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A time-synchronized multimodal monitoring system for general anesthesia

Medicine in Novel Technology and Devices 2024年第3期23卷 116-127页

作者： Zhenhu Liang Guanwei Geng Qifeng Song Mengmeng Tang Institute of Electrical Engineering Yanshan UniversityQinhuangdao066004China Key laboratory of Intelligent Rehabilitation and neuromodulation of Hebei Province Qinhuangdao066004China

In clinical settings,different kinds of patient monitoring systems and depth of anesthesia monitoring(DoA)systems have been widely used to assess the depth of sedation and patient's ***,all these monitoring systems are independent of each *** date,no monitoring system has focused on the synchronized neural activities,cerebral metabolism,autonomic nervous system,and drug effects on the brain,as well as their interactions between neural activities and cerebral metabolism(i.e.,neurovascular coupling),and between brain and heart(i.e.,brain-heart coupling).In this study,we developed a time-synchronized multimodal monitoring system(TSMMS)that integrates electroencephalogram(EEG),near-infrared spectroscopy(NIRS),and standard physiological monitors(electrocardiograph,blood pressure,oxygen saturation)to provide a comprehensive view of the patient's physiological state during *** coherence and Granger causality(GC)methods were used to quantify the neurovascular coupling and brain-heart *** response surface model was used to estimate the combined propofol-remifentanil drug effect on the *** integrates data from various devices for a comprehensive analysis of vital *** enhances anesthesia monitoring through detailed EEG features,neurovascular,and brain-heart coupling ***,a response surface model estimates the combined effects of propofol and remifentanil,aiding anesthesiologists in drug *** conclusion,TSMMS provides a new tool for studying the coupling mechanism among neural activities,cerebral metabolism,and autonomic nervous system during general anesthesia.

关键词： General anesthesia Multimodal monitoring system Time-synchronized Neurovascular coupling Brain-heart coupling

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Tetherless Optical neuromodulation:Wavelength from Orange-red to Mid-infrared

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Neuroscience Bulletin 2024年第8期40卷 1173-1188页

作者： Chao Sun Qi Fan Rougang Xie Ceng Luo Bingliang Hu Quan Wang Key laboratory of Spectral Imaging Technology Xi'an Institute of Optics and Precision Mechanics(XIOPM)Chinese Academy of SciencesXi'an 710119China Key laboratory of Biomedical Spectroscopy of Xi'an Key Laboratory of Spectral Imaging TechnologyXIOPMChinese Academy of SciencesXi'an 710119China Department of Neurobiology School of Basic MedicineFourth Military Medical UniversityXi'an 710032China

Optogenetics,a technique that employs light for neuromodulation,has revolutionized the study of neural mechanisms and the treatment of neurological disorders due to its high spatiotemporal resolution and cell-type ***,visible light,particularly blue and green light,commonly used in conventional optogenetics,has limited penetration in biological *** limitation necessitates the implantation of optical fibers for light delivery,especially in deep brain regions,leading to tissue damage and experimental *** overcome these challenges,the use of orange-red and infrared light with greater tissue penetration has emerged as a promising approach for tetherless optical *** this review,we provide an overview of the development and applications of tetherless optical neuromodulation methods with long *** first discuss the exploration of orange-red wavelength-responsive rhodopsins and their performance in tetherless optical ***,we summarize two novel tetherless neuromodulation methods using near-infrared light:upconversion nanoparticle-mediated optogenetics and photothermal *** addition,we discuss recent advances in mid-infrared optical neuromodulation.

关键词： Optical neuromodulation Tetherless Orange-red wavelength responding rhodopsins Upconversion nanoparticle-mediated optogenetics Photothermal neuromodulation

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Functional near-infrared spectroscopy in non-invasive neuromodulation

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Neural Regeneration Research 2024年第7期19卷 1517-1522页

作者： Congcong Huo Gongcheng Xu Hui Xie Tiandi Chen Guangjian Shao Jue Wang Wenhao Li Daifa Wang Zengyong Li Beijing Advanced Innovation Center for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Beijing Key laboratory of Rehabilitation Technical Aids for Old-Age Disability National Research Center for Rehabilitation Technical AidsBeijingChina School of Mechatronic Engineering and Automation Foshan UniversityFoshanGuangdong ProvinceChina School of Rehabilitation Engineering Beijing College of Social AdministrationBeijingChina Key laboratory of Neuro-functional Information and Rehabilitation Engineering of the Ministry of Civil Affairs BeijingChina

Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson’s disease,and mental *** significant advances have been made in neuromodulation technologies,the identification of optimal neurostimulation paramete rs including the co rtical target,duration,and inhibition or excitation pattern is still limited due to the lack of guidance for neural *** r,the neural mechanism unde rlying neuromodulation for improved behavioral performance remains poorly ***,advancements in neuroimaging have provided insight into neuromodulation *** near-infrared spectroscopy,as a novel non-invasive optical brain imaging method,can detect brain activity by measuring cerebral hemodynamics with the advantages of portability,high motion tole rance,and anti-electromagnetic *** functional near-infra red spectroscopy with neuromodulation technologies offe rs an opportunity to monitor the cortical response,provide realtime feedbac k,and establish a closed-loop strategy integrating evaluation,feedbac k,and intervention for neurostimulation,which provides a theoretical basis for development of individualized precise neuro *** aimed to summarize the advantages of functional near-infra red spectroscopy and provide an ove rview of the current research on functional near-infrared spectroscopy in transcranial magnetic stimulation,transcranial electrical stimulation,neurofeedback,and braincomputer ***,the future perspectives and directions for the application of functional near-infrared spectroscopy in neuromodulation are *** conclusion,functional near-infrared spectroscopy combined with neuromodulation may promote the optimization of central pellral reorganization to achieve better functional recovery form central nervous system

关键词： brain-computer interface cerebral neural networks functional near-infrared spectroscopy neural circuit neurofeedback neurological diseases neuromodulation non-invasive brain stimulation transcranial electrical stimulation transcranial electrical stimulation

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Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty:a prospective,double-blind,pilot,randomised controlled trial

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General Psychiatry 2024年第2期37卷 224-233页

作者： Jie Yang Mingshu Tao Rongguang Liu Jiaxing Fang Chunyan Li Dexian Chen Qi Wei Xingyu Xiong Wenxin Zhao Wen Tan Yuan Han Hongxing Zhang He Liu Song Zhang Junli Cao Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Hospital of Chengdu University of Traditional Chinese Medicine&Traditional Chinese Medicine Hospital of Sichuan ProvinceChengduSichuanChina NMPA Key laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs&Jiangsu Province Key laboratory of Anesthesiology&Jiangsu Key laboratory of Applied Technology of Anesthesia and Analgesia Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Eye&ENT Hospital of Fudan UniversityShanghaiChina Department of Anesthesiology&Clinical Research Center for Anesthesia and Perioperative Medicine&Huzhou Key laboratory of Basic Research and Clinical Translation for neuromodulation The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University||Huzhou Central Hospital||The Affiliated Huzhou HospitalZhejiang University School of Medicine||Affiliated Central Hospital Huzhou UniversityHuzhouZhejiangChina Department of Anesthesiology Renji Hospital School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Postoperative sleep disturbance(PSD)is a common and serious postoperative complication and is associated with poor postoperative *** This study aimed to investigate the effect of transcranial direct current stimulation(tDCS)on PSD in older patients undergoing lower limb major *** In this prospective,double-blind,pilot,randomised,sham-controlled trial,patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS(a-tDCS)or sham tDCS(s-tDCS).The primary outcomes were the objective sleep measures on postoperative nights(N)1 and *** 116 inpatients were assessed for eligibility,and a total of 92 patients were enrolled;47 received a-tDCS and 45 received *** improved PSD by altering the following sleep measures in the a-tDCS and s-tDCS groups;the respective comparisons were as follows:the promotion of rapid eye movement(REM)sleep time on N1(64.5(33.5-105.5)vs 19.0(0.0,45.0)min,F=20.10,p<0.001)and N2(75.0(36.0-120.8)vs 30.0(1.3-59.3)min,F=12.55,p<0.001);the total sleep time on N1(506.0(408.0-561.0)vs 392.0(243.0-483.5)min,F=14.13,p<0.001)and N2(488.5(455.5-548.5)vs 346.0(286.5-517.5)min,F=7.36,p=0.007);the deep sleep time on N1(130.0(103.3-177.0)vs 42.5(9.8-100.8)min,F=24.4,p<0.001)and N2(103.5(46.0-154.8)vs 57.5(23.3-106.5)min,F=8.4,p=0.004);and the percentages of light sleep and REM sleep on N1 and N2(p<0.05 for each).The postoperative depression and anxiety scores did not differ significantly between the two *** significant adverse events were *** In older patients undergoing lower limb major arthroplasty,a single session of anodal tDCS over the left dorsolateral prefrontal cortex showed a potentially prophylactic effect in improving postoperative short-term objective sleep ***,this benefit was temporary and was not maintained over time.

关键词： sleep stimulation postoperative

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Variable frequency deep brain stimulation of subthalamic nucleus to improve freezing of gait in Parkinson's disease

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National Science Review 2024年第6期11卷 102-104页

作者： Fumin Jia Aparna Wagle Shukla Wei Hu Yu Ma Jianguo Zhang Leonardo Almeida Chris Kao Yi Guo Shizhong Zhang Yingqun Tao Zhipei Ling Xin Xu Zhiquan Yang Fan-gang Meng Xinhua Wan Hesheng Liu Peter E.Konard Luming Li National Engineering laboratory for neuromodulation Tsinghua University University of Florida Center for Movement Disorders and Neurorestoration Tsinghua University Yuquan Hospital Beijing Tiantan Hospital Capital Medical University School of Medicine Vanderbilt University Peking Union Medical College Hospital ZhuJiang Hospital of Southern Medical University The General Hospital of Shenyang Military Chinese PLA General Hospital Xiangya Hospital Central South University Beijing Neurosurgical Institute Capital Medical University Athinoula A. Martinos Center for Biomedical Imaging Harvard Medical School Precision Medicine & Healthcare Research Center Tsinghua-Berkeley Shenzhen Institute Man-Machine-Environment Engineering Institute School of Aerospace EngineeringTsinghua University Center of Epilepsy Beijing Institute for Brain Disorders

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a welle-stablished therapy for patients with Parkinson’s disease (PD) presenting with medication refractory tremors, motor fluctuations and dyskinesias induced by dopaminergic medications [1]. However,traditional high-frequency stimulation(HFS) does not effectively control axial symptoms such as gait dysfunction,postural instability and freezing of gait(FOG)[2,3].

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Characteristics of the induced voltage between deep brain stimulation(DBS) device electrodes by a transcranial magnetic stimulation(TMS) device

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Science China(Technological Sciences) 2015年第6期58卷 1062-1071页

作者： LI QingFeng CHEN ShaoBo WANG WeiMing HAO HongWei LI LuMing School of Aerospace Tsinghua University National Engineering laboratory for neuromodulation Center of Epilepsy Beijing Institute for Brain Disorders

The combination of deep brain stimulation(DBS) and transcranial magnetic stimulation(TMS) is expected to provide additional insights into the pathophysiology of some brain diseases. However, when using TMS in patients with DBS implants, the induced voltage between DBS electrodes presents the greatest risk of brain damage. This paper describes the characteristics of the induced DBS electrode voltage due to TMS. We first examined the TMS stimulus signal and the DBS output impedance characteristics, and then experimentally investigated the induced DBS electrode voltage for various DBS and TMS conditions. The results show that many factors impact the induced electrode voltage. The induced electrode voltage with DBS device working in the unipolar mode is greater than that with DBS device working in the bipolar mode. No matter DBS device is turned on or turned off, the induced electrode voltage is almost the same, but it can provide a significant addition to the original stimulus waveform. There are no significant differences in the induced DBS electrode voltage when the DBS system is working at different stimulus intensities. Lowering the TMS stimulus intensity could effectively reduce the induced DBS electrode voltage. The induced electrode voltage is also strongly related to the position of the TMS coil relative to the DBS lead. This study provides further information about the characteristics of the induced DBS electrode voltage in TMS applications and a reference for the combined use of DBS and TMS.

关键词： deep brain stimulation transcranial magnetic stimulation induced electrode voltage signal characteristics electromagneticcompatibility

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Analysis of the optimal target node to reduce seizure-like discharge in networks

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Chinese Physics B 2024年第5期33卷 712-720页

作者：闫璐瑶张红慧孙中奎 School of Mathematics and Statistics Northwestern Polytechnical UniversityXi'an 710129China MIIT Key laboratory of Dynamics and Control of Complex Systems Xi'an 710129China

Network approaches have been widely accepted to guide surgical strategy and predict outcome for epilepsy *** study starts with a single oscillator to explore brain activity,using a phenomenological model capable of describing healthy and epileptic *** ictal number of seizures decreases or remains unchanged with increasing the speed of oscillator excitability and in each seizure,there is an increasing tendency for ictal duration with respect to the *** underlying reason is that the strong excitability speed is conducive to reduce transition behaviors between two attractor ***,the selection of the optimal removal node is estimated by an indicator proposed in this *** show that when the indicator is less than the threshold,removing the driving node is more possible to reduce seizures significantly,while the indicator exceeds the threshold,the epileptic node could be the removal ***,the driving node is such a potential target that stimulating it is obviously effective in suppressing seizure-like activity compared to other nodes,and the propensity of seizures can be reduced 60%with the increased stimulus *** results could provide new therapeutic ideas for epilepsy surgery and neuromodulation.

关键词： epilepsy driving node epileptic node seizure regulation

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Enhanced Beta2-band Oscillations Denote Auditory Hallucination in Schizophrenia Patients and a Monkey Model of Psychosis

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Neuroscience Bulletin 2024年第3期40卷 325-338页

作者： Shuo Ma Tianzhen Chen Wenjun Jia Jie Liu Shihan Ding Puzhe Li Hong Gan Dapeng Zhang Shuxin Shao Mu-Ming Poo Min Zhao Bomin Sun Jian Jiang Department of Neurosurgery Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200020China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai200030China Shanghai Center for Brain Science and Brain-inspired Technology Lingang LaboratoryShanghai201602China University of California at Berkeley BerkeleyCA94720USA School of Life Science and Technology ShanghaiTech UniversityShanghai201210China Institute of Neuroscience CAS Center for Excellence in Brain Science and Intelligence TechnologyCAS Key Laboratory of Primate NeurobiologyState Key Laboratory of NeuroscienceChinese Academy of SciencesShanghai200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Lingang LaboratoryShanghai201210China Fuyang Third People’s Hospital Fuyang Mental Health CenterFuyang236052China Shanghai Key laboratory of Psychotic Disorders Shanghai200030China Institute of Psychological and Behavioral Science Shanghai Jiao Tong UniversityShanghai200030China Shanghai Quanlan Technology Co. LtdShanghai201602China

An electroencephalographic(EEG)signature of auditory hallucinations(AHs)is important for facilitating the diagnosis and treatment of AHs in *** recorded EEG from 25 schizophrenia patients with recurrent *** the period of AHs,EEG recordings exhibited significantly elevated beta2-band power in the temporal region,as compared to those recorded in the absence of AHs or during stimulation with verbal *** further generated methamphetamine-treated rhesus monkeys exhibiting psychosis-like behaviors,including repetitive sudden searching actions in the absence of external intrusion,suggesting the occurrence of *** EEG beta2-band power in the temporal region of these monkeys was enhanced immediately after methamphetamine treatment and positively correlated with the frequency of sudden searching ***,the enhancement of temporal beta2-band oscillations represents a signature for AHs in both patients and a monkey model of psychosis,and this monkey model can be used for developing closed-loop neuromodulation approaches for the treatment of refractory AHs in schizophrenia.

关键词： Schizophrenia Auditory hallucinations Non-human primate Methamphetamine Electroencephalography

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Opportunities and challenges for developing closed-loop bioelectronic medicines

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Neural Regeneration Research 2019年第1期14卷 46-50页

作者： Patrick D.Ganzer Gaurav Sharma Medical Devices and neuromodulation Battelle Memorial Institute

The peripheral nervous system plays a major role in the maintenance of our physiology. Several peripheral nerves intimately regulate the state of the brain, spinal cord, and visceral systems. A new class of therapeutics, called bioelectronic medicines, are being developed to precisely regulate physiology and treat dysfunction using peripheral nerve stimulation. In this review, we first discuss new work using closed-loop bioelectronic medicine to treat upper limb paralysis. In contrast to open-loop bioelectronic medicines, closed-loop approaches trigger ‘on demand' peripheral nerve stimulation due to a change in function(e.g., during an upper limb movement or a change in cardiopulmonary state). We also outline our perspective on timing rules for closedloop bioelectronic stimulation, interface features for non-invasively stimulating peripheral nerves, and machine learning algorithms to recognize disease events for closed-loop stimulation control. Although there will be several challenges for this emerging field, we look forward to future bioelectronic medicines that can autonomously sense changes in the body, to provide closed-loop peripheral nerve stimulation and treat disease.

关键词： spinal cord injury stroke plasticity closed-loop bioelectronic medicine machine learning nerve stimulation vagus nerve

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Improving the efficiency of magnetic coupling energy transfer byetching fractal patterns in the shielding metals

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Frontiers of Information Technology & Electronic Engineering 2016年第1期17卷 74-82页

作者： Qing-feng LI Shao-bo CHE Wei-ming WANG Hong-wei HAO Lu-ming LI School of Aerospace Tsinghua University Beijing 100084 China National Engineering laboratory for neuromodulation Beijing 100084 China Center of Epilepsy Beijing Institute for Brain Disorders Beijing 100084 China

Thin metal sheets are often located in the coupling paths of magnetic coupling energy transfer(MCET) systems. Eddy currents in the metals reduce the energy transfer efficiency and can even present safety risks. This paper describes the use of etched fractal patterns in the metals to suppress the eddy currents and improve the efficiency. Simulation and experimental results show that this approach is very effective. The fractal patterns should satisfy three features, namely, breaking the metal edge, etching in the high-intensity magnetic field region, and etching through the metal in the thickness direction. Different fractal patterns lead to different results. By altering the eddy current distribution, the fractal pattern slots reduce the eddy current losses when the metals show resistance effects and suppress the induced magnetic field in the metals when the metals show inductance effects. Fractal pattern slots in multilayer high conductivity metals(e.g., Cu) reduce the induced magnetic field intensity significantly. Furthermore, transfer power, transfer efficiency, receiving efficiency, and eddy current losses all increase with the increase of the number of etched layers. These results can benefit MCET by efficient energy transfer and safe use in metal shielded equipment.

关键词： Fractal pattern,Metal-layer-shield,Eddy current,Magnetic coupling energy transfer

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