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Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

Science China Chemistry 2025年第01期 329-336页

作者： Yuzhu Li Yumeng Gao Feng Tian Yu Wang Yuan Yao Shaoliang Lin Xiang Ma Binbin Xu Shanghai Key laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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Structural and immunogenomic insights into B-cell receptor activation

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Journal of Genetics and Genomics 2020年第1期47卷 27-35页

作者： Yangyang Feng Yu Wang Shaocun Zhang Kabeer Haneef Wanli Liu MOE Key laboratory of protein Sciences Center for Life SciencesCollaborative Innovation Center for Diagnosis and Treatment o f Infectious DiseasesSchool of Life SciencesBeijing Key Lab for Immunological Research on Chronic DiseasesInstitute for ImmunologyTsinghua UniversityBeijingJ00084China

B cells express B-cell receptors(BCRs) which recognize antigen to trigger signaling cascades for B-cell activation and subsequent antibody production. BCR activation has a crucial influence on B-cell fate. How BCR is activated upon encountering antigen remains to be solved, although tremendous progresses have been achieved in the past few years. Here, we summarize the models that have been proposed to explain BCR activation, including the cross-linking model, the conformation-induced oligomerization model, the dissociation activation model, and the conformational change model. Especially, we elucidate the partially resolved structures of antibodies and/or BCRs by far and discusse how these current structural and further immunogenomic messages and more importantly the future studies may shed light on the explanation of BCR activation and the relevant diseases in the case of dysregulation.

关键词： B-cell receptor B-cell activation BCR structure Immunogenomics

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Retinoic acid inducible gene-I,more than a virus sensor

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protein & Cell 2011年第5期2卷 351-357页

作者： Feng Liu Jun Gu National Key laboratory of protein Engineering and Plant Gene Engineering LSCPeking UniversityBeijing 100871China

Retinoic acid inducible gene-I(RIG-I)is a caspase recruitment domain(CARD)containing protein that acts as an intracellular RNA receptor and senses virus *** binding to double stranded RNA(dsRNA)or 5′-triphosphate single stranded RNA(ssRNA),RIG-I transforms into an open conformation,translocates onto mitochondria,and interacts with the downstream adaptor mitochondrial antiviral signaling(MAVS)to induce the production of type Ⅰ interferon and inflammatory factors via IRF3/7 and NF-κB pathways,***,accumulating evidence suggests that RIG-I could function in non-viral systems and participate in a series of biological events,such as inflammation and inflammation related diseases,cell proliferation,apoptosis and even *** we review recent advances in antiviral study of RIG-I as well as the functions of RIG-I in other fields.

关键词： retinoic acid inducible gene-I(RIG-I) antiviral signaling inflammation innate immunity

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Specific staining and precise killing of cancer cells through fusion of pharmaceutical chemistry and π-bridge effect design philosophy

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Science China Chemistry 2025年

作者： Qiong Liu Qiyun Deng Changxu Zhu Kongqi Chen Lidan Chen Zhaohui Sun Ben Zhong Tang Zhiming Wang AIE Institute Center for Aggregation-Induced Emission State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province South China University of Technology Department of laboratory Medicine General Hospital of Southern Theater Command School of Life Sciences The Chinese University of Hong Kong Shenzhen Institute of Aggregate Science and Technology School of Science and Engineering The Chinese University of Hong Kong HKUST-Shenzhen Research Institute

The development of an advanced phototheranostic platform that combines imaging and therapy in a single agent is an appealing yet challenging *** this study,we successfully constructed three novel fluorescent probes by leveraging pharmaceutical chemistry and the design philosophy of theπ-bridge *** a systematic comparative analysis of their fluorescence properties,water solubility,molecular conformation,and electrostatic potential,we revealed the fundamental principles governing the optical behavior and biological selectivity of these ***,the probe TPhIQ-CNTh demonstrated extended fluorescence in the near-infrared region,a significant aggregation-induced emission (AIE) effect,and the ability to distinguish tumor cells from normal ***,it efficiently generated reactive oxygen species (ROS) and specifically labeled lipid droplets,enabling the precise staining and killing of cancer *** study presents a practical strategy for designing precise tumor treatments that integrate efficient imaging-guided photodynamic therapy (PDT) by harnessing the unique properties of AIE materials.

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Low Temperature Induced conformation Changes of Aminoacylase

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Tsinghua Science and Technology 2004年第1期9卷 76-80页

作者：谢强孟凡国周海梦 Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 China protein Science laboratory of the Ministry of Education School of Life Science and Engineering Tsinghua University Beijing 100084 China

Control of aggregation, by lowering temperature and protein concentrations, can enhance the extent of successful refolding. The low temperature has been used in protein folding studies, as undesired aggregations often occur at higher temperatures. Therefore, it is very important to study the effects of low temperature on the native enzyme to help understand the factors that affect the structure of the proteins. In this paper, aminoacylase was studied at different temperatures by measuring enzyme activity, fluorescence emission spectra, and ultraviolet difference spectra. The results show that aminoacylase conformation changes as the temperature changes, becoming more compact at low temperatures, and having more secondary structural content. However, the activity is very low at low temperature, and totally diminishes at 4℃. Aminoacylase tends therefore to be more condense, with less residues exposed and low enzyme activities at low temperature. This observation might explain the self-protection of organisms under conditions of extreme temperature.

关键词： low temperature aminoacylase secondary structure

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Design high-performance narrowband emitters for blue light-emitting diodes through manipulating resonance structure of aromatic heterocycles

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Science China Chemistry 2025年

作者： Yue Yu Lei Xu Wenle Tan Yuyu Pan Jiyin Xiao Bohan Wang Guangjun Tian Yuguang Ma Lei Ying Institute of Polymer Optoelectronic Materials and Devices Guangdong Basic Research Center of Excellence for Energy and Information Polymer Materials State Key Laboratory of Luminescent Materials and Devices South China University of Technology School of Petrochemical Engineering Shenyang University of Technology Key laboratory for Microstructural Material Physics of Hebei Province School of Science Yanshan University

Narrowband light-emitting materials play critical roles in improving the color gamut and energy consumption of electroluminescence. Herein we demonstrated that by regulating the ground state resonance structure form of emitters with polycyclic aromatic heterocycles, the high-energy vibration of the C–C bond can be effectively suppressed, resulting in narrow emission like classical cyanine dyes. The designed compounds consist of twist and planar conformation, while having differences in the orientation of the positioning electron-donating(nitrogen) and electron-accepting(carbonyl) groups in the polycyclic aromatic hydrocarbon skeleton. The resulting compound Ac-Ph-Ac with a dominated zwitterionic resonance structure exhibits a relatively wide electroluminescent profile with the full width at half maximum(FWHM) of 42 nm and moderate device performance. In contrast, the “soliton transition” of 2AcPh based on the cyanine limit character effectively suppresses C–C stretching vibration in the polycyclic aromatic heterocycle skeleton, leading to a narrow electroluminescent profile with FWHM of 30 nm(0.16 eV)associated with an impressively high external quantum efficiency of 28.52%, which is among the highest efficiencies of so far reported non-sensitized organic light-emitting diodes.

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PII,the key regulator of nitrogen metabolism in the cyanobacteria

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Science China(Life Sciences) 2008年第12期51卷 1056-1065页

作者： ZHANG Ying & ZHAO JinDong State Key laboratory of protein and Plant Genetic Engineering, College of Life Science, Peking University, Beijing 100871, China 1. State Key laboratory of protein and Plant Genetic Engineering College of Life Science Peking University Beijing 100871 China

PII proteins are a protein family important to signal transduction in bacteria and plants. PII plays a critical role in regulation of carbon and nitrogen metabolism in cyanobacteria. Through conformation change and covalent modification, which are regulated by 2-oxoglutarate, PII interacts with different target proteins in response to changes of cellular energy status and carbon and nitrogen sources in cyanobacteria and regulates cellular metabolism. This article reports recent progress in PII research in cyanobacteria and discusses the mechanism of PII regulation of cellular metabolism .

关键词： carbon metabolism cyanobacteria nitrogen metabolism PII protein

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Impairment of autophagic signaling in murine forebrain disrupts GABAA receptor trafficking leading to excitatoryinhibitory imbalance and ASD-like behaviours

Impairment of autophagic signaling in murine forebrain disru...

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中国神经科学学会第十二届全国学术会议

作者： Kelvin Hui Noriko Takashima Hiroshi Matsukawa Akiko Watanabe Per Nilsson Ryo Endo Takaomi Saido Shigeyoshi Itohara Takeo Yoshikawa Motomasa Tanaka laboratory for protein conformation diseases RIKEN Brain Science Institute laboratory for Behavioral Genetics RIKEN Brain Science Institute laboratory for Molecular Psychiatry RIKEN Brain Science Institute Laboroatory for Proteolytic Neuroscience RIKEN Brain Science Institute Department of Neurobiology Care Sciences and Society Karolinska Institutet

Many syndromic forms of autism spectrum disorder(ASD) are caused by mutations in proteins such as PTEN, TSC1, TSC2, and FMRP, which lie within the m TOR signaling pathway. While recent work has primarily focused on the dysregulation of protein translation via the deletion of these genes, few studies have examined how disruption of autophagy, another major downstream branch of m TOR signaling,contributes to neuronal dysfunction and ASD pathogenesis. To this end, we and others have previously examined mice deficient for autophagy in forebrain excitatory neurons via the deletion of Atg7 by Ca MKII-cre and observed ASD-like behavioural abnormalities in addition to neuronal dysfunctions from the molecular to the network level. As ASD is believed to be caused by an imbalance between excitatory and inhibitory signals in the brain, we have further extended our analysis to examine disruption of autophagy in forebrain GABAergic interneurons. Similar to disrupted autophagy in other neuronal and non-neuronal cell types, Atg7 deletion by Dlx5-cre results in time-dependent ubiquitin+ and p62+ aggregate formation in affected neurons. Notably, Dlx5-cre Atg7 c KO mice exhibit an overlapping set of ASD-like behavioural abnormalities previously observed in Ca MKII-cre Atg7 c KO animals. Furthermore, we have detected a disruption of the excitatory-inhibitory balance in both Ca MKII-cre and Dlx5-cre Atg7 c KO mice. Using primary cultured neurons, a specific reduction of surface GABAA receptors was observed in Atg7 c KO neurons. Unbiased mass spectrometric and subsequent antibody-based analyses demonstrated that members of the GABARAP(GABA receptor-associated protein) protein family accumulate and mislocalize to p62+ aggregates formed in affected neurons of both Ca MKII-cre and Dlx5-cre Atg7 c KO brains. Genetic manipulation of GABARAP family proteins and p62 in wild-type or Atg7 c KO neurons further revealed that GABAA receptor trafficking are influenced by p62 aggregates as they intera

关键词： autophagy autism protein aggregation GABAA receptors GABARAP

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Structural basis for prokaryotic calciummediated regulation by a Streptomyces coelicolor calcium binding protein

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protein & Cell 2010年第8期1卷 771-779页

作者： Xiaoyan Zhao Hai Pang Shenglan Wang Weihong Zhou Keqian Yang Mark Bartlam laboratory of Structural Biology Tsinghua UniversityBeijing 100084China Center for Microbial Metabolism and Metabolic Engineering Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Tianjin Key laboratory of protein Science College of Life SciencesNankai UniversityTianjin 300071China

The important and diverse regulatory roles of Ca2+in eukaryotes are conveyed by the EF-hand containing calmodulin ***,the calcium-regulatory proteins in prokaryotes are still poorly *** this study,we report the three-dimensional structure of the calcium-binding protein from Streptomyces coelicolor,named CabD,which shares low sequence homology with other known helix-loop-helix EF-hand *** CabD structure should provide insights into the biological role of the prokaryotic calcium-binding *** unusual structural features of CabD compared with prokaryotic EF-hand proteins and eukaryotic sarcoplasmic calcium-binding proteins,including the bending conformation of the first C-terminalα-helix,unpaired ligand-binding EF-hands and the lack of the extreme Cterminal loop region,suggest it may have a distinct and significant function in calcium-mediated bacterial physiological processes,and provide a structural basis for potential calcium-mediated regulatory roles in prokaryotes.

关键词： calcium-binding protein crystal structure Streptomyces coelicolor calcium-mediated regulation EFhand

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Arabidopsis PDLP7 modulated plasmodesmata function is related to BG10-dependent glucosidase activity required for callose degradation

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Science Bulletin 2024年第19期69卷 3075-3088页

作者： Xin Chen Wan-Wan Li Jin Gao Zhiguo Wu Juan Du Xiaoming Zhang Yu-Xian Zhu State Key laboratory of protein and Plant Gene Research College of Life SciencesPeking UniversityBeijing 100871China State Key laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Advanced Studies Wuhan UniversityWuhan 430072China

The microdomains of plasmodesmata,specialized cell-wall channels responsible for communications between neighboring cells,are composed of various plasmodesmata-located proteins(PDLPs)and ***,we found that,among all PDLP or homologous proteins in Arabidopsis thaliana genome,PDLP5 and PDLP7 possessed a C-terminal sphingolipid-binding motif,with the latter being the only member that was significantly upregulated upon turnip mosaic virus and cucumber mosaic virus ***7mutant plants exhibited significantly reduced callose deposition,larger plasmodesmata diameters,and faster viral *** plants exhibited increased glucosidase activity but no change in callose synthase ***7 interacted specifically with glucan endo-1,3-β-glucosidase 10(BG10).Consistently,higher levels of callose deposition and slower virus transmission in bg10 mutants were *** interaction between PDLP7 and BG10 was found to depend on the presence of the Gnk2-homologous 1(Gn K2-1)domain at the N terminus of PDLP7 with Asp-35,Cys-42,Gln-44,and Leu-116 being *** vitro supplementation of callose was able to change the conformation of the Gn K2-1 *** data suggest that the Gn K2-1 domain of PDLP7,in conjunction with callose and BG10,plays a key role in plasmodesmata opening and closure,which is necessary for intercellular movement of various molecules.

关键词： Plasmodesmata PDLP7 Callose β-1,3-glucosidase

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