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effects of rare earth elements La and Yb on the morphological and functional development of zebrafish embryos

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Journal of Environmental Sciences 2012年第2期24卷 209-213页

作者： Jun＇an Cui Zhiyong Zhang Wei Bai Ligang Zhang Xiao He Yuhui Ma Yan Liu Zhifang Chai Key laboratory of Nuclear Analytical Techniques and Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics the Chinese Academy of Sciences Beijing 100049 China Qingdao University of Science and Technology College of Environment and Safety Engineering Qingdao 266042 China

In recent years,with the wide applications and mineral exploitation of rare earth elements,their potential environmental and health effects have caused increasing public *** of rare earth elements La and Yb on the morphological and functional development of zebrafish embryos were *** embryos were exposed to La3＋ or Yb3＋ at 0,0.01,0.1,0.3,0.5 and 1.0 mmol/L,*** life stage parameters such as egg and embryo mortality,gastrula development,tail detachment,eyes,somite formation,circulatory system,pigmentation,malformations,hatching rate,length of larvae and mortality were *** results showed La3＋ and Yb3＋ delayed zebrafish embryo and larval development,decreased survival and hatching rates,and caused tail malformation in a concentration-dependent ***,heavy rare-earth ytterbium led to more severe acute toxicity of zebrafish embryo than light rare-earth lanthanum.

关键词： zebrafish embryo development lanthanum ytterbium toxicity

Remote substituent effects on catalytic activity of metal-organic frameworks: a linker orbital energy model

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npj Computational Materials 2023年第1期9卷 1747-1755页

作者： Zhenzhen Wang Huan Meng Xuejiao J.Gao Jia-Jia Zheng Xingfa Gao laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and Technology of ChinaBeijingChina CAS Key laboratory for biomedical effects of nanomaterials and nanosafety National Center for Nanoscience and Technology of ChinaBeijingChina College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchangChina

The Hammett equation is commonly used to theoretically depict the remote electronic effects of substituents on catalytic activitiesof metal nodes of metal-organic frameworks (MOFs). However, the application of the theory to MOF catalysts usually encountersproblems because it relies heavily on empirical parameters with unknown transferability. To develop an alternative predictiontheory, the linker orbital energy model has been proposed by density functional theory calculations. The model provides a simplemethod to approximately depict the remote electronic substituent effects on catalytic activities of metal nodes of MOFs, and itsgeneral applicability to MOFs is supported by extensively revisiting the structure-activity relationships reported in the *** model can be used to design catalytic activity of metal nodes of MOFs by engineering the electronic properties of linkers andsubstituents.

关键词： substituent catalytic orbital

Second near-infrared window persistent luminescence nanomaterials for in vivo bioimaging

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Science China Chemistry 2021年第9期64卷 1439-1440页

作者： Yuliang Zhao CAS Key laboratory for biomedical effects of nanomaterials&nanosafety National Center for Nanoscience and TechnologyBeijing100190China GBA National Institute for Nanotechnology Innovation Guangzhou510770China University of Chinese Academy of Sciences Beijing100049China

Optical imaging in the second near-infrared(NIR-II,1,000-1,700 nm)window with much reduced tissue scattering plays a crucial role in life sciences due to its high sensitivity and high spatio-temporal resolutions^([1])... 详细信息

关键词： Second near-infrared window persistent luminescence nanomaterials for in vivo bioimaging

Manufactured nanoparticle:A prediction model for understanding PM2.5 toxicity to human

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Green Energy & Environment 2017年第1期2卷 3-4页

作者： Weiyue Feng Yuliang Zhao CAS Excellence Center for Nanosciences National Center for Nanoscience and Technology of China CAS Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences (CAS)

Epidemiological studies have demonstrated that chronic exposure to polluted concentration of fine ambient particulate matter(PM2.5)can induce markedly harmful effects on human health,however,an enormous research effort is still need to the comprehensive understanding of PM2.5 induction of new negative health ***,Maher and colleges[1]from Environmental Magnetism and Paleomagnetism at Lancaster University

关键词： PM Manufactured nanoparticle:A prediction model for understanding PM2.5 toxicity to human

Dual-functional extracellular vesicles enable synergistic treatment via m^(6)A reader YTHDF1-targeting epigenetic regulation and chemotherapy

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Nano Research 2023年第12期16卷 13309-13321页

作者： Rong Du Qing You Jingyi Liu Chen Wang Ling Zhu Yanlian Yang CAS Key laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory of Biological Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Chemotherapy remains one of the most prevailing strategies for cancer ***,its treatment effect is hampered by drug resistance,nonspecific tumor targeting,and severe toxic side *** chemotherapy with synergistic effect has become an attractive tumor therapy.N6-methyladenosine(m6A)regulators determine the fate of m6A-modified transcripts and play vital roles in cancer development and drug *** therapy such as small interfering RNA(siRNA)is a promising strategy to reduce the abnormal gene expression of m6A ***,its poor selectivity and high systemic toxicity necessitate the use of delivery vectors to target specific cells and ***,we constructed a dual-functional targeted nanodrug platform for the synergetic m6A-associated epigenetic regulation and chemotherapy of ovarian *** encapsulated siRNA targeting the m6A reader YT521-B homology(YTH)N6-methyladenosine RNA-binding protein 1(YTHDF1)and docetaxel(DTX),the first-line chemotherapeutic agent of ovarian cancer,into mesenchymal stem cell-derived small extracellular vesicles(MsEVs).This nanosystem exhibits significant tumor targeting and endo/lysosomal escape of *** effectively depletes YTHDF1 and suppresses the protein translation of eukaryotic translation initiation factor 3 subunit C(EIF3C)in an m6A-dependent *** combination of YTHDF1-targeting epigenetic regulation significantly enhances the anti-tumor effect of DTX and effectively inhibits ovarian cancer progression without causing significant systemic *** co-delivery nanoplatform offers a promising approach for combinational cancer treatment,showing improved anti-tumor efficacy through the synergistic effects of epigenetic regulation and chemotherapeutic inhibition.

关键词： extracellular vesicles N6-methyladenosine(m6A)modulators docetaxel small interfering RNA(siRNA)delivery ovarian cancer

Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups

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Journal of Environmental Sciences 2019年第3期31卷 198-209页

作者： Yichun Xie Bin Wan Yu Yang Xuejing Cui Yan Xin Liang-Hong Guo State Key laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences CAS Key laboratory for biomedical effects of nanomaterials and nanosafety National Center for Nanoscience and Technology of China Institute of Environment and Health Jianghan University

Graphene quantum dots(GQDs) possess great potential in various applications due to their superior physicochemical properties and wide array of available surface ***, the toxicity of GQDs has not been systematically assessed, thus hindered their further development; especially, the risk of surface modifications of GQDs is largely unknown. In this study, we employed a lung carcinoma A549 cells as the model to investigate the cytotoxicity and autophagy induction of three types GQDs, including cGQDs(COOH-GQDs), hGQDs(OH-GQDs), and aGQDs(NH_2-GQDs). The results showed hGQDs was the most toxic, as significant cell death was induced at the concentration of 100 μg/mL,determining by WST-1 assay as well as Annexin-V-FITC/PI apoptosis analysis, whereas cGQDs and aGQDs were non-cytotoxic within the measured concentration. Autophagy detection was performed by TEM examination, LC3 fluorescence tracking, and Westernblot. Both aGQDs and hGQDs induced cellular autophagy to various degrees except for cGQDs. Further analysis on autophagy pathways indicated all GQDs significantly activated p-p38 MAPK; p-ERK1/2 was inhibited by aGQDs and hGQDs but activated by c GQDs. p-JNK was inhibited by aGQDs and c GQDs, while activated by hGQDs. Simultaneously, Akt was activated by hGQDs but inhibited by aGQDs. Inhibition of autophagy by 3-MA significantly increased the cytotoxicity of GQDs, suggesting that autophagy played a protective role against the toxicity of GQDs. In conclusion, c GQDs showed excellent biocompatibility and may be considered for biological applications. Autophagy induction may be included in the health risk assessment of GQDs as it reflects the stress status which may eventually lead to diseases.

关键词： Graphene quantum dots Cytotoxicity Autophagy Surface functional group

Functionalization of carbon nanotubes/graphene by polyoxometalates and their enhanced photo-electrical catalysis

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Chinese Physics B 2014年第8期23卷 37-49页

作者：张双双刘荣基张光晋谷战军 Key laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of Sciences University of Chinese Academy of Sciences Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences

Carbon nanotubes and graphene are carbon-based materials, which possess not only unique structure but also prop- erties such as high surface area, extraordinary mechanical properties, high electronic conductivity, and chemical stability. Thus, they have been regarded as an important material, especially for exploring a variety of complex catalysts. Considerable efforts have been made to functionalize and fabricate carbon-based composites with metal nanoparticles. In this review, we summarize the recent progress of our research on the decoration of carbon nanotubes/graphene with metal nanoparticles by using polyoxometalates as key agents, and their enhanced photo-electrical catalytic activities in various catalytic reactions. The polyoxometalates play a key role in constructing the nanohybrids and contributing to their photo-electrical catalytic properties.

关键词： carbon nanotube graphene polyoxometalate photo-electro-catalysis

A multiple-labelling method for cells using Au nanoparticles with different shapes

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Chinese Science Bulletin 2013年第21期58卷 2640-2645页

作者： ZHANG Ke FENG JianTao SUN QuanMei JIN Lin LI Jing WU XiaoChun HAN Dong Chinese Academy of Sciences Key laboratory of Standardisation and Measurement for Nanotechnology National Centre for Nanoscience and Technology laboratory for Biological effects of nanomaterials and nanosafety National Centre for Nanoscience and Technology

An important and difficult issue is simultaneously identifying the detailed locations of various molecules on the cell surface, as this identification requires a synergistic effect between more than one molecule in a living cell. Au nanoparticles (NPs) with different shapes can be readily recognised under low vacuum scanning electron microscopy (lvSEM). Anisotropic Au nanorods (NRs) possess unique surface plasmon resonance (SPR) properties, which can be further utilised for two photon luminescence (TPL) and other optical imaging techniques. In this paper, Au NRs and Au nanooctahedra (Au NOs) are introduced as biomarkers for ICAM-1 and Integrin β1. Combined with the advantages of lvSEM, this multiple-labelling method is a new method for studying the interactions between specific, functional molecules.

关键词：金纳米粒子细胞表面形状扫描电子显微镜标签表面等离激元 ICAM-1 自然保护区

Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents

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Nano Research 2015年第4期8卷 1259-1268页

作者： Rongli Cui Juan Li Huan Huang Mingyi Zhang Xihong Guo Yanan Chang Min Li Jinquan Dong Baoyun Sun Gengmei Xing CAS Key laboratory for biomedical effects of Nanomaterial & nanosafety Institute of High Energy Physics Chinese Academy otScience (CAS) Beijing 700049 China

Novel carbon nanohybrids based on unmodified metallofullerenes have been successfully fabricated for use as a new magnetic resonance imaging （MRI） contrast agent. The nanohybrids showed higher R1 relaxivity and better brightening effect than Gd@C82（OH）x, in Tl-weighted MR images in vivo. This is a result of the proton relaxivity from the original gadofullerenes, which retained a perfect carbon cage structure and so might completely avoid the release of Gd^3＋ ions. A ＂secondary spin-electron transfer＂ relaxation mechanism was proposed to explain how the encaged Gd^3＋ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities for developing highly efficient and low toxicity MRI contrast agents.

关键词： graphene oxide metallofullerene magnetic resonanceimaging (MRI) nanohybrids