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The endogenous antioxidant ability of royal jelly in Drosophila is independent of Keap1/Nrf2 by activating oxidoreductase activity

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Insect Science 2024年第2期31卷 503-523页

作者： Dongjing Wen Jiayu Xie Yao Yuan Lirong Shen Yufeng Yang Wenfeng Chen Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouChina School of Medicine Chongqing UniversityChongqingChina College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhouChina

Royal jelly(RJ)is a biologically active substance secreted by the hypopharyngeal and mandibular glands of worker *** is widely claimed that RJ reduces oxidative ***,the antioxidant activity of RJ has mostly been determined by in vitro chemical detection methods or by external administration drugs that cause oxidative *** RJ can clear the endogenous production of reactive oxygen species(ROS)in cells remains largely ***,we systematically investigated the antioxidant properties of RJ using several endogenous oxidative stress models of *** found that RJ enhanced sleep quality of aging Drosophila,which is decreased due to an increase of oxidative damage with *** supplementation improved survival and suppressed ROS levels in gut cells of flies upon exposure to hydrogen peroxide or to the neurotoxic agent ***,RJ supplementation moderated levels of ROS in endogenous gut cells and extended lifespan after exposure of flies to heat *** deprivation leads to accumulation of ROS in the gut cells,and RJ attenuated the consequences of oxidative stress caused by sleep loss and prolonged ***,RJ prevented cell oxidative damage caused by heat stress or sleep deprivation,with the antioxidant activity in vivo independent of Keap1/Nrf2 *** supplementation activated oxidoreductase activity in the guts of flies,suggesting its ability to inhibit endogenous oxidative stress and maintain health,possibly in humans.

关键词： antioxidant biological oxidations Drosophila oxidative stress royal jelly sleep loss

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Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1637-1650页

作者： Yuanliang Yan Shangjun Zhou Xi Chen Qiaoli Yi Songshan Feng Zijin Zhao Yuanhong Liu Qiuju Liang Zhijie Xu Zhi Li Lunquan Sun Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008China Xiangya Cancer Center Xiangya HospitalCentral South UniversityChangsha 410008China Key laboratory of Molecular Radiation Oncology Hunan Province Changsha 410008China institute of Cancer Research National Clinical Research Center for Geriatric Disorders(Xiangya)Xiangya HospitalCentral South UniversityChangsha 410008China

Temozolomide(TMZ)represents a standard-of-care chemotherapeutic agent in glioblastoma(GBM).However,the development of drug resistance constitutes a significant hurdle in the treatment of malignant *** specific innovative approaches,such as immunotherapy,have shown favorable clinical outcomes,the inherent invasiveness of most gliomas continues to make them challenging to ***,there is an urgent need to identify effective therapeutic targets for gliomas to overcome chemoresistance and facilitate drug *** investigation used mass spectrometry to examine the proteomic profiles of six pairs of GBM patients who underwent standard-of-care treatment and surgery for both primary and recurrent tumors.A total of 648 proteins exhibiting significant differential expression were *** Set Enrichment Analysis(GSEA)unveiled notable alterations in pathways related to METABOLISM_OF_LIPIDS and biological_oxidations between the primary and recurrent *** through glioma tissue arrays and the Xiangya cohort confirmed substantial upregulation of inositol 1,4,5-triphosphate(IP3)kinase B(ITPKB)in the recurrence group,correlating with poor survival in glioma *** TMZ-resistant cells,the depletion of ITPKB led to an increase in reactive oxygen species(ROS)related to NADPH oxidase(NOX)activity and restored cell sensitivity to ***,the decreased phosphorylation of the E3 ligase Trim25 at the S100 position in recurrent GBM samples accounted for the weakened ITPKB ***,in turn,elevated ITPKB stability and impaired ROS ***,ITPKB depletion or the ITPKB inhibitor GNF362 effectively overcome TMZ chemoresistance in a glioma xenograft mouse *** findings reveal a novel mechanism underlying TMZ resistance and propose ITPKB as a promising therapeutic target forTMZ-resistant GBM.

关键词： TMZ homeostasis impaired

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Agnuside Reduces Visceral Adipocyte Size,Improves Insulin Sensitivity and Reverses Hepatic Steatosis in Ovariectomized Rats

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Journal of Pharmacy and Pharmacology 2019年第4期7卷 133-147页

作者： Franciele Neves Moreno Eduardo Hideo Gilglioni Rosangela Fernandes Garcia Naiara Cristina Lucredi Sandra Mara Ferreira Nilton Almeida Brito Marcia do Nascimento Brito Emy Luiza Ishii-Iwamoto Clairce Luzia Salgueiro-Pagadigorria laboratory of Experimental Steatosis Department of BiochemistryState University of MaringaMaringa 87020-900PRBrazil laboratory of biological oxidations Department of BiochemistryState University of MaringaMaringa 87020-900PRBrazil Department of Physiological Sciences State University of MaringaMaringa 87020-900PRBrazil laboratory of biological oxidations Department of BiochemistryFederal University of Santa CatarinaFlorianopolis 88040-900SCBrazil Department of Structural and Functional Biology Institute of BiologyState University of Campinas(UNICAMP)Campinas 13083-970SPBrazil

This study aimed to investigate the effects of agnuside(AGN),a phytoestrogen in Vitex agnus-castus,on cellular and metabolic alterations induced by ovariectomy in ***(OVX)Wistar rats were used as an animal model of postmenopausal metabolic *** visceral and subcutaneous adipocyte sizes,the peripheral insulin sensitivity and the occurrence of nonalcoholic fatty liver disease(NAFLD)and liver oxidative damage were *** results were compared with those obtained from control rats(sham-operated)and OVX rats treated daily with *** OVX rats exhibited visceral adipocyte hypertrophy and developed glucose intolerance,hyperinsulinemia,NAFLD and *** exerted beneficial effects on several metabolic parameters in OVX rats,including the improvement in glucose intolerance,hyperinsulinemia and ***,AGN promoted a general improvement in the liver redox *** the reduction of the mesenteric adipocyte size is very likely to be an important mode of action of AGN,some actions of AGN could also involve the interaction with estrogen receptors.

关键词： Metabolic syndrome ovariectomized rats adipocyte size NAFLD agnuside

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Oxidative Cascade Prognosis, Antioxidants &Selected Trace Elements in COVID-19

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Open Journal of Applied Sciences 2020年第11期10卷 688-700页

作者： Rizwan Ahmad Ansari Karimah Mohammed Rabiu Department of Biochemistry Yobe State University Damaturu Nigeria Department of biological Sciences Yobe State University Damaturu Nigeria

COVID-19 pandemic has now become a challenging global public health concern, having higher risk of developing fatal respiratory disease due to severe inflammatory responses associated with the virus-mediated oxidative stress. The respiratory system is most preferred target organ for this novel virus as the lung is well oxygenated and having large surface area available to the virus for exposure and successively augmenting the health complications. Oxidative stress (OS) is an important factor causing metabolic and physiological alteration and various disease augmentations within the body. Respiratory viral infection has general consociation with cytokine production, inflammation, cell death and other pathophysiological processes which may be the result of perturbed redox balance. Apart from this, the presence of conditions likes aging, diabetes and hypertension and chronic obstructive pulmonary diseases (COPD) are the risk factor for making severity of such infection outcome. It has been well established that an overproduction of reactive oxygen species (ROS) and antioxidant mechanisms deprivation are vital step for viral replica production and consequent release of pro-inflammatory cytokines is also an important factor of the innate immune responses to the pathogens that may result into acute lung damage. Additionally, ROS can damage various vital biological molecules and inactivation of essential enzymes. Oxidative stress is an important factor causing metabolic and other pathophysiological alterations, such as protein oxidations and various associated diseases. Therefore, in this paper, the significant adverse impact of virus on host

关键词： COVID-19 COPD ROS Oxidative Stress Cytokines Inflammation

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Trimetallic nanostructures and their applications in electrocatalytic energy conversions

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Journal of Energy Chemistry 2022年第2期31卷 329-351页

作者： Shushay Hagos Gebre Marshet Getaye Sendeku College of Natural and Computational Science Department of ChemistryJigjiga University1020 JigjigaEthiopia CAS Center for Excellence in Nanoscience CAS Key Laboratory of Nanosystem and Hierarchical FabricationNational Center for Nanoscience and TechnologyBeijing 100190China

The advancement and growth of nanotechnology lead to realizing new and novel multi-metallic nanostructures with well-defined sizes and morphology,resulting in an improvement in their performance in various catalytic *** trimetallic nanostructured materials are synthesized and designed in different architectures for energy conversion *** as-synthesized trimetallic nanostructures have found unique physiochemical properties due to the synergistic combination of the three different metals in their structures.A vast array of approaches such as hydrothermal,solvothermal,seedgrowth,galvanic replacement reaction,biological,and other methods are employed to synthesize the trimetallic ***,the trimetallic nanostructures showed better performance and durability in the electrocatalytic fuel *** the present review,we provide a comprehensive overview of the recent strategies employed for synthesizing trimetallic nanostructures and their energy-related *** a particular focus on hydrogen evolution,alcohol oxidations,oxygen evolution,and others,we highlight the latest achievements in the field.

关键词： Trimetallic nanoparticle Electrooxidation Electrocatalysis Alloy Energy conversion

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Kinetics and mechanisms of oxidation of d-fructose and d-lactose by permanganate ion in acidic medium

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Natural Science 2012年第7期4卷 466-478页

作者： Rafia Azmat Raheela Naz Noshab Qamar Imran Malik Department of Chemistry University of Karachi Department of Chemistry Jinnah University for Women 5-C Nazimabad Karachi Pakistan International Centre of Chemical and biological Sciences (ICCBS) University of Karachi

The oxidations of D-fructose and D-lactose were monitored spectrophotometrically by potassium permanganate in acidic medium at λmax 545 nm. Reaction demonstrated that the two oxidative species of permanganate were involved in an acidic oxidation of the sugars. It was established that respective acids of sugars as well as arabinonic and formic acid were the oxidation products. Respective acids of sugars were the results of reactive oxygen species of permanganate ions in acidic conditions while arabinonic and formic acids due to the cleavage of C__C bond through MnO-4 species. It was first order kinetics with respect to [MnO-4 ], [fructose], [lactose] and [H+]. Hg was used to accelerate the slow oxidation of lactose. Effect of varying salt electrolyte concentration was insignificant showing that the molecular species was involved in the rate determining step. Formic and arabinonic acids and respective acids were analyzed through spot and spectroscopic studies respectively. Reaction was monitored at different temperatures and thermodynamics activation parameters were determined. A mechanism consistent with kinetic studies, spectral evidences, stoichiometry of the reactions and product analysis has been proposed for the oxidation of fructose and lactose in absence and presence of catalyst respectively.

关键词： Fructose Lactose KMnO4 Hg Formic Acid Arabinonic Acid

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Carotenoids in Aquaculture:An Overview

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Journal of Animal Science and Biotechnology 2011年第1期2卷 44-58页

作者： Jin Niu Lixia Tian Heizhao Lin Yongjian Liu2 South China Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Guangzhou Guangdong510300 China Nutrition laboratory Institute of Aquatic Economic Animals School of Life Science Sun Yat-sen University Guangzhou Guangdong 510275 China

Recent studies on the role of carotenoids in aquaculture have investigated their function in regulating pigmentation, growth, survival, and immune activity of aquatic animals. These carotenoids include astaxanthin, canthaxanthin, lutein, zeaxanthin, and tunaxanthin. Astaxanthin and canthaxanthin are the main synthetic carotenoids used world-wide in the aquaculture industry. They play an important role in protecting cells and organisms against photosensitized oxidations. Direct evidence of carotenoids functioning as antioxidants in vivo has been reported in animal models. In addition to their established biological effects as antioxidants, carotenoids appear to have a great variety of cellular actions that make them remarkable physiological modulators. Consequently, recent attention has been focused on improving our understanding of carotenoids on the physiology and metabolism in aquatic animals with a view to enhance the efficacy of astaxanthin as a carotenoid pigment. This review aims to summarize the function and research progress of carotenoids in aquaculture. We discuss the methods used to study the absorption, transport, metabolic transformation and deposition of carotenoids, and their spatial and temporal expression.

关键词： absorption and transport aquaculture caromnoids function metabolism and deposition

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