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稀有金属材料与工程 2025年第1期54卷 10-16页

作者： Zhao Yanchun Jin Bo Feng Yuanfei Ma Huwen Yu Zhiqi Feng Li Liaw Peter K State Key laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou 730050China Wenzhou Pump and valve Engineering Research Institute of Lanzhou University of Technology Wenzhou 325105China Department of Materials Science and Engineering University of TennesseeKnoxville TN37996USA

(TiZrHf)_(50)Ni_(30)Cu_(20-x)Co_(x)(x=2,4,6,at%)high-entropy high-temperature shape memory alloys were fabricated by watercooled copper crucible in a magnetic levitation vacuum melting furnace,and the effects of Co content on microstructure and mechanical properties were *** results indicate that the grain size of the alloy decreases with increasing the Co *** the as-cast state,the alloy consists primarily of the B19′phase,with a trace of B2 *** fracture morphology is predominantly composed of the B19′phase,whereas the B2 phase is nearly *** the Co content or reducing the sample dimensions(d)markedly enhance the compressive strength and ductility of the *** d=2 mm,the(TiZrHf)_(50)Ni_(30)Cu_(14)Co_(6) alloy demonstrates the optimal mechanical properties,achieving a compressive strength of 2142.39±1.8 MPa and a plasticity of 17.31±0.3%.The compressive cyclic test shows that with increasing the compressive strain,the residual strain of the(TiZrHf)_(50)Ni_(30)Cu_(14)Co_(6) alloy increases while the recovery ability *** superelastic recovery capability of the alloy is continuously *** superelastic recovery rate increases from 1.36%to 2.12%,the residual strain rate rises from 1.79%to 5.52%,the elastic recovery rate ascends from 3.86%to 7.36%,while the total recovery rate declines from 74.48%to 63.20%.

关键词： high-temperature shape memory alloy high-entropy alloy microstructure mechanical property

Impact of Startup Strategy and Buffer Tank Volume on the Compressor Inlet State for a 3-MW sCO_(2)Brayton Cycle

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Journal of Thermal Science 2025年第1期34卷 159-175页

作者： ZHAO Decai WANG Bo Key laboratory of Advanced Energy and Power Institute of Engineering Thermophysics(IET)Chinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The supercritical carbon dioxide(sCO_(2))Brayton cycle system has become an emerging and highly promising method of thermal power conversion due to its efficiency advantage,system compactness,and excellent adaptability of the heat *** the low carbon sCO_(2)Brayton cycle testbed with cycle output power approaching 3 MW,a relatively detailed dynamic simulation model of the entire system is constructed to explore the dynamic response characteristics of the system with different startup strategies and different buffer tank volumes during the startup *** simulation results indicate that the smaller the volume of the buffer tank,the more rapid and obvious the parameter fluctuation in the buffer tank during the *** the allowable relative deviation limit of density is 5%,then the ratio of the buffer tank volume to the volume of the entire closed loop should not be lower than 36.80%.The strategy of simultaneous temperature and speed increase during turbine bypass start can effectively reduce the fluctuation of compressor inlet parameters and reach the steady-state more *** paper provides the recommended matching table for the opening of the turbine bypass valve(TBV)and the main regulating valve(MGV)to reduce the parameter fluctuation during the bypass *** effectiveness of the proposed turbine bypass and bypass switching startup strategy is verified by simulation,which may be used as a reference for test bench's future debugging and operation.

关键词： sCO_(2)Brayton cycle dynamic model buffer tank startup strategy dynamic characteristic

Intracellular and extracellular synergistic therapy for restoring macrophage functions via anti-CD47 antibody-conjugated bifunctional nanoparticles in atherosclerosis

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Bioactive Materials 2024年第4期34卷 326-337页

作者： Qiang Luo Liqun Dai Junli Li Heyanni Chen Ying Hao Qing Li Lili Pan Chengxiang Song Zhiyong Qian Mao Chen laboratory of heart valve disease West China HospitalSichuan University#37 Guoxue AlleyChengdu610064China State Key laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan UniversityCollaborative Innovation Center of BiotherapyChengdu610041China West China Medical School Sichuan UniversityChengdu610041SichuanChina Department of Nuclear Medicine Laboratory of Clinical Nuclear MedicineWest China HospitalSichuan UniversityChengdu610041SichuanChina

Atherosclerosis is a significant contributor to global cardiovascular *** the formation of atherosclerotic plaque effectively can lead to a decrease in cardiovascular ***,controlling macrophage function is *** study presents the creation of a bifunctional nanoparticle that is specific to macrophages to achieve intracellular and extracellular synergistic therapy for restoring macrophage *** nanoparticle is conjugated with anti-CD47 antibody to modulate extracellular CD47-SIRPαphagocytic signaling axis on the outer surface of macrophages and encapsulates the NLRP3 inhibitor(CY-09)to regulate intracellular inflammation response of *** results showed that the nanoparticles accumulate in the atherosclerotic plaque,alter macrophage phagocytosis,inhibit NLRP3 inflammasome activation,and decrease the plaque burden in Apoe^(-/-)mice whilst ensuring *** of single-cell RNA sequencing indicates that this multifunctional nanoparticle decreases the expression of genes linked to inflammation and manages inflammatory pathways in the plaque *** study proposes a synergistic therapeutic approach that utilizes a bifunctional nanoparticle,conjugated with anti-CD47,to regulate the microenvironment of plaques.

关键词： Anti-CD47 Atherosclerosis Bifunctional Anti-inflammation NLRP3

Intermediate and Long-Term Follow-Up of Transcatheter Closure of Congenital Coronary Cameral Fistulas in Infants and Children:Experience from a Single Center

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Congenital heart disease 2023年第4期18卷 413-430页

作者： Yifan Li Zewen Chen Yumei Xie Shushui Wang Zhiwei Zhang Department of Pediatric Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangdong Provincial Key Laboratory of South China Structural Heart DiseaseGuangzhou510100China Department of Cardiac Surgery Guangdong Cardiovascular InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangdong Provincial Key Laboratory of South China Structural Heart DiseaseGuangzhou510100China

Background:Limited data are available regarding intermediate and long-term outcomes of transcatheter closure(TCC)of coronary cameral fistulas(CCFs)in the pediatric ***:All pediatric patients diagnosed with CCFs who were scheduled to undergo TCC between 2005 and 2019 were retrospectively enrolled in the ***:A total of 66 patients(median age:3.93 years,median weight:15 kg)underwent attempted TCC of *** successful device implantation was achieved in 62 patients,and immediate complete occlusion was achieved in 44 patients(44/62%,71.0%).The closure procedure was waived in 2 patients due to anatomical factors.A total of 6 periprocedural complications occurred in 5 patients,including acute myocardial infarction(n=3),procedure-related death(n=1),device embolization(n=1),and rupture of tricuspid chordae tendineae(n=1).The acute procedural success rate was 89.4%(59/66),while the acute complication rate was 9.1%(6/66).Follow-up data were collected for 58(93.5%)out of 62 patients at a median of 9.3 years(range:3.0–15.7 years).10 adverse events occurred in 9 patients,including 5 follow-up complications(1 aortic valve perforation,1 coronary thrombosis,1 progressive aneurysmal dilation after reintervention,and 2 cases of new-onset tricuspid valve prolapse with significant regurgitation),and 5 closure failure with large residual *** intermediate and long-term adverse event rate was 17.2%(10/58).The anatomical features associated with both acute and follow-up adverse events were large CCFs(p=0.005),and giant coronary artery aneurysms(CAAs)(p=0.029).Conclusions:TCC of CCFs in infants and children appears to be effective and is associated with a relatively low complication *** CCFs and giant CAAs represent a higher risk of both acute and intermediate and long-term adverse events after closure.

关键词： Coronary cameral fistulas transcatheter closure pediatric

Stenting for Aorto-Ostial In-Stent Restenosis via Side Strut of an Excessively Protruding Stent Guided by Intracoronary Imaging

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Chinese Medical Journal 2018年第22期131卷 2767-2768页

作者： Yu Du Ying-Xin Zhao Wei Liu Jian-Wei Zhang Zhen-Xian Yan Yu-Jie Zhou Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseBeijing 100029China

To the Editor:A 54-year-old man was admitted for progressive chest *** years ago,the patient had surgical aortic valve replacement (SAVR),and preoperative multislice computed tomography (MSCT)showed no coronary stenosis.A year after SAVR,he presented with chest pain,and coronary angiogram revealed an isolated ostial left main coronary artery (LMCA) stenosis [Figure 1a].A 4.0mm × 18.0mm stent (Medtronic Vascular, Santa Rosa,CA,USA)was implanted without a high-pressure postdilation [Figure 1b].The patient was discharged on aspirin, ticagrelor (replaced with clopidogrel after 3months),and statins. Unfortunately,the stent was found to protrude into the aorta by approximately 10mm by MSCT at 4-month follow-up [Figure 1c].

关键词： Stenting Aorto-Ostial In-Stent Restenosis via Side Strut

Effect of Friction Stir Welding on Bulk Metallic Glasses

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Journal of Wuhan University of Technology(Materials Science) 2021年第5期36卷 624-628页

作者： ZHANG Xiangyun ZHANG Mi CHEN Wenbin YUAN Zizhou State Key laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou 730050China Wenzhou Engineering Institute of Pump&valve Lanzhou University of TechnologyWenzhou 325105China

In order to enlarge the size of bulk metallic glasses(BMGs),two Cu_(36)Zr_(48)Al_(8)Ag_(8) BMGs plates were successfully welded by friction stir welding(FSW)without obvious *** effect of friction stir welding on microstructure and mechanical properties of the BMGs was investigated.X-ray diffraction(XRD)and scanning electron microscope(SEM)were used to evaluate the changes of the crystalline particles in the *** was applied to analyze the changes of the amorphous ***-hardness of the stir zone before and after FSW was tested to explore changes of the mechanical *** show that the original Al3Zr particles in the BMGs were refined and some cavities parallel to the rotating direction of the pin were observed in the amorphous matrix after ***,micro-hardness of the stirred zone rises approximately 50 Hv compared with the as-cast sample due to structure relaxation of the amorphous matrix.

关键词： bulk metallic glasses friction stir welding micro-hardness nanoindentation

Effect of Cu addition on the microstructure and tribological performance of Ni60 directional structure coating

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International Journal of Minerals,Metallurgy and Materials 2023年第4期30卷 715-723页

作者： Xiaotian Yang Xinhua Wang Jun Zhou Hengli Wei Rong Zeng Wensheng Li School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou 730050China State Key laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou 730050China Wenzhou Engineering Institute of Pump&valve Lanzhou University of TechnologyWenzhou 325105China

The Ni60/15wt% Cu directional structure coating was prepared by the composite technology of flame spraying, induction remelting,and forced cooling, and the effect of Cu on the microstructure, phase, hardness, and wear performance of Ni60 coatings was investigated. Results showed that Cu addition makes the microstructure of Ni60 directional structure coating more compact, and Cu is mainly enriched within the crystal grain, resulting in the formation of Cu_(3.8)Ni as the bonding phase. Compared with Ni60 directional structure coating, Ni60/Cu directional structure coating has a lower hardness, lower friction coefficient, and lower wear rate, which indicate that Cu can effectively enhance the antifriction performance of Ni60 directional structure coating.

关键词： induction remelting directional structure coating microstructure tribological performance

Nursing experience for postoperative complications of transcatheter aortic valve replacement

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South China Journal of Cardiology 2017年第4期18卷 333-339页

作者：周锦秀李芸 Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention Guangdong General HospitalGuangdong Academy of Medical Sciences

Aortic stenosis is one of the major causes of death in cardiovascular diseases, and transcatheter aortic valve implantation （TAVI） is a milestone in the field of cardiovascular intervention. Since the first implemen... 详细信息

关键词： Nursing experience postoperative complications transcatheter aortic valve replacement

Association of serum lipoprotein(a) level with the severity and prognosis of calcific aortic valve stenosis: a Chinese cohort study

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Journal of Geriatric Cardiology 2020年第3期17卷 133-140页

作者： Shuo-Lin LIU Rynat Rozi Hui-Wei SHI Ying GAO Yuan-Lin GUO Yi-Da TANG Jian-Jun LI Na-Qiong WU Endocrinology&Cardiometabolic Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background There was a causal relationship between elevated lipoprotein(a)[Lp(a)]levels and increased risk of calcific aortic valve stenosis(CAVS)in whites and *** present study aimed to investigate whether Lp(a)levels were associated with aortic stenosis(AS)severity and clinical events in Chinese *** Levels of serum Lp(a)were measured in 652 patients with CAVS,whom all underwent baseline echocardiographic *** clinical endpoint was defined as a composite of aortic valve replacement(AVR)and cardiac *** Patients in the tertile 3 of Lp(a)had a higher percentage of severe AS compared with those in the tertile 1 and 2 of Lp(a)(46.2%vs.33.9%,P=0.005).Moreover,the top tertile of Lp(a)was an independent predictor of severe AS(OR=1.78,95%CI:1.18-2.66,P=0.006).However,there was no significant association between tertile 3 of Lp(a)and clinical events(hazard ratio:0.73;95%CI:0.43-1.24;P=0.239)in the multivariate Cox regression analysis during a mean follow-up time of 3.16±2.74 *** Elevated Lp(a)level was an independent predictor of severe AS by echocardiography in the Chinese population,but was not associated with the increased risk of AVR and cardiac death,suggesting that Lp(a)levels might be helpful in the risk stratification of patients with CAVS.

关键词： Aortic stenosis Calcification Severity Lipoprotein(a) Prognosis

ntrauterine Cardiac Intervention for Fetal Pulmonary valve Obstruction Lesion

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Chinese Medical Journal 2018年第1期131卷 103-104页

作者： Jin-Jin Yu Wei Pan Zhi-Wei Zhang Cheng-Bin Zhou Cheng-Cheng Pang Xu Zhang Yu-Fen Li Jian Zhuang Department of Pediatric Cardiology Guangdong Cardiovascular Institute Guangdong Provincial Key Laboratory of South China Structural Heart Disease Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 China Department of Maternal-Fetal Cardiology Guangdong Cardiovascular Institute Guangdong Provincial Key Laboratory of South China Structural Heart Disease Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 China Department of Cardiac Surgery Guangdong Cardiovascular Institute Guangdong Provincial Key Laboratory of South China Structural Heart Disease Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 China

Most of the congenital heart diseases can be diagnosed in utero using fetal echocardiography. With the development of ultrasonography and intrauterine cardiac intervention technique, fetal cardiac intervention （FC1） for critical aortic stenosis, highly restrictive or intact atrial septum, pulmonary atresia with an intact ventricular septum （PA/ IVS）, and critical pulmonary stenosis （CPS） are available in more countries.

关键词： ntrauterine Cardiac Intervention Obstruction Lesion