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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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DNA DAMAGE INDUCED IN MAMMALIAN CELLS BY ACTIVE OXYGEN SPECIES

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Science China Chemistry 1988年第6期31卷 676-686页

作者：郑荣梁 A.A.LESKO P.O.P.TS’O The Johns Hopkins University Baltimore laboratory of biophysics. department of biology School of Hygiene & Public Health Lanzhou University Division of biophysics USA

The active oxygen species generated by ionizing radiation, hyperoxia, paraquat and hydrogen perox-ide induced unscheduled DNA synthesis and DNA synthesis rate inhibition in human fetal lung fibroblast(IMR-90) and transformed cell line derived from Syrian hamster embryo fibroblast (BP6T). The D-glu-cose and sucrose, which were unable to generate active oxygen species, could induce neither unscheduledDNA synthesis nor DNA synthesis rate inhibition. The indicator of DNA synthesis rate inhibition for ac-tive oxygen species was more sensitive than that of unscheduled DNA synthesis. All the enhancing chem-icals on active oxygen species aggravated DNA damage, while all the inhibiting chemicals alleviatedDNA damage. Results showed that active oxygen species do damge DNA. The active oxygen speciesmechanism for carcinogenesis, mutation and aging is applicable.

关键词： DNA DAMAGE INDUCED IN MAMMALIAN CELLS BY ACTIVE OXYGEN SPECIES DDC

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Light-Induced Charge Separation and Transfer in Bacteriorhodopsin

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Chinese Physics Letters 2000年第4期17卷 301-303页

作者： HUANG Yu-hua ZHAO You-yuan ZHANG Zhong-bin OU-YANG Xiao-Ping GONG Qin-Gan CHEN Ling-Bing LI Fu-ming LIU Jian DING Jian-dong LI Qing-guo State Key laboratory for Materials ModiScation by Laser Ion and Electron Beams Department of Physicst department of biology and biophysics Fudan Universityf Shanghai 200433

The photo-voltage signals in bacteriorhodopsin(bR)excited by 1064nm pulse laser are different from those by 532 or 355 *** shows that the positive and negative photoelectric signals are produced by the motion of the positive and negative charges,respectively,and more energy is needed for producing the positive charges than the *** mechanism of light-induced charge generation and charge transfer in bR was studied and analyzed by measuring the photoelectric signals with different impedance of measuring circuit and different pulse-width of 532 nm laser as pump light.

关键词： pump pulse laser

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Cu(Ⅱ), Fe(Ⅲ) and Mn(Ⅱ) combinations as environmental stress factors have distinguishing effects on Enterococcus hirae

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Journal of Environmental Sciences 2015年第2期27卷 95-100页

作者： Zaruhi Vardanyan Armen Trchounian department of biophysics Faculty of Biology Yerevan State University department of Microbiology Plants and Microbes Biotechnology Faculty of Biology Yerevan State University

Pollution by various heavy metals as environmental stress factors might affect bacteria. It was established that iron（Fe（Ⅲ））, manganese（Mn（Ⅱ）） and copper（Cu（Ⅱ）） ion combinations caused effects on Enterococcus hirae that differed from the sum of the effects when the metals were added separately. It was shown that the Cu2＋–Fe3＋combination decreased the growth and ATPase activity of membrane vesicles of wild-type E. hirae ATCC9790 and atp D mutant（with defective FoF1-ATPase） MS116. Addition of Mn2＋–Fe3＋combinations within the same concentration range had no effects on growth compared to control（without heavy metals）. ATPase activity was increased in the presence of Mn2＋–Fe3＋, while together with0.2 mmol/L N,N′-dicyclohexylcarbodiimide（DCCD）, ATPase activity was decreased compared to control（when only 0.2 mmol/L DCCD was present）. These results indicate that heavy metals ion combinations probably affect the FOF1-ATPase, leading to conformational changes. Moreover the action may be direct or be mediated by environment redox *** effects observed when Fe3＋was added separately disappeared in both cases, which might be a result of competing processes between Fe3＋and other heavy metals. These findings are novel and improve the understanding of heavy metals ions effects on bacteria,and could be applied for regulation of stress response patterns in the environment.

关键词： Heavy metal ions Environmental stress Bacterial growth ATPase activity Enterococci

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Preliminarily Investigating the Polymorphism of Self-organized Actin Filament in Vitro by Atomic Force Microscope

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Acta Biochimica et Biophysica Sinica 2004年第9期36卷 637-643页

作者： Jun ZHANG1,2, Yuan-Liang WANG1*, Xin-Yong Chen3, Chuang-Long HE1, Chao CHENG1, and Yang CAO1 1Key Lab of Biomechanics & Tissue Engineering, Chongqing University, Chongqing 400044, China biology department, Chongqing University of Medicine Sciences, Congqing 400016, China 3laboratory of biophysics.and Surface Analysis, University of Nottingham, Nottingham NG7 2RD, United Kingdom Key Lab of Biomechanics & Tissue Engineering Chongqing University biology department Chongqing University of Medicine Sciences laboratory of biophysics.and Surface Analysis University of Nottingham

With the atomic force microscope (AFM), we preliminarily investigated the large-scale structure of actin filaments formed in low concentration protein solution (5 μg/ml) via self-organization without the presence of any F-actin dynamic interfering factors (such as phalloidin) in vitro. It was found that the G-actin could be polymerized into ordered filamentous structures with different diameter from the slimmest filament of single F-actin to giant filament in tree-like branched aggregates. The observed polymerized actin filaments, to which our most intense attention was attracted, was discretely distributed and showed obvious polymorphism distinctly different from those in the presence of phalloidin or actin binding proteins (fimbrin, gelsolin, etc.) in previous experiments. Latter structures were mainly composed of single F-actin and/or multifilaments clearly consisting of several single F-actin. The experimental results clearly demonstrated that non-interference with the F-actin intrinsic dynamics in self-organizing could lead to the polymorphism of actin filamentous structures, and further analysis implied that the disturbance of normal F-actin dynamics by many factors could prevent the emergence of structural polymorphism, more often than not, give rise to formation of specific structures instead and different interference would bring about various particular structures under certain conditions.

关键词： actin self-organization filamentous structure polymorphism atomic force microscope

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Quantum entanglement between the two-mode fields and atomic entropy squeezing in the system of a moving atom interacting with two-mode entangled coherent field

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Chinese Physics B 2009年第7期18卷 2794-2800页

作者：邹艳李永平 department of Physics Dezhou University Key biophysics.laboratory in Universities of Shandong

This paper investigates the entropy squeezing of a moving two-level atom interacting with the two-mode entangled coherent field via two-photon transition by using an entropic uncertainty relation and the degree of entanglement between the two-mode fields by using quantum relative *** results obtained from numerical calculation indicate that the squeezed period,the duration of entropy squeezing and the maximal squeezing can be controlled by appropriately choosing the intensity of the light field,the atomic motion and the field-mode *** atomic motion leads to the periodic recovery of the initial maximal degree of entanglement between the two-mode ***,there exists a corresponding relation between the time evolution properties of the atomic entropy squeezing and those of the entanglement between the two-mode fields.

关键词： entropy squeezing quantum relative entropy atomic motion and field-mode structure two-mode entangled light field

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Single-atom entropy squeezing and quantum entanglement in Tavis-Cummings model with atomic motion

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Chinese Physics B 2010年第7期19卷 276-283页

作者：邹艳 department of Physics Dezhou University Key biophysics.laboratory in Universities of Shandong

We examine the single-atom entropy squeezing and the atom-field entanglement in a system of two moving twolevel atoms interacting with a single-mode coherent field in a lossless resonant cavity. Our numerical calculations indicate that the squeezing period, the squeezing time and the maximM squeezing can be controlled by appropriately choosing the atomic motion and the field-mode structure. The atomic motion leads to a periodical time evolution of entanglement between the two-atom and the field. Moreover, there exists corresponding relation between the time evolution properties of the atomic entropy squeezing and that of the entanglement between the two atoms and the field.

关键词： atomic entropy squeezing quantum reduced entropy Tavis-Cummings model atomicmotion and field-mode structure

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A brief introduction of cryo-EM revolution—the Nobel Prize in Chemistry 2017

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Science China(Life Sciences) 2018年第3期61卷 368-370页

作者： Kai Zhang Zheng Liu Structural Studies MRC Laboratory of Molecular Biology Francis Crick Avenue department of Biochemistry and Molecular biophysics Columbia University

Seeing is believing! Cryo-electron microscopy （cryo-EM） has greatly expanded the limit of human vision. The Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for their development of cryo-EM. This method has revolutionized the structural study of biomolecules in the past few years. Now, scientists can routinely visualize many different kinds of biological ma- chineries with unprecedented details.

关键词：诺贝尔化学奖金电子显微镜弗兰克习惯性科学家

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The convergent point of the endocytic and autophagicpathways in leydig cells

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Cell Research 1999年第4期9卷 243-253页

作者： YI JING XUE MING TANG(department of biophysics.and Cell biology, Shanghai Second Medical University, Shanghai 200025, China) department of biophysics.and Cell biology Shanghai Second Medical University Shanghai 200025 China

INTRODUCTIONEndocytosisandalltophagocytosis(alltophagy)arethemajorpathwaysformaterialstobetransportedtolysosolnesillanimalcells,theformerbeingresponsibleforuptakeofextracellular***... 详细信息

INTRODUCTIONEndocytosisandalltophagocytosis(alltophagy)arethemajorpathwaysformaterialstobetransportedtolysosolnesillanimalcells,theformerbeingresponsibleforuptakeofextracellular***...

关键词： Autophagocytosis endocytosis endosomes lysosomes.

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Microbial Dark Matter: from Discovery to Applications

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Genomics, Proteomics & Bioinformatics 2022年第5期20卷 867-881页

作者： Yuguo Zha Hui Chong Pengshuo Yang Kang Ning MOE Key laboratory of Molecular biophysics Hubei Key Laboratory of Bioinformatics and Molecular-imagingCenter of Artificial Intelligence BiologyDepartment of Bioinformatics and Systems BiologyCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

With the rapid increase of the microbiome samples and sequencing data,more and more knowledge about microbial communities has been ***,there is still much more to learn about microbial communities,including billions of novel species and genes,as well as countless spatiotemporal dynamic patterns within the microbial communities,which together form the microbial dark *** this work,we summarized the dark matter in microbiome research and reviewed current data mining methods,especially artificial intelligence(AI)methods,for different types of knowledge discovery from microbial dark *** also provided case studies on using AI methods for microbiome data mining and knowledge *** summary,we view microbial dark matter not as a problem to be solved but as an opportunity for AI methods to explore,with the goal of advancing our understanding of microbial communities,as well as developing better solutions to global concerns about human health and the environment.

关键词： Microbiome Dark matter Artificial intelligence Knowledge discovery Application

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