检索结果-南通市图书馆

L-Norvaline, a new therapeutic agent against Alzheimer’s disease

Neural Regeneration Research 2019年第9期14卷 1562-1572页

作者： Baruh Polis Kolluru D.Srikanth Vyacheslav Gurevich Hava Gil-Henn Abraham O.Samson Drug Discovery laboratory The Azrieli Faculty of MedicineBar-Ilan UniversitySafedIsrael laboratory of Cell Migration and Invasion The Azrieli Faculty of MedicineBar-Ilan UniversitySafedIsrael laboratory of cancer personalized medicine and diagnostic genomics The Azrieli Faculty of MedicineBar-Ilan UniversitySafedIsrael

Growing evidence highlights the role of arginase activity in the manifestation of Alzheimer’s disease(AD).Upregulation of arginase was shown to contribute to *** of arginase activity appears to be a promising approach for interfering with the pathogenesis of ***,the enzyme represents a novel therapeutic *** this study,we administered an arginase inhibitor,L-norvaline(250 mg/L),for 2.5 months to a triple-transgenic model(3×Tg-AD)harboring PS1M146V,APPSwe,and tauP301L ***,the neuroprotective effects of L-norvaline were evaluated using immunohistochemistry,proteomics,and quantitative polymerase chain reaction ***,we identified the biological pathways activated by the ***,L-norvaline treatment reverses the cognitive decline in AD *** treatment is neuroprotective as indicated by reduced beta-amyloidosis,alleviated microgliosis,and reduced tumor necrosis factor transcription ***,elevated levels of neuroplasticity related postsynaptic density protein 95 were detected in the hippocampi of mice treated with ***,we disclosed several biological pathways,which were involved in cell survival and neuroplasticity and were activated by the *** these modes of action,L-norvaline has the potential to improve the symptoms of AD and even interferes with its *** such,L-norvaline is a promising neuroprotective molecule that might be tailored for the treatment of a range of neurodegenerative *** study was approved by the Bar-Ilan University Animal Care and Use Committee(approval No.82-10-2017)on October 1,2017.

关键词： dementia arginase inhibition arginine urea cycle microgliosis neuroinflammation cytokines tumor necrosis factor mTOR neurodegeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Next-generation sequencing and its clinical application

引用

cancer Biology & medicine 2019年第1期16卷 4-10页

作者： Dahui Qin Molecular diagnostic laboratory Department of Pathology Moffitt Cancer Center

Next-generation sequencing (NGS) is a new technology used for DNA and RNA sequencing and variant/mutation detection. NGS can sequence hundreds and thousands of genes or whole genome in a short period of time. The sequence variants/mutations detected by NGS have been widely used for disease diagnosis, prognosis, therapeutic decision, and follow up of patients. The capacity of its massive parallel sequencing offers new opportunities for personalized precision medicine.

关键词： NGS DNA capacity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Somatic DNA copy number alterations and their potential clinical utility for predicting lethal prostate cancer

引用

Asian Journal of Andrology 2013年第5期15卷 586-587页

作者： Wennuan Liu Li Wang Jianfeng Xu Center for cancer genomics Winston-Salem NC 27157 USA Center for genomics and personalized medicine Research Wake Forest University School of Medicine Winston-Salem NC 27157 USA Fudan Institute of Urology Huashan Hospital Fudan University Shanghai 200040 China

Current clinicopathologic indicators are insufficient to distinguish the small percentage of aggressive prostate cancer （PCa） from the vast majority of indolent disease at diagnosis, leading to overtreatment of PCa. A recent study reported and confirmed a strong association of PCa-specific mortality with somatic DNA copy number alterations （CNAs） in primary pro- state tumors.

关键词： Somatic DNA clinical utility prostate cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gallbladder cancer harboring ERBB2 mutation on the primary and metastatic site: A case report

引用

World Journal of Gastrointestinal Oncology 2019年第9期11卷 761-767页

作者： Chiaki Inagaki Daichi Maeda Akie Kimura Toru Otsuru Yoshifumi Iwagami Naohiro Nishida Daisuke Sakai Ryo Shitotsuki Shinichi Yachida Yuichiro Doki Taroh Satoh Department of Frontier Science for cancer and Chemotherapy Osaka University Graduate School of MedicineSuita 5650871OsakaJapan Department of Clinical genomics Osaka University Graduate School of MedicineSuita 5650871OsakaJapan Gastroenterological Surgery Osaka University Graduate School of MedicineSuita 5650871OsakaJapan Center for cancer genomics and personalized medicine Osaka University Graduate School of MedicineSuita 5650871OsakaJapan Department of cancer Genome Informatics Osaka University Graduate School of MedicineSuita 5650871OsakaJapan

BACKGROUND Bile duct cancer constitutes gallbladder cancer(GBC),intrahepatic cholangiocarcinoma(ICA),and extrahepatic cholangiocarcinoma(ECA).These three entities show morphological and immunohistochemical resemblance so that it is difficult to differentiate between primary ICA and liver metastasis of GBC,which sometimes becomes a point of discussion in clinical *** these cancers demonstrate significant differences in their mutational landscape,several reports demonstrated shared genomic alteration in paired primary and metastatic site aids in distinguishing metastatic recurrence from second primary *** SUMMARY We present a 73-year-old female patient who underwent curative resection for GBC harboring epidermal growth factor receptor 2(ERBB2)activating mutation on next-generation sequencing(NGS)-based genomic *** year later,a hepatic lesion was observed on follow-up imaging and she underwent surgical resection for a pathological *** histological findings of the hepatic lesion were similar to those of the primary ***,using NGS panel testing,the hepatic lesion was found to have ERBB2 activating mutation,which is the identical mutation detected in the sequencing result of the primary ***2 activating mutation occurs more frequently in GBC than ICA and ***,in the present case,we think this molecular finding potentiated the diagnosis of the liver mass toward a metastatic ***,this patient underwent HER2-targeted treatment with lapatinib in combination with capecitabin and obtained clinical *** This case illustrated NGS panel usefulness in distinguishing GBC recurrence from second primary cancer and HER2-targeted agent efficacy on ERBB2 mutated GBC.

关键词： Gall bladder cancer Bile duct cancer ERBB2 mutation Precision medicine Mutation-driven targeted treatment Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomic alterations in pancreatic cancer and their relevance to therapy

引用

World Journal of Gastrointestinal Oncology 2015年第10期7卷 250-258页

作者： Erina Takai Shinichi Yachida Division of cancer genomics National Cancer Center Research Institute

Pancreatic cancer is a highly lethal cancer type, for which there are few viable therapeutic options. But, with the advance of sequencing technologies for global genomic analysis, the landscape of genomic alterations in pancreatic cancer is becoming increasingly well understood. In this review, we summarize current knowledge of genomic alterations in 12 core signaling pathways or cellular processes in pancreatic ductal adenocarcinoma, which is the most common type of malignancy in the pancreas, including four commonly mutated genes and many other genes that are mutated at low frequencies. We also describe the potential implications of these genomic alterations for development of novel therapeutic approaches in the context of personalized medicine.

关键词： Pancreatic cancer Genomic alterations Signaling pa

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Circulating tumor DNA as a liquid biopsy target for detection of pancreatic cancer

引用

World Journal of Gastroenterology 2016年第38期22卷 8480-8488页

作者： Erina Takai Shinichi Yachida Division of cancer genomics National Cancer Center Research InstituteTokyo

Most pancreatic cancer patients present with advanced metastatic disease, resulting in extremely poor 5-year survival, mainly because of the lack of a reliable modality for early detection and limited therapeutic options for advanced disease. Therefore, there is a need for minimally-invasive diagnostic tools for detecting pancreatic cancer at an early stage, when curative surgery and also novel therapeutic approaches including precision medicine may be feasible. The "liquid biopsy" addresses these unmet clinical needs based on the concept that simple peripheral blood sampling and detection of circulating tumor DNA(ct DNA) could provide diagnostic information. In this review, we provide an overview of the current status of bloodbased tests for diagnosis of pancreatic cancer and the potential utility of ct DNA for precision medicine. We also discuss challenges that remain to be addressed in developing practical ct DNA-based liquid biopsy approaches for early diagnosis of pancreatic cancer.

关键词： Circulating tumor DNA Pancreatic cancer Biomarker Precision medicine Liquid biopsy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Novel ATM Antisense Transcript ATM-AS Positively Regulates ATM Expression in Normal and Breast cancer Cells

引用

Current Medical Science 2022年第4期42卷 681-691页

作者： He CHENG Er-shao ZHANG Xiao SHI Ping-ping CAO Bei-jing PAN Xin-xin SI Yue LIU Nan YANG Ying CHU Xu-chun WANG Xiao HAN Zhi-hong ZHANG Yu-jie SUN Key laboratory of Human Functional genomics of Jiangsu Province Nanjing Medical UniversityNanjing 210000China Department of Pathology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210000China Key laboratory of cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjing 210000China Department of Cell Biology Nanjing Medical UniversityNanjing 210000China

Objective:The ataxia telangiectasia mutated(ATM)gene is a master regulator in cellular DNA damage *** dysregulation of ATM expression is frequent in breast cancer,and is known to be involved in the carcinogenesis and prognosis of ***,the underlying mechanism remains *** bioinformatic analysis predicted a potential antisense transcript ATM-antisense(AS)from the opposite strand of the ATM *** purpose of this study was to identify ATM-AS and investigate the possible effect of ATM-AS on the ATM gene ***:Single strand-specific RT-PCR was performed to verify the predicted antisense transcript ATM-AS within the ATM gene ***-PCR and Western blotting were used to detect the expression levels of ATM-AS and ATM in normal and breast cancer cell lines as well as in tissue *** reporter gene assays,biological mass spectrometry,ChIP-qPCR and RIP were used to explore the function of ATM-AS in regulating the ATM *** and host-cell reactivation(HCR)assay were performed to evaluate the biological significance of ATM-AS in ATM-mediated DNA damage *** cancer tissue samples were used for evaluating the correlation of the ATM-AS level with the ATM expression as well as prognosis of the ***:The ATM-AS significantly upregulated the ATM gene activity by recruiting KAT5 histone acetyltransferase to the gene *** reduced ATM-AS level led to the abnormal downregulation of ATM expression,and impaired the ATM-mediated DNA damage repair in normal breast cells in *** ATM-AS level was positively correlated with the ATM expression in the examined breast cancer tissue samples,and the patient ***:The present study demonstrated that ATM-AS,an antisense transcript located within the ATM gene body,is an essential positive regulator of ATM expression,and functions by mediating the binding of KAT5 to the ATM *** findings uncover the novel mechanism und

关键词： antisense transcript ataxia telangiectasia mutated ataxia telangiectasia mutatedantisense breast cancer KAT5

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biological functions and potential implications of circular RNAs

引用

The Journal of Biomedical Research 2023年第2期37卷 89-99页

作者： Lan Ma Haiyan Chu Meilin Wang Zhengdong Zhang Department of Genetic Toxicology The Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Environmental genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China.

Circular RNAs(circRNAs) are characterized by a covalent closed-loop structure with an absence of both 5′ cap structure and 3′ polyadenylated tail. Numerous studies have found that circRNAs play an important role in various diseases and have a variety of biological regulatory mechanisms, including acting as microRNA sponges,interacting with proteins, modulating the expression of related genes and translating into peptides or *** have also been used as biomarkers for a number of diseases, which could improve clinical *** review summarizes the most recent advances in biogenesis and knowledge of the biological functions of circRNAs as well as the related bioinformatics databases. We specifically describe developments in understanding of circRNA functions in the field of environmental exposure-induced diseases. Finally, we focus on potential clinical implications of circRNAs to facilitate their clinical transformation into disease treatment.

关键词： circular RNAs biogenesis mechanisms database biomarkers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Application of liquid biopsy in precision medicine： opportunities and challenges

引用

Frontiers of medicine 2017年第4期11卷 522-527页

作者： Junyun Wang Shuang Chang Guochao Li Yingli Sun Key laboratory of Genomic and Precision medicine China Gastrointestinal Cancer Research CenterBeijing Institute of GenomicsChineseAcademy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosis and treatment of individuals. Detecting circulating tumor cell （CTC） or circulating tumor DNA （ctDNA） in plasma or serum could serve as liquid biopsy, which would be useful for numerous diagnostic applications. Liquid biopsies can help clinicians screen and detect cancer early, stratify patients to the most suitable treatment and real-time monitoring of treatment response and resistance mechanisms in the tumor, evaluate the risk for metastatic relapse, and estimate prognosis. We summarized the advantages and disadvantages of tissue and liquid biopsies. We also further compared and analyzed the advantages and limitations of detecting CTCs, ctDNAs, and exosomes. Furthermore, we reviewed the literature related with the application of serum or plasma CTCs, ctDNAs, and exosomes for diagnosis and prognosis of cancer. We also analyzed their opportunities and challenges as future biomarkers. In the future, liquid biopsies could be used to guide cancer treatment. They could also provide the ideal scheme to personalize treatment in precision medicine.

关键词： liquid biopsy circulating tumor cells cell-free ctDNA exosomes precision medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Single-cell transcriptomics reveals cell type diversity of human prostate

引用

Journal of Genetics and genomics 2022年第11期49卷 1002-1015页

作者： Yang Chen Peng Zhang Jinling Liao Jiwen Cheng Qin Zhang Tianyu Li Haiying Zhang Yonghua Jiang Fangxing Zhang Yanyu Zeng Linjian Mo Haibiao Yan Deyun Liu Qinyun Zhang Chunlin Zou Gong-Hong Wei Zengnan Mo Center for Genomic and personalized medicine Guangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Key laboratory of Metabolism and Molecular medicine of the Ministry of Education&Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFudan University Shanghai Cancer CenterFudan UniversityShanghai 201114China Biocenter Oulu Faculty of Biochemistry and Molecular MedicineUniversity of OuluOuluFinland Key laboratory of Longevity and Ageing-Related Disease of Chinese Ministry of Education Center for Translational Medicine and School of Preclinical MedicineGuangxi Medical UniversityNanningGuangxi 530021China

Extensive studies have been performed to describe the phenotypic changes occurring during malignant transformation of the ***,the cell types and associated changes that contribute to the development of prostate diseases and cancer remain elusive,largely due to the heterogeneous composition of prostatic ***,we conduct a comprehensive evaluation of four human prostate tissues by singlecell RNA sequencing(sc RNA-seq)to analyze their cellular *** identify 18 clusters of cell types,each with distinct gene expression profiles and unique features;of these,one cluster of epithelial cells(Ep)is found to be associated with immune *** addition,we characterize a special cluster of fibroblasts and aberrant signaling changes associated with prostate cancer(PCa).Moreover,we provide insights into the epithelial changes that occur during the cellular senescence and *** results expand our understanding of the unique functional associations between the diverse prostatic cell types and the contributions of specific cell clusters to the malignant transformation of prostate tissues and PCa development.

关键词： scRNA-seq Human prostate Cell type diversity Immunity Cellular senescence Prostate cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：