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Association between Per and Polyfluoroalkyl Substance and Abdominal Fat Distribution:A Trait Spectrum Exposure Pattern and Structure-Based Investigation

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Biomedical and Environmental Sciences 2025年第1期38卷 3-14页

作者： Zhi Li Shilin Shan Chenyang Song Chengzhe Tao Hong Qian Qin Yuan Yan Zhang Qiaoqiao Xu Yufeng Qin Yun Fan Chuncheng Lu State Key laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Key laboratory of Modern toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Department of Public Health Kangda College of Nanjing Medical UniversityLianyungang 222000JiangsuChina Department of Microbes and Infection School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina

Objective To investigate the associations between eight serum per-and polyfluoroalkyl substances(PFASs)and regional fat depots,we analyzed the data from the National Health and Nutrition Examination Survey(NHANES)2011-2018 *** Multiple linear regression models were developed to explore the associations between serum PFAS concentrations and six fat compositions along with a fat distribution score created by summing the concentrations of the six fat *** associations between structurally grouped PFASs and fat distribution were assessed,and a prediction model was developed to estimate the ability of PFAS exposure to predict obesity *** Among females aged 39-59 years,trunk fat mass was positively associated with perfluorooctane sulfonate(PFOS).Higher concentrations of PFOS,perfluorohexane sulfonate(PFHxS),perfluorodecanoate(PFDeA),perfluorononanoate(PFNA),and n-perfluorooctanoate(n-PFOA)were linked to greater visceral adipose tissue in this *** men,exposure to total perfluoroalkane sulfonates(PFSAs)and long-chain PFSAs was associated with reductions in abdominal fat,while higher abdominal fat in women aged 39-59 years was associated with short-chain *** prediction model demonstrated high accuracy,with an area under the curve(AUC)of 0.9925 for predicting obesity *** PFAS exposure is associated with regional fat distribution,with varying effects based on age,sex,and PFAS *** findings highlight the potential role of PFAS exposure in influencing fat depots and obesity risk,with significant implications for public *** prediction model provides a highly accurate tool for assessing obesity risk related to PFAS exposure.

关键词： Per-and polyfluoroalkyl substances Regional fat depots Obesity Structure-based NHANES

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The Cause of Hirschsprung’s Disease in Bardet Biedl Syndrome in Children

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Surgical Science 2025年第1期16卷 15-25页

作者： Naga Venkata Chakra Satyanarayana Amarthi Terry Oroszi Department of Pharmacology and toxicology Boonshoft School of Medicine Wright State University Dayton Ohio USA

Hirschsprung’s disease (HSCR) is a developmental disorder characterized by the absence of ganglion cells in the distal colon, leading to functional obstruction. Bardet-Biedl syndrome (BBS) is a rare ciliopathy associated with various clinical features, including HSCR. This review article aims to explore the underlying causes of HSCR in children with BBS, focusing on the genetic and developmental factors contributing to the pathogenesis of both conditions. We reviewed relevant literature, including peer-reviewed journal articles and case reports, to provide a comprehensive overview of the current understanding of the relationship between HSCR and BBS. Our findings highlight the complex interplay of genetic mutations, signaling pathways, and developmental processes involved in the pathogenesis of HSCR in BBS. Further research is needed to elucidate the precise mechanisms underlying this association and to develop targeted therapeutic strategies for children with HSCR and BBS.

关键词： Hirschsprung’s Disease Bardet-Biedl Syndrome Ciliopathy genetics Developmental Disorder

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Health risks of rare earth elements exposure:Impact on mitochondrial DNA copy number and micronucleus frequency

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Journal of Environmental Sciences 2025年第5期151卷 150-160页

作者： Shiyi Hong Yali Zhang Qiaojian Zhang Zekang Su Guiping Hu Li Wang Shanfa Yu Xiaojun Zhu Guang Jia Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100083China School of Engineering Medicine and Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing 100083China Department of toxicology School of Public HealthBaotou Medical CollegeBaotouInner Mongolia 014040China Henan Institute for Occupational Medicine Zhengzhou 450052China National Center for Occupational Safety and Health Beijing 102308China Beijing Key laboratory of Toxicological Research and Risk Assessment for Food Safety School of Public HealthPeking UniversityBeijing 100083China

Toxic effects in terms of mitochondria and hereditary substances have been characterized in vitro for individual rare earth elements,while,the joint effects of mixed elements exposure in the population remain *** on the Occupational Chromate Exposure Dynamic Cohort of China,this study investigated the relationship between 15 blood rare earth elements(cerium,dysprosium,erbium,europium,gadolinium,holmium,lanthanum,lutetium,neodymium,praseodymium,samarium,terbium,thulium,yttrium,and ytterbium)and mitochondrial DNA copy number(MtDNACN)as well as peripheral blood lymphocyte micronucleus frequency(MNF).The elastic net was used to select elements highly correlated with effect indicators,whose dose-response relationships were further illustrated by restricted cubic *** kernel regressionwas employed to explore the combined effects of elements and the contributions of single *** results showed that most rare earth elementswere positively correlatedwith effect indicators,with yttrium showing the strongest association(β(95%CI):0.139(0.1089–0.189)for MtDNACN,0.937(0.345–1.684)for MNF).In the mixed exposure model,with the exposure level fixed at the 50th percentile as the reference,the effect estimates on MtDNACN and MNF increased by 0.228 and 0.598 units,respectively,at the 75th *** single effect analysis implied that yttrium,lanthanum and terbium contributed the most to the elevation of MtDNACN,while yttrium posed the highest risk for genetic damage,accordingly,we provided recommendations to prioritize these elements of *** addition,we observed a chief mediating effect of MtDNACN on the elevation of MNF caused by lanthanum,whereas further mechanistic exploration is required to confirm this finding.

关键词： Rare earth elements Mitochondrial DNA copy number Micronucleus frequency Mixed effect

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Aerodynamic Optimization and Flow Mechanism for a Compressor Cascade at Low Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 92-109页

作者： LI Lin ZHANG Jianshe CHEN Caiyan TAN Wei ZHANG Yanfeng Key laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Key laboratory of Science and Technology on Advanced Light-duty Gas-turbine Beijing 100190China

Low-Reynolds-number effect is an important factor affecting the performance of compressors and other main components of high-altitude long-endurance unmanned aerial *** improve the flow condition and reduce flow loss under the condition of high altitude and low Reynolds number(Re),this paper proposes an optimization process based on a surrogate model,which combines the class-shape transformation method(CST),the Latin hypercube sampling(LHS)method,the light gradient-boosting machine algorithm(LightGBM),and a genetic algorithm(GA)to optimize a high-subsonic compressor *** surrogate model is verified to be accurate and can be used in the optimization *** accuracy of the GA is higher than the other algorithms under common test *** optimization results are verified by numerical simulation,and the flow differences before and after optimization are compared,especially the flow within the boundary *** changing the blade shape,the optimization process adjusts the loading distribution to delay the transition of the optimized blade on the suction surface,which changes the turbulent reattachment in the laminar separation bubble(LSB)into laminar ***,the mixing loss induced by the turbulent reattachment of the LSB and the wake loss of turbulent separation at the trailing edge are significantly reduced,and the performance of the compressor profile is finally *** addition,turbulent separation of the optimized profile is delayed reducing the range of the wake region on the suction *** this optimization process,the reduction of total pressure loss coefficient at Re of 2.5×10^(5),3.5×10^(5),and 4.5×10^(5) are 16.32%,20.76%,and 22.16%,respectively.

关键词： low Reynolds numbers compressor optimization boundary layer transition

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Two APETALA2/ETHYLENE RESPONSE FACTORS coordinately with Ca MYC2 positively regulate capsaicinoid biosynthesis in pepper(Capsicum annuum)

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Horticultural Plant Journal 2025年第1期11卷 275-289页

作者： Jiali Song Renjian Liu Guoju Chen Jianjun Lei Zuoyang Ning Xiangru Tang Xiaowan Xu Muxi Chen Bihao Cao Changming Chen Zhangsheng Zhu Key laboratory of Biology and genetic Improvement of Horticultural Crops(South China) Ministry of Agriculture and Rural AffairsCollege of HorticultureSouth China Agricultural UniversityGuangzhouGuangdong 510642China Guangdong Vegetable Engineering and Technology Research Center South China Agricultural UniversityGuangzhouGuangdong 510642China Henry Fok College of Biology and Agriculture Shaoguan UniversityShaoguanGuangdong 512005China College of Agriculture South China Agricultural UniversityGuangzhouGuangdong510642China Guangdong Key laboratory for New Technology Research of Vegetables Vegetable Research InstituteGuangdong Academy of Agricultural SciencesGuangzhouGuangdong 510640China Guangdong Helinong Seeds CO.LTD.ShantouGuangdong 515800China

The transcriptional cascade and regulatory loop play crucial roles in regulating plant-specialized metabolite *** are unique to the genus Capsicum and confer a pungent flavor to its ***,the transcriptional regulation of capsaicinoid biosynthesis remains largely *** this study,two AP2/ERF transcription factors(TFs),CaERF102 and CaERF111,were characterized for their role in the capsaicinoid biosynthesis *** analysis of two ERFs and capsaicinoid biosynthetic genes(CBGs)suggested that they were associated with capsaicinoid *** ERFs encode nuclear-localized proteins and function as transcriptional activators through their C-terminal activation *** two ERF TFs participated in capsaicinoid biosynthesis by directly activating the promoters of key CBGs,and this activation was significantly enhanced when CaMYC2 was ***,CaERF102 and CaERF111 were found to interact with *** study helps elucidate the AP2/ERF TF regulatory network that governs capsaicinoid biosynthesis in Capsicum species.

关键词： Capsicum Specialized metabolites Pungency Transcription factor AP2/ERF MYC

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Quantification of flupirtine maleate polymorphs using X-ray powder diffraction

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Chinese Chemical Letters 2016年第11期27卷 1666-1672页

作者： Yu-Mei Zhao Zhi-Bing Zheng Song Li laboratory of Computer-Aided Drug Design & Discovery Beijing Institute of Pharmacology and Toxicology laboratory of Structure Identification Beijing Institute of Pharmacology and Toxicology State Key laboratory of toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology

Flupirtine maleate, a pharmaceutical compound for treating psychotic disease in clinics, has seven polymorphs. Form A, with better crystal stability and bioavailability, has been widely used as the pharmaceutical crystal form. Unfortunately, it is usually found in a polymorphic mixture with form B. In this study, pure crystal forms of A and B were prepared and characterized by X-ray powder diffraction （XRPD）, Fourier transform infrared spectroscopy （FT-IR） and thermal analysis. An XRPD-based method for the quantitative determination of the amount of the flupirtine maleate polymorphs form A and form B was also established through a systematic optimization of instrumental parameters. The results of the analytical methodology validation showed that the XPRD method had a broad quantitative range of 0- 100% （w/w）, good linear relationship, with R2= 0.999, excellent repeatability and precision and low limits of detection （LoD） of 0.15% （w/w） and quantification （LoQ） of 0.5% （w/w）. The results also showed that the single-peak method was not as good as the whole pattern in reducing the influence of the preferred orientation, but this can be compensated for by a systematic optimization of instrumental parameters and validating the analytical methodology to reduce errors and obtain a good, repeatable, sensitive, and accurate method. This XRPD method can be used to analyze mixtures of flupirtine maleate polymorphs （forms A and B） quantitatively and control the quality of the bulk drug.

关键词： Flupirtine maleate X-ray powder diffraction Quantitative analysis of polymorphs Preferred orientation Transmission

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Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant

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Military Medical Research 2019年第1期6卷 78-88页

作者： Xiao-rui Zhang Wen-xia Zhou Yong-xiang Zhang State Key laboratory of toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology

AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase(SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard(SM), nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome(ARS). AEOL-10150 performed well in animal safety studies, and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated, indicating that AEOL-10150 has potential as a new catalytic antioxidant drug. In this article, we review improvements in AEOL-10150 in preclinical pharmacodynamic studies, especially regarding anti-SM,chlorine gas and radiation exposure studies.

关键词： Catalytic antioxidant Metalloporphyrins Chemical warfare agent Radiation damage Pharmacodynamics Pharmacokinetics

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Development and molecular cytogenetic identification of a new wheat-rye 6RL ditelosomic addition and 1R(1B)substitution line with powderymildew resistance

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Journal of Integrative Agriculture 2025年第1期24卷 72-84页

作者： Guohao Han Jing Wang Hanwen Yan Lijun Cao Shiyu Liu Xiuquan Li Yilin Zhou Wei Liu Tiantian Gu Zhipeng Shi Hong Liu Lihui Li Diaoguo An Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050022China National Key Facility for Crop Gene Resources and genetic Improvement/Institute of Crop Sciences Chinese Academy of AgriculturalSciencesBeijing 100081China State Key laboratory for Biology of Plant Disease and Insect Pests/Institute of Plant Protection Chinese Academy of Agricultural SciencesBeijing 100193China Innovation Academy of Seed Design Chinese Academy of SciencesBeijing 100101China

Powdery mildew is a serious disease caused by Blumeria graminis ***(Bgt)that critically threatens the yield and quality of wheat(Triticum aestivum L.).Using effective powdery mildew resistance genes is the optimal method for controlling this *** the background of high genetic homogeneity among the modern commercial cultivars that are mainly derived from conventional interbreeding,the resistance genes from wheat relatives have especially prominent *** triticale,produced from common wheat and rye(Secale cereale L.)through distant hybridization,is a new synthetic species and valuable gene donor for wheat *** this study,we developed the wheat-rye line YT5 through the hybridization of octaploid triticale and two wheat ***5 was confirmed to be a 6RL ditelosomic addition and 1R(1B)substitution line using genomic in situ hybridization(GISH),multicolor fluorescence in situ hybridization(mc-FISH),multicolor GISH(mc-GISH)and molecular marker *** analysis showed that the powdery mildew resistance in YT5 was derived from the rye chromosome arm *** inoculation with different Bgt isolates at the seedling stage,YT5 had compound reaction patterns with both obvious spores and hypersensitivity,and it gradually became highly resistant until the adult-plant stage,thus showing a resistance response significantly different from the reported Pm genes from rye chromosome ***5 also showed promising agronomic performance,so it is expected to be an elite resistance donor for wheat *** promote the transfer of the chromosome arm 6RL of YT5 in marker-assisted selection(MAS)breeding,we selected and verified two 6RL-specific kompetitive allelespecific PCR(KASP)markers that can be applied to efficiently detect this chromosome arm in different wheat backgrounds.

关键词： powdery mildew common wheat Triticale 6RL ditelosomic addition line agronomic performance marker-assisted selection(MAS)

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Powerful QTL mapping and favorable allele mining in an all-in-one population:a case study of heading date

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National Science Review 2024年第8期11卷 60-74页

作者： Pengfei Wang Ying Yang Daoyang Li Zhichao Yu Bo zhang Xiangchun Zhou Lizhong Xiong Jianwei Zhang Lei Wang Yongzhong Xing National Key laboratory of Crop genetic Improvement Hubei Hongshan Laboratory Huazhong Agricultural University Institute of Tropical Crop genetic Resources Chinese Academy of Tropical Agricultural Sciences Yazhouwan National laboratory

The multiparent advanced generation intercross(MAGIC) population is characterized with great potentials in power and resolution of quantitative trait locus(QTL) mapping,but single nucleotide polymorphism(SNP)-based GWAS does not fully reach its *** this study,a MAGIC population of 1021 lines was developed from four Xian and four Geng varieties from five subgroups of rice.A total of 44 000 genes showed functional polymorphisms among eight parents,including frameshift variations or premature stop codon variations,which provides the potential to map almost all genes of the MAGIC *** component analysis results showed that the MAGIC population had a weak population structure.A high-density bin map of 24 414 bins was *** distortion occurred in the regions possessing the genes underlying genetic incompatibility and gamete ***-based association analysis and bin-based linkage analysis identified 25 significant loci and 47 QTLs for heading date,including14 known heading date *** mapping resolution of genes is dependent on genetic effects with offset distances of genetic effects were identified from eight parents,providing flexibility for the improvement of rice heading *** most cases,japonica rice carries weak alleles,and indica rice carries strong alleles and nonfunctional *** results confirm that the MAGIC population provides the exceptional opportunity to detect QTLs,and its use is encouraged for mapping genes and mining favorable alleles for breeding.

关键词： MAGIC population population structure bin map novel casual variant superior allele

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Metagenomics reveals the resistance patterns of electrochemically treated erythromycin fermentation residue

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Journal of Environmental Sciences 2025年第2期148卷 567-578页

作者： Jieya Zhou HaoWu Haiyan Wang ZongruWu Lihu Shi Shulei Tian Li-an Hou State Key laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China State Key laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Inner Mongolia Autonomous Region Solid Waste and Soil Ecological Environment Technology Center Hohhot 010020China

Erythromycin fermentation residue(EFR)represents a typical hazardous waste produced by the microbial pharmaceutical *** electrolysis is promising for EFR disposal,its microbial threats remain ***,metagenomics was coupled with the random forest technique to decipher the antibiotic resistance patterns of electrochemically treated *** showed that 95.75%of erythromycin could be removed in 2 *** temporarily influenced EFRmicrobiota,where the relative abundances of Proteobacteria and Actinobacteria increased,while those of Fusobacteria,Firmicutes,and Bacteroidetes decreased.A total of 505 antibiotic resistance gene(ARG)subtypes encoding resistance to 21 antibiotic types and 150 mobile genetic elements(MGEs),mainly including plasmid(72)and transposase(52)were assembled in *** linear regression models were identified among microbial richness,ARG subtypes,and MGE numbers(r^(2)=0.50-0.81,p<0.001).Physicochemical factors of EFR(Total nitrogen,total organic carbon,protein,and humus)regulated ARG and MGE assembly(%IncMSE value=5.14-14.85).The core ARG,MGE,and microbe sets(93.08%-99.85%)successfully explained 89.71%-92.92%of total ARG and MGE ***,gene aph(3 )-I,transposase tnpA,and Mycolicibacterium were the primary drivers of the resistance dissemination *** study also proposes efficient resistance mitigation measures,and provides recommendations for future management of antibiotic fermentation residue.

关键词： Erythromycin fermentation residue (EFR) Microbial pharmaceutical industry Disposal strategy Metagenomics Antibiotic fermentation residue management

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