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在更低的极限的长骨头的骨样的骨瘤的指导 CT 的 radiofrequency 脱离

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World Journal of Radiology 2012年第6期4卷 278-282页

作者： Yoshiki Asayama Akihiro Nishie Kousei Ishigami Daisuke Kakihara Yasuhiro Ushijima Yukihisa Takayama Nobuhiro Fujita Tsuyoshi Tajima Kengo Yoshimitsu Shuichi Matsuda Yukihide Iwamoto Hiroshi Honda Department of Clinical Radiology Graduate School of Medical SciencesKyushu University3-1-1 MaidashiHigashikuFukuoka 812-8582Japan Department of Molecular Imaging and Diagnosis Kyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan Department of Diagnostic Imaging and nuclear medicine Tokyo Women’s Medical University8-1 KawadachoShinjuku-kuTokyo 162-8666Japan Department of Radiology Fukuoka University7-45-1 NanakumaJonan-kuFukuoka 814-0180Japan Department of Orthopaedic Surgery Kyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan

AIM:To present our initial experience with computed tomography guided radiofrequency ablation(RFA) of osteoid osteoma(OO) in our ***:RFA was performed on eight patients(5 males and 3 females) with clinically and radiologically diagnosed OO(femoral neck,n = 4;femoral diaphysis,n = 2;tibial diaphysis,n = 1;fibular diaphysis,n = 1).Ablation was performed using an electrode with a 10-mm exposed tip for a total of 4-6 min at a targeted temperature of 90 degrees *** cooling system was *** intervention was accepted as technically successful if the tip of the electrode could be placed within the center of the *** defined clinical success as a disappearance within 2 wk after treatment of symptoms that had manifested at ***:All procedures were technically *** major or immediate complications were *** success was achieved in six of eight patients in the first procedure.A second procedure was performed for two patients who had recurrent or continued pain,and one of these cases was successfully *** overall rate of success was 87.5%(7/8).No complication was ***:Our preliminary results indicate a favorable success rate and no complications and are compatible with the previous reports of RFA of OO.

关键词： Ablation Osteoid osteoma Computed tomography

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PET/CT在前列腺癌放疗规划中的应用

中华核医学与分子影像杂志 2020年第9期40卷 567-576页

作者：李冠男(译) 李林(审校) Jeremie Calais Minsong Cao Nicholas G.Nickols 四川大学华西医院核医学科成都610041 Ahmanson Translational Imaging Division Department of Molecular and Medical PharmacologyUCLALos AngelesCalifornia Department of Radiation Oncology UCLALos AngelesCalifornia Department of Radiation Oncology VA Greater Los Angeles Healthcare SystemLos AngelesCalifornia

放疗及根治性前列腺切除术是局限性前列腺癌的最终治疗选择。根治性前列腺切除术后前列腺特异抗原水平升高提示前列腺癌复发,此类患者仍可通过挽救性放疗治愈。为了使治愈机会最大化,放疗靶区应包括疾病的所有范围。因此,无论是根治性... 详细信息

放疗及根治性前列腺切除术是局限性前列腺癌的最终治疗选择。根治性前列腺切除术后前列腺特异抗原水平升高提示前列腺癌复发,此类患者仍可通过挽救性放疗治愈。为了使治愈机会最大化,放疗靶区应包括疾病的所有范围。因此,无论是根治性还是挽救性放疗,准确估计疾病位置对放疗规划至关重要。目前一线显像方法对前列腺癌的早期分期和生化复发的检测灵敏度均有限。将PET纳入前列腺癌患者的常规评估可以提高分期的准确性和放疗计划的规范性。目前,18F-脱氧葡萄糖(FDG)PET/CT已被常规用于多种癌症的放疗规划,但其对前列腺癌的灵敏度较低。其他评估前列腺癌的PET探针包括18F-NaF、11C-乙酸盐、11C或18F标记的胆碱、抗1-氨基酸-3-18F-氟环丁烷-1羧酸(18F-fluciclovine)和68Ga或18F标记的配体,均可与前列腺特异膜抗原(PSMA)结合。PSMA似乎是最灵敏和特异的配体,但其尚未获得美国食品与药品监督管理局(FDA)的新药申请批准。回顾性和前瞻性研究显示,PET/CT对前列腺放疗计划可能有潜在的重要价值。将患者随机分配到常规放疗计划与PET/CT辅助放疗计划的前瞻性试验或许可以得出很有意义的临床结果。目前正在进行前瞻性临床试验,评估利用18F-fluciclovine PET/CT对具有临床终点的挽救性放疗进行规划;建议进行前瞻性试验,评估PSMA PET/CT对前列腺放疗计划的临床影响。

关键词：前列腺肿瘤前列腺特异膜抗原 PET/CT 辐射

在 7T 的多原子的磁性的回声光谱学的应用

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World Journal of Radiology 2011年第4期3卷 105-113页

作者： Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris The Sir Peter Mansfield Magnetic Resonance Centre School of Physics and AstronomyUniversity of Nottingham School of Biomedical Sciences University of Nottingham Medical School Academic Radiology University of Nottingham Molecular medicine PfizerSandwich

AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of *** at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies.

关键词： Magnetic resonance spectroscopy 13C 1H 7 Tesla Glutamate Glutamine γ-aminobutyric acid

使用配置CZT探头的临床前SPECT显像仪同时采集99Tc~m和123I标记的放射性示踪剂

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中华核医学与分子影像杂志 2017年第4期37卷 252-253页

作者：李梦婷李丹兰晓莉 Masato Kobayashi Ichiro Matsunari Kodai Nishi Asuka Mizutani Yoshiharu Miyazaki Kazuhiro Ogai Jyunko Sugama Kazuhiro Shiba Keiichi Kawai Seigo Kinuya 华中科技大学同济医学院附属协和医院核医学科同济大学附属第十人民医院核医学科 Wellness Promotion Science Center Institute of MedicalPharmaceutical and Health SciencesKanazawa University

目的对配置碲锌镉(CZT)探头的临床前SPECT仪同时采集Tc~m和I数据进行评估。方法采用含约37 MBqTc~m-替曲膦(Tc~m-TF)或37 MBqI-15-(p-碘苯基)-3R,S-甲基十五酸(I-BMIPP)的10 ml圆柱形注射器,用于评价SPECT放射性计数和放射性活度的关系... 详细信息

目的对配置碲锌镉(CZT)探头的临床前SPECT仪同时采集Tc~m和I数据进行评估。方法采用含约37 MBqTc~m-替曲膦(Tc~m-TF)或37 MBqI-15-(p-碘苯基)-3R,S-甲基十五酸(I-BMIPP)的10 ml圆柱形注射器,用于评价SPECT放射性计数和放射性活度的关系。取2个含有100或300 MBqTc~m-TF和100 MBqI-BMIPP的10 ml注射器,分别评估Tc~m上散射和I下散射的影响。另取大鼠型号的圆柱形体模1个,同样含有100或300 MBqTc~m-TF和100 MBqIBMIPP;2个10 ml注射器与体模均采用大鼠针孔准直器进行扫描。对心肌梗死模型大鼠行300 MBqTc~m-TF和100 MBqI-BMIPP显像。取1 ml注射器2个,分别含有105 MBqTc~m标记的六甲基丙基新霉胺肟(Tc~m-HMPAO)和35 MBqI标记的N-ω-氟代丙基-2β-甲酯基-3β-(4-碘苯基)降托烷(I-FP-CIT),采用小鼠针孔准直器进行扫描。对正常小鼠行105 MBqTc~m-HMPAO和35 MBqI-FP-CIT显像。结果 SPECT放射性计数和放射性活度间关系优良。在125~150 keV下,对于未行散射校正(SC)的300 MBqTc~m-TF,I-BMIPP的下散射污染显示出较少的放射性计数;在150~175 keV时,Tc~m-TF无上散射污染。由于没有进行SC,在125~150 keV下,大鼠型号体模中的300 MBqTc~m-TF放射性计数率降至4.0%。对于大鼠,采用双示踪剂的Tc~m-TF心肌图像和放射性计数与单一注射Tc~m-TF的结果一致。在125~150 keV下,未行SC的I-FP-CIT下散射污染为4.2%。在先注射Tc~m-HMPAO后注射I-FP-CIT的正常小鼠中,其脑部显像和Tc~m-HMPAO放射性计数与仅注射Tc~m-HMPAO的结果相似;在先注射I-FP-CIT后注射Tc~m-HMPAO的正常小鼠中,脑部显像和放射性计数与仅注射I-FP-CIT的结果未见明显差别。结论Tc~m和I标记的放射性双示踪剂显像可用于配置CZT探头的临床前SPECT显像;采用较I标记放射性示踪剂具有更高放射性活度的Tc~m标记示踪剂时,量化Tc~m和I标记的放射性示踪剂无需校正。

关键词：双探针 99Tc~m 123I 小动物SPECT扫描仪碲锌镉

Splenunculi mimicking metastases in a patient with locally advanced prostate cancer

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World Journal of Clinical Urology 2016年第3期5卷 93-96页

作者： Darren Foreman Sophie A Plagakis Department of Urology Flinders Medical CentreFlinders University Discipline of Surgery Adelaide University Department of Urology Royal Adelaide Hospital

A 61-year-old man with locally advanced prostate cancer was found to have multiple solid intra-abdominal solid lesions during staging *** some were in the pelvis,they were not located in the common landing sites for prostate cancer metastases,and his prostate specific antigen was not significantly elevated to suggest a high burden of metastatic *** reported a history of a blunt abdominal trauma due to a motor vehicle accident more than forty years ago which had been conservatively *** staging imaging revealed a lack of a discrete spleen in his left upper abdomen and this raised the suspicion that these solid lesions may represent ectopic splenic *** with nuclear medicine scintigraphy confirmed the lesions in his upper abdomen and pelvis to be *** proceeded with a combination of androgen deprivation therapy and external beam radiotherapy for locally advanced,non-metastatic prostate *** it has been described in patients with low risk prostate cancer,this is the first case report of splenunculi mimicking metastases in a patient with locally advanced prostate cancer.

关键词： Prostate cancer Splenosis Metastasis Locally advanced Splenunculus

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皮质下小血管病诊断的共识声明

国际脑血管病杂志 2016年第6期24卷 481-496页

作者： Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师张劼陈涵丰俞娅美徐子奇罗本燕 Department of Neurology University of New Mexico Albuquerque New Mexico USA Institute of Neuroscience and Physiology Sahlgrenska Academy Gothenburg University Gothenburg Sweden Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK Department of Clinical Neurosciences University of Cambridge Cambridge UK Neurovascular Research laboratory Vail d'Hebron Research Institute Universitat Auto'noma de Barcelona Barcelona Spain Department of Neurology University of Connecticut Health Center Farmington Connecticut USA Feil Family Brain and Mind Research Institute Weill Cornell Medical College New York New York USA Department of Physiology and biophysics Zilkha Neurogenetic Institute Keck School of Medicine University of Southern Califomia Los Angeles California USA INSERM U1161 Paris France Institute for Stroke and Dementia Research Klinikum der Universitat Mtinchen Munich Germany Department of Neurology Medical University of Graz Graz Austria Tel-Aviv University medical School Ramat Aviv Israel Department of Neurology Memory and Aging Center and Department of Pathology University of Califomia San Francisco California USA University of Sao Paulo medical School Sao Paulo Brazil Department of Neurology University of Southern California Medical School Los Angeles California USA Department of Clinical Neurological Sciences University Hospital University of Western Ontario London Ontario Canada 浙江大学医学院附属第一医院杭州310003

血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病（Binswanger＇s disease, BD）的进行性白质损害患者构成了从单纯血管性... 详细信息

血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病（Binswanger＇s disease, BD）的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组，存在缺氧缺血、腔隙性梗死和炎症，它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物，这将有助于诊断以及将来协作性治疗试验的患者选择。

关键词：宾斯旺格病血脑屏障通透性脑脊液炎症白质疏松

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iNOS基因在胶质细胞中转录激活机制初探

中国交通医学杂志 2005年第6期19卷 565-567页

作者：沈勤张然施建华殷冬梅顾建兰南通大学基础医学院生物化学与分子生物学教研室江苏226001 Neurology medicine University of South Carolina Charleston

目的:通过瞬时转染p38MAPK途径中上游激酶:组成激活型MAPK激酶3(MKK3b)和MAPK激酶6(MKK6b),进一步了解p38MAPK级联传导信号系统调节iNOS基因在胶质细胞中的转录激活机制。方法:MKK3b或MKK6b与接有荧光素酶(luciferase,Luc)的大鼠iNOS启... 详细信息

目的:通过瞬时转染p38MAPK途径中上游激酶:组成激活型MAPK激酶3(MKK3b)和MAPK激酶6(MKK6b),进一步了解p38MAPK级联传导信号系统调节iNOS基因在胶质细胞中的转录激活机制。方法:MKK3b或MKK6b与接有荧光素酶(luciferase,Luc)的大鼠iNOS启动基因质粒(iNOS-Luc);cAMP反应元件(CRE-Luc)和核因子κB(NFκB-Luc)联合转染C6胶质细胞株。结果:MKK3b/MKK6b能引起iNOS-Luc的激活,并都能够被p38MAPK抑制剂SB203580所抑制。MKK可以诱导cAMP反应元件(CRE-Luc)介导的和核因子κB(NFκB-Luc)依赖的转录活性。显性抑制型(dominantnegative,dn)CRE结合蛋白(dnCREB)和CCAAT/增强子结合蛋白(C/EBP)都是p38MAPK的靶向作用目标。结论:转染这两种转录因子产生相反的影响:dnCRE增强了iNOS-Luc的表达,而dnC/EBP则引起抑制作用,对CRE-Luc也具有相同的影响。

关键词： p38MAPK 核因子可诱导型氧化氮合酶胶质细胞联合转染

冠状动脉CTA联合CT心肌灌注成像与有创性冠状动脉造影联合负荷SPECT心肌灌注显像预测主要心血管不良事件的价值:CORE320多中心研究

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国际医学放射学杂志 2017年第5期 586-586页

作者： M.Y.Chen C.E.Rochitte A.Arbab-Zadeh M.Dewey R.T.George J.M.Miller 樊响 Johns Hopkins Hospital and School of medicine

摘要目的比较CTA联合负荷CT心肌灌注成像与有创性冠状动脉造影(ICA)联合负荷SPECT心肌灌注显像的预后价值[到发生主要心血管不良事件(MACE)的时间]。材料

关键词：主要心血管不良事件冠状动脉造影心肌灌注显像 CORE320 CT 心肌灌注成像 SPECT CTA

计算机辅助诊断系统用于全身骨显像探测乳腺癌骨转移

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中华核医学与分子影像杂志 2017年第9期37卷 599-599页

作者：洪智慧唐军 Misugi Urano Yumi Maki Hiroko Nishikawa Tatsuya Kawai Norio Shiraki Yuta Shibamoto 苏州大学附属第二医院核医学科 Department of Radiology Nagoya CityUniversity Graduate School of Medical Sciences

目的比较乳腺癌患者全身骨显像中平面显像（PI）和通过计算机辅助诊断系统（CAD）获得的图像（VSBONE）对于探测骨转移的诊断能力。方法共81例女性乳腺癌患者（中位年龄56岁,32～79岁）纳入该研究。静脉注射740 MBq;Tc;-羟基亚甲基二膦... 详细信息

目的比较乳腺癌患者全身骨显像中平面显像（PI）和通过计算机辅助诊断系统（CAD）获得的图像（VSBONE）对于探测骨转移的诊断能力。方法共81例女性乳腺癌患者（中位年龄56岁,32～79岁）纳入该研究。静脉注射740 MBq;Tc;-羟基亚甲基二膦酸盐后行全身骨显像,显像共分析1 066处骨（颅骨162处,脊柱和骨盆657处,胸骨和肋骨223处,上肢18处及下肢6处）。由2位放射科医师独立分析单独PI、单独VSBONE和PI-VSBONE联合显像诊断骨转移的结果,最终结果由MRI证实。采用Fisher确切概率法和McNemar法分析各方法的灵敏度及特异性。2位医师诊断结果的一致性采用Kappa检验进行评估。结果 43例患者（442处阳性病灶）被确诊为骨转移。PI、VSBONE及PI-VSBONE的灵敏度分别为40.8%、50.2%和61.8%,特异性分别为97.8%、97.5%和97.6%;Kappa值分别为0.62、0.69和0.77。结论 VSBONE检测乳腺癌患者骨转移的灵敏度优于PI,但仍需对CAD系统进行改进,以减少假阴性。

关键词：乳腺癌转移筛查骨显像计算机辅助诊断