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research 2024年第1期6卷 687-706页

作者： Qianqian Huang chaoqing Jiang Xue Xia Yufan Wang chenxing Yan Xiaorong Wang Ting Lei Xiaotong Yang Wenqin Yang Guo cheng Huile Gao Key laboratory of Drug-Targeting and Drug Delivery System of the education ministry West China School of PharmacySichuan UniversityChengdu 610041P.R.China laboratory of molecular Translational medicine Center for Translational MedicineKey Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationDepartment of PediatricsWest China Second University HospitalSichuan UniversityChengdu 610041P.R.China

inflammatory responses,manifested in excessive oxidative stress and microglia overactivation,together with metal ion-triggered amyloid-beta(Aβ)deposition,are critical hallmarks of Alzheimer’s disease(AD).The intricate pathogenesis causes severe impairment of neurons,which,in turn,exacerbates Aβaggregation and facilitates AD ***,multifunctional melanin-like metal ion chelators and neuroinflammation regulators(named PDA@K)were constructed for targeted treatment of *** this platform,intrinsically bioactive material polydopamine nanoparticles(PDA)with potent metal ion chelating and rOS scavenging effects were decorated with the KLVFF peptide,endowing the system with the capacity of enhanced pathological blood–brain barrier(BBB)crossing and lesion site accumulation via Aβ*** vitro and in vivo experiment revealed that PDA@K had high affinity toward Aβand were able to hitch a ride on Aβto achieve increased pathological BBB *** engineered PDA@K effectively mitigated Aβaggregate and alleviated neuroinflammation.

关键词： oxidative aggregation chelating

Wave reflection by rectangular Breakwaters for coastal Protection

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Fluid Dynamics & materials Processing 2024年第3期20卷 579-593页

作者： Hasna Akarni Hamza mabchour Laila el Aarabi Soumia mordane laboratory of Polymer Physics Mechanical Sciences and MaterialsFaculty of Sciences Ben M’SikHassan II University of CasablancaCasablanca20670Morocco

in this study,we focus on the numerical modelling of the interaction between waves and submerged structures in the presence of a uniform flow *** the same and opposite senses of wave propagation are *** main objective is an understanding of the effect of the current and various geometrical parameters on the reflection *** wave used in the study is based on potential theory,and the submerged structures consist of two rectangular breakwaters positioned at a fixed distance from each other and attached to the bottom of a wave *** numerical modeling approach employed in this work relies on the Boundary element method(Bem).The results are compared with experimental data to validate the *** findings of the study demonstrate that the double rectangular breakwater configuration exhibits superior wave attenuation abilities if compared to a single rectangular breakwater,particularly at low ***,the study reveals that wave mitigation is more pronounced when the current and wave propagation are coplanar,whereas it is less effective in the case of opposing current.

关键词： Wave current breakwaters Boundary element method(Bem) reflection coefficient

Gate-controlled supercurrent effect in dry-etched Dayem bridges of non-centrosymmetric niobium rhenium

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Nano research 2024年第7期17卷 6575-6581页

作者： Jennifer Koch carla cirillo Sebastiano Battisti Leon ruf Zahra makhdoumi Kakhaki Alessandro Paghi Armen Gulian Serafim Teknowijoyo Giorgio De Simoni Francesco Giazotto carmine Attanasio elke Scheer Angelo Di Bernardo Department of Physics University of KonstanzUniversitätsstraße 1078464 KonstanzGermany cNr-Spin c/o Universitàdegli Studi di Salernovia Giovanni Paolo II 13284084 Fisciano(SA)Italy NeST Istituto Nanoscienze-CNR and Scuola Normale SuperiorePiazza San Silvestro 1256127 PisaItaly Dipartimento di Fisica“e.r.caianiello” Universitàdegli Studi di SalernoVia Giovanni Paolo II 13284084 Fisciano(SA)Italy Advanced Physics laboratory Institute for Quantum StudiesChapman UniversityBurtonsvilleMD 20866USA

The application of a gate voltage to control the superconducting current flowing through a nanoscale superconducting constriction,named as gate-controlled supercurrent(GcS),has raised great interest for fundamental and technological *** gain a deeper understanding of this effect and develop superconducting technologies based on it,the material and physical parameters crucial for the GcS effect must be ***-down fabrication protocols should also be optimized to increase device scalability,although studies suggest that top-down fabricated devices are more resilient to show a ***,we investigate gated superconducting nanobridges made with a top-down fabrication process from thin films of the noncentrosymmetric superconductor niobium rhenium with varying ratios of the constituents(Nbre).Unlike other devices previously reported and made with a top-down approach,our Nbre devices systematically exhibit a GcS effect when they were fabricated from Nbre thin films with small grain size and etched in specific *** observations pave the way for the realization of top-down-made GcS devices with high *** results also imply that physical parameters like structural disorder and surface physical properties of the nanobridges,which can be in turn modified by the fabrication process,are crucial for a GcS observation,providing therefore also important insights into the physics underlying the GcS effect.

关键词： superconductivity non-centrosymmetric superconductors superconducting devices gated devices gate-controlled supercurrent top-down fabrication

Neutrophils are shaped by the tumor microenvironment:novel possibilities for targeting neutrophils in cancer

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1788-1790页

作者： carlos Silvestre-roig Lydia Kalafati Triantafyllos chavakis institute of experimental Pathology(exPat) Center for Molecular Biology of Inflammation(ZMBE)University of MünsterMünsterGermany institute for clinical chemistry and laboratory medicine University Hospital and Faculty of MedicineTechnische Universität DresdenDresdenGermany

in a recent paper published in Science,Ng et *** seminal insights into the process through which neutrophils are reprogrammed by the tumor environment,leading to a convergent transition from different neutrophil states towards a unique end-stage differentiated pro-tumor phenotype.1 These findings have major translational implications as they provide potential neutrophil-related targets for tumor immunotherapy.

关键词： al. neutrophils tumor

A review on Nanomaterial-based Strategies for manipulating Tumor microenvironment to enhance chemodynamic Therapy

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chemical research in chinese Universities 2024年第2期40卷 202-212页

作者： cAO mengyu XiNG Xiner SHeN Xiaotong OUYANG Jin NA Na Key laboratory of radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing100875P.R.China Department of chemistry College of Arts and SciencesBeijing Normal University at ZhuhaiZhuhai519087P.R.China State Key laboratory of Biogeology and environmental Geology China University of GeosciencesWuhan430074P.R.China

cancer is a leading cause of death worldwide,and a series of strategies has been reported for tumor-specific ***,chemodynamic therapy(cDT)has become a research hotspot for antitumor treatment due to its advantages of high specificity,endogenous stimulation,and high ***,the therapeutic effects of cDT are normally limited in the complex tumor microenvironment(Tme),such as insufficient acidity,tumor hypoxia,low hydrogen peroxide(H2O2),and high glutathione(GSH).consequently,different kinds of multifunctional nanomaterials have been designed to manipulate Tme conditions,which provided more opportunities to improve the efficiency of *** review focuses on nanomaterial-based strategies for enhancing cDT through manipulating *** cDT enhancements,this review would provide a reference for the future development of efficient cDT nanomaterials.

关键词： chemodynamic therapy Tumor microenvironment Nanomaterial manipulating strategy Fenton/Fenton-like reaction

electrostatic and hydrophobic interaction cooperative nanochaperone regulates protein folding

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Aggregate

Aggregate 2024年第1期5卷 419-426页

作者： Xiaohui Wu Fei Deng Yujie chen mengchen Xu Feihe ma Linqi Shi Key laboratory of Functional Polymer materials of ministry of education State Key Laboratory of Medicinal Chemical BiologyInstitute of Polymer Chemistry and College of ChemistryNankai UniversityTianjinP.R.China School of materials Science and engineering and State Key laboratory of Separation membranes and membrane Processes Tiangong UniversityTianjinP.R.China

Natural molecular chaperones utilize spatially ordered multiple molecular forces to effectively regulate protein ***,synthesis of such molecules is a big *** concept of“aggregate science”provides insights to construct chemical entities(aggregates)beyond molecular levels to mimic both the structure and function of natural *** by this concept,herein we fabricate a novel multi-interaction(i.e.,electrostatic and hydrophobic interaction)cooperative nanochaperone(multi-co-nchap)to regulating protein *** multi-co-nchap is fabricated by rationally introducing electrostatic interactions to the surface(corona)and confined hydrophobic microdomains(shell)of traditional single-hydrophobic interaction *** demonstrate that the corona electrostatic attraction facilitates the diffusion of clients into the hydrophobic microdomains,while the shell electrostatic interaction balances the capture and release of *** finely synergizing corona electrostatic attraction with shell electrostatic repulsion and hydrophobic interaction,the optimized multi-co-nchap effectively facilitated de novo folding of nascent ***,the synergy between corona electrostatic attraction,shell electrostatic attraction and shell hydrophobic interaction significantly enhanced the capability of multi-co-nchap to protect native proteins from denaturation at harsh *** work provides important insights for understanding and design of nanochaperone,which is a kind of ordered aggregate with chaperone-like activity that beyond the level of single molecule.

关键词： chaperone-like activity cooperative effect nanochaperones ordered aggregates protein folding

GPU-accelerated OcT imaging: real-time data processing and artifact suppression for enhanced monitoring of 3D bioprinted tissues and vascular-like networks

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Journal of innovative Optical Health Sciences 2024年第6期17卷 67-82页

作者： Shanshan Yang Jinhao Zhou Hao Guo Ling Wang mingen Xu Hangzhou Dianzi University Automation College HangzhouZhejiangP.R.China Zhejiang Provincial Key laboratory of medical information and Biological 3D Printing Hangzhou ZhejiangP.R.China

Optical coherence tomography(OcT)imaging technology has significant advantages in in situ and noninvasive monitoring of biological ***,it still faces the following challenges:including data processing speed,image quality,and improvements in three-dimensional(3D)visualization *** technology,especially functional imaging techniques like optical coherence tomography angiography(OcTA),requires a long acquisition time and a large data *** the substantial increase in the acquisition speed of swept source optical coherence tomography(SS-OcT),it still poses significant challenges for data ***,during in situ acquisition,image artifacts resulting from interface reflections or strong reflections from biological tissues and culturing containers present obstacles to data visualization and further ***,a customized frequency domainfilter with anti-banding suppression parameters was designed to suppress artifact ***,this study proposed a graphics processing unit(GPU)-based real-time data processing pipeline for SS-OcT,achieving a measured line-process rate of 800 kHz for 3D fast and high-quality data ***,a GPU-based realtime data processing for cc-OcTA was integrated to acquire dynamic ***,a vascular-like network chip was prepared using extrusion-based 3D printing and sacrificial materials,with sacrificial material being printed at the desired vascular network locations and then removed to form the vascular-like *** imaging technology was used to monitor the progression of sacrificial material removal and vascular-like network ***,GPU-based OcT enables real-time processing and visualization with artifact suppression,making it particularly suitable for in situ noninvasive longitudinal monitoring of 3D bioprinting tissue and vascular-like networks in microfluidic chips.

关键词： SS-OcT GPU acceleration artifact noise 3D bioprinted microfluidic chip.

Soil conditioning of clay based on interface adhesion mechanism:microscopic simulation and laboratory experiment

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Underground Space 2024年第5期18卷 239-255页

作者： Yong Fang Bin Zhuo ruyue Zhang Yubo Wang Liupan Dou Yuxiang Yao Key laboratory of Transportation Tunnel engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 610031China

clogging frequently occurs in the cutter head,excavation chamber or screw conveyor when an earth pressure balance(ePB)shield machine is tunneling in soft or silty clay ground with high clay mineral *** this paper,montmorillonite,kaolinite,and illite were selected as research objects,and molecular dynamics simulation and laboratory experiment were *** the microscopic scale,dynamic contact behavior and interfacial mechanical behavior of the interface between clay minerals and water/surfactant solution was simulated and the interfacial adhesion and conditioning mechanism between clay minerals and water/surfactant solution was ***,sodium dodecyl benzene sulfonate surfactant was selected as the main composition of the soil ***,the adhesion stress before and after soil conditioning and the contact angles between clay minerals and water/surfactant solution were tested and analyzed at the macroscopic *** result shows that the contact angle between droplet and clay mineral surface is an important parameter to characterize soil *** simulation rules of the microscopic contact angle are consistent with the experiment ***,the adsorption energy between microscopic substances is dominated by electrostatic force,which can reflect the adhesion stress between macroscopic *** adhesion stress can be effectively decreased by adding the surfactant to the soil conditioner.

关键词： ePB clogging clay minerals microscopic simulation mechanism analysis laboratory experiment Adhesion stress

Anomalous negative magnetoresistance in quantum dot Josephson junctions with Kondo correlations

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Science china(Physics,mechanics & Astronomy) 2024年第8期67卷 3-13页

作者： mingtang Deng chunlin Yu Guangyao Huang rosa López Philippe caroff Sepideh Ghalamestani Gloria Platero Hongqi Xu institute for Quantum information&State Key laboratory of High Performance computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China NanoLund and Division of Solid State Physics Lund UniversityLund S-22100Sweden china Greatwall Quantum laboratory Changsha 410006China institut de Física interdisciplinària i de Sistemes complexos iFiSc Palma de Mallorca E-07122Spain instituto de ciencia de materiales de madrid Madrid 28049Spain Beijing Key laboratory of Quantum Devices Key Laboratory for the Physics and Chemistry of Nanodevicesand Department of ElectronicsPeking UniversityBeijing 100871China Beijing Academy of Quantum information Sciences Beijing 100193China Hefei National laboratory Hefei 230088China

The interplay between superconductivity and the Kondo effect has stimulated significant interest in condensed matter *** compete when their critical temperatures are close and can give rise to a quantum phase transition that can mimic majorana zero ***,we have fabricated and measured Al-inSb nanowire quantum dot-Al *** the Kondo regime,a supercurrent-induced zero-bias conductance peak *** zero-bias peak shows an anomalous negative magnetoresistance(Nmr)at weak magnetic *** attribute this anomalous Nmr to quasiparticle trapping at vortices in the superconductor leads as a weak magnetic field is *** trapping effect lowers the quasiparticle-caused dissipation and thus enhances the Josephson *** work connects the vortex physics and the supercurrent tunneling in Kondo regimes and can help further understand the physics of Josephson quantum dot system.

关键词： quantum dot Kondo correlation inSb nanowire quasiparticle trapping

Synthesis and Properties of Ferrocene conjugated macrocycles with illusory Topology of the Penrose Stairs

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chemical research in chinese Universities 2024年第5期40卷 881-886页

作者： XU Jindong LAN Bin ZHU Lingyun XU Hui cHeN Xinyu Li Wenjuan YUAN Yaofeng YAN Jianfeng Li Yuanming Key laboratory of molecule Synthesis and Function Discovery(Fujian Province University) College of ChemistryFuzhou UniversityFuzhou350108P.R.China Henan Key laboratory of Biomolecular recognition and Sensing College of Chemistry and Chemical EngineeringShangqiu Normal UniversityShangqiu476000P.R.China

Polyferrocene macrocycles hold immense potential in the fields of molecular electronics and electrochemistry,primarily due to their multiple metal ***,developing highly efficient synthetic strategies for constructing these rings remains a significant *** this study,we successfully synthesized triferrocenyl macrocycles using Pt-mediated coupling strategy and determined their configuration using single-crystal X-ray diffraction analysis,revealing a structure reminiscent of the Penrose *** comprehensively investigated the macrocycle’s structure,photophysical properties,and employed density functional theory(DFT)calculations to gain further ***,this macrocycle exhibits several advantageous features,including a flexible structure,good solubility,and a highly efficient synthetic pathway.

关键词： conjugated macrocycle Organometallic macrocycle Pt-template method