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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan Qi Biao Shi Ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for stem cells School of Life Sciences and TechnologyTongji University Translational Medical Center for stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu Guang-Hui Liu State Key laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key laboratory of stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

3D printed microfluidic devices:a review focused on four fundamental manufacturing approaches and implications on the field of healthcare

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Bio-Design and Manufacturing 2021年第2期4卷 311-343页

作者： Viraj Mehta Subha N.Rath Regenerative Medicine and stem cells laboratory Department of Biomedical EngineeringIndian Institute of Technology HyderabadKandiTelangana 502285India

In the last fewyears,3D printing has emerged as a promising alternative for the fabrication ofmicrofluidic devices,overcoming some of the limitations associated with conventional ***(SLA),extrusion-based technology,and inkjet 3D printing are three of the widely used 3D printing technologies owing to their accessibility and *** devices can be 3D printed by employing a manufacturing approach from four fundamental manufacturing approaches classified as(1)direct printing approach,(2)mold-based approach,(3)modular approach,and(4)hybrid *** evaluate the feasibility of 3D printing technologies for fabricating microfluidic devices,a review focused on 3D printing fundamental manufacturing approaches has been *** a broad spectrum of additive manufacturing materials,3D printed microfluidic devices have been implemented in various fields,including biological,chemical,and material ***,some crucial challenges are associated with the same,including low resolution,low optical transparency,cytotoxicity,high surface roughness,autofluorescence,non-compatibility with conventional sterilization methods,and low gas *** recent research progress in materials related to additive manufacturing has aided in overcoming some of these ***,we outline possible implications of 3D printed microfluidics on the various fields of healthcare such as in vitro disease modeling and organ modeling,novel drug development,personalized treatment for cancer,and cancer drug screening by discussing the current state and future outlook of 3D printed‘organs-on-chips,’and 3D printed‘tumor-on-chips.’We conclude the review by highlighting future research directions in this field.

关键词： 3D printing Additive manufacturing Microfluidics Lab-on-a-chip Organ-on-a-chip Tumor-on-a-chip

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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World Journal of stem cells 2020年第12期12卷 1553-1575页

作者： Nikolaos Kokkorakis Maria Gaitanou laboratory of Cellular and Molecular Neurobiology-stem cells Hellenic Pasteur InstituteAthens 11521Greece

Dual-specificity tyrosine phosphorylation-regulated kinase 1B(DYRK1B),also known as minibrain-related kinase(MIRK)is one of the best functionally studied members of the DYRK kinase *** comprise a family of protein kinases that are emerging modulators of signal transduction pathways,cell proliferation and differentiation,survival,and cell *** were found to participate in several signaling pathways critical for development and cell *** this review,we focus on the DYRK1B protein kinase from a functional point of view concerning the signaling pathways through which DYRK1B exerts its cell type-dependent function in a positive or negative manner,in development and human *** particular,we focus on the physiological role of DYRK1B in behavior of stem cells in myogenesis,adipogenesis,spermatogenesis and neurogenesis,as well as in its pathological implication in cancer and metabolic ***,understanding of the molecular mechanisms that regulate signaling pathways is of high *** studies have identified a close regulatory connection between DYRK1B and the hedgehog(HH)signaling ***,we aim to bring together what is known about the functional integration and cross-talk between DYRK1B and several signaling pathways,such as HH,RAS and PI3K/mTOR/AKT,as well as how this might affect cellular and molecular processes in development,physiology,and ***,this review summarizes the major known functions of DYRK1B kinase,as well as the mechanisms by which DYRK1B exerts its functions in development and human diseases focusing on the homeostasis of stem and cancer stem cells.

关键词： Dual-specificity tyrosine-regulated kinase 1B Minibrain-related kinase stem cells Cancer stem cells Quiescence Cell proliferation/differentiation Cell survival Cancer Hedgehog

Human pluripotent stem cell-derived extracellular vesicles:From now to the future

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World Journal of stem cells 2023年第5期15卷 453-465页

作者： Bruno Moises de Matos Marco Augusto Stimamiglio Alejandro Correa Anny Waloski Robert stem cells Basic Biology laboratory Carlos Chagas InstituteCuritiba 81350010ParanáBrazil

Extracellular vesicles(EVs)are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication ***,in various biological contexts,EVs are reported to engage in immune modulation,senescence,and cell proliferation and ***,EVs could be key elements for potential off-the-shelf cell-free *** has been studied regarding EVs derived from human pluripotent stem cells(hPSC-EVs),even though hPSCs offer good opportunities for induction of tissue regeneration and unlimited proliferative *** this review article,we provide an overview of studies using hPSC-EVs,focusing on identifying the conditions in which the cells are cultivated for the isolation of EVs,how they are characterized,and applications already *** topics reported in this article highlight the incipient status of the studies in the field and the significance of hPSC-EVs’prospective applications as PSC-derived cell-free therapy products.

关键词： Pluripotent stem cells Extracellular vesicles Exosome Cell-free therapy

Influence of donor age on the differentiation and division capacity of human adipose-derived stem cells

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World Journal of stem cells 2020年第12期12卷 1640-1651页

作者： Cintia DS Horinouchi María Julia Barisón Anny W Robert Crisciele Kuligovski Alessandra M Aguiar BrunoDallagiovanna stem cells Basic Biology laboratory Instituto Carlos ChagasCuritiba 81350010ParanáBrazil

BACKGROUND Human adipose-derived stromal/stem cells(hASCs)are one of the most useful types of mesenchymal stromal/stem cells,which are adult multipotent cells with great therapeutic potential for the treatment of several ***,for successful clinical application,it is critical that high-quality cells can be *** factors seem to be able to influence cell quality and performance,especially factors related to donors’intrinsic characteristics,such as ***,there is no consensus regarding this characteristic,and there is conflicting information in the *** To investigate the growth kinetics and differentiation potential of adipose-derived stem cells isolated from the lipoaspirates of elderly and young *** hASCs were harvested from liposuctioned adipose tissue obtained from female donors(aged 20-70 years).cells were distributed into two groups according to age range:old hASCs(oASCs,≥55 years,n=9)and young hASCs(yASCs,≤35 years,n=9).For each group,immunophenotypic characterization was performed by flow *** doubling time was assessed over seven *** adipogenic potential evaluation,lipid deposits were assessed after 7 d,14 d and 21 d of adipogenic *** potential was verified by analyzing cell mineralization after 14 d,21 d and 28 d of osteogenic *** expression of PPARγ2,CEBPA and Runx2 were detected by quantitative reverse transcription polymerase chain *** hASCs were successfully obtained,cultured,and grouped according to their age:yASCs(26.33±4.66 years old)and oASCs(64.78±4.58 years old).After maintenance of the cells in culture,there were no differences in morphology between cells from the young and old ***,both groups showed classical immunophenotypic characteristics of mesenchymal stem/stromal *** average doubling time indicated that yASCs(4.09±0.94 d)did not significantly differ from oASCs(4.19±1.29 d).Concerning differentiation pot

关键词： Adipose-derived stem cells stem cells Adipogenesis Osteogenesis Cell differentiation Donor age

Inflammatory niche:Mesenchymal stromal cell priming by soluble mediators

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World Journal of stem cells 2020年第9期12卷 922-937页

作者： Aleksandra Jauković Tamara Kukolj Hristina Obradović Ivana Okić-Đorđević Slavko Mojsilović Diana Bugarski laboratory for Experimental Hematology and stem cells Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Mesenchymal stromal/stem cells(MSCs)are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell *** play a critical role in tissue homeostasis and wound healing,as well as in regulating the inammatory microenvironment through interactions with immune ***,MSCs have garnered great attention as promising candidates for tissue regeneration and cell *** the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs,priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these *** this paper,we review how soluble mediators of the inflammatory niche(cytokines and alarmins)influence the regenerative and immunomodulatory capacity of MSCs,highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed *** data summarized in this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy.

关键词： Mesenchymal stem cells Pro-inflammatory cytokines Alarmins Priming Boosting the therapeutic potential