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Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function

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neural Regeneration Research 2023年第11期18卷 2449-2458页

作者： Jinpiao Zhu Chang Chen Zhen Li Xiaodong Liu Jingang He Ziyue Zhao Mengying He Binbin Nie Zili Liu Yingying Chen Kuanpin Su Xiang Li Juxiang Chen Hongbing Xiang Fuqiang Xu Kangguang Lin Zongze Zhang Jie Wang Department of Anesthesiology Brain Research CenterDepartment of NeurosurgeryZhongnan HospitalWuhan UniversityWuhanHubei ProvinceChina Department of Anesthesiology and Pain Medicine Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Anesthesia and Intensive Care Peter Hung Pain Research InstituteThe Chinese University of Hong KongHong Kong Special Administration RegionChina Key laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhanHubei ProvinceChina Key laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina The Brain Cognition and Brain Disease Institute(BCBDI) NMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhenGuangdong ProvinceChina Mind-Body Interface Research Center(MBI-Lab) China Medical University HospitalTaichungTaiwanChina An-Nan Hospital China Medical UniversityTainanTaiwanChina Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghaiChina Department of Affective Disorders The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei ProvinceChina University of Chinese Academy of Sciences BeijingChina

Sleep benefits the restoration of energy metabolism and thereby suppo rts neuronal plasticity and cognitive ***6 is a NAD+-dependent protein deacetylase that has been recognized as an essential regulator of energy metabolism because it modulates various transcriptional regulators and metabolic *** aim of this study was to investigate the influence of Sirt6 on cerebral function after chronic sleep deprivation(CSD).We assigned C57BL/6J mice to control or two CSD groups and subjected them to AAV2/9-CMV-EGFP or AAV2/9-CMV-Sirt6-EGFP infection in the prelimbic cortex(PrL).We then assessed cerebral functional connectivity(FC) using resting-state functional MRI,neuron/astrocyte metabolism using a metabolic kinetics analysis;dendritic spine densities using sparse-labeling;and miniature excitato ry postsynaptic currents(mEPSCs) and action potential(AP) firing rates using whole-cell patchclamp *** addition,we evaluated cognition via a comprehensive set of behavioral *** with controls,Sirt6 was significantly decreased(P<0.05) in the PrL after CSD,accompanied by cognitive deficits and decreased FC between the PrL and accumbens nucleus,piriform cortex,motor co rtex,somatosensory co rtex,olfactory tubercle,insular cortex,and ***6 ove rexpression reve rsed CSD-induced cognitive impairment and reduced *** analysis of metabolic kinetics using [1-13C] glucose and [2-13C] acetate showed that CSD reduced neuronal Glu4and GABA2synthesis,which could be fully restored via forced Sirt6 ***,Sirt6 ove rexpression reversed CSD-induced decreases in AP firing rates as well as the frequency and amplitude of mEPSCs in PrL pyramidal *** data indicate that Sirt6 can improve cognitive impairment after CSD by regulating the PrL-associated FC network,neuronal glucose metabolism,and glutamatergic ***,Sirt6 activation may have potential as a novel strategy for treating sleep disorder-related diseases.

关键词： chronic sleep deprivation cognitive impairment functional connectivity glutamatergic neurons metabolic kinetics neuronal-astrocytic glucose metabolism prelimbic cortex REM sleep Sirt6 synaptic function

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Stability and dynamics of dendritic spines in macaque prefrontal cortex

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National Science Review 2022年第9期9卷 145-154页

作者：陈铭漆俊倩蒲慕明杨扬 Institute of Neuroscience State Key Laboratory of Neuroscience Key Laboratory of Primate Neurobiology Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University University of Chinese Academy of Sciences Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Lingang Laboratory

Formation and elimination of synapses reflect structural plasticity of neuronal connectivity. Here we performed high-resolution two-photon imaging of dendritic spines in the prefrontal cortex of four macaque monkeys and found that spines were in general highly stable, with low percentages undergoing synaptic turnover. By observing the same spines at weekly intervals, we found that newly formed spines were more susceptible to elimination, with only 40% persisting over a period of months. Analyses of spatial distribution of large numbers of spines revealed that spine distribution was neither uniform nor random, favoring inter-spine distances of 2–4 μm. Furthermore, spine formation and elimination occurred more often in low-and high-density dendritic segments, respectively, and preferentially within a hot zone of ～4 μm from existing spines. Our results demonstrate long-term stability and spatially regulated spine dynamics in the macaque cortex and provide a structural basis for understanding neural circuit plasticity in the primate brain.

关键词： long-term two-photon imaging macaque monkey spine plasticity dendritic spine distribution regulation of spine dynamics dorsal lateral prefrontal cortex

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N-methyl-D-aspartate receptor functions altered by neuronal PTP1B activation in Alzheimer’s disease and schizophrenia models

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neural Regeneration Research 2022年第10期17卷 2208-2210页

作者： Alexandre F.R.Stewart Hsiao-Huei Chen Department of Biochemistry Microbiology and ImmunologyUniversity of Ottawaand University of Ottawa Heart InstituteOttawaONCanada Centre for Infection Immunity and InflammationOttawaONCanada Medicine Cellular and Molecular MedicineUniversity of Ottawa Brain and Mind InstituteOttawa Hospital Research InstituteOttawaONCanada

Glutamate is the main exc i tatory neurotransmitter in the brain and binds to two major classes of receptors,theα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid(AMPA)and the N-methyl-D-aspartate(NMDA)*** AMPA receptors that are immediately activated by glutamate release,NMDA receptors are blocked by magnesium and can only be activated by glutamate after membrane ***,NMDA receptors are only activated after repeated AMPA receptor activation by *** receptors are,for the most part,calcium-permeable *** influx through NMDA receptors modulates synaptic transmission in neurons based on prior history of excitation,and provides a means of scaling the strength of synapses required for Hebbian plasticity.

关键词： PTP1B aspartate NMDA

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Culture observation and molecular phylogenetic analysis on the blooming green alga Chaetomorpha valida (Cladophorales, Chlorophyta) from China

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Chinese Journal of Oceanology and Limnology 2013年第3期31卷 552-559页

作者：邓蕴彦汤晓荣詹子锋滕林宏丁兰平黄冰心 Institute of Oceanology Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences Key laboratory of Marine Genetics and Breeding (Ocean University of China) Ministry of Education Shantou University

The marine green alga Chaetomorpha valida fouls aquaculture ponds along the coastal cities of Dalian and Rongcheng, China. Unialgal cultures were observed under a microscope to determine the developmental morphological characters of C. valida. Results reveal that gametophytic filaments often produce lateral branches under laboratory culture conditions, suggesting an atypical heteromorphic life cycle of C. valida between unbranched sporophytes and branched gametophytes, which differs from typical isomorphic alternation of Chaetomorpha species. The shape of the basal attachment cell, an important taxonomic character within the genus, was found variable depending on environmental conditions. The 18S rDNA and 28S rDNA regions were used to explore the phylogenetic affinity of the taxa. Inferred trees from 18S rDNA sequences revealed a close relationship between C. valida and Chaetomorpha moniligera. These results would enrich information in general biology and morphological plasticity of C. valida and provided a basis for future identification of green tide forming algae.

关键词： blooming green algae Chaetomorpha valida branch culture observation heteromorphic lifecycle molecular phylogeny

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Tissue with high intelligence quotient Adipose-derived stem cells in neural regeneration

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neural Regeneration Research 2009年第12期4卷 1116-1120页

作者： George N.Chaldakov Marco Fiore Anton B.Tonchev Mariyana G.Hristova Vesselka Nikolova Luigi Aloe Division of Cell Biology Medical University Institute of Neurobiology and molecular Medicine National Research Council and Rita Levi-Montalcini European Brain Research Institute Department of Endocrinology Medical Center Third Clinic of Cardiology Intensive Cardiac Care UnitUniversity St Marina Hospital

The aim of the present review is to highlight the possible neuroregenerative potential ol adipose-derived stem cells. The key property of stem cells is plasticity including self-renewal, multilineage differentiation, and migration, whereas the required property is transplantability. For a long time, embryonic stem cells were thought to be the only source of pluripotency, a dogma that has been challenged during the last decade. Today, an alternative option might be adipose-derived stem cells, as easily accessible, ethical and autologous cellular source. Recent knowledge of adipobiology increasingly recognizes that adipose tissue is the major endo- and paracrine organ of the human body. Likewise, numerous neuropetides, neurotrophic factors, neurotransmitters, hypothalamic and steroid hormones and their receptors are shared by adipose tissue and brain. Accordingly, the regenerative potential of neuroprotective factor-secreting adipose-derived stem cells is outlined. Whether the possible benefits of adipose stem cell-based therapy may be mediated via cell transdifferentiation and/or paracrine mechanisms remains to further be evaluated.

关键词： adipose tissue neurodegeneration neurotrophic factors regeneration stem cells

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Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat

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Science China(Life Sciences) 2023年第4期66卷 819-834页

作者： Hongcui Pei Wan Teng Lifeng Gao Hengbin Gao Xueni Ren Yanhong Liu Jizeng Jia Yiping Tong Yonghong Wang Zefu Lu Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China State Key laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai’an 271018China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China The State Key laboratory for Plant Cell and Chromosome Engineering the Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China

Expression divergence caused by genetic variation and crosstalks among subgenomes of the allohexaploid bread wheat(Triticum aestivum.L.,BBAADD)is hypothesized to increase its adaptability and/or ***,the molecular basis of expression divergence remains *** promoter-binding protein-like(SPL)transcription factors are critical for a wide array of biological *** this study,we constructed expression regulatory networks by combining DAP-seq for 40 SPLs,ATACseq,and *** findings indicate that a group of low-affinity SPL binding regions(SBRs)were targeted by diverse SPLs and caused different sequence preferences around the core GTAC *** SBRs including the low-affinity ones are evolutionarily conserved,enriched GWAS signals related to important agricultural ***,those SBRs are highly diversified among the cis-regulatory regions(CREs)of syntenic genes,with less than 8%SBRs coexisting in triad genes,suggesting that CRE variations are critical for subgenome *** out of Ta SPL7A/B/D and Ta SPL15A/B/D subfamily further proved that both high-and low-affinity SBRs played critical roles in the differential expression of genes regulating tiller number and spike *** results have provided baseline data for downstream networks of SPLs and wheat improvements and revealed that CRE variations are critical sources for subgenome divergence in the allohexaploid wheat.

关键词： wheat(Triticum aestivum L.) squamosa promoter-binding protein-like(SPL) transcriptional regulation cis-regulatory regions polyploidization low-affinity binding sites

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Glutamate receptor delocalization in postsynaptic membrane and reduced hippocampal synaptic plasticity in the early stage of Alzheimer's disease

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neural Regeneration Research 2019年第6期14卷 1037-1045页

作者： Ning Li Yang Li Li-Juan Li Ke Zhu Yan Zheng Xiao-Min Wang Department of Neurobiology Capital Medical University Key laboratory for Neurodegenerative Disorders of the Ministry of Education Capital Medical University Beijing Institute for Brain Disorders Department of Physiology Capital Medical University

Mounting evidence suggests that synaptic plasticity provides the cellular biological basis of learning and memory, and plasticity deficits play a key role in dementia caused by Alzheimer's disease. However, the mechanisms by which synaptic dysfunction contributes to the pathogenesis of Alzheimer's disease remain unclear. In the present study, Alzheimer's disease transgenic mice were used to determine the relationship between decreased hippocampal synaptic plasticity and pathological changes and cognitive-behavioral deterioration, as well as possible mechanisms underlying decreased synaptic plasticity in the early stages of Alzheimer's disease-like diseases. APP/PS1 double transgenic(5 XFAD; Jackson laboratory) mice and their littermates(wild-type, controls) were used in this study. Additional 6-weekold and 10-week-old 5 XFAD mice and wild-type mice were used for electrophysiological recording of hippocampal dentate gyrus. For10-week-old 5 XFAD mice and wild-type mice, the left hippocampus was used for electrophysiological recording, and the right hippocampus was used for biochemical experiments or immunohistochemical staining to observe synaptophysin levels and amyloid beta deposition levels. The results revealed that, compared with wild-type mice, 6-week-old 5 XFAD mice exhibited unaltered long-term potentiation in the hippocampal dentate gyrus. Another set of 5 XFAD mice began to show attenuation at the age of 10 weeks, and a large quantity of amyloid beta protein was accumulated in hippocampal cells. The location of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor and N-methyl-D-aspartic acid receptor subunits in synaptosomes was decreased. These findings indicate that the delocalization of postsynaptic glutamate receptors and an associated decline in synaptic plasticity may be key mechanisms in the early onset of Alzheimer's disease. The use and care of animals were in strict accordance with the ethical standards of the Animal Ethics Committee of Ca

关键词： nerve regeneration Alzheimer’s disease synaptic plasticity hippocampus learning and memory long-term potentiation βamyloid glutamate receptor synaptic strength neural regeneration

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Contactins in the central nervous system: role in health and disease

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neural Regeneration Research 2019年第2期14卷 206-216页

作者： Madhurima Chatterjee Detlev Schild Charlotte E.Teunissen Amsterdam UMC VU University Medical Center Department of Clinical Chemistry Amsterdam Neuroscience Institute of Neurophysiology and Cellular Biophysics University of G?ttingen DFG Research Center for Nanoscale Microscopy and molecular Physiology of the Brain (CNMPB) University of G?ttingen DFG Excellence Cluster 171 University of G?ttingen

Contactins are a group of cell adhesion molecules that are mainly expressed in the brain and play pivotal roles in the organization of axonal domains, axonal guidance, neuritogenesis, neuronal development, synapse formation and plasticity, axo-glia interactions and neural regeneration. Contactins comprise a family of six members. Their absence leads to malformed axons and impaired nerve conduction. Contactin mediated protein complex formation is critical for the organization of the axon in early central nervous system development. Mutations and differential expression of contactins have been identified in neuro-developmental or neurological disorders. Taken together, contactins are extensively studied in the context of nervous system development. This review summarizes the physiological roles of all six members of the Contactin family in neurodevelopment as well as their involvement in neurological/neurodevelopmental disorders.

关键词： cell adhesion molecule Contactins axonal domain,neurogenesis synaptogenesis autism spectrum disorder neuro-developmental disorder neurological disease

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Intraspecific DNA methylation polymorphism in the non-edible oilseed plant castor bean

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Plant Diversity 2017年第5期39卷 300-307页

作者： Shan He Wei Xu Fei Li Yue Wang Aizhong Liu Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Investigation of the relationships of phenotypic and epigenetic variations might he a good way to dissect the genetic or molecular basis of phenotypic variation and plasticity in plants, Castor bean （Ricinus cornraunis L）, an important non-edible oilseed crop, is a mono-species genus plant in the family Euphorbiaceae. Since it displays rich phenotypic variations with low genetic diversity, castor bean is a good model to investigate the molecular basis of phenotypic and epigenetic variations. Cytosine DNA methylation represents a major molecular mechanism of epigenetic occurrence. In this study, epigenetic diversity of sixty landrace accessions collected worldwide was investigated using the methylation- sensitive amplification polymorphism （MSAP） technique, Results showed that the epigenetic diversity （based on the polymorphism of DNA methylated loci） exhibited a medium variation （Ne = 1.395, He = 0.242, I = 0.366） at the population level though the variation was great, ranging from 3,80% to 3431% among accessions. Both population structure analysis and the phylogenetic construction （using the neighbor-joining criteria） revealed that the two main clades were identified, but they did not display a distinct geographic structure, After inspecting the location of polymorphic methylated loci on genome we identified that the polymorphic methylated loci occur widely in nuclear and organelle genomes. This study provides new data to understand phenotypic and epigenetic variations in castor bean,

关键词： jRicinus communis L. Epigenetic diversity Methylation-sensitive amplification polymorphism DNA methylation

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Changes of synaptic structures associated with learning, memory and diseases

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Translational Neuroscience and Clinics 2018年第2期4卷 99-117页

作者： Yang Yang Ju Lu Yi Zuo School of Life Science and Technology ShanghaiTech University Department of molecular Cell and Developmental Biology University of California

Synaptic plasticity is widely believed to be the cellular basis of learning and memory. It is influenced by various factors including development, sensory experiences, and brain disorders. Long-term synaptic plasticity is accompanied by protein synthesis and trafficking, leading to structural changes of the synapse. In this review, we focus on the synaptic structural plasticity, which has mainly been studied with in vivo two-photon laser scanning microscopy. We also discuss how a special type of synapses, the multi-contact synapses(including those formed by multi-synaptic boutons and multi-synaptic spines),are associated with experience and learning.

关键词： synaptic plasticity spine axonal bouton sensory deprivation learning neurological disease multi-synaptic bouton multi-synaptic spine

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