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Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2017年第19期23卷 3407-3417页

作者： Flavia A Cimini Ilaria Barchetta Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini Department of Experimental Medicine Sapienza University of Rome laboratory of microscopic and ultrastructural anatomy(CIR) Faculty of MedicineUniversity Campus Bio-Medico Internal Medicine and Hepatology University Campus Bio-Medico

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease *** pathogenesis is complex and not yet fully *** the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the"multiple parallel hits"*** to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and *** these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial *** studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and ***,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and *** purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD.

关键词： Adipose tissue dysfunction Vitamin D Non-alcoholic fatty liver disease Steatosis Non-alcoholic steatohepatitis Obesity Adipokines

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Electrical Characteristics of InGaN/AlGaN and InGaN/GaN MQW Near UV-LEDs

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Chinese Physics Letters 2007年第11期24卷 3245-3248页

作者：穆森于彤军黄柳冰贾传宇潘尧波杨志坚陈志忠秦志新张国义 State Key laboratory of Artificial Microstructure and microscopic Physics School of Physics Peking University Beijing 100871

Electrical characteristics of In0.05 Ga0.95N/Al0.07Ga0.9aN and In0.05 Ga0.95N/GaN multiple quantum well （MQW） ultraviolet light-emltting diodes （UV-LEDs） at 400hm wavelength are measured. It is found that for InGaN/AlGaN MQW LEDs, both ideality factor and parallel resistance are similar to those of InGaN/GaN MQW LEDs, while series resistance is two times larger. It is suggested that the Al0.07Ga0.93N barrier layer did not change crystal quality and electrical characteristic of p-n junction either, but brought larger series resistance. As a result, InGaN/AlGaN MQW LEDs suffer more serious thermal dissipation problem although they show higher light output efficiency.

关键词： coated conductor buffer layer self-epitaxy CeO2

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Overview of studies of the vitamin D/vitamin D receptor system in the development of non-alcoholic fatty liver disease

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World Journal of Gastrointestinal Pathophysiology 2019年第2期10卷 11-16页

作者： Flavia Agata Cimini Ilaria Barchetta Simone Carotti Sergio Morini Maria Gisella Cavallo Department of Experimental Medicine Sapienza University of RomeRome I-00161Italy Department of Medicine and Surgery Laboratory of Microscopic and Ultrastructural AnatomyUniversity Campus Bio-Medico of RomeRome I-00128Italy

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the *** is known to be associated with obesity,type 2 diabetes,metabolic syndrome and increased cardiovascular events:for these reasons,it is becoming a global public health problem and represents an important challenge in terms of prevention and *** mechanisms behind the pathogenesis of NAFLD are multiple and have not yet been completely unraveled;consequently,at moment there are not effective *** the past few years a large body of evidence has been assembled that attributes an important role in hepatic aberrant fat accumulation,inflammation and fibrosis,to the vitamin D/vitamin D receptor(VD/VDR)axis,showing a strong association between hypovitaminosis D and the diagnosis of ***,the data currently available,including clinical trials with VD supplementation,still provides a contrasting *** purpose of this editorial is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to VD/*** on recent data from literature,we focused in particular on the hypothesis that VDR itself,independently from its traditional ligand VD,may have a crucial function in promoting hepatic fat *** might also offer new possibilities for future innovative therapeutic approaches in the management of NAFLD.

关键词： Vitamin D Vitamin D receptor Non-alcoholic fatty liver disease Type 2 diabetes

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Optical Defect in GaN-Based Laser Diodes Detected by Cathodoluminescence

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Chinese Physics Letters 2008年第12期25卷 4342-4344页

作者：赵璐冰吴洁君徐科包魁杨志坚潘尧波胡晓东张国义 Research Center for Wide Gap Semiconductors Peking University State Key Laboratory for Artificial Microstrueture and Microscopic Physics School of Physics Peking University Beijing 100871

GaN-based laser diodes （LDs） with 399 nm wavelength are grown on sapphire substrates by metal organic chemical vapour deposition （MOCVD）. Electroluminescence spectra of the fabricated LDs show that the LDs from some grown wafers failed to emit laser. The SEM and XRD results show the similar surface morphology and interface qualities of multi quantum wells （MQWs） and super-lattices between LDs that succeed and fail to emit laser. However, the cathodoluminescence （CL） measurements reveal a kind of optical defect rather than structural defect in un-emitted LDs. Further depth-dependent CL imaging observation indicates that such optical defects originate from the MQWs to the surface of LDs as a non-irradiative recombination centre that should cause the failure of laser emitting of LDs.

关键词： field emission molybdenum dioxide enhancement factor

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ELECTRON microscopic OBSERVATION OF DIFFERENTIATION OF LEUKEMIC CELL CLONE AFTER CFU-MIX CULTURE

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Chinese Journal of Cancer Research 1992年第1期4卷 45-50页

作者：陈燕王辨明李崇渔喻东姣阮幼冰郑清平 Institute of Hematology Tongji Medical University Wuhan Departmet of ultrastructural Pathology Tongji Medical University Wuhan

By scanning and transmission electron microscopy, leukemlc celb were obwrved after CFU-Mix culture. Even though granulocytlc growth factor, erythropoietin and lymphocytlc growth factor were added at vitor, acute leukemlc celb still showed defects In differentiation and maturation. These were characterized by abnormal colony which consisted of smooth cells, bizarre shape, nuclear-cytoplasmic asynchrony In development, and appearance of nuclear bleb. However, chronic myelogenous leukemlc celb were more nature than the acute ones, manifesting in normal colony with finger- like projections and ruffled membrane. Macrophages and eosinophils could be observed. It b suggested that there b a difference In differentiation between acute and chronic leukemia cells.

关键词： In cell ELECTRON microscopic OBSERVATION OF DIFFERENTIATION OF LEUKEMIC CELL CLONE AFTER CFU-MIX CULTURE CML CFU AML

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Comparison of displacement damage effects on the dark signal in CMOS image sensors induced by CSNS back-n and XAPR neutrons

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Nuclear Science and Techniques 2024年第10期35卷 29-40页

作者： Yuan-Yuan Xue Zu-Jun Wang Wu-Ying Ma Min-Bo Liu Bao-Ping He Shi-Long Gou State Key laboratory of Intense Pulsed Irradiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an 710024China State Key laboratory of Artificial Microstructure and microscopic Physics School of Physics Peking UniversityBeijing 100871China

This study investigates the effects of displacement damage on the dark signal of a pinned photodiode CMOS image sensor(CIS)following irradiation with back-streaming white neutrons from white neutron sources at the China spallation neutron source(CSNS)and Xi'an pulsed reactor(XAPR).The mean dark signal,dark signal non-uniformity(DSNU),dark signal distribution,and hot pixels of the CIS were compared between the CSNS back-n and XAPR neutron *** nonionizing energy loss and energy distribution of primary knock-on atoms in silicon,induced by neutrons,were calculated using the open-source package *** analysis combining experimental and simulation results showed a noticeable proportionality between the increase in the mean dark signal and the displacement damage dose(DDD).Additionally,neutron energies influence DSNU,dark signal distribution,and hot *** neutron energies at the same DDD level may lead to pronounced dark signal non-uniformity and elevated hot pixel values.

关键词： Displacement damage effects CMOS image sensor(CIS) CSNS back-n XAPR neutrons Geant4 Dark signal non-uniformity(DSNU)

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Studies on the Electron microscopic Localization of Con A and WGA Receptors in Human Peritoneal Macrophages

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Journal of Medical Colleges of PLA(China) 1990年第3期5卷 210-214页

作者：王福安张学庸张太和史勤 laboratory of Gastroenterology Xijing HospitalXi'an 710032 Department of ultrastructural Pathology Jinling HospitalNanjing 210002

The electron microscopic topology of Con A and WGA receptors was investi-gated in human peritoneal macrophagcs by utilizing avidin-gold *** observa-tions confirmed that both the receptors were distributed on the cell membranes,yet thereceptor expression showed variations among the individual *** cells had abun-dant receptors,while others had only few *** data obtained in the presentstudy indicate that human peritoneal macrophages may be a functionally andbiochemically heterogenous population,and the study may also serve as a theorcticalreference for future clinical exploitation of human peritoneal macrophages.

关键词： human peritoneal macrophages lectins colloidal gold electron microscopy

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Starring role of toll-like receptor-4 activation in the gutliver axis

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World Journal of Gastrointestinal Pathophysiology 2015年第4期6卷 99-109页

作者： Simone Carotti Michele Pier Luca Guarino Umberto Vespasiani-Gentilucci Sergio Morini laboratory of microscopic and ultrastructural anatomy School of MedicineUniversity Campus Bio-Medico of Rome Gastroenterology Unit School of Medicine University Campus Bio-Medico of Rome Clinical Medicine and Hepatology Unit School of Medicine University Campus Bio-Medico of Rome

Since the introduction of the term "gut-liver axis", many studies have focused on the functional links of intestinal microbiota, barrier function and immune responses to liver physiology. Intestinal and extra-intestinal diseases alter microbiota composition and lead to dysbiosis, which aggravates impaired intestinal barrier function via increased lipopolysaccharide translocation. The subsequent increased passage of gut-derived product from the intestinal lumen to the organ wall and bloodstream affects gut motility and liver biology. The activation of the toll-like receptor 4(TLR-4) likely plays a key role in both cases. This review analyzed the most recent literature on the gut-liver axis, with a particular focus on the role of TLR-4 activation. Findings that linked liver disease with dysbiosis are evaluated, and links between dysbiosis and alterations of intestinal permeability and motility are discussed. We also examine the mechanisms of translocated gut bacteria and/or the bacterial product activation of liver inflammation and fibrogenesis via activity on different hepatic cell types.

关键词： Gut microbiota Dysbiosis Toll-like receptor 4 Gut

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Strain Effect on Photoluminescences from InGaN MQWs with Different Barriers Grown by MOCVD

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Chinese Physics Letters 2007年第5期24卷 1365-1367页

作者：于彤军康香宁潘尧波秦志新陈志忠杨志坚张国义 Research Center for Wide Band Gap Semiconductors Peking University 100871 State Key laboratory of Artificial Microstructure and microscopic Physics School of Physics Peking University Beijing 100871

InGaN/GaN MQWs, InGaN/AlGaN MQWs and InGaN/AlInGaN MQWs are grown on （0001） sapphire substrates by MOCVD. Membrane samples are fabricated by laser lift-off technology. The photoluminescence spec-ra of membranes show a blue shift of peak positions in InGaN/GaN MQWs, a red shift of peak positions in InGaN/AlGaN MQWs and no shift of peak positions in InGaN/AIlnGaN MQWs from those of samples with substrates. Different changes in Raman scattering spectra and HR-XRD （0002） profile of InGaN/AlInGaN MQWs, from those of InGaN/GaN MQWs and InGaN/AlGaN MQWs, are observed. The fact that the strain changes differently among InGaN MQWs with different barriers is confirmed. The AIlnGaN barrier could adjust the residual stress for the least strain-induced electric field in InGaN/AIlnGaN quantum wells.

关键词： MULTIPLE-QUANTUM WELLS SAPPHIRE

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Extended Power Law and Hall Anomaly of High-Temperature Superconductors

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Chinese Physics Letters 2009年第3期26卷 248-250页

作者：贺丽胡翔尹澜徐晓林郭建栋李传义尹道乐 Department of Physics and State Key laboratory for microscopic Physics Peking University Beijing 100871

Starting from the free energy of a moving vortex, we obtain the extended power law form of longitudinal resistivity pxx and the analytical form of Hall resistivity *** on them, we obtain a scaling relation which agrees well with the experimental data of different kinds of high-temperature superconductors. Furthermore, the theoretical results well fit the scaling results.

关键词：高温超导体电量法异常霍尔电阻实验数据标度关系自由能电阻率

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