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Antimicrobial lipids:Emerging effector molecules of innate host defense

World Journal of Immunology 2015年第2期5卷 51-61页

作者： Edith Porter Daniel C Ma Sandy Alvarez Kym F Faull Department of Biological Sciences California State University Los Angeles Department of Medicine Geffen School of MedicineUniversity of California Los Angeles University of Iowa Carver College of Medicine Pasarow Mass Spectrometry laboratory David Geffen School of Medicine at the University of California Los Angeles

The antimicrobial properties of host derived lipids have become increasingly recognized and evidence is mounting that antimicrobial lipids(AMLs),like antimicrobial peptides,are effector molecules of the innate immune system and are regulated by its conserved *** review,with primary focus on the human body,provides some background on the biochemistry of lipids,summarizes their biological functions,expands on their antimicrobial properties and site-specific composition,presents modes of synergism with antimicrobial peptides,and highlights the more recent reports on the regulation of AML production as well as bacterial resistance *** on extant data a concept of innate epithelial defense is proposed where epithelial cells,in response to microbial products and proinflammatory cytokines and through activation of conserved innate signaling pathways,increase their lipid uptake and up-regulate transcription of enzymes involved in lipid biosynthesis,and induce transcription of antimicrobial peptides as well as cytokines and *** subsequently secreted antimicrobial peptides and lipids then attack and eliminate the invader,assisted by or in synergism with other antimicrobial molecules delivered by other defense cells that have been recruited to the site of infection,in most of the *** review invites reconsideration ofthe interpretation of cholesteryl ester accumulation in macrophage lipid droplets in response to infection as a solely proinflammatory event,and proposes a direct antimicrobial role of lipid droplet-associated cholesteryl ***,for the interested,but new-to-the-field investigator some starting points for the characterization of AMLs are *** it is possible to utilize AMLs for anti-infectious therapeutic and prophylactic approaches,we need to better understand pathogen responses to these lipids and their role in the pathogenesis of chronic infectious disease.

关键词：免疫医学英文文摘

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水稻抗白叶枯病基因Xa21转基因水稻及其杂交稻研究

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作物学报 2001年第1期27卷 29-34页

作者：吴家道杨剑波许传万李莉向太和倪大虎汪秀峰贾士荣唐益雄张世平 Claude M Fauquet 安徽省农业科学院水稻研究所中国农业科学院生物技术研究所北京100081 International laboratory for Tropical Agricultural Biotechnology The Scripps Research Institute La Jolla

用基因枪转基因技术将高抗白叶枯病的Ｘａ２１基因导入中国三系杂交稻恢复系（明恢６３）和保持系（皖Ｂ）中，获得转基因水稻系，其中４个株系只含有Ｘａ２１基因，不合选择标记潮霉素抗性基因ｈｐｈ。筛选抗白叶枯病转基因纯合系，... 详细信息

用基因枪转基因技术将高抗白叶枯病的Ｘａ２１基因导入中国三系杂交稻恢复系（明恢６３）和保持系（皖Ｂ）中，获得转基因水稻系，其中４个株系只含有Ｘａ２１基因，不合选择标记潮霉素抗性基因ｈｐｈ。筛选抗白叶枯病转基因纯合系，在田间种植６代，用ＰＣＲ检测证明，Ｘａ２１基因能稳定遗传表达。用转基因水稻配制两系杂交稻，杂交组合Ｆ１含有Ｘａ２１基因，既抗白叶枯病，又有较大的增产潜力。

关键词： Xa21基因转基因水稻杂交稻抗白叶枯病

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Lawsone-encapsulated chitosan/polyethylene oxide nanofibrous mat as a potential antibacterial biobased wound dressing

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Engineered Regeneration 2021年第1期2卷 219-226页

作者： Fatemeh Saniee Abadehie Ali Hasanpour Dehkordi Mahdi Zafari Mitra Bagheri Satar Yousefiasl Samiramis Pourmotabed Leila Mahmoodnia Majid Validi Milad Ashrafizadeh Ehsan Nazarzadeh Zare Navid Rabiee Pooyan Makvandi Esmaeel Sharifi Cellular and Molecular Research Center Basic Health Science InstituteShahrekord University of Medical SciencesShahrekordIran Social Determinants of Health Research Center Department of Medical-SurgicalFaculty of Nursing and MidwiferyShahrekord University of Medical SciencesShahrekordIran National Cell Bank Pasteur Institute of IranTehranIran School of Dentistry Hamadan University of Medical Sciences*** HamadanIran Department of Emergency Medicine School of MedicineHamadan University of Medical Sciences***HamadanIran Department of Internal Medicine Shahrekord University of Medical SciencesShahrekordIran Department of Medical laboratory Sciences School of Allied Medical SciencesShahrekord University of Medical SciencesShahrekordIran Faculty of Engineering and Natural Sciences Sabanci UniversityOrta MahalleUniversite Caddesi No.27OrhanliTuzlaIstanbul 34956Turkey Sabanci University Nanotechnology Research and Application Center(SUNUM) TuzlaIstanbul 34956Turkey School of Chemistry Damghan UniversityDamghan 36716-41167Iran Department of Physics Sharif University of TechnologyP.O.Box 11155-9161TehranIran School of Engineering Macquarie UniversitySydneyNew South Wales2109Australia Istituto Italiano di Tecnologia Centre for Materials Interfacesviale Rinaldo Piaggio 3456025 PontederaPisaItaly Department of Tissue Engineering and Biomaterials School of Advanced Medical Sciences and TechnologiesHamadan University of Medical SciencesHamadanIran

Biodegradable and absorptive wound dresses with antibacterial activity are in demand to accelerate wound heal-ing along with eliminating bacterial ***-derived naphthoquinones compounds such as lawsone have shown sustained antibacterial functions to avoid development of bacterial resistance by reducing pH or attaching to bacterial *** the nanofibrous mats based on chitosan/polyethylene oxide(PEO)fibers containing various concentrations of lawsone(0,1,3,7,10%wt.)were fabricated by electrospinning for potential applications as wound dressing *** results exhibited that the chitosan/PEO/Lawsone nanofibers possess antibacterial activity toward Gram-negative and-positive ***,the addition of lawsone in the proper amount into chitosan/PEO nanofibers not only introduced an antithetical property but also reduced the platform’s cytotoxicity,promoting cell viability of normal human fibroblast ***,the achieved data suggest the potential application of biocompatible nanofibrous mats as an antibacterial wound dressing material.

关键词： Chitosan Lawsone Antibacterial wound dressing Nanofibrous mat

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Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy

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Bioactive Materials 2021年第8期6卷 2629-2642页

作者： Gabriela Graziani Katia Barbaro Inna V.Fadeeva Daniele Ghezzi Marco Fosca Enrico Sassoni Gianluca Vadalà Martina Cappelletti Francesco Valle Nicola Baldini Julietta V.Rau IRCSS Istituto Ortopedico Rizzoli Laboratory of NanoBiotechnologyvia di Barbiano 1/1040136BolognaItaly Istituto Zooprofilattico Sperimentale Lazio e Toscana“M.Aleandri” Via Appia Nuova 1411-00178RomeItaly A.A.Baikov Institute of Metallurgy and Materials Science Russian Academy of SciencesLeninsky prospect 49119334MoscowRussia Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere100-00133RomeItaly University of Bologna Department of CivilChemicalEnvironmental and Materials Engineeringvia Terracini 2840131BolognaItaly UniversitàCampus Bio-Medico di Roma Research Unit of Orthopaedic SurgeryFaculty of Medicine and SurgeryVia Alvaro del Portillo 2100128RomeItaly University of Bologna Department of Pharmacy and Biotechnologyvia Irnerio 4240126BolognaItaly Institute of Nanostructured Materials National Research Council(ISMN-CNR)Via Piero Gobetti10140129BolognaItaly IRCSS Istituto Ortopedico Rizzoli BST Biomedical Science and Technologies Labvia di Barbiano 1/1040136BolognaItaly University of Bologna Department of Biomedical and Neuromotor SciencesVia Massarenti940128BolognaItaly Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8build.2119991MoscowRussia

Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure *** address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on *** morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is *** efficacy is investigated against four Gram positive and Gram negative bacterial strains and against *** fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of ***,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also *** indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical *** studies show a good efficacy against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell *** cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADMSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of ***,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when *** findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications.

关键词： Tricalcium phosphate Silver Nanostructured coatings Antibacterial coatings Orthopedics Antibacterial ceramics

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Isolation of Multi-Drug Resistant Paenibacillus sp. from Fertile Soil： An Imminent Menace of Spreading Resistance

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Journal of Life Sciences 2010年第5期4卷 15-19页

作者： Pallavi B. Pednekar Roopesh Jain Narsinh L. Thakur Girish B. Mahajan Department of Biotechnology The KET＇s V.G. Vaze College Mumbai University Navi-mumbai 400709 India Department of Natural Products Piramal Life Sciences Limited Mumbai 400063 India Bio-organic Chemistry laboratory National Institute of Oceanography （CSIR） Goa 403004 India

There are a good number of reports in the literature stating spread of resistance from normal soil flora to nosocomial microorganism through various ways. Similarly during the study of antimicrobial susceptibility pattern in the microflora, a multi-drug resistant bacterium has been isolated from soil collected in Maharashtra state (India). The bacterium exhibited a resistance to various classes of antibiotics namely glycopeptide, beta-lactams, aminoglycosides, macrolides and lincosomides. The bacterial strain showed its resemblance to the genus Paenibacillus. This constitutes the first report of its kind as to the multi-drug resistance trait in the genus Paenibacillus phenotype, especially in close phylogenetic neighbour of Paenibacillus daejeonensis. The resistance pattern displayed by this strain particularly highlights the possible presence of multiple resistant determinants in microflora of the soil rhizosphere. In view of the recent reports about the Paenibacillus spp. in clinical derived strains, such multi-drug resistance factors in this genus adds to menace of transmission of resistance to common soil originating pathogen. The data also supports the fact that the resistances to certain antibiotics need not always be due to exposure to particular antibiotic or similar substance.

关键词：芽孢杆菌属多药耐药性传播土壤分离威胁氨基糖苷类 β-内酰胺类

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Succession of bacterial Community Inhabited Acid Mine Drainage under High Fe（Ⅱ） Concentration

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Journal of Environmental Science and Engineering 2010年第8期4卷 46-55页

作者： M.X. Wan Y. Yang W.M. Zeng J.L. Xia X.D. Liu W.Q. Qin G.Z. Qiu School of Minerals Processing and Bioengineering Central South University Hunan 410083 China Department of Chemical ＆ Biomolecular Engineering Johns Hopkins University MD 21218 USA Key laboratory of Biometalhtrgy of Ministry of Education Hunan 410083 China CSIRO Process Science and Engineering Clayton VIC 3168 Australia

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Novel Functions of Interleukin-1 Beta in Spotted Halibut (Verasper variegatus) at Its Embryonic and Metamorphic Stages

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中国海洋大学学报（英文版） 2018年第5期 1197-1208页

作者： LI Zan LIU Xiumei CAO DANDan LIU Yuezhong WANG Xubo LIU Jinxiang WANG Zhigang ZHANG Quanqi YU Haiyang School of Agriculture Ludong University Key laboratory of Marine Genetics and Breeding of Ministry of Education College of Marine Life SciencesOcean University of China

Interleukin-1 beta(IL-1β) is a cytokine involved in the control of inflammatory *** functions of IL-1β have been extensively studied in many ***,few studies focused on the functions of IL-1β in the spotted halibut(Verasper variegatus),an endangered aquatic fish that easily suffers from bacterial and viral *** first cloned and sequenced the IL-1β gene from ***(Vv IL-1β).Its conservative interleukin-1 propeptide and interleukin-1/18 domains corresponding regions,characteristics of the IL-1 protein family and TA-rich motifs relating to inflammatory responses were similar to those of the IL-1β genes from other teleost and *** phylogenetic analysis showed that Vv IL-1β was homologous to the IL-1β gene of other *** with pathogen-associated molecular patterns(PAMPs) induced a significant and rapid up-regulation of Vv IL-1β expression in the peripheral blood leukocytes(PBLs),revealing that Vv IL-1β is actively involved in the host immune responses against bacterial and viral *** expression level of Vv IL-1β was relatively high in the PBLs,gill,and intestine,indicating the immunological function of Vv IL-1β.Vv IL-1β also had interesting expression patterns at specific developmental stages,implying that the IL-1β of flatfishes may have some novel functions during embryonic development and *** 3 D structure prediction also provided information about how Vv IL-1β interacts with its receptor *** results suggested that Vv IL-1β may have multiple functions in *** and provided us valuable information for understanding the novel functions of IL-1β.

关键词：变形期胚胎星鲽 IL-1 脊椎动物 Β基因哺乳动物种系发生

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Isolation, Identification and Pathogenicity Analysis of Streptococcus suis Type 2

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Agricultural Biotechnology 2019年第4期8卷 64-68页

作者： Zicheng MA Yan LI Jinyuan GU Tao PENG Zhaohu LIU Hongyu WANG Fanliang MENG Fangkun WANG Sidang LIU College of Animal Science and Technology Shandong Agricultural UniversityTaian 271018China Shandong Provincial Key laboratory of Animal Biotechnology and Disease Control and Prevention Shandong Agricultural UniversityTaian 271018China Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention Taian 271018China

[Objectives]This study aimed to investigate the pathogenicity,growth characteristics and drug resistance of Streptococcus suis type 2.[Methods]bacterial isolation and identification,biochemical experiments,determination of growth curve and correlation curve between OD 600 values and viable counts,drug susceptibility tests,pathogenicity analysis,and histopathological observations were carried out.[Results]The Streptococcus strain isolated from infected pigs was identified as Streptococcus suis type 2,which was named TA01 ***01 strain reached the growth peak at 6-8 h post-incubation,and viable counts gradually declined after 8 h of *** correlation equation between OD 600 values and viable counts is y=24.659 x-1.076 1,R^2=0.996 ***01 strain was sensitive to penicillin,erythromycin,florfenicol and oxacillin,and resistant to ciprofloxacin,polymyxin B and *** to the results of pathogenicity analysis,all the mice in 3.6×10^9 cfu/mouse group died within 48,and these dead mice exhibited acute pyaemia *** on the Reed-Muench formula,it was calculated that LD 50 of TA01 strain was 1.137×10^8 cfu/*** examination showed obvious blue-stained bacteria clusters,accompanied by neutrophil infiltration.[Conclusions]TA01 strain was a virulent strain of Streptococcus suis type *** with Streptococcus strains which were isolated and reported in China,TA01 strain exhibited strong virulence and rapid proliferation.

关键词： Streptococcus suis type 2 Isolation and identification Growth curve Drug sensitivity test Pathogenicity LD 50 determination

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Characteristics of Vertical Distributions of Fatty Acids in Surface Sediments of the Yellow Sea and East China Sea

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中国海洋大学学报（英文版） 2018年第5期 1123-1134页

作者： LOPESEvanildoO. WANGMengqi CHENYing YANGGuipeng andDINGHaibing College of Chemistry and Chemical Engineering Ocean University of China China State Shipbuilding Corporation Electronics Technology Co.Ltd. Key laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of China Qingdao Collaborative Innovation Center of Marine Science and Technology Ocean University of China Qingdao National laboratory of Marine Science and Technology

Fatty acids（FAs） in sediment collected from three different stations in the Yellow Sea and the East China Sea were analyzed for their distributions and to determine evidence of harmful algal blooms in the sediment *** diverse FAs were found in the Yellow Sea（YS） station,whereas in the two stations of the East China Sea（ECS） the FAs were more *** of some FA species in the two ECS stations displayed an occasional surge in their vertical *** highest concentration of FAs was found in the surface layer of station QT3(43.28 μg g-1).Monounsaturated FAs were more susceptible to degradation compared to their saturated counterparts,and changes of 16:0,18:2 and 20:5 accounted for the most variability in total concentrations of FAs as those species made up most of the quantified *** origins of the major fraction of FAs were attributed to autotrophic sources,and bacterial FAs accounted for only a small fraction of the total FAs in the *** availability was a possible regulating factor controlling bacteria abundances in marine sediments in the ECS and the YS.A principal component analysis（PCA） was applied to analyze the FA dataset and to reveal the principal environmental factors that control the composition of FAs in the ***2,which explains 15% of the variance,was estimated to reflect the diagenetic effects on the FA compositional changes in sediments influenced by bacterial degradation.

关键词：表面沉积垂直分布东海黄海特征沉积控制营养物质可获得性

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Role of quorum sensing in bacterial infections

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World Journal of Clinical Cases 2015年第7期3卷 575-598页

作者： Israel Castillo-Juárez Toshinari Maeda Edna Ayerim Mandujano-Tinoco María Tomás Berenice Pérez-Eretza Silvia Julieta García-Contreras Thomas K Wood Rodolfo García-Contreras Colegio de Postgraduados Campus Montecillo Department of Biological Functions and Engineering Kyushu Institute of Technology Epigenetics of Cancer laboratory Division of Basic ResearchNational Institute of Genomic Medicine Department of Microbiology Instituto de Investigación Biomédica de A Coruña(INIBIC)Complexo Hospitalario Universitario de A Coruña(CHUAC)SergasUniversidade da Coruña(UDC)15006 A CoruñaSpain Departamento de Microbiología y Parasitología Facultad de MedicinaUniversidad Nacional Autónoma de México Centro Médico Coyoacán Department of Chemical Engineering Pennsylvania State UniversityUniversity Park Department of Biochemistry and Molecular Biology Pennsylvania State UniversityUniversity Park

Quorum sensing(QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed.

关键词： Quorum sensing Virulence Infections Pseudomonas aeruginosa Staphylococcus aureus Animal models

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