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Journal of Rare Earths 2011年第8期29卷 783-786页

作者： Maciej Zalas Mariusz Walkowiak Grzegorz Schroeder Faculty of Chemistry Adam Mickiewicz University Institute of Non-Ferrous Metals Branch in Poznań Central Laboratory of Batteries and Cells

Modified with gadolinium-containing layer, nanoporous titania electrode and its application in dye-sensitized solar cells were reported. The electrode prepared was characterized with UV-Vis and X-ray diffraction （XRD） techniques. The amount of gadolinium was measured with inductively coupled plasma-optical emission spectrometry （ICP-OES） experiments. The modified electrode showed reduced N3 dye adsorption ability, but increased light conversion efficiency in comparison with the non-modified electrode. The overall conversion efficiencies, determined under 400 W/m2 irradiation with tungsten-halogen lamp at room temperature, were 0.55% for non-modified and 0.74% for modified electrodes.

关键词： dye-sensitized solar cell surface modification of TiO2 Gd-doped TiO2 rare earths

The molecular mechanism of embryonic stem cell pluripotency and self-renewal

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Science China(Life Sciences) 2007年第5期50卷 619-623页

作者： LIU YuXiao JI Lei TEN Yue WANG YunFang PEI XueTao laboratory of stem Cell Biology Beijing Institution of Transfusion Medicine Beijing 100850 China Laboratory of Stem Cell Biology Beijing Institution of Transfusion Medicine Beijing 100850 China Laboratory of Stem Cell Biology Beijing Institution of Transfusion Medicine Beijing 100850 China Laboratory of Stem Cell Biology Beijing Institution of Transfusion Medicine Beijing 100850 China Laboratory of Stem Cell Biology Beijing Institution of Transfusion Medicine Beijing 100850 China

The self-renewal and pluripotency of embryonic stem cells (ESCs) is regulated by a network, which consists of a series of cell factors in microenviroments, a chain of transcription factors and certain signal conductio... 详细信息

关键词： embryonic stem cells (ESCs), self-renewal, signal network, molecular mechanism

D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2280-2291页

作者： Bowen Wang Li Wang Sijie Gu Yankun Yu Huaxing Huang Kunlun Mo He Xu Fanzhu Zeng Yichen Xiao Lulu Peng Chunqiao Liu Nan Cao Yizhi Liu Jin Yuan Hong Ouyang State Key laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510623China Program of stem cells and Regenerative Medicine Fifth Affiliated HospitalZhongshan School of MedicineSun Yat-Sen UniversityGuangdong 510080China

Accumulated oxidative damage may lead to irreversible retinal pigmented epithelium(RPE)cell death,which is considered to be the primary cause of dry age-related macular degeneration(AMD),leading to blindness in the ***,an effective therapy for this disease is ***,we described a robust high-content screening procedure with a library of 814 protective compounds and found that D609 strongly protected RPE cells from sodium iodate(SI)-induced oxidative cell death and prolonged their healthy survival.D609 effectively attenuated excessive reactive oxygen species(ROS)and prevented severe mitochondrial loss due to oxidative stress in the RPE ***,the potent antioxidative effects of D609 were not achieved through its own reducibility but were primarily dependent on its ability to increase the expression of *** injection of this small water-soluble molecule also showed an explicit protective effect of the RPE layer in an SI-induced AMD mouse *** findings suggested that D609 could serve as a novel antioxidative protector of RPE cells both in vitro and in vivo and unveiled a novel antioxidative mechanism of D609,which may ultimately have clinical applications for the treatment of AMD.

关键词： D609 degeneration protective

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Single-cell sequencing delivers hematopoietic stem cell specification

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Science Bulletin 2016年第18期61卷 1419-1421页

作者： Jiani Cao Tongbiao Zhao State Key laboratory of stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences

Recently,Zhou et al.[1]have successfully traced the hematopoietic stem cell(HSC)specification during the stepwise development of HSC from the pre-HSC stage at single-cell *** findings offer fundamental insights into mouse HSC fate decision and provide extensive information that may lead to novel discoveries in HSC ***,standing at the apex of the hierarchy

关键词：造血干细胞单细胞测序 HSC 细胞分化分辨率扩展性小鼠

Inside-out Ostwald ripening： A facile process towards synthesizing anatase TiO2 microspheres for high- efficiency dye-sensitized solar cells

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Nano Research 2016年第7期9卷 1891-1903页

作者： Yong Ding Xin Xia Wangchao Chen Linhua Hu Li'e Mo Yang Huang Songyuan Dai Beijing Key laboratory of Novel Thin-Film Solar cells North China Electric Power University Beijing 102205 China Key laboratory of Novel Thin-film Solar cells Institute of Applied Technology Hefei Institutes of Physical Science Chinese Academy ot Sciences Hefei 230031 China

A facile inside-out Ostwald ripening route to the morphology-controlled preparation of TiO2 microspheres is developed. Here, TiO2 hollow microspheres （HM） and solid microspheres （SM） are prepared by adjusting the volume ratio of isopropanol （IPA） to acetylacetone （Acac） in the solvothermal process. During the formation process of HM, precipitation of solid cores, subsequent deposition of outer shells on the surface of cores, and simultaneous core dissolution and shell recrystallizafion are observed, which validate the inside-out Ostwald ripening mechanism. Design and optimization of the properties （pore size, surface area, and trap state） of TiO2 microspheres are vital to the high performance of dye- sensitized solar cells （DSSCs）. The optimized TiO2 rnicrospheres （rHM and rSM） obtained by post-processing on recrystallization, possess large pore sizes, high surface areas and reduced trap states （Ti3~ and oxygen vacancy）, and are thus ideal materials for photovoltaic devices. The power conversion efficiency of DSSCs fabricated using rHM photoanode is 11.22%, which is significantly improved compared with the 10.54% efficiency of the rSM-based DSSC. Our work provides a strategy for synthesizing TiO2 microspheres that simultaneously accommodate different physical properties, in terms of surface area, crystallinity, morphology, and mesoporosity.

关键词： Ostwald ripening dye-sensitized solar cell TiO2 microsphere hollow structure acetylacetone

Awakening of ancient retrovirus:a new sign of aging in humans?

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Science China(Life Sciences) 2023年第6期66卷 1454-1455页

作者： Yuliang Qu Jichang Wang Department of histology and embryology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China Key laboratory for stem cells and Tissue Engineering(Sun Yat-sen University) Ministry of EducationGuangzhou510080China

Endogenous retroviruses(ERVs)are viral elements that have been incorporated into the host genomes of mammals over time and have evolved to become part of the host *** ERVs have been domesticated and serve a role in host development and ***-2,a recently integrated family of human endogenous retrovirus K(HERVK)(Garcia-Montojo et al.,2018),is an example of such ERVs and is transcribed during early human development to encode viral proteins that are proposed to promote antiviral immune response and specialization of primordial germ cells(Grow et al.,2015;Xiang et al.,2022).

关键词： endogenous aging

Ng Ago: an exciting new tool for genome editing

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Science Bulletin 2016年第14期61卷 1074-1075页

作者： Haoyi Wang State Key laboratory of stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences

Site-directed DNA endonucleases are powerful tools for genome *** introduced into cells,these systems can bind to a target DNA sequence in the genome and create a DNA double-strand break(DSB),the repair

关键词：编辑工具基因组 DNA双链断裂 DNA序列免疫系统核酸内切酶兴奋 RNA

Control of embryonic stem cell metastability by L-proline catabolism

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Journal of Molecular Cell Biology 2011年第2期3卷 108-122页

作者： Laura Casalino Stefania Comes Giuseppina Lambazzi Benedetta De Stefano Stefania Filosa Sandro De Falco Dario De Cesare Gabriella Minchiotti Eduardo Jorge Patriarca stem Cell Fate laboratory Institute of Genetics and Biophysics“A.Buzzati-Traverso”CNRNaplesItaly

The molecular mechanisms controlling mouse embryonic stem cell(ESC)metastability,*** capacity to fluctuate between different states of pluripotency,are not fully *** developed and used a novel automation platform,the Cellmaker,to screen a library of metabolites on two ESC-based phenotypic assays(*** and colony phenotype)and identified two metabolically related amino acids,namely L-proline(L-Pro)and L-ornithine(L-Orn),as key regulators of ESC *** compounds,but mainly L-Pro,force ESCs toward a novel epiblast stem cell(EpiSC)-like state,in a dose-and time-dependent *** EpiSCs,L-Pro-induced cells(PiCs)contribute to chimeric embryos and rely on leukemia inhibitor factor(LIF)to ***,PiCs revert to ESCs or differentiate randomly upon removal of either L-Pro or LIF,***,PiC generation depends on both L-Pro metabolism(uptake and oxidation)and Fgf5 induction,and is strongly counteracted by antioxidants,mainly L-ascorbic acid(vitamin C,Vc).ESCs↔PiCs phenotypic transition thus represents a previously undefined dynamic equilibrium between pluripotent states,which can be unbalanced either toward an EpiSC-like or an ESC phenotype by L-Pro/L-Orn or Vc treatments,*** together,our data provide evidence that ESC metastability can be regulated at a metabolic level.

关键词： embryonic stem cells L-proline vitamin C colony phenotype pluripotent states metastability

Tracing and targeting cancer stem cells:New venture for personalized molecular cancer therapy

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World Journal of stem cells 2017年第10期9卷 169-178页

作者： Ramin Radpour Tumor Immunology and Cancer stem cells InselspitalBern University HospitalDepartment for BioMedical ResearchUniversity of Bern3008 BernSwitzerland

Tumors consist of a mixture of heterogeneous cell types. Cancer stem cells(CSCs) are a minor sub-population within the bulk cancer fraction which has been foundto reconstitute and propagate the disease and to be frequently resistant to chemotherapy, irradiation, cytotoxic drugs and probably also against immune attack. CSCs are considered as the seeds of tumor recurrence, driving force of tumorigenesis and metastases. This underlines the urgent need for innovative methods to identify and target CSCs. However, the role and existence of CSCs in therapy resistance and cancer recurrence remains a topic of intense debate. The underlying biological properties of the tumor stem cells are extremely dependent on numerous signals, and the targeted inhibition of these stem cell signaling pathways is one of the promising approaches of the new antitumor therapy approaches. This perspective review article summarizes the novel methods of tracing CSCs and discusses the hallmarks of CSC identification influenced by the microenvironment or by having imperfect detection markers. In addition, explains the known molecular mechanisms of therapy resistance in CSCs as reliable and clinically predictive markers that could enable the use of new targeted antitumor therapy in the sense of personalized medicine.

关键词： Cancer stem cells Cancer recurrence Cancer therapy Combination therapy Chemotherapy Radiation therapy Immunotherapy