs into brain tissue have been limited by the challenge of crossing the blood-brain barrier(BBB).Fortunately,recent endeavors using gold-based nanomaterials(GBNs)have indicated the potential of these materials to cross the BBB.Therefore,GBNs might be an attractive therapeutic strategy against brain cancer.Herein,we aim to present a comprehensive summary of current understanding of the critical effects of the physicochemical properties and surface modifications of GBNs on BBB penetration for applications in brain cancer treatment.Furthermore,the most recent GBNs and their impressive performance in precise bioimaging and efficient inhibition of brain tumors are also summarized,with an emphasis on the mechanism of their effective BBB penetration.Finally,the challenges and future outlook in using GBNs for brain cancer treatment are discussed.We hope that this review will spark researchers'interest in constructing more powerful nanoplatforms for brain disease treatment.

关键词： Gold-based nanomaterials BBB penetration brain cancer therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecularly engineered truncated tissue factor with therapeutic aptamers for tumor-targeted delivery and vascular infarction

引用

Acta Pharmaceutica Sinica B 2021年第7期11卷 2059-2069页

作者： Bozhao Li Jingyan Wei Chunzhi Di Zefang Lu Feilong Qi Yinlong Zhang Wei Sun Leong Lele Li Guangjun Nie Suping Li College of pharmaceutical science Jilin UniversityChangchun 130021China CAS Key laboratory for Biomedical Effects of nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Materials science and Engineering National University of Singapore117575Singapore

Selective occlusion of tumor vasculature has proven to be an effective strategy for cancer therapy.Among vascular coagulation agents,the extracellular domain of coagulation-inducing protein tissue factor,truncated tissue factor(tTF),is the most widely used.Since the truncated protein exhibits no coagulation activity and is rapidly cleared in the circulation,free tTF cannot be used for cancer treatment on its own but must be combined with other moieties.We here developed a novel,tumor-specific tTF delivery system through coupling tTF with the DNA aptamer,AS1411,which selectively binds to nucleolin receptors overexpressing on the surface of tumor vascular endothelial cells and is specifically cytotoxic to target cells.Systemic administration of the tTF-AS1411 conjugates into tumor-bearing animals induced intravascular thrombosis solely in tumors,thus reducing tumor blood supply and inducing tumor necrosis without apparent side effects.This conjugate represents a uniquely attractive candidate for the clinical translation of vessel occlusion agent for cancer therapy.

关键词： Tumor targeted delivery Truncated tissue factor(tTF) AS1411 aptamer Thrombosis Tumor infarction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NIR-Ⅱ photothermal therapy for effective tumor eradication enhanced by heterogeneous nanorods with dual catalytic activities

引用

Nano Research 2022年第5期15卷 4310-4319页

作者： Linghua Zhang Wenjie Wang Meng Ou Xiaoxiao Huang Yu Ma Jiayue Tang Ting Hou Sheng Zhang Li Yin Huan Chen Yanglong Hou Ya Ding Key laboratory of Drug Quality Control and Pharmacovigilance Ministry of EducationChina Pharmaceutical UniversityNanjing 210009China Beijing Key laboratory for Magnetoelectric Materials and Devices Beijing Innovation Center for Engineering Science and Advanced TechnologySchool of Materials Science and EngineeringPeking UniversityBeijing 100871China Department of Biochemistry School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 210009China

Rational design and exploitation of nanomaterials with superior treatment properties for suitable indications is a way out to relieve cost constraint of therapy and solve the unsatisfactory efficacy for cancer patients.In this work,we propose a greatly facile approach to produce heterogeneous Pd-Au nanorods(Pd-Au NRs)that solve the current bottleneck problems of photothermal thermal therapy(PTT)as well as completely eliminate tumors in animal models without toxic side effects.Depositing Pd clusters on both tips of Au NRs offers Pd-Au NRs three novel functions,i.e.,the extension of the absorption into NIR-Ⅱ region,the activation of prodrug of 5-fluorouracil(5-Fu)via the bioorthogonal reaction,and the peroxidase-mimic activity to produce·OH.The heterogeneous nanorods showed a high and stable photothermal conversion efficiency(52.07%)in a safer NIR-Ⅱ irradiation region(1,064 nm),which not only eliminate most of tumor cells at only one dose of the irradiation for 5 min but also improve the in situ conversion of 5-fluoro-1-propargyluracil and H2O2 into active 5-Fu and·OH to eradicate residual tumors for inhibiting tumor metastasis.This dual catalytic activity-synergistic mechanism of PTT demonstrates the importance of material design in solving current bottleneck problem of tumor therapy.

关键词： heterogeneous nanorods Pd-Au photothermal therapy bioorthogonal catalysis peroxidase-mimic activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：