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DNA vaccine prime and replicating vaccinia vaccine boost induce robust humoral and cellular immune responses against MERS-CoV in mice

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Virologica Sinica 2024年第3期39卷 490-500页

作者： Xiuli Shen Shuhui Wang Yanling Hao Yuyu Fu Li Ren Dan Li Wenqi Tang Jing Li Ran Chen Meiling Zhu Shuo Wang Ying Liu Yiming Shao National Key laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Changping laboratory Yard 28Science Park RoadChangping DistrictBeijing 102206China State Key laboratory for Diagnosis and Treatment of Infectious diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

As of December 2022,2603 laboratory-identified Middle East respiratory syndrome coronavirus(MERS-CoV)infections and 935 associated deaths,with a mortality rate of 36%,had been reported to the World Health Organization(WHO).However,there are still no vaccines for MERS-CoV,which makes the prevention and control of MERS-CoV *** this study,we generated two DNA vaccine candidates by integrating MERS-CoV Spike(S)gene into a replicating Vaccinia Tian Tan(VTT)*** to homologous immunization with either vaccine,mice immunized with DNA vaccine prime and VTT vaccine boost exhibited much stronger and durable humoral and cellular immune *** immunized mice produced robust binding antibodies and broad neutralizing antibodies against the EMC2012,England1 and KNIH strains of ***-Boost immunization also induced strong MERS-S specific T cells responses,with high memory and poly-functional(CD107a-IFN-γ-TNF-α)effector CD8t T *** conclusion,the research demonstrated that DNA-Prime/VTT-Boost strategy could elicit robust and balanced humoral and cellular immune responses against *** study not only provides a promising set of MERS-CoV vaccine candidates,but also proposes a heterologous sequential immunization strategy worthy of further development.

关键词： MERS-CoV VTT vaccine DNA vaccine Humoral and cellular immune responses Prime/boost strategy

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A Case of Brucellosis Concomitant with Severe Fever with Thrombocytopenia Syndrome—Weifang City,Shandong Province,China,2023

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China CDC weekly 2024年第27期6卷 677-680页

作者： Qingqing Xu Cuiping Wu Hui Liu Chao Geng Jinhui Zhang Dongri Piao Hongyan Zhao Yu Fan Guozhong Tian Hai Jiang National Key laboratory of Intelligent Tracing and Forecasting for Infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of Infectious diseases Yidu Central Hospital of WeifangWeifang CityShandong ProvinceChina Institute of Bacterial Disease Jinan Center for Disease Control and PreventionJinan CityShandong ProvinceChina Tongliao Center for Disease Control and Prevention Tongliao CityInner Mongolia Autonomous RegionChina

Summary What is already known about this topic?Brucellosis and severe fever with thrombocytopenia syndrome(SFTS)are neglected zoonoses,attributable respectively to Brucella and the SFTS virus(SFTSV).While the incidence of these diseases has been rising,instances of co-infection remain *** is added by this report?This represents the first documented case of a rare coinfection involving Brucella and SFTSV.

关键词： neglected instance Shandong

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Geographically and Temporally Weighted Regression in Assessing Dengue Fever Spread Factors in Yunnan Border Regions

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Biomedical and Environmental Sciences 2024年第5期37卷 511-520页

作者： ZHU Xiao Xiang WANG Song Wang LI Yan Fei ZHANG Ye Wu SU Xue Mei ZHAO Xiao Tao National Key laboratory of Intelligent Tracking and Forecasting for Infectious diseases Chinese Center for Disease Control and PreventionBeijing 102211China Yunnan Institute of Parasitic diseases Pu’er 665000YunnanChina

Objective This study employs the Geographically and Temporally Weighted Regression(GTWR)model to assess the impact of meteorological elements and imported cases on dengue fever outbreaks,emphasizing the spatial-temporal variability of these factors in border *** We conducted a descriptive analysis of dengue fever’s temporal-spatial distribution in Yunnan border *** annual data from 2013 to 2019,with each county in the Yunnan border serving as a spatial unit,we constructed a GTWR model to investigate the determinants of dengue fever and their spatio-temporal heterogeneity in this *** The GTWR model,proving more effective than Ordinary Least Squares(OLS)analysis,identified significant spatial and temporal heterogeneity in factors influencing dengue fever’s spread along the Yunnan ***,the GTWR model revealed a substantial variation in the relationship between indigenous dengue fever incidence,meteorological variables,and imported cases across different *** In the Yunnan border areas,local dengue incidence is affected by temperature,humidity,precipitation,wind speed,and imported cases,with these factors’influence exhibiting notable spatial and temporal variation.

关键词： Dengue fever Meteorological factor Geographically and temporally weighted regression

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Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration

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Chinese Chemical Letters 2024年第6期35卷 358-364页

作者： Xin Zhang Junyu Chen Xiang Pei Linxin Yang Liang Wang Luona Chen Guangmei Yang Xibo Pei Qianbing Wan Jian Wang State Key laboratory of Oral diseases National Clinical Research Center for Oral DiseasesChengdu 610041China Department of Prosthodontics West China Hospital of StomatologySichuan UniversityChengdu 610041China

Surface modification of microporous bone scaffolds using nanoparticles has been broadly studied in bone tissue *** at improving vascularized bone regeneration(VBR),zeolitic imidazolate framework-8(ZIF-8)was encapsulated with dimethyloxallyl glycine(DMOG)and the drug-carrying nanoparticles(D@Z)could be uniformly coated onto the surface of the bone *** osteogenic and angiogenic actions of D@Z are closely correlated with the amount of slowly released DMOG,and in general,exhibited a favorable ***,the D7.5@Z group,which showed the greatest capacity to induce in vitro osteogenesis-angiogenesis coupling,was utilized for surface modification of the bone *** processes including phosphate-containing compound metabolic process,cell differentiation,cell proliferation and cell motility might contribute to enhanced ability to induce VBR by the coated scaffold and signaling pathways such as Rap1,Ras,phosphatidylinositol 3-kinase/protein kinase B(PI3K-AKT)and vascular endothelial growth factor(VEGF)signaling pathways participated in these ***,as depicted by in vitro real time-polymerase chain reaction(RT-PCR),Western blot(WB)and in vivo cranial bone defect model,the microporous scaffold coated with nano-D7.5@Z greatly promoted *** conclude,nano-D@Z has significant promise for practical application in modification of microporous bone scaffolds to enhance VBR,and DMOG loading quantity has a beneficial influence on D@Z to improve osteogenesis-angiogenesis coupling.

关键词： Drug-loading nanoparticles Surface coating Microporous bone scaffold Vascularization bone regeneration

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Prognostic significance of SOX2 for chemotherapeutic patients with oral squamous cell carcinoma

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Journal of Pharmaceutical Analysis 2024年第4期14卷 619-621页

作者： Xuefeng Zhang Hao Xu Tong Zhou Xiaodong Feng Qianming Chen State Key laboratory of Oral diseases National Center of StomatologyNational Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China

Oral squamous cell carcinoma(OSCC)is the most common oral cancers worldwide,accounting for over 90%of all oral malignancies[1].Despite encouraging improvements in therapeutic approaches,including surgical resection,chemotherapy,and radiotherapy,the five-year overall survival rate of OSCC has not been improved significantly over the past decades,mainly due to the high ratio of tumor recurrence and metastasis.

关键词： SOX2 therapeutic squamous

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p38 Signaling Mediates Naringin-Induced Osteogenic Differentiation of Porcine Metanephric Mesenchymal Cells

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Chinese Journal of Integrative Medicine 2024年第9期30卷 818-825页

作者： JI Peng-cheng XIE Yuan-sheng GUO Wen-kai FU Bo CHEN Xiang-mei Chinese PLA Medical School Beijing100853China Department of Nephrology First Medical Center of Chinese PLA General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney DiseasesBeijing100853China School of Medicine Nankai UniversityTianjin300071China

Objective:To explore the potential of metanephric mesenchymal cells(MMCs)for osteogenesis and naringin’s ability to enhance this process and its molecular ***:Porcine MMCs at 70 days of gestation were used as tool cells,cultured in osteogenic induction medium,identified by immunocytochemistry *** potential of porcine MMCs and naringin’s ability to enhance this process was tested by detecting changes in cell viability,alkaline phosphatase(ALP)activity,the expression of runt-related transcription factor 2(Runx2),osteopontin(OPN)and osteocalcin(OCN),and the formation of mineralized nodules,and the application of the p38 signaling pathway inhibitor SB203580 vitiated the osteogenesis-promoting effect of ***:Immunocytochemical staining showed that the cells were Vimentin and Six2(+),E-cadherin and CK-18(−).Naringin can activate the p38 signaling pathway to enhance the osteogenesis of porcine MMCs by increasing cell viability,ALP activity,the expressions of Runx2,OPN and OCN,and the formation of mineralized nodules(P<0.05).The application of p38 signaling pathway inhibitor SB203580 vitiated the osteogenesis-promoting effect of naringin,manifested by decreased ALP activity,the expressions of Runx2,OPN and OCN,and the formation of mineralized nodules(P<0.05).Conclusion:Naringin,the active ingredient of Chinese herbal medicine Rhizoma Drynariae for nourishing Shen(Kidney)and strengthening bone,enhances the osteogenic differentiation of renal MMCs through the p38 signaling pathway.

关键词： metanephric mesenchymal cells naringin osteogenesis differentiation

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Variations in the Prevalence of Anemia of Varying Severity Among Urban non-Pregnant Women—China,2021

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China CDC weekly 2024年第10期6卷 175-180页

作者： Xiaoxi Liu Bo Wang Sailimai Man Heling Bao Yuanyuan Huang Canqing Yu Jun Lyu Linhong Wang Liming Li Hui Liu Institute of Medical Information Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Peking University Health Science Center Meinian Public Health Institute BeijingChina Meinian Institute of Health BeijingChina Peking University Center for Public Health and Epidemic Preparedness&Response BeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Key laboratory of Epidemiology of Major diseases(Peking University) Ministry of EducationBeijingChina National Center for Chronic and non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Anemia is a significant public health issue affecting women *** studies in China predominantly concentrated on anemia in pregnant or reproductiveage women,leaving a gap i... 详细信息

关键词： Anemia anemia China.

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Efficacy of substances containing 3 types of active ingredients-saponins, flavones, and alkaloids in regulation of cytokines in autoimmune diseases a systematic review and Meta-analysis based on animal studies

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Journal of Traditional Chinese Medicine 2024年第3期44卷 417-426页

作者： ZHU Ruifang ZHANG Jun LYU Yaru CHEN Yulu HAN Shifan WANG Hongwei Key laboratory for Molecular Diagnosis and Treatment of Hematologic diseases Second Hospital of Shanxi Medical UniversityShanxi 030001China School of Nursing Shanxi Medical UniversityShanxi 030001China Editorial Office First Hospital of Shanxi Medical UniversityShanxi 030001China

OBJECTIVE: To investigate the efficacy of substances containing 3 types of active ingredients-saponins,flavones, and alkaloids on experimental animals with autoimmune diseases(AIDs).METHODS: The protocol for this systematic review and Meta-analysis was prospectively registered with PROSPERO(CRD42023395741). Searches were conducted in the China National Knowledge Infrastructure, Wanfang, Chinese Science and Technology Journals, China Biomedical, Pub Med,Cochrane Library, and Embase databases to screen for animal studies investigating the therapeutic effects of saponins, flavones, or alkaloids on autoimmune diseases;consequently, corresponding data extraction tables were prepared. Systematic Review Centre for laboratory Animal Experimentation was used to assess the risk of methodological bias in the included literature. RevMan 5.4 was used for the Meta-analysis on the 8 serum ***: A total of 31 studies were included, all of which were randomized controlled studies. Meta-analysis indicated that substances rich in saponins, flavones, and alkaloids reduced serum levels of interleukin(IL)-1β[standardized mean difference(SMD) =-1.94, 95%confidence interval(CI)(-2.99,-0.90), P = 0.0003], IL-6 [SMD =-1.65, 95% CI(-2.33,-0.97,) P diseases in the future.

关键词： autoimmune diseases saponins flavones alkaloids system evaluation Meta-analysis

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Mitochondria at the Crossroads of Cholestatic Liver Injury:Targeting Novel Therapeutic Avenues

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 792-801页

作者： Xutao Li Tianyin Ruan Siyuan Wang Xin Sun Chenghai Liu Yuan Peng Yanyan Tao Institute of Liver diseases Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Shanghai Key laboratory of Traditional Chinese Clinical Medicine ShanghaiChina Key laboratory of Liver and Kidney diseases Ministry of EducationShanghaiChina

Bile acids are byproducts of cholesterol metabolism in the liver and constitute the primary components of *** of bile flow leads to cholestasis,characterized by the accumulation of hydrophobic bile acids in the liver and *** accumulation can exacerbate liver *** review discussed recent developments in understanding how bile acids contribute to liver damage,including disturbances in mitochondrial function,endoplasmic reticulum stress,inflammation,and autophagy *** play a pivotal role in cholestatic liver injury by influencing hepatocyte apoptosis and *** findings linking bile acids to liver damage highlight new potential treatment targets for cholestatic liver injury.

关键词： Bile acids Mitochondria Endoplasmic reticulum Inflammatory Cholestatic liver injury Review

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Decoding m^(6)A mRNA methylation by reader proteins in liver diseases

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Genes & diseases 2024年第2期11卷 711-726页

作者： Lijiao Sun Xin Chen Sai Zhu Jianan Wang Shaoxi Diao Jinyu Liu Jinjin Xu Xiaofeng Li Yingyin Sun Cheng Huang Xiaoming Meng Xiongwen Lv Jun Li Inflammation and Immune Mediated diseases laboratory of Anhui Province Anhui Institute of Innovative DrugsSchool of PharmacyAnhui Medical UniversityHefeiAnhui 230032China The Key laboratory of Anti-inflammatory and Immune Medicines Anhui Medical UniversityMinistry of EducationHefeiAnhui 230032China Institute for Liver diseases of Anhui Medical University ILD-AMUAnhui Medical UniversityHefeiAnhui 230032China Department of Nephropathy The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230032China

N6-methyladenosine(m^(6)A)is a dynamic and reversible epigenetic *** the most prevalent internal post-transcriptional modification in eukaryotic RNA,it participates in the regulation of gene expression through various mechanisms,such as mRNA splicing,nuclear export,localization,translation efficiency,mRNA stability,and structural *** involvement of m^(6)A in the regulation of gene expression depends on the specific recognition of m^(6)A-modified RNA by reader *** the pathogenesis and treatment of liver disease,studies have found that the expression levels of key genes that promote or inhibit the development of liver disease are regulated by m^(6)A modification,in which abnormal expression of reader proteins determines the fate of these gene *** this review,we introduce m^(6)A readers,summarize the recognition and regulatory mechanisms of m^(6)A readers on mRNA,and focus on the biological functions and mechanisms of m^(6)A readers in liver cancer,viral hepatitis,non-alcoholic fatty liver disease(NAFLD),hepatic fibrosis(HF),acute liver injury(ALI),and other liver *** information is expected to be of high value to researchers deciphering the links between m^(6)A readers and human liver diseases.

关键词： IGF2BPs Liver diseases m^(6)A modification m^(6)A reader mRNA metabolism YTH domain protein

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