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Salt reduction in cured meat products: A review on strategies and mechanisms

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food Science and Human Wellness 2024年

作者： Qi Chen Jinxuan Cao Wenhai She Weidong Bai Xiaofang Zeng Hao Dong School of food and Health， Beijing technology and Business University Guangzhou Luxu food Ltd. Guangdong Provincial Key laboratory of Lingnan Specialty food Science and technology， Key laboratory of Green Processing and Intelligent Manufacturing of Lingnan Specialty food， Ministry of Agriculture， College of Light Industry and food Sciences， Academy of Contemporary Agricultural Engineering Innovations， Zhongkai University of Agriculture and Engineering

Sodium chloride is one of the most widely used additives in meat curing. However， cured meat products contribute to a portion of the total sodium dietary intake. Consumers and researchers’ concern about excessive sodium intake has prompted the food industry to consider ways to reduce salt content of cured meat products. The aim of this review is to provide a broad but comprehensive understanding of salt reduction strategies for cured meat products. The impact and limitations of each approach were discussed. Green technologies treatments， such as ultrasonic technology， high-pressure processing， seem to be potential to ensure microbiological safety in low-sodium cured meat products. However， these novel technologies can cause protein and fat oxidization in meat products. A combination of multiple treatments could give the desired effect. In addition， different parameter conditions need to be set according to the specific meat to achieve better salt reduction effect.

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Innovations in measuring and mitigating phytohemagglutinins,a key food safety concern in beans

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food Quality and Safety 2024年第1期8卷 1-11页

作者：吕晨泽房智慧杨素宁康徐敏 Arnaud Buhot Yanxia Hou 胡培雅徐沛 Key laboratory of Specialty Agri-products Quality and Hazard Controlling technology of Zhejiang Province College of Life SciencesChina Jiliang UniversityHangzhouChina University Grenoble Alpes CEACNRSINAC-SyMMESGrenobleFrance

Phytohemagglutinin(PHA)is a seed storage protein and a type of lectin originally discovered in the common bean(Phaseolus vulgaris)for its blood-agglutinating *** to its interactions with gut epithelia and digestive enzymes and its potential to trigger allergic reactions,PHA can lead to various symptoms in the human *** a result,it has been regarded as a signifcant antinutritional factor in beans and other *** several published works have summarized its structural,biochemical,and toxicological features,there is a scarcity of literature that reviews the detection,quantifcation,and reduction of PHA in beans,which is fundamental for the development of safer bean *** this review,we present a comprehensive analysis of traditional and innovative bio-sensing methods for measuring PHA,including the recently available ultrapure liquid chromatography–tandem mass spectrometry and emerging aptamer sensor-based techniques,while discussing their respective advantages and *** also revisit existing studies dedicated to creating PHA-depleted common bean varieties and explore the potential for reducing PHA content in beans without compromising their resistance to biotic ***,we offer insights into the potential for controlling PHA content using the latest biotechnologies and breeding ***,this review compiles rare and valuable information from studies that solely focuses on detection and depletion of PHA to shed light on and apply technological advancements in addressing potential food safety risks associated with the consumption of common beans.

关键词： Phytohemagglutinin common bean food safety breeding quantifcation.

Insights into the interplay between gut microbiota and lipid metabolism in the obesity management of canines and felines

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1761-1777页

作者： Kaiqi Li Xiangyu Xiao Yuling Li Sichen Lu Jianghang Zi Xiaoqiang Sun Jia Xu Hao‑Yu Liu Xiaoqiong Li Tongxing Song Demin Cai laboratory of Animal Physiology and Molecular Nutrition Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular DesignCollege of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China College of Animal Science and technology Huazhong Agricultural UniversityWuhan 430070China School of Life Science and Engineering Foshan UniversityFoshan 528231China State Key laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‑products Institute of Food ScienceZhejiang Academy of Agricultural SciencesHangzhouZhejiang 310021People’s Republic of China College of Agriculture Jinhua PolytechnicJinhua 321017China

Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals,including dogs and *** occurs with multiple comorbidities,such as diabetes,hypertension,heart disease and osteoarthritis in dogs and cats.A direct link between lipid metabolism dysregulation and obesity-associated diseases has been ***,the understanding of such pathophysiology in companion animals is *** review aims to address the role of lipid metabolism in various metabolic disorders associated with obesity,emphasizing the involvement of the gut ***,we also discuss the management of obesity,including approaches like nutritional interventions,thus providing novel insights into obesity prevention and treatment for canines and felines.

关键词： Cat Dog Gut microbiota Lipid metabolism Obesity Management

Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 765-780页

作者： Siqin He Lulu Wang Dongxu Wu Fan Tong Huan Zhao Hanmei Li Tao Gong Huile Gao Yang Zhou Key laboratory of tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Key laboratory of Drug-Targeting and Drug Delivery System West China School of PharmacySichuan UniversityChengdu 610041China Revvity Inc. WalthamMA 02451USA School of food and Biological Engineering Chengdu UniversityChengdu 610106China

A major challenge facing photodynamic therapy(PDT) is that the activity of the immuneinduced infiltrating CD8^(+)T cells is subject to the regulatory T lymphocytes(Tregs), leaving the tumor at risk of recurrence and metastasis after the initial ablation. To augment the antitumor response and reprogram the immunosuppressive tumor microenvironment(TME), a supramolecular photodynamic nanoparticle(DACss) is constructed by the host-guest interaction between demethylcantharidin-conjugated β-cyclodextrin(DMC-CD) and amantadine-terminated disulfide-conjugated FFVLGGGC peptide with chlorin e6 decoration(Ad-ss-pep-Ce6) to achieve intelligent delivery of photosensitizer and immunomodulator for breast cancer treatment. The acid-labile β-carboxamide bond of DMC-CD is hydrolyzed in response to the acidic TME, resulting in the localized release of DMC and subsequent inhibition of *** guest molecule Ad-ss-pep-Ce6 can be cleaved by a high level of intracellular GSH, reducing photosensitizer toxicity and increasing photosensitizer retention in the tumor. With a significant increase in the CTL/Treg ratio, the combination of Ce6-based PDT and DMC-mediated immunomodulation adequately achieved spatiotemporal regulation and remodeling of the TME, as well as improved primary tumor and in situ lung metastasis suppression with the aid of PD-1 antibody.

关键词： Photodynamic therapy Immunosuppressive microenvironment Immunomodulator Dual-responsive Supramolecularassembly Checkpointblockade

Immunological disturbance effect of exogenous histamine towards key immune cells

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food Science and Human Wellness 2024年第4期13卷 1856-1863页

作者： Yanan Liu Huan Li Chong Wang Shanjun Chen Renjie Lian Weiqiang Wang Linglin Fu Yanbo Wang food Safety Key laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Jinghai Group Co. Ltd.Rongcheng 264307China Jinhua Jinnian Ham Co. Ltd.Jinhua 321041China School of food and Health Beijing Technology and Business UniversityBeijing 100048China

Histamine in food has attracted widespread attention due to the potential toxicity and associated health ***,its influences on immunological components,especially the function of key immune cells,are still poorly *** this work,we explored the effects of exogenous histamine on the function of key immune cells such as intestinal epithelial cells,dendritic cells,and T *** results showed that histamine could affect the expression of allergy-related genes in CMT93 cells at a high dose of ***,it’s found that histamine could cause an imbalance in the levels of relevant immune factors secreted by dendritic cells and T cells,especially those related to *** the same time,the proportion of MHC class IIpositive dendritic cells and the proportion of T helper 2(Th2)cells in CD4^(+)T cells increased after histamine *** concluded that the presence of a certain level of histamine in food may affect the expression of allergy-related cytokines,disrupt the balance of the immune homeostasis,and potentially lead to adverse immune *** work demonstrated the importance of including the estimation of histamine’s immune safety in aquatic products rather than merely considering the potential risk of food poisoning.

关键词： Histamine Immunological disturbance food allergy Immune factor Edible safety

A tribo-chemical view on astringency of plant-based food substances

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Friction 2024年第7期12卷 1392-1407页

作者： Samuel S.GAMANIEL Paloma S.DUEÑAS ROBLES Hans TROMP Els H.A.de HOOG Sissi de BEER Emile van der HEIDE laboratory for Surface technology and Tribology Faculty of Engineering TechnologyUniversity of TwenteEnschede 7522 LWthe Netherlands NIZO food Research B.V. Ede6710 BAthe Netherlands Department of Molecules and Materials MESA+Institute for Nanotechnology University of TwenteEnschede 7500 AEthe Netherlands

Consumption of plant-based food products having high composition of polyphenols leads to the sensation of *** sliding oral surfaces,friction is an essential property during the oral perception of roughness and dryness which are attributes associated with *** factors including the chemical composition of interacting layers,structure and operation of interfaces have an effect on the astringency development *** manner of interactions occurring at oral interfaces suggest there is a system dependence of astringency and highlights the importance of adopting a tribosystems *** measurement techniques have shown an existing relationship between salivary protein-polyphenol interaction and an astringent ***,the tribo-chemistry involved in this multifaceted sensation remains largely unexplored in a comprehensive *** this review the underlying tribo-chemical processes useful in understanding the mechanism of astringency are highlighted and discussed considering current techniques employed to investigate astringency *** of lubrication on oral surfaces owing to the tribo-chemical interactions involving saliva and astringent plant proteins requires subsequent deformations of oral tissues which are significant enough to induce strains at mechanoreceptor locations,leading to the sensation of *** is proposed that micro-scale contact modelling on the interaction of food particles/aggregates,boundary layers and oral surfaces shows potential in addressing the knowledge gap between tribo-chemical measurement techniques and panel tests,making it possible to attain a predictor for astringency.

关键词： oral lubrication astringency tribo-chemistry tribology

Unveiling the Role of Acetate in Probiotic-Mediated Promotion of Intestinal Serotonin Production Using Intestinal Organoids

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food Science and Human Wellness 2024年

作者： Peijun Tian Zheng Wang Xin Qian Jianxin Zhao Gang Wang Wei Chen State Key laboratory of food Science and Resources， Jiangnan University School of food Science and technology， Jiangnan University National Engineering Research Center for Functional food， Jiangnan University (Yangzhou) Institute of food Biotechnology， Jiangnan University

The neurotransmitter 5-hydroxytryptamine （5-HT）， primarily produced by intestinal enterochromaffin cells （EC）， relies on Tryptophan hydroxylase （TPH1） for synthesis. Research suggested Bifidobacterium breve CCFM1025's potential in regulating Tph1 gene expression， maintaining 5-HT levels in stressed mice， but its precise mechanisms were unclear. This study used metabolomic techniques to assess probiotic fermentation products， revealing acetate as the crucial element in Bb-CCFM1025's regulation of gut 5-HT synthesis. Further exploration correlated acetate with Tph1 transcription in intestinal organoids. Transcriptomic methods and qRT-PCR validation demonstrated how acetate facilitated 5-HT synthesis and secretion. It unveiled that acetate orchestrates signaling pathways (PI3K-AKT， PLC-pERK， and PLC-IP3-Ca2+) within EC cells， enabling 5-HT production. These findings elucidate the biochemical mechanisms behind specific probiotics' effects， aiding in the targeted selection of similar beneficial strains. This study offers theoretical support for choosing probiotics with analogous functionalities based on their physiological impacts.

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Protective effect of marine animals hydrolysis-peptides on adjuvant-induced arthritis in mice by gut microbiota and SCFAs

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food Science and Human Wellness 2024年

作者： Zhen Zhang Shasha Tang Ziyan Wang Jiaojiao Han Jun Zhou Chenyang Lu Bin Liu Xiaoling Sun Rongxian Yu Rixin Wang Xiurong Su School of Marine Science， Ningbo University State Key laboratory for Quality and Safety of Argo-products， Ningbo University Vigor technology Group

Marine fauna provides a plentiful repository of peptides and bioactive proteins. Peptides and proteins isolated from marine animals have been studied and applied in the development of food supplements， drugs， and cosmeceutical products because of their special bioactivities， such as anti-inflammatory and antioxidant effects This study focused on exploring the alleviating effects of five major marine animal-derived peptides (Apostichopus japonicus， Acaudina leucoprocta， Melanogrammus aeglefinus， Phascolosoma esculenta and Rhopilema esculentum) on adjuvant-induced arthritis (AIA). The treatment with five marine animals-derived peptides downregulated the expression levels of pro-inflammatory cytokines of IL-1β， IL-17 and TNF-α in the bones of the mice with AIA and alleviated the rough surface of bone tissues significantly. A. japonicus-treatment ameliorates inflammation by restoring NF-κB pathway in AIA mice. High-throughput sequencing of the gut microbiota based on 16S rRNA sequencing revealed that A. japonicus peptide-treated AIA mice showed alterations and imbalance of intestinal flora and an increased abundance of Lactobacillus and Clostridium. Furthermore， metabolomic analysis showed that the level of SCFAs in the feces was enhanced to different degrees in mice treated with five major marine animal-derived peptides. Taken together， we propose that major marine animal-derived peptides can alleviate arthritis by improving the imbalance in the gut flora and increasing SCFA production to varying degrees.

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Melatonin delays leaf senescence in pak choi(Brassica rapa ***)by regulating biosynthesis of the second messenger cGMP

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Horticultural Plant Journal 2024年第1期10卷 145-155页

作者： Xuesong Liu Ronghui An Guofeng Li Shufen Luo Huali Hu Pengxia Li Institute of Agricultural Facilities and Equipment Jiangsu Academy of Agricultural SciencesNanjingJiangsu 210014China School of food and Biological Engineering Jiangsu UniversityZhenjiangJiangsu 212013China Jiangsu Key laboratory for Horticultural Crop Genetic Improvement NanjingJiangsu 210014China Key laboratory of Cold Chain Logistics technology for Agro-products Ministry of Agriculture and Rural AffairsNanjingJiangsu 210014China Jinan Fruit Research Institute All China Federation of Supply and Marketing CooperativesJinanShandong 250220China

Melatonin(MT)is a low molecular weight compound with multiple biological functions in *** is known to delay leaf senescence in various ***,no data are available on the MT signaling pathway in postharvest *** study demonstrates that MT increases cGMP concentration and the expression of the cGMP synthesis gene BcGC1 in pak *** c GMP inhibitor LY83583 destroys effect of MT delaying the leaf ***83583 also prevents MT treatment from reducing the expression of chlorophyll metabolism-related genes(BcNYC1,BcNOL,BcPPH1/2,BcSGR1/2,and BcPAO)and senescence genes(BcSAG12 and BcSAG21).It also inhibits MT from reducing the activity of the key chlorophyll catabolism enzymes Mg-dechelatase,pheophytinase,and pheide a ***,the ability of MT to maintain high levels of chlorophyll metabolites is also *** Arabidopsis c GMP synthetic gene mutant atgc1 was used to confirm that delayed leaf senescence caused by MT is mediated,at least in part,by the second messenger c GMP.

关键词： Pak choi Melatonin cGMP Chlorophyll degradation Senescence