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Evolutionary dynamics and comparative pathogenicity of clade 2.3.4.4b H5 subtype avian influenza viruses,China,2021–2022

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Virologica Sinica 2024年第3期39卷 358-368页

作者： Siru Lin Junhong Chen Ke Li Yang Liu Siyuan Fu Shumin Xie Aimin Zha Aiguo Xin Xinyu Han Yuting Shi Lingyu Xu Ming Liao Weixin Jia National Avian Influenza Para-Reference laboratory Guangdong Engineering Laboratory for Medicament of Zoonosis Prevention and ControlKey Laboratory of Zoonoses Prevention and Control of Guangdong ProvinceLaboratory for Lingnan Modern AgricultureCollege of Veterinary MedicineSouth China Agricultural UniversityGuangzhou510642China Key laboratory of Zoonoses Key Laboratory of Animal Vaccine DevelopmentMinistry of AgricultureGuangzhou510642China Institute of Poultry Management and Diseases Yunnan Animal Science and Veterinary InstituteKunming650000China

The recent concurrent emergence of H5N1,H5N6,and H5N8 avian influenza viruses(AIVs)has led to significant avian mortality *** 2020,frequent human-animal interactions have been *** gain insight into the novel H5 subtype AIVs(i.e.,H5N1,H5N6 and H5N8),we collected 6102 samples from various regions of China between January 2021 and September 2022,and identified 41 H5Nx *** analyses on the evolution and biological properties of these isolates were *** analysis revealed that the 41 H5Nx strains belonged to clade 2.***.4.4b,with 13 related to H5N1,19 to H5N6,and 9 to *** based on global 2.***.4.4b viruses showed that all the viruses described in this study were likely originated from H5N8,exhibiting a heterogeneous evolutionary history between H5N1 and H5N6 during 2015–2022 worldwide.H5N1 showed a higher rate of evolution in 2021–2022 and more sites under positive selection pressure in 2015–*** antigenic profiles of the novel H5N1 and H5N6 exhibited notable *** hemagglutination inhibition assay suggested that some A(H5N1)viruses may be antigenically distinct from the circulating H5N6 and H5N8 *** challenge assays demonstrated that the H5N8 virus(21GD001_H5N8)displayed the highest pathogenicity in mice,followed by the H5N1 virus(B1557_H5N1)and then the H5N6 virus(220086_H5N6),suggesting a heterogeneous virulence profile of H5 AIVs in the mammalian *** on the above results,we speculate that A(H5N1)viruses have a higher risk of emergence in the ***,these findings unveil a new landscape of different evolutionary history and biological characteristics of novel H5 AIVs in clade 2.***.4.4b,contributing to a better understanding of designing more effective strategies for the prevention and control of novel H5 AIVs.

关键词： Avian influenza virus(AIV) H5 subtypes AIVs Evolutionary Pathogenicity

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Rare variants in FANCJ induce premature ovarian insufficiency in humans and mice

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Journal of Genetics and Genomics 2024年第2期51卷 252-255页

作者： Xi Yang Shuting Ren Jialin Yang Yuncheng Pan Zixue Zhou Qing Chen Yunzheng Fang Lingyue Shang Feng Zhang Xiaojin Zhang Yanhua Wu State Key laboratory of Genetic Engineering at School of Life Sciences Human Phenome InstituteObstetrics and Gynecology HospitalFudan UniversityShanghai 200438China Obstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentState Key Laboratory of Genetic Engineering at School of Life SciencesFudan UniversityShanghai 200011China human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Obstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China State Key laboratory of Genetic Engineering at School of Life Sciences Obstetrics and Gynecology HospitalFudan UniversityShanghai 200438China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China

Premature ovarian insufficiency(POI)is a severe female reproductive disorder that affects 1%of women in general populations(European Society for human Reproduction and Embryology[ESHRE]Guideline Group on POI et al.,2016).An increasing prevalence up to 3.7%has been reported in a recent meta-analysis(Golezar et al.,2019).POl can lead to infertility or subfertility,as well as a range of complex complications suffering multi-organ systems,seriously threatening women's health and reducing the life *** contrast,POl is a representative heterogeneous disease with multiple *** more than 70 causative POI genes have been identified,the etiology of more than half of the POI patients is still ambiguous(Jiao et al.,2018).Unreported POI causative genes,therefore,remain to be identified.

关键词： insufficiency fertility

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Anemoside B4 inhibits SARS-CoV-2 replication in vitro and in vivo

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Chinese Herbal Medicines 2024年第1期16卷 106-112页

作者： Mingyue Xiao Ronghua Luo Qinghua Liang Honglv Jiang Yanli Liu Guoqiang Xu Hongwei Gao Yongtang Zheng Qiongming Xu Shilin Yang College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Key laboratory of Animal Models and human Disease Mechanisms of Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Jiangsu Key laboratory of Neuropsychiatric Diseases and Jiangsu Key laboratory of Preventive and Translational Medicine for Geriatric Diseases Soochow UniversitySuzhou 215123China College of Pharmacy Guangxi University of Chinese MedicineNanning 530000China

Objective: Anemoside B4(AB4), the most abundant triterpenoidal saponin isolated from Pulsatilla chinensis, inhibited influenza virus FM1 or Klebsiella pneumoniae-induced pneumonia. However, the anti-SARS-CoV-2 effect of AB4 has not been unraveled. Therefore, this study aimed to determine the antiviral activity and potential mechanism of AB4 in inhibiting human coronavirus SARS-CoV-2 in vivo and in ***: The cytotoxicity of AB4 was evaluated using the Cell Counting Kit-8(CCK8) assay. SARS-CoV-2 infected HEK293T, HPAEpiC, and Vero E6 cells were used for in vitro assays. The antiviral effect of AB4 in vivo was evaluated by SARS-CoV-2-infected hACE2-IRES-luc transgenic mouse model. Furthermore,label-free quantitative proteomics and bioinformatic analysis were performed to explore the potential antiviral mechanism of action of AB4. Type Ⅰ IFN signaling-associated proteins were assessed using Western blotting or immumohistochemical ***: The data showed that AB4 reduced the propagation of SARS-CoV-2 along with the decreased Nucleocapsid protein(N), Spike protein(S), and 3C-like protease(3CLpro) in HEK293T cells. In vivo antiviral activity data revealed that AB4 inhibited viral replication and relieved pneumonia in a SARS-CoV-2 infected mouse model. We further disclosed that the antiviral activity of AB4 was associated with the enhanced interferon(IFN)-β response via the activation of retinoic acid-inducible gene Ⅰ(RIG-1) like receptor(RLP) pathways. Additionally, label-free quantitative proteomic analyses discovered that 17 proteins were significantly altered by AB4 in the SARS-CoV-2 coronavirus infections cells. These proteins mainly clustered in RNA ***: Our results indicated that AB4 inhibited SARS-CoV-2 replication through the RLR pathways and moderated the RNA metabolism, suggesting that it would be a potential lead compound for the development of anti-SARS-CoV-2 drugs.

关键词： anemoside B4 interferon RNA metabolism quantitative proteomics SARS-CoV-2

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Prospective life cycle assessment of CO2 conversion by photocatalytic reaction

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Green Chemical Engineering 2024年第3期5卷 383-389页

作者： Jun-Qi Wang Xiang-Jun Liu Jing-Jing Ma Shuai Zhang Hao-Ran Liu Yong-Li Dong Qing-Yuan Yang School of human Settlements and Civil Engineering Xi'an Jiaotong University School of Chemical Engineering and Technology Xi'an Jiaotong University

CO2conversion is gradually seen as a better way for society to effectively use carbon sources and avoid climate crisis associated with fossil CO2emissions. And the decision to deploy CO2technology scale should be relied on its environmental impact. In this work, life cycle assessment model evaluates the environmental performance of CO2conversion by photocatalytic reaction process with two different catalysts（NiAl-LDH and Co-ZIF-9）. Six impact categories considered in this analysis, including climate change, acidification potential, depletion of abiotic resources, eutrophication potential, ozone layer depletion potential, and photochemical oxidation potential. Results indicated that CO2conversion with Co-ZIF-9 photocatalyst has a better environmental impact than the NiAl-LDH photocatalyst route. Moreover, the Co-ZIF-9 catalyst scenario also has a lower total environmental burden than the conventional CO production route. Sensitivity analysis shows that recycle performance of the catalyst is highly sensitive to the production process in two scenarios. This study could provide a framework for robust decisions in CO2conversion by photocatalytic reaction, which is useful for policymakers to decide the feasibility of industrialization.

关键词： Life cycle assessment (LCA) CO 2 Photocatalytic reaction Sensitivity analysis Uncertainty analysis

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Removal and fluorescence detection of antibiotics from wastewater by layered double oxides/metal-organic frameworks with different topological configurations

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Chinese Chemical Letters 2024年第8期35卷 401-405页

作者： Zhiqiang Liu Qiang Gao Wei Shen Meifeng Xu Yunxin Li Weilin Hou Hai-Wei Shi Yaozuo Yuan Erwin Adams Hian Kee Lee Sheng Tang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China National Medical Products Administration Key laboratory for Impurity Profile of Chemical Drugs Nanjing 210019China Chemical Drug Inspection laboratory 2 Jiangsu Institute for Food and Drug ControlNanjing 210019China Department of Pharmaceutical and Pharmacological Sciences Pharmaceutical AnalysisKU LeuvenHerestraat 49O&N2PB 923Leuven B-3000Belgium Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore

Owing to the serious potential side-effects on the environment and human health,the rapid detection and removal of antibiotics have become an important research *** this work,four zinc-based metal-organic frameworks(MOFs)with different functional groups,i.e.,Zn-MOF,Zn-MOF-CH_(3),Zn-MOF-NO_(2),Zn-MOF-COOH,were utilized for the construction of LDO/MOF composite materials with a nickel-iron-cobalt-based layered double oxide,*** results showed that the LDO/MOF composites not only had high sensitivity in detecting sulfonamide and quinolone antibiotics,but also had an appreciable ability to adsorb them from *** maximum adsorption capacities of all the four types of LDO@Zn-MOFs to all antibiotics can at least reach 150 mg/g,and the limits of detection in relation to all four antibiotics were at least as low as 100μg/*** work suggested the dual-function extraction performance can be attributed to the synergistic effects between the LDO and the ***,the strong ferromagnetism derived from the LDO provided great convenience for the separation and regeneration of the LDO/MOF composites.

关键词： Light-emitting metal-organic frameworks Layered double oxides Antibiotics Topological configurations Fluorescence detection

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Genetic landscape and clinical significance of cuproptosis-related genes in liver hepatocellular carcinoma

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Genes & Diseases 2024年第2期11卷 516-519页

作者： Dingtao Hu Yichuan Wang Xu Shen Tiantian Mao Xijun Liang Tengjiao Wang Weifeng Shen Yugang Zhuang Jin Ding Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghai 200433China Department of Emergency Shanghai Tenth People's HospitalTongji UniversitySchool of MedicineShanghai 200072China Bioinformatics analysis laboratory Center for Translational MedicineNaval Medical UniversityShanghai 200433China The Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China

Recently,Peter et al reported a novel form of cell death(cuproptosis)that was different from other known death mechanisms.1 They found that accumulation of copper ions could induce destabilization of Fe-S cluster proteins and aggregation of mitochondrial lipoylated proteins,ultimately resulting in cuproptosis.1 of note,ten genes were identified as cuproptosis-related genes(CRGs)in copper ion-induced cell death,including PDHB,PDHA1,DLAT,DLD,LIPT1,LIAS,FDX1,CDKN2A,GLS,and MTF1.1 Since dysregulation of copper metabolism is involved in many cancers,cuproptosis and CRGs may play vital roles in cancer development and treatment.1.2 Herein,our pancancer analysis revealed the coordinated upregulation of 9 of 10 CRGs in human liver hepatocellular carcinoma(LIHC)across 33 solid tumors(Fig.S1A;Fig.1A),suggesting the distinct role of CRGs in *** then explored the genetic landscape,biological function,and clinical significance of CRGs in LIHC,and validated our bioinformatic findings by in vitro experiments and clinical *** detailed methods were described in the supplementary material.

关键词： clinical metabolism hepatocellular

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The CropGPT project:Call for a global,coordinated effort in precision design breeding driven by Al using biological big data

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Molecular Plant 2024年第2期17卷 215-218页

作者： Wanchao Zhu Rui Han Xiaoyang Shang Tao Zhou Chengyong Liang Xiaomeng Qin Hong Chen Zaiwen Feng Hongwei Zhang Xingming Fan Weifu Li Lin Li National Key laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Key laboratory of Biology and Genetic Improvement of Maize in Arid Area of Northwest Region College of AgronomyNorthwest A&F UniversityYanglingShaanxi712100China College of Informatics Huazhong Agricultural UniversityWuhan 430070China State Key laboratory of Crop Gene Resources and Breeding Institute of Crop ScienceChinese Academy of Agricultural SciencesBeijing 100081China institute of Food Crops Sciences Yunnan Academy of Agricultural Sciences2238 Beijing RoadKunmingYunnan 650200China Hubei Hongshan laboratory Wuhan 430070China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityWuhan 430070China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China

Since the beginning of humanity,people have been seeking practical solutions to meet their most basic need:*** advent of agriculture greatly increased the food supply and led to a rapid increase in the human *** food production via agriculture can be attributed to both improved crop management practices and crop breeding through ***(crop)breeding has been categorized into four major stages based on the techniques employed(Wallace et al.,2018).

关键词： breeding seeking Wallace

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基因组倒位变异参与塑造了水稻遗传和表型的多样性

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Science Bulletin 2024年第5期69卷 593-596页

作者：贺文闯贺慧英袁巧玲张海李笑霞王天依杨映雪杨龙波杨玉亭刘相培魏华张泓张斌郭明亮冷月施传琳吕阳陈武汪贤猛张志鹏于博汇张彬涛许强钱宏革周永锋王少奎钱前商连光 Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China School of Life Sciences Xiamen UniversityXiamen 361005China State Key laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Provincial Key Laboratory of Plant Molecular BreedingSouth China Agricultural UniversityGuangzhou 510642China State Key laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China Yazhouwan National laboratory Sanya 572024China

Genomic structural variations affected widely gene function and morphological traits in *** inversions(INVs),as an important form of structural variation,can be large and extend to megabases in length[1],and form the genetic basis of local adaptation and ecotypic differentiation in sunflowers[2],Boechera stricta[3],monkeyflowers[4],mimetic butterflies[5]and ruffs[6],sex determination in nine-spined stickleback[7]and cancer and neurodevelopmental disease in human[8].At present,structural variants,and in particular,INVs,remain largely uncharacterized in plants despite their importance for local adaptation in a variety of species[1],with only a few studies exploring INVs polymorphisms at the population ***,it remains unclear whether adaptive INVs can directly shape the genetic basis for diverse phenotypes in plants,especially in domesticated crops.

关键词：水稻遗传 flowers adaptation

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Evaluation of soil erosion vulnerability in Hubei Province of China using RUSLE model and combination weighting method

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Journal of Mountain Science 2024年第10期21卷 3318-3336页

作者： YANG Yanpan TIAN Pei JIA Tinghui WANG Fei YANG Yang HUANG Jianwu Key laboratory for Geographical Process analysis&Simulation of Hubei Province Central China Normal UniversityWuhan 430079China College of Urban and Environmental Sciences Central China Normal UniversityWuhan 430079China Department of Civil and Environmental Engineering University of AlbertaEdmontonABT6G 1H9Canada

Soil erosion has been recognized as a critical environmental issue *** previous studies have primarily focused on watershed-scale soil erosion vulnerability from a natural factor perspective,there is a notable gap in understanding the intricate interplay between natural and socio-economic factors,especially in the context of spatial heterogeneity and nonlinear impacts of human-land *** address this,our study evaluates the soil erosion vulnerability at a provincial scale,taking Hubei Province as a case study to explore the combined effects of natural and socio-economic *** developed an evaluation index system based on 15 indicators of soil erosion vulnerability:exposure,sensitivity,and *** addition,the combination weighting method was applied to determine index weights,and the spatial interaction was analyzed using spatial autocorrelation,geographical temporally weighted regression and geographical *** results showed an overall decreasing soil erosion intensity in Hubei Province during 2000 and *** soil erosion vulnerability increased before 2000 and *** areas with high soil erosion vulnerability were mainly confined in the central and southern regions of Hubei Province(Xiantao,Tianmen,Qianjiang and Ezhou)with obvious spatial aggregation that intensified over *** factors(habitat quality index)had negative impacts on soil erosion vulnerability,whereas socio-economic factors(population density)showed substantial spatial variability in their *** was a positive correlation between soil erosion vulnerability and erosion intensity,with the correlation coefficients ranging from-0.41 and *** increase of slope was found to enhance the positive correlation between soil erosion vulnerability and intensity.

关键词： Soil erosion vulnerability RUSLE model Combination weighting method Driving factors Spatial heterogeneity

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Transcriptomic Landscape analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： Zi-Yuan Zou Tian-Yi Ren Jia-Qi Li Ting-Ying Jiao Meng-Yu Wang Lei-Jie Huang Shuang-Zhe Lin Yuan-Yang Wang Xiao-Zhen Guo Ye-Yu Song Rui-Xu Yang Cen Xie Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

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