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Contribution of plasma membrane Ca^(2+) ATPase to cerebellar synapse function

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World Journal of Biological Chemistry 2010年第5期1卷 95-102页

作者： Helena Huang Raghavendra Y Nagaraja Molly L Garside Walther Akemann Thomas Knpfel Ruth M Empson Department of Physiology Brain Health and Repair Research CentreUniversity of Otago School of Biological Sciences Royal Holloway University of London laboratory for neuronal circuit dynamics RIKEN Brain Science Institute

The cerebellum expresses one of the highest levels of the plasma membrane Ca2+ATPase,isoform 2 in the mammalian *** highly efficient plasma membrane calcium transporter protein is enriched within the main output neurons of the cerebellar cortex;i.e. the Purkinje neurons(PNs) .Here we review recent evidence,including electrophysiological and calcium imaging approaches using the plasma membrane calcium ATPase 2(PMCA2) knockout mouse,to show that PMCA2 is critical for the physiological control of calcium at cerebellar synapses and cerebellar dependent *** studies have also revealed that deletionof PMCA2 throughout cerebellar development in the PMCA2 knockout mouse leads to permanent signalling and morphological alterations in the PN dendrites. Whilst these findings highlight the importance of PMCA2 during cerebellar synapse function and development,they also reveal some limitations in the use of the PMCA2 knockout mouse and the need for additional experimental approaches including cell-specific and reversible manipulation of PMCAs.

关键词： Plasma membrane Ca2+ ATPase Cerebellum Calcium Purkinje neuron

Sound insulation performance of plates with interconnected distributed piezoelectric patches

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Chinese Journal of Aeronautics 2017年第1期30卷 99-108页

作者： Yi Kaijun Li Lin Mohamed Ichchou Manuel Collet laboratory of Tribology and Systems dynamics Ecole Centrale de Lyon School of Energy and Power Engineering Beihang University

This paper deals with the sound insulation performance of a thin plate with interconnected distributed piezoelectric patches. Piezoelectric patches are periodically bonded on the surfaces of the plate in a collocated fashion, and are interconnected via an inductive circuit network. This piezoelectric system is termed as piezo-electromechanical（PEM） plate in the *** methods are involved under a sub-wavelength assumption to analytically develop the dynamical equations for the PEM plate. The dispersion relationships and energy densities of the wave modes propagating in the PEM plate are studied; the sub-wavelength assumption is verified for the simulations in this paper. The coincidence frequency of the PEM plate is researched, and results show that the coincidence frequency of the PEM plate will disappear at certain circumstances; mathematical and physical explanations are made for this phenomenon. The disappearance of the coincidence frequency is used to optimize the value of inductance, for the purpose of improving the sound transmission loss of the PEM plate.

关键词： Coincidence frequency Homogenization Piezoelectric material Sound transmission loss Wave propagation

Non-reciprocal Sound Transmission in Electro-acoustic Systems with Time-Modulated circuits

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Acta Mechanica Solida Sinica 2022年第6期35卷 940-948页

作者： Yu Huang Xiaoming Zhou Key laboratory of dynamics and Control of Flight Vehicle Ministry of EducationSchool of Aerospace EngineeringBeijing Institute of TechnologyBeijing100081China

Non-reciprocal sound transmission is demonstrated in an electro-acoustic system consisting of two shunt loudspeakers with time-modulated *** shunt circuit is modulated by periodically varying the resistance in time sequence,and a phase difference of time modulation is set between two sets of loudspeakers to produce a spatial *** spatiotemporal modulation of acoustic properties is thus formed to break the *** theoretical model based on the transfer-matrix method is developed to predict acoustic scatterings of electro-acoustic *** asymmetric transmission in opposite directions is disclosed by the model and is verified by time-domain simulation results based on the finite-difference time-domain *** transmission in multiple frequency bands can be created by tuning circuit parameters,showing their ability in regulating acoustic non-reciprocal *** study may provide a platform for the design of compact and non-reciprocal acoustic devices with applications to efficient noise control.

关键词： Non-reciprocity Shunt loudspeaker Time-varying circuits Spatiotemporal modulation

Inflammatory diseases modelling in zebrafish

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World Journal of Experimental Medicine 2016年第1期6卷 9-20页

作者： Camila Idelí Morales Fénero Alicia Angelina Colombo Flores Niels Olsen Saraiva Camara laboratory of Transplantation Immunobiology Department of Immunology Institute of Biomedical Sciences IV University of S?o Paulo Cidade Universitária laboratory of neuronal circuit and Craniofacial Development Anatomy and Developmental Biology Program ICBM University of Chile

The ingest of diets with high content of fats and carbohydrates, low or no physical exercise and a stressful routine are part of the everyday lifestyle of most people in the western world. These conditions are triggers for different diseases with complex interactions between the host genetics, the metabolism, the immune system and the microbiota, including inflammatory bowel diseases(IBD), obesity and diabetes. The incidence of these disorders is growing worldwide; therefore, new strategies for its study are needed. Nowadays, the majority of researches are in use of murine models for understand the genetics, physiopathology and interaction between cells and signaling pathways to find therapeutic solutions to these diseases. The zebrafish, a little tropical water fish, shares 70% of our genes and conserves anatomic and physiological characteristics, as well as metabolical pathways, with mammals, and is rising as a new complementary model for the study of metabolic and inflammatory diseases. Its high fecundity, fast development, transparency, versatility and low cost of maintenance makes the zebrafish an interesting option for new researches. In this review, we offer a discussion of the existing genetic and induced zebrafish models of two important Western diseases that have a strong inflammatory component, the IBD and the obesity.

关键词： Zebrafish Western diseases Inflammatory disorders Obesity Inflammatory bowel diseases

Dendritic shrinkage after injury: a cellular killer or a necessity for axonal regeneration?

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Neural Regeneration Research 2019年第8期14卷 1313-1316页

作者： An Beckers Lieve Moons Neural circuit Development and Regeneration Research Group Department of BiologyKU Leuven

Dendrites form an essential component of the neuronal circuit have been largely overlooked in regenerative research. Nevertheless, subtle changes in the dendritic arbors of neurons are one of the first stages of various neurodegenerative diseases, leading to dysfunctional neuronal networks and ultimately cellular death. Maintaining dendrites is therefore considered an essential neuroprotective strategy. This mini-review aims to discuss an intriguing hypothesis, which postulates that dendritic shrinkage is an important stimulant to boost axonal regeneration, and thus that preserving dendrites might not be the ideal therapeutic method to regain a full functional network upon central nervous system damage. Indeed, our study in zebrafish, a versatile animal model with robust regenerative capacity recently unraveled that dendritic retraction is evoked prior to axonal regrowth after optic nerve injury. Strikingly, inhibiting dendritic pruning upon damage perturbed axonal regeneration. This constraining effect of dendrites on axonal regrowth has sporadically been proposed in literature, as summarized in this short narrative. In addition, the review discusses a plausible underlying mechanism for the observed antagonistic axon-dendrite interplay, which is based on energy restriction inside neurons. Axonal injury indeed leads to a high local energy demand in which efficient axonal energy supply is fundamental to ensure regrowth. At the same time, axonal lesion is known to induce m让ochondrial depolarization, causing energy depletion in the axonal compartment of damaged neurons. Mitochondria, however, become mostly stationary after development, which has been proposed as a potential underlying reason for the low regenerative capacity of adult mammals. Per contra, upon reduced neuronal activity, mitochondrial mobility enhances. In this view, dendritic shrinkage after axonal injury in zebrafish could result in less synaptic input and hence, a release of mitochondria within the so

关键词： axonal regeneration dendritic remodeling retina central nervous system zebrafish mitochondrial transport mitochondrial dynamics energy supply

Experimental study on surface arc plasma actuation-based hypersonic boundary layer transition flow control

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Plasma Science and Technology 2022年第9期24卷 108-116页

作者： Hesen YANG Hua LIANG Shanguang GUO Yanhao LUO Mengxiao TANG Chuanbiao ZHANG Yun WU Yinghong LI Science and Technology on Plasma dynamics laboratory Air Force Engineering UniversityXi’an 710038People’s Republic of China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710048People’s Republic of China

Effective control of hypersonic transition is *** order to avoid affecting the structural proflle of the aircraft,as well as reducing power consumption and electromagnetic interference,a low-frequency surface arc plasma disturbance experiment to promote hypersonic transition was carried out in theΦ0.25 m double-throat Ludwieg tube wind tunnel at Huazhong University of Science and *** printed circuit board sensors and non-contact focused laser differential interferometry testing technology were used in *** results showed that the low-frequency surface arc plasma actuation had obvious stimulation effects on the second-mode unstable wave and could promote boundary layer transition by changing the spectral characteristics of the second-mode unstable *** the same time,the plasma actuation could promote energy exchange between the second-mode unstable wave and other unstable ***,the corresponding control mechanism is discussed.

关键词： plasma actuation flow control surface arc discharge hypersonic boundary layer transition experimental study

Solar Wind：A Possible Factor Driving the Interannual Sea Surface Temperature Tripolar Mode over North Atlantic

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Journal of Meteorological Research 2016年第3期30卷 312-327页

作者：肖子牛李德琳 Chinese Academy of Meteorological Sciences Beijing 100081 State Key laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029

The effect of solar wind（SW） on the North Atlantic sea surface temperature（SST） in boreal winter is examined through an analysis of observational data during *** North Atlantic SSTs show a pronounced meridional tripolar pattern in response to solar wind speed（SWS） *** pattern is broadly similar to the leading empirical orthogonal function（EOF） mode of interannual variations in the wintertime SSTs over North *** time series of this leading EOF mode of SST shows a significant interannual period,which is the same as that of wintertime *** response also appears as a compact north-south seesaw of sea level pressure and a vertical tripolar structure of zonal wind,which simultaneously resembles the North Atlantic Oscillation（NAO） in the overlying *** compared with the typical low SWS winters,during the typical high SWS winters,the stratospheric polar night jet（PNJ） is evidently enhanced and extends from the stratosphere to the troposphere,even down to the North Atlantic Ocean ***,the North Atlantic Ocean is an exclusive region in which the SW signal spreads downward from the stratosphere to the ***,it seems that the SW is a possible factor for this North Atlantic SST tripolar *** dynamical process of stratosphere-troposphere coupling,together with the global atmospheric electric circuit-cloud microphysical process,probably accounts for the particular downward propagation of the SW signal.

关键词： solar wind speed North Atlantic SST tripolar mode stratosphere^troposphere coupling globalatmospheric electric circuit-cloud microphysical process

Resistivity response of coal under hydraulic fracturing with different injection rates:A laboratory study

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International Journal of Mining Science and Technology 2022年第4期32卷 807-819页

作者： Mingyang Song Quangui Li Qianting Hu Yanqing Wu Guanhua Ni Yangcheng Xu Yuebing Zhang Liangping Hu Jialin Shi Jichuan Liu Yize Deng State Key laboratory of Coal Mine Disaster dynamics and Control Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Chongqing UniversityChongqing 400044China College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266510China

Resistivity will have different response characteristics to the hydraulic fracture propagation process. In this work, a resistivity testing system for hydraulic fracturing specimens was established. Resistivity and acoustic emission(AE) information were jointly analysed to determine the dynamic response characteristics of resistivity during hydraulic fracture propagation. The results show that the water and fracture exert a competitive influence on the connection structure of the circuit, and there are two significant peak resistivity points in the curve, presenting a double peak therein. The peak resistivity data of the specimen with a larger fracture area are much different from the initial value. With the increase of the rate of injection, the range of variation of the highest value that can be reached with the specimen resistivity decreases. High resistivity rates or high resistivity fluctuations exhibit rapid a release of fracture energy. The fracture failure mode dominated by shear fractures makes the formation produce a “series+parallel” electrical connection structure;a calculation model of formation resistivity based on shear and tensile failure was proposed to characterize the proportion of different types of hydraulic fractures and elucidate the control effect of matrix resistivity on the electrical performance of the overall circuit structure.

关键词： Resistivity Hydraulic fracturing Injection rate Fracture extension Acoustic emission

Experience-dependent maturation of intracortical parvalbumin expressing-cell circuit in developing mouse visual cortex

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Experience-dependent maturation of intracortical parvalbumin...