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Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon

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Infectious Diseases of Poverty 2018年第1期7卷 448-459页

作者： Virginia Araujo Pereira Juan Camilo Sanchez-Arcila Mariana Pinheiro Alves Vasconcelos Amanda Ribeiro Ferreira Lorene de Souza Videira Antonio Teva Daiana Perce-da-Silva Maria Teresa Queiroz Marques Luzia Helena de Carvalho Dalma Maria Banic Luiz Cristovao Sobrino Porto Joseli Oliveira-Ferreira laboratory of Immunoparasitology Oswaldo Cruz Institute/FiocruzAv.Brasil 4365ManguinhosRio de JaneiroBrazil Institute of Infectology Emilio Ribas São PauloSao PauloBrazil laboratory of Immunodiagnosis Departament of Biological SciencesNational School of Public Health/FiocruzRio de JaneiroBrazil laboratory of Clinical Immunology Oswaldo Cruz Institute/FiocruzRio de JaneiroBrazil laboratory of histocompatibility and cryopreservation–hla of dhe/ibrag/uerj Rio de JaneiroBrazil Molecular Biology and Malaria Immunology Research Group Centro de Pesquisas Rene Rachou/FiocruzBelo HorizonteMinas GeraisBrazil

Background:Brazil has seen a great decline in malaria and the country is moving towards ***,for eventual elimination,the control program needs efficient tools in order to monitor malaria exposure and *** this study,we aimed to evaluate whether seroprevalence to the circumsporozoite protein(CSP)is a good tool for monitoring the exposure to and/or evaluating the burden and distribution of Plasmodium species in the Brazilian ***:Cross-sectional surveys were conducted in a rural area of Porto Velho,Rondônia *** infection was detected by microscopy and polymerase chain *** to the sporozoite CSP repeats of Plasmodium vivax,***,and ***(PvCS,PfCS,and PmCS)were detected using the enzyme-linked immunosorbent assay *** leukocyte antigen(hla)-DRB1 and DQB1 genes were typed using Luminex®xMAP®***:The prevalence of immunoglobulin G against *** CSP peptide(62%)was higher than ***(49%)and ***(46%)CSP *** of the studied individuals had antibodies to at least one of the three peptides(72%),34%had antibodies to all three peptides and 28%were *** the majority of the population was not infected at the time of the survey,74.3%of parasite-negative individuals had antibodies to at least one of the ***,among individuals carrying the haplotypes DRB1*04~DQB1*03,there was a significantly higher frequency of PfCS responders,and DRB1*16~DQB1*03 haplotype for PvCS and PfCS *** contrast,hla-DRB1*01 and hla-DQB1*05 allelic groups were associated with a lack of antibodies to *** and *** CSP repeats,and the haplotype DRB1*01~DQB1*05 was also associated with non-responders,including non-responders to ***:Our results show that in low transmission settings,naturally acquired antibody responses against the CSP repeats of ***,***,and *** in a single cross-sectional study may n

关键词： Malaria Circumsporozoite protein Serological marker Human leucocyte antigen IgG antibody Porto Velho Rondônia Brazil

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KIR and a specific hla-C gene are associated with susceptibility and resistance to hepatitis B virus infection in a Brazilian population

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Cellular & Molecular Immunology 2014年第6期11卷 609-612页

作者： Patricia Araujo Giovana Goncalves Flavia Latini Orlando Ferreira Luis Cristovao Porto Jose Augusto Barreto Manoel Joao Castelo Girao Ricardo Sobhie Diaz Colsan - Associacao Beneficente de Coleta de Sangue Sao Paulo SP Brazil Department of Gynecology Federal University ofao Paulo (UNIFESP) Sao Paulo SP Brazil Molecular Virology laboratory Biology Institute Federal University of Rio de Janeiro (UERJ) Rio de Janeiro R J Brazil histocompatibility and cryopreservation laboratory Federal University of Rio de Janeiro (UERJ) Rio de Janeiro R J Brazil Retrovirology laboratory Federal University of Sao Paulo (UNIFESP) Sao Paulo SP Brazil

BRIEF REPORT The activity of natural killer （NK） cells is partially regulated by killer cell immunoglobulin-like receptors （KIRs） interacting with human leukocyte antigen C （hla-C） ligands.1 The ligands of sever... 详细信息

关键词： infection Brazilian population

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hla antigens in individuals with down syndrome and alopecia areata

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World Journal of Clinical Cases 2014年第10期2卷 541-545页

作者： Juliany L Estefan Juliana C Oliveira Eliane D Abad Simone B Saintive Luis Cristóvao MS Porto Marcia Ribeiro Pediatric Dermatology Service Martagao Gesteira Pediatric Institute Federal University of Rio de JaneiroRio de Janeiro RJ 21941-901 Brazil Medical Genetics Service Martagao Gesteira Pediatric Institute Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-901 Brazil histocompatibility and cryopreservation-hla laboratory State University of Rio de Janeiro Policlínica Piquet Carneiro/UERJ Rio de JaneiroRJ 21941-901 Brazil

AIM: To describe human leukocyte antigen(hla) alleles in individuals with Down syndrome and alopecia areata. METHODS: A cross-sectional study was conducted, which evaluated 109 individuals. Ten with down syndrome(DS) and alopecia areata(AA), ten with DS without AA and ten with AA without DS, and their fami-lies. The individuals were matched by gender and age. The following data were computed: gender, age, ethnic group, karyotype, clinical presentation and family history of alopecia areata. Descriptive analysis: measures of central tendency and frequency distribution. Inferential analysis: Fisher's exact test to compare categorical data between the three groups and Kruskal-Wallis ANOVA test for numerical ***: Seventy per cent of evaluated individuals in the DS and AA group were male; presented mean age of 18.6(SD ± 7.2) years and 70% were Caucasian. We observed involvement of the scalp, with a single lesion in 10% and multiple in 90% of subjects. It was observed that there is no significant difference in the frequency distributions of the alleles hla loci A, B, C, DRB1 and DQB1 of subjects studied. However, according to Fisher's exact test, there is a trend(P = 0.089) of DS group to present higher proportions of hla-A 36 and hla-B 15 than the AA group and AA and DS ***: There was a tendency for the DS group, to present proportion of hla-A 36 and hla-B 15 higher than the AA group and group of individuals with AA and DS. However, there was no significant difference in the frequency distribution of the alleles.

关键词： Down syndrome Alopecia areata Human leukocyte antigen antigens Immunology Genetic

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