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Context-dependent role of sirtuin 2 in inflammation

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Neural Regeneration Research 2025年第3期20卷 682-694页

作者： NoemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado Elena Puerta Department of Pharmaceutical Sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain Navarra Institute for Health Research(IdiSNA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation NLRP3 nuclear factorκB sirtuin 2

Recent advances in essential oils and their nanoformulations for poultry feed

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1802-1819页

作者： Fatemeh Movahedi Nilesh Nirmal Pengyuan Wang Hongping Jin Lisbeth Grondahl Li Li Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD 4072Australia Institute of nutrition Mahidol University999 Phutthamonthon 4 RoadSalayaNakhon Pathom 73170Thailand Oujiang laboratory Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhou 325000ZhejiangChina JECHO Biopharmaceuticals Co. Ltd.No.2633Zhongbin AvenueSino‑Singapore Tianjin Eco‑cityBinhai New AreaTianjinChina School of Chemistry and Molecular biosciences The University of QueenslandBrisbaneQLD 4072Australia

Antibiotics in poultry feed to boost growth performance are becoming increasingly contentious due to concerns over antimicrobial resistance *** oils(EOs),as natural,plant-derived compounds,have demonstrated antimicrobial and antioxidant *** may potentially improve poultry health and growth performance when included in poultry ***,the incorporation of EOs as nutritional additives is hindered by their high volatility,low water solubility,poor intestinal absorption,and sensitivity to environmental ***,nanoencapsulation strategies using nanoformulations have emerged as a potential solution to these challenges,improving the stability and bioavailability of EOs,and enabling targeted delivery in poultry *** review provides an overview of the antioxidant and antibacterial properties of EOs,the current limitations of their applications in poultry feed,and the recent advancements in nano-engineering to overcome these ***,we outline the potential future research direction on EO nanoformulations,emphasizing their promising role in advancing sustainable poultry nutrition.

关键词： Antibacterial activities Antioxidants Essential oils Nanoformulations Poultry additives

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and pharmacology Karolinska InstitutetStockholmSweden Department of biosciences and nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

MicroRNAs as novel molecular targets of green tea polyphenol epigallocatechin-3-gallate(EGCG): relevance and importance to nutrition sciences and cancer prevention

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Food Science and Human Wellness 2024年

作者： Yu Li Q.Ping Dou Bo Li Yongli Wang Xiushan Wang Hui Guan Dapeng Li Feng Li College of Food Science and Engineering， Shandong Agricultural University Key laboratory of Food nutrition and Human Health in Universities of Shandong Barbara Ann Karmanos Cancer Institute， Departments of Oncology， pharmacology and Pathology， Wayne State University School of Medicine Jinan Vocational College of Nursing

MicroRNAs (miRNAs) are a class of single-stranded and non-coding endogenous RNAs with 18-25 nucleotides in length. By binding to the complementary sequences in the 3’untranslated region (3’UTR) of protein coding genes， miRNAs regulate posttranscriptionally the mRNA expression of target genes and enzymes involved in various biological processes. The application of high-throughput sequencing， bioinformatics analysis， and novel detection methods has high-lighted promising roles of miRNAs as both novel biomarkers for tumor diagnosis and critical regulators involved in almost all stages of carcinogenesis including cancer initiation， promotion and progression. Epigallocatechin-3-gallate (EGCG)， the most investigated active catechin in green tea， has been linked to various health-promoting benefits including chemoprevention and treatment of cancers. In this review， we first present a brief description of EGCG and its major metabolic pathway. It is followed by reviewing the roles of EGCG in the modulation of oncogenic and tumor suppressing miRNAs in some common cancers. These findings suggest that the capacity of EGCG to regulate expression of specific miRNAs provides insights of its new mechanisms of action underlying its chemopreventive and potential beneficial activities against various cancers.

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Alternative therapeutic strategies in diabetes management

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World Journal of Diabetes 2024年第6期15卷 1142-1161页

作者： Alessia Annicchiarico Barbara Barile Cinzia Buccoliero Grazia Paola Nicchia Giacomina Brunetti Department of biosciences Biotechnologies and EnvironmentUniversity of Bari Aldo MoroBari 70125Italy

Diabetes is a heterogeneous metabolic disease characterized by elevated blood glucose levels resulting from the destruction or malfunction of pancreaticβcells,insulin resistance in peripheral tissues,or both,and results in a non-sufficient production of *** adjust blood glucose levels,diabetic patients need exogenous insulin administration together with medical nutrition therapy and physical *** the aim of improving insulin availability in diabetic patients as well as ameliorating diabetes comorbidities,different strategies have been *** first approaches included enhancing endogenousβcell activity or transplanting new *** protocol for this kind of intervention has recently been optimized,leading to standardized *** is indicated for diabetic patients with severe hypoglycemia,complicated by impaired hypoglycemia awareness or exacerbated glycemic *** has been associated with improvement in all comorbidities associated with diabetes,quality of life,and ***,different trials are ongoing to further improve the beneficial effects of ***,to overcome some limitations associated with the availability of islets/pancreas,alternative therapeutic strategies are under evaluation,such as the use of mesenchymal stem cells(MSCs)or induced pluripotent stem cells for *** cotransplantation of MSCs with islets has been successful,thus providing protection against proinflammatory cytokines and hypoxia through different mechanisms,including exosome *** use of induced pluripotent stem cells is recent and requires further *** advantages of MSC implantation have also included the improvement of diabetes-related comorbidities,such as wound *** the number of advantages of the direct injection of MSCs,new strategies involving biomaterials and scaffolds have been developed to improve the efficacy of mesenchymal cell delivery with promising resul

关键词： Diabetes Pancreas/islet transplantation Mesenchymal stem cells Induced pluripotent stem cells Exosomes Scaffolds

Exploring a novel class tryptophan hydroxylase 1 inhibitor derived from Sambucus williamsii Hance for the osteoporosis treatment

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Acupuncture and Herbal Medicine 2024年第1期4卷 102-112页

作者： Yu-Xin Zhu Zi-Ling Tang Lu Lu Zuo-Cheng Qiu Dabo Pan Yang Yu Hui-Hui Xiao Man-Sau Wong State Key laboratory of Chinese Medicine and Molecular pharmacology(Incubation) The Hong Kong Polytechnic University Shenzhen Research InstituteShenzhenChina Guangzhou Key laboratory of Formula-Pattern of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Guangdong Provincial Key laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhouChina Department of Food Science and nutrition The Hong Kong Polytechnic UniversityHong KongChina Research Center for Chinese Medicine Innovation The Hong Kong Polytechnic UniversityHong KongChina

Objective:Gut-derived serotonin strongly inhibits bone formation by inhibiting osteoblast *** previous study demonstrated that the lignan-rich fraction prepared from Sambucus willimasii Hance,a folk herbal medicine used to treat bone fractures and joint diseases in China,exerted bone-protective effects,and its actions were modulated by suppressing the synthesis of gut-derived serotonin via the inhibition of intestinal tryptophan hydroxylase 1(TPH-1).However,there is no direct evidence for the action of lignans on *** study aimed to verify the direct action of lignans on the TPH-1 and its influence on serotonin synthesis and bone ***:Molecular docking and surface plasmon resonance were performed to determine the affinities of lignans to *** cell viability and the protein activity and expression of TPH-1 were measured in RBL2H3 *** serum serotonin level and bone mineral density upon lignan treatment in ovariectomized mice were ***:The lignans showed high binding scores and binding affinities to TPH-1,inhibited the activity and protein expression of TPH-1,suppressed the serum serotonin levels in ovariectomized mice as well as promoted bone mineral ***:This is the first study to report that lignans are novel TPH-1 inhibitors and that these lignans could be potential agents for the management of serotonin-related diseases,including osteoporosis.

关键词： Lignan Osteoporosis Sambucus williamsii Hance Serotonin TPH-1 inhibitor

Bacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1980-1995页

作者： Koki Nishihara Clothilde Villot Lautaro Cangiano Le Luo Guan Michael Steele Department of Animal biosciences Animal Science and NutritionUniversity of GuelphGuelphON N1G 1Y2Canada Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada Lallemand SAS Blagnac F‑31702France Department of Animal and Dairy Sciences University of Wisconsin-MadisonMadisonWIUSA Faculty of Land and Food Systems The University of British ColumbiaVancouverBC V6T 1Z4Canada Present Address:Department of Animal biosciences University of GuelphGuelphON N1G 2W1Canada

Background As Holstein calves are susceptible to gastrointestinal disorders during the first week of life,understanding how intestinal immune function develops in neonatal calves is important to promote better intestinal *** probiotics in early life may contribute to host intestinal health by facilitating beneficial bacteria colonization and developing intestinal immune *** objective of this study was to characterize the impact of early life yeast supplementation and growth on colon mucosa-attached bacteria and host immune *** Twenty Holstein bull calves received no supplementation(CON)or Saccharomyces cerevisiae boulardii(SCB)from birth to 5 d of *** tissue biopsies were taken within 2 h of life(D0)before the first colostrum feeding and 3 h after the morning feeding at d 5 of age(D5)to analyze mucosa-attached bacteria and colon *** sequencing showed that there was no difference inαandβdiversity of mucosa-attached bacteria between day and treatment,but bacteria related to diarrhea were more abundant in the colon mucosa on D0 compared to *** addition,q PCR indicated that the absolute abundance of Escherichia coli(***)decreased in the colon mucosa on D5 compared to D0;however,that of Bifidobacterium,Lactobacillus,and Faecalibacterium prausnitzii,which could competitively exclude ***,increased in the colon mucosa on D5 compared to ***-sequencing showed that there were no differentially expressed genes between CON and SCB,but suggested that pathways related to viral infection such as“Interferon Signaling”were activated in the colon mucosa of D5 compared to *** Growth affected mucosa-attached bacteria and host immune function in the colon mucosa during the first 5 d of life in dairy calves independently of SCB *** early life,opportunistic pathogens may decrease due to intestinal environmental changes by beneficial bacteria and/or host immune *** activation

关键词： Colon biopsy Dairy calves RNA-sequencing Saccharomyces cerevisiae boulardii 16S rRNA amplicon-sequencing

MicroRNAs in inflammatory bowel disease:What do we know and what can we expect?

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World Journal of Gastroenterology 2024年第16期30卷 2184-2190页

作者： Ellen Cristina Souza de Oliveira Ana Elisa Valencise Quaglio Thais Gagno Grillo Luiz Claudio Di Stasi Ligia Yukie Sassaki Department of Internal Medicine Medical SchoolSão Paulo State University(Unesp)Botucatu 18618-686São PauloBrazil Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Biophysics and pharmacology Institute of BiosciencesSão Paulo State University(Unesp)Botucatu 18618-689São PauloBrazil

MicroRNAs(miRNAs),small non-coding RNAs composed of 18–24 nucleotides,are potent regulators of gene expression,contributing to the regulation of more than 30%of protein-coding *** that miRNAs are regulators of inflammatory pathways and the differentiation of intestinal epithelial cells,there is an interest in exploring their importance in inflammatory bowel disease(IBD).IBD is a chronic and multifactorial disease of the gastrointestinal tract;the main forms are Crohn's disease and ulcerative *** studies have investigated the dysregulated expression of miRNAs in IBD,demonstrating their important roles as regulators and potential biomarkers of this *** editorial presents what is known and what is expected regarding miRNAs in *** the important regulatory roles of miRNAs in IBD are clearly established,biomarkers for IBD that can be applied in clinical practice are lacking,emphasizing the importance of further *** regarding the influence of miRNAs on the inflammatory process and the exploration of their role in gene regulation are expected to provide a basis for the use of miRNAs not only as potent biomarkers in IBD but also as therapeutic targets for the control of inflammatory processes in personalized medicine.

关键词： MicroRNAs Inflammatory bowel disease Crohn’s disease Ulcerative colitis Biomarker Therapy

Disparities in Prevalence and Determinants of Hypertension amongst Bamiléké Adults Residing in Two Different Agroecological Zones of Cameroon

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Open Journal of Epidemiology 2024年第3期14卷 419-443页

作者： Maxwell Wandji Nguedjo Nanhah Kamga Jules Vidal Alice Louise Woguia Pauline Vervaine Hagbe David Goda Dany Joël Ngassa Ngoumen Hippolyte Tene Mouafo Boris Gabin Kingue Azantsa Judith Laure Ngondi Julius Enyong Oben Department of Biochemistry Faculty of Sciences University of Yaounde I Yaounde Cameroon laboratory of Epidemiology and nutritional Status Centre for Food Food Security and Nutrition Research Institute of Medical Research and Medicinal Plant Studies Yaounde Cameroon Department of pharmacology Faculty of Health Sciences School of Clinical Medicines University of Fee State Bloemfontein South Africa laboratory Development of Food Technology Centre for Food Food Security and Nutrition Research Institute of Medical Research and Medicinal Plant Studies Yaounde Cameroon

Background: Cardiovascular diseases such as hypertension (HTN) are one of the main causes of death in Cameroon. This study aimed at assessing prevalence disparities and determinants of hypertension amongst Bamiléké adults residing in two different agroecological zones of Cameroon. Methods: A cross-sectional and descriptive survey was conducted among Bamiléké population living in the Highlands zone (Western region) and in the Monomodal Rainforest zone (Littoral region) of Cameroon from August 2016 to August 2017. Participants (962) were aged at least 20 years old. Data on sociodemographic, hemodynamic, anthropometric, and biochemical parameters and lifestyle of the participants were collected. Results: Results obtained revealed that 34.2% were hypertensive and those residing in the highland zone were more affected than those living in the monomodal rainforest zone (44.5% vs 22.9%). The different subtypes of HTN (Isolated systolic hypertension (14.1%), isolated diastolic hypertension (7.2%) and Systo-diastolic hypertension (23.3%)) were also more prevalent in the Highlands Zone. The most prevalent stage of HTN was pre-HTN (31.5%). However, people living in the monomodal rainforest zone were more affected by pre-HTN compared to Bamiléké living in the highland zone (33.6% vs. 29.6%). Results also showed that high consumption (≥ 3 times/week) of carbohydrate- and fat-rich foods, ageing, obesity, and marital status were associated with high blood pressure in both agroecological zones. Besides, secondary education (OR = 0.68;95% CI: 0.42 - 0.99) in the Highlands Zone and high (≥3 times/week) vegetable consumption (OR = 0.66;95% CI: 0.44 - 0.98) in the Monomodal Rainforest Zone had a protective effect on elevated blood pressure of population. Conclusion: There is a disparity in the prevalence of hypertension and some of its determinants among Bamiléké adults residing in different agroecological zones. This work highlights the need to advocate for local and ethno-cultural he

关键词： Hypertension Disparities Determinants Bamiléké Ethnic Group Agroecological Zone