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In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis

Science Bulletin 2025年第3期70卷 407-418页

作者： Da-Yong Hou Ni-Yuan Zhang Peng Zhang Xiang-Peng Li Jiong-Cheng Wu Mei-Yu Lv Zhi-Jia Wang Xing-Jie Hu Jian-Xiao Liang Hong-Lei Wang Yue-Ze Wang Hui-Hui You Hong-Wei An Hao Wang Wanhai Xu NHC Key laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in UrologyHarbin Medical UniversityHarbin 150001China Department of PET-CT/MRI Harbin Medical University Cancer HospitalHarbin 150001China CAS Key laboratory for biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Tumor metastasis accounts for over 90%of tumor-related deaths,prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal ***,early detection of metastasis lesions by tracking tumor markers alone has proven to be ***,we reported a glycopeptide-based bispecific fluorescence probe(bsProbe)for earlier detection of bladder cancer and *** simultaneously recognition(tumor&tumor microenvironment)and in vivo self-assembly,the tumor accumulation of bsProbe(12.3%ID/g)was obviously increased by∼6 fold compared with that in CXCR4 specific fluorescence probe(sProbe),indicating the obvious advantages of bsProbe over existing tumor metastasis detection ***,bsProbe substantially broadens the tumor diagnosis window and enhances the detection signal to noise ratio(SNR:approximately 9.5),permitting early diagnosis of lung micro-metastasis(∼1 mm),precise identifying of tumor boundaries and micro-tumors in orthotopic tumor *** importantly,bsProbe was demonstrated to distinguish malignant from benign specimen with a specificity of 90.48%and sensitivity of 92.22%in 195 clinical specimens of bladder cancer *** together,this novel synergetic targeting(CD206×CXCR4)strategy provides an attractive method for earlier detection of bladder cancer and metastasis,which might be further extended to the imaging-guided surgery of clinical invisible tumors.

关键词： Self-assembly Peptide Nanomaterial Fluorescence imaging Bladder cancer

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Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Regulation of graphdiyne-based nanozymes with enhanced oxidaselike activity by cobalt and nitrogen codoping

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Nano Research 2025年第1期18卷 21-29页

作者： Jiali Liu Xiaoli Wang Yongfu Lian Xue Wang Xiuxiu Wang Xingfa Gao Baoyun Sun Xihong Guo CAS Key laboratory for biomedical effects of Nanomaterial&nanosafety Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China Key laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The development of nanozymes with excellent intrinsic oxidase-like activity and specificity has received increasing ***(GDY)could be a promising choice for designing nanozymes with enhanced oxidase(OXD)-like activity due to its unique structure and ***,Co-N-GDY with high OXD activity but no peroxidase(POD)activity was synthesized by codoping of cobalt(Co)and nitrogen(N)into GDY and compared with other GDY-based nanozymes(including GDY,Co-GDY,and N-GDY).Upon analyzing the doping effect of Co and N on the OXD-like and POD-like activities,we found that the combination of Co and N in GDY played a significant role in enhancing the OXD-like activity,and even reversed the POD-like activity of N-GDY to OXD-like activity of *** electrochemical experiment and the theoretical calculations provided an explanation for the mechanism and showed that the activity was closely linked to the reduction ability of O_(2) or H_(2)O_(2) on the nanozyme substrates,which was determined by the ratedetermining step of the catalytic reaction.

关键词： nanozymes oxidase-like activity graphdiyne heteroatom doping regulation

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biomedical effects and nanomaterials： nanosafety of Engineered Recent Progress

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Chinese Journal of Chemistry 2012年第9期30卷 1931-1947页

作者：王晓峰朱墨桃李敬源 CAS Key laboratoryfor biomedical effects of nanomaterials and nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key laboratory for biomedical effects of nanomaterials and nanosafety National Center for Nanoscience and Technology of ChinaBeijing 100190China

With the development of nanotechnology, there are growing concerns about biological effects and biosafety of engineered nanomaterials. On the other hand, nanoparticles are widely used in medical fields based on their novel interactions with biological entities. However, there are still a lot of challenges to establish systematic knowledge about nanotoxicology and develop biologically safer biomedical materials due to the variety of factors determining their biomedical effects and nanotoxicity. Understanding the interactions of engineered nanomaterials with the bio- logical entities becomes crucial to the further development of nanoscience and nanotechnology. In the past decade, colleagues in our laboratory intensively studied the toxic properties of various kinds of nanomaterials and their chemical mechanisms. In this paper we review the recent advance in the research on the biological effects of engi- neered nanomaterials and nanosafety issue, by focusing on the studies about representative nanomaterials in our la- boratory.

关键词： nanomaterials biomedical effect nanotoxicology surface chemistry

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The new face of iron oxide nanoparticles: the bullets targeting tumor microenvironment for cancer therapy

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Science Bulletin 2016年第23期61卷 1788-1790页

作者： Jinxia Li Feng Zhao Chunying Chen CAS Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences CAS Key laboratory for biomedical effects of nanomaterials and nanosafety National Center for Nanoscience and Technology

Ferumoxytol, an iron replacement product in clinic practices, is an agent of superparamagnetic iron oxide nanoparticles coated with polyglucose sorbitol carboxymethylether. It is approved for the intravenous therapy o... 详细信息

关键词：铁纳米粒子肿瘤治疗氧化微环境子弹缺铁性贫血临床实践替代产品

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Nanotechnology in the programmed cell therapy:nowhere to escape of cancer

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Science Bulletin 2016年第1期61卷 45-47页

作者： Jinxia Li Yuliang Zhao CAS Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences CAS Key laboratory for biomedical effects of nanomaterials and nanosafety National Center for Nanosciences and Technology

For lymphomas,the transport of chemotherapeutic drugs usually meets physical barriers to the lymph nodes where disseminated tumor cells frequently *** new findings show that autologous T cells as live vectors combined with nanotechnology-based drug delivery can provide a novel opportunity for the improved chemotherapy toward lymphomas.

关键词：纳米技术细胞疗法程序性癌症化疗药物肿瘤细胞淋巴瘤淋巴结

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Analytical methods for nano-bio interface interactions

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Science China Chemistry 2016年第11期59卷 1467-1478页

作者： Jing Wang Waseem Akthar Quershi Yiye Li Jianxun Xu Guangjun Nie CAS Key laboratory for biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology

Knowledge on the interactions between engineered nanomaterials(ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano-bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface characterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level.

关键词： engineered nanomaterial nano-bio interface nano-bio interaction analytical methods protein corona synchrotron radiation

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Synthesis, Crystal Structure and Hydrogenation Catalysis of a CF_3-BINAP(O)-Rh-COD Complex

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Chinese Journal of Structural Chemistry 2012年第11期31卷 1669-1675页

作者：杨红芬卢伟刘蕾刘宇吴海臣 Key laboratory for biomedical effects of nanomaterials & nanosafety Institute of High Energy Physics Chinese Academy of Sciences

The complex [（CF3-BINAP（O））Rh（COD）][ClO4]·Et2O （2, CFa-BINAP（O） = 2- {bis[3,5-bis（trifluoromethyl）phenyl]phosphino } -2 ＇- {bis [3,5-bis（trifluoromethyl）phenyl]phosphinyl } -1,1、-binaphthyl, COD = 1,5-cyclooctadiene） was obtained directly from the reaction of CF3- BINAP（O） ligand with [Rh（COD）][C104]. Complex 2 has been characterized by single-crystal X-ray diffraction. The crystal adopts space group P21/n with a = 19.0727（4）, b = 15.6275（4）, c = 22.3039（6） A, fl = 112.3570（10）°, V= 6148.2（3） A3, Z = 4, Dc = 1.693 g/cm3, F（000） = 3144, μ（MoKa） = 0.500 mm-1, the final R = 0.0947 and wR = 0.2501. Structural studies reveal that Rh（I） is coordinated by one oxygen and one phosphorus in the same ligand. Asymmetric hydrogenation of acetami- docinnamic acid with compound 2 was also evaluated.

关键词： BINAP(O) ligand rhodium complex crystal structure asymmetric hydrogenation

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Bottlebrush prodrug provides a novel strategy for nanomedicine-mediated combination therapy of multiple myeloma

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Science China Materials 2023年第7期66卷 2951-2952页

作者： Haozhi Xu Shuang Zhu Zhanjun Gu Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

A method to enhance the limitation of synergistic chemodrugs based on nanomedicine delivering to tumors was proposed in a recent paper published in Nature Nanotechnology[1].This research not only improves current front-line combination therapies for multiple myeloma(MM),but also offers a novel design idea for nanomedicine of other diseases.

关键词： myeloma drugs therapy

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Multifunctional nanoparticle systems for combined chemo- and photothermal cancer therapy

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Frontiers of Materials Science 2013年第2期7卷 118-128页

作者： Hai WANG Yu-Liang ZHAO Guang-Jun NIE CAS Key laboratory for biomedical effects of nanomaterials & nanosafety National Center for Nanoscience and Technology (NCNST) 11 Beiyitiao Zhongguancun Beijing 100190 China CAS Key laboratory for biomedical effects of nanomaterials & nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

Hyperthermia has long been considered as an adjuvant therapy for treating various diseases. Cancer treatment exploiting hyperthermia shows great clinical potential for a wide range of tumors. Importantly, the efficacy of hyperthermal therapy has recently been enhanced by the development of functional nanomaterials. The unique physicochemical properties of nanomaterials afford the specific localization of hyperthermia to primary tumors and early-stage cancers. In particular, due to their high rate of light-to-heat conversion and their capacity to be activated by tissue-penetrating electromagnetic radiation, near-infrared （NIR） light-absorbing plasmonic nanomaterials have attracted considerable attention as candidates for noninvasive photothermal therapy. The purpose of this article is to provide a overview on the current development in multifunctional nanomaterials capable of combined hyperthermia-chemotherapy delivery.

关键词： combination therapy multifunctional nanoparticle drug delivery hyperthermia photothermal therapy

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