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Elastic and Stretchable Functional Fibers: A Review of Materials, Fabrication Methods, and Applications

Advanced Fiber Materials 2021年第1期3卷 1-13页

作者： Mengxiao Chen Zhe Wang Kaiwei Li Xiandi Wang Lei Wei School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore Institute of Photonics Technology Jinan UniversityGuangzhou 511443China department of Biomedical Engineering Key Laboratory for Biomedical Engineering of Ministry of EducationZhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness AppraisalZhejiang UniversityHangzhou 310027China CINTRA CNRS/NTU/THALES UMI3288Research Techno Plaza50 Nanyang DriveSingapore 637553Singapore

Elastic and stretchable functional fibers have drawn attentions from wide research field because of their unique advantages including high dynamic bending elasticity,stretchability and high mechanic *** of efforts have been made to find promising soft materials and improve the processing methods to fabricate the elastomer fibers with controllable fiber geometries and designable *** progress has been made and various interdisciplinary applications have been demonstrated based on their unique mechanical performance.A series of remarkable applications,involving biomedicine,optics,electronics,human machine interfaces etc.,have been successfully ***,we summarize main processing methods to fabricate soft and stretchable functional fibers using different types of elastic materials,which are either widely used or specifically *** also introduce some representative applications of multifunctional elastic fibers to reveal this promising research *** these reported applications indicate that the fast innovated interdisciplinary area is of great potential and inspire more remarkable ideas in fiber sensing,soft electronics,functional fiber integration and other related research fields.

关键词： Elastic fibers Stretchable fibers Fiber sensing Multifunctional fibers

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Neuroprotection of ginsenoside Rgl on Aβ 25-35-induced toxicity in primary cultured rat cortical neurons via NF-κB/NO pathway

Neuroprotection of ginsenoside Rgl on Aβ 25-35-induced toxi...

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2015年浙江省医学会临床药学分会、浙江省中西医结合学会中药分会学术会议

作者： Jiaying Wu Hongyu Yang Qingwei Zhao Xingguo Zhang Yijia Lou department of Pharmacy The First Affiliated HospitalCollege of MedicineZhejiang University Division of Cardio-cerebral vascular and Hepatic Pharmacology College of Pharmaceutical SciencesZhejiang University

Ginsenoside Rg1(Rg1) is a multipotent triterpene saponins extracted from the traditional Chinese medicine ginseng,and has been proven to be a nootropic agent against diverse neurological *** c

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Quantified assessment of deep brain stimulation on Parkinson’s patients with task fNIRS measurements and functional connectivity analysis:a pilot study

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Chinese Neurosurgical Journal 2021年第3期7卷 171-181页

作者： Ningbo Yu Siquan Liang Jiewei Lu Zhilin Shu Haitao Li Yang Yu Jialing Wu Jianda Han College of Artificial Intelligence Nankai UniversityTianjinChina Tianjin Key Laboratory of Intelligent Robotics Nankai UniversityTianjinChina department of Neurosurgery Tianjin Huanhu HospitalTianjinChina department of Neurorehabilitation Tianjin Huanhu HospitalTianjinChina department of Neurology Tianjin Huanhu HospitalTianjinChina Laboratory of cerebral vascular and Neurodegenerative Diseases Tianjin Neurosurgical InstituteTianjin Huanhu HospitalTianjinChina

Background:deep brain stimulation(DBS)has proved effective for Parkinson’s disease(PD),but the identification of stimulation parameters relies on doctors’subjective judgment on patient ***:Five PD patients performed 10-meter walking tasks under different brain stimulation *** walking tests,a wearable functional near-infrared spectroscopy(fNIRS)system was used to measure the concentration change of oxygenated hemoglobin(ΔHbO_(2))in prefrontal cortex,parietal lobe and occipital *** functional connectivity and global efficiency were calculated to quantify the brain ***:We discovered that both the global and regional brain efficiency of all patients varied with stimulation parameters,and the DBS pattern enabling the highest brain efficiency was optimal for each patient,in accordance with the clinical assessments and DBS treatment decision made by the ***:Task fNIRS assessments and brain functional connectivity analysis promise a quantified and objective solution for patient-specific optimization of DBS *** registration:Name:Accurate treatment under the multidisciplinary cooperative diagnosis and treatment model of Parkinson’s *** number is *** of registration is April 23,2019.

关键词： deep brain stimulation programming Parkinson’s disease Brain efficiency Functional connectivity

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Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease

Identification of RNF213 as a Susceptibility Gene for Moyamo...

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2018环境与健康学术会议--精准环境健康：跨学科合作...

作者： Yue Wang Qian Li Michael Mambiya Zhengshan Zhang Shan Liu Luping Yang Qian Zhang Mengwei Liu Kaili Zhang Lian Duan Wanyang Liu department of Nutrition and Food Hygiene School of Public HealthChina Medical University department of Neurosurgery 307HospitalPLA Center for Cerebral Vascular Disease

Objectives Moyamoya disease(MMD) is an idiopathic disorder characterized by occlusive lesions in the supraclinoid internal carotid artery and its main branches in the circle of *** studies have revealed several risk factors associated with MMD,including Asian ethnicity,female gender and a family history of the *** that 15%of moyamoya patients have a family history of the disease,genetic analysis of familial MMD has considerable potential to disclose *** previous studies have explored genetic factors and revealed four loci associated with MMD:3 p24-p26,6 q25,8 q23 and 17 q25,but the susceptibility gene is *** major aim of the present study was to identify the causative gene for familial and sporadic ***,to make our conclusion reliable and stable,a meta-analysis by us was conducted to address the association between the susceptibility gene and MMD *** We conducted genome-wide linkage analysis and exome analysis in eight three-generation families with *** analysis combined with association study was conducted to confirm that RNF213 p.R4810 K was the susceptibility gene for Chinese familial and sporadic ***,a meta-analysis including 1745 cases and 6175 controls were available to address the association between the RNF213 p.R4810 K and MMD susceptibility,the fixed-effects model was used to calculate the summary crude odds ratios(ORs) and corresponding 95%confidence intervals(CIs) in the dominant *** Genome-wide linkage analysis revealed that linkage to 17 q25.3(Pdemonstrated a 1.5-Mb disease locus bounded by D17 S1806 and *** was a common variant of p.R4810 K in RNF213 in the 1.5-Mb locus of the eight index *** analysis confirmed that RNF213 p.R4810 K was segregated in 18 of 47(38.30%) Chinese families with MMD.A case-control study(138 cases and 2903 controls) demonstrated strong association of p.R4810 K with MMD in Chinese population wi

关键词： Moyamoya disease RNF213 p.R4810K Genome-wide linkage analysis Exome analysis

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Studies on monitoring hemodynamics and oxygen dynamics of adult respiratory distress syndrome secondary to high altitude pulmonary edema

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Engineering Sciences 2013年第2期11卷 34-37页

作者： Ma Siqing Wu Tianyi Cheng Qiang Li Pei Bian Huiping Intensive Care Unit of Qinghai Provincial People's Hospital High Altitude Medical Research Institute High Altitude Medical Research Center Tibet University Qinghai Cardio-cerebral-vascular Hospital

To study monitoring hemodynamics and oxygen dynamics of adult respiratory distress syndrome (ARDS) secondary to high altitude pulmonary edema (HAPE),we performed clinic and laboratory studies in 8 patients who preliminarily developed high altitude cerebral edema (HACE) and then ARDS occurred at an altitude of 4 500 m. After an initial emergency treatment on high mountains,all the patients were rapidly transported to a hospital at a lower altitude of 2 808 m. The right cardiac catheterizations were carried out within 5 h after hospitalized. The monitoring hemodynamics and oxygen dynamics were studied via a thermodilution Swan-Gaze catheter. The results showed that before treatments at the beginning of monitoring,there presented a significant pulmonary artery hypertension with a decreased cardiac function,and a lower oxygen metabolism in all the 8 patients. However,after some effective treatments,including mechanical ventilation and using dexamethasone,furosemide,etc,four days later the result of a repeated monitoring showed that their pulmonary artery pressure had been decreased with an improved cardiac function with all the oxygen metabolic indexes increased significantly. Our studies suggested that performing monitoring hemodynamics in patients with ARDS secondary to HAPE will define the clinical therapeutic measures which will benefit the outcome.

关键词：血流动力学氧代谢肺水肿综合征监测高原继发呼吸

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Comparison of Elastic Properties of Bilateral Carotid Arteries in Relation to Site of Acute Ischemic Stroke Using Velocity Vector Imaging

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Chinese Medical Journal 2015年第21期128卷 2960-2963页

作者： Jun-Li Hu Xian Li Xi-Ming Wang Zhao-Ping Cheng Dong-Feng Chen Shao-Chun Wang Qing-Xia Kong Shandong Provincial Key Laboratory of Diagnosis and Treatment of Cardio-cerebral vascular Diseases Shandong Medical Imaging Research Institute Shandong University Jinan Shandong 250021 China department of Ultrasound Affiliated Hospital of Jining Medical University Jining Shandong 272029 China department of Medical Imaging No. 2 Clinical Institute Jining Medical University Jining Shandong 272100 China department of Neurology Affiliated Hospital of Jining Medical University Jining Shandong 272029 China

INTRODUCTIONlschemic stroke accounts for 70% of all the cerebrovascular diseases. Severe stenosis and occlusions ofextracranial and intracranial artery are all important risk factors causing ischemic stroke. Based on the widespread observation worldwide, intracranial atherosclerosis is the most common vascular lesions in Asians, Hispanics, and Africans. Therefore, accurate and noninvasive methods fbr early diagnosis of stroke in individuals without significant stenosis of the extracranial carotid artery is of considerable clinical interest.

关键词： Acute Carotid lschemic Stroke Velocity Vector Imaging

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Fetal umbilical vein transplantation for the repair of middle cerebral artery injury

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Neural Regeneration Research 2013年第34期8卷 3249-3254页

作者： Xuhui Hou Yi Yuan Jian Yin Songbai Yang Lili Xie Shiji Wang department of vascular Surgery China-Japan Friendship Hospital of Jilin University department of Critical Care Medicine First Hospital of Jilin University

It is necessary to investigate the longitudinal tensile mechanical characteristics of the middle cere- bral artery and the fetal umbilical vein prior to applying fetal umbilical vein transplantation for repair of injured middle cerebral artery. Fifteen fresh fetal umbilical vein specimens and 15 normal human fresh cadaver middle cerebral artery specimens were collected for longitudinal tensile testing at the speed of 0.5 mm/min and at normal human temperature. The results showed that under 16.0 kPa physiological stress, the strain value of fetal umbilical vein specimens was larger, while the maximal stress and elastic modulus values were less than those of middle cerebral artery specimens. Our findings indicate that fetal umbilical vein has good elastic properties and the stress-strain curve of the fetal umbilical vein is similar to that of the middle cerebral artery. Fetal umbilical vein transplan- tation can, therefore, potentially repair the injured middle cerebral artery.

关键词： neural regeneration middle cerebral artery fetal umbilical vein tension stress strain elasticmodulus biomechanics transplantation repair neuroregeneration

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Correlation analysis of internal jugular vein abnormalities and cerebral venous sinus thrombosis

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Chinese Medical Journal 2012年第20期125卷 3671-3674页

作者： JIA Ling-yun HUA Yang JI Xun-ming LIU Jiang-tao department of vascular Ultrasonography Beijing 100053China department of Neurosurgery Beijing 100053China department of Radiology Beijing 100053China

Background cerebral venous sinus thrombosis （CVST） is a special form of stroke with multiple causes and risk factors. However, there are still a portion of cases with unknown reasons. The aim of this study was to investigate the relationship between internal jugular vein （IJV） abnormalities and the development of CVST. Methods A total of 51 CVST patients and 30 healthy controls were enrolled. The diameter, the maximum velocity （Vmax） and the reflux time in bilateral IJVs were measured by color Doppler flow imaging （CDFI）. The paired t test was used to compare the numeric values between the bilateral IJVs. The Pearson chi-square test was used to evaluate the relationship between IJV abnormality and CVST, IJV abnormality and IJV reflux, respectively. Results Among the 51 CVST patients, 20 （39%） patients were with normal IJV and 31 （61%） patients were with abnormal IJV. The types of IJV abnormality included annulus stenosis 19 cases （61%）, hypoplasia 9 cases （29%）, thrombosis 2 cases （7%） and anomalous valve 1 case （3%）. In patients with unilateral IJV abnormality, the minimum diameter of the IJV on the lesion side was significantly smaller than that of the contralateral side （P 〈0.0001）. When compared with contralateral side, the Vmax of the lesion side with unilateral annulus stenosis was significant higher, however, it was obvious lower in patients with unilateral hypoplasia （P 〈0.05）. Furthermore, among 27 cases with unilateral IJV abnormality, all the CYST occurred on the same side as the IJV lesions.

关键词： IJV abnormality closely correlated with the development of CVST which is a newly identified risk factor forCVST.

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development of a Wireless-Controlled LED Array for the Tunable Optogenetic Control of Cellular Activities

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Engineering 2018年第6期4卷 745-747页

作者： Yuankai Qi Junye Chen Xuechun Liu Xiaoxu Zhou Jiannan Fan Ping Shentu Olof Idevall-Hagren Yingke Xu department of Biomedical Engineering Key Laboratory for Biomedical Engineering of Ministry of EducationZhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness AppraisalZhejiang UniversityHangzhou 310027China department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China department of Medical Cell Biology Uppsala Biomedical CentreUppsala UniversityUppsala 75123Sweden

*** In order to decipher a complex biological process,tools are required to perturb the various players involved to gain information about the important *** modules are genetically encoded molecular reagents that,when expressed in cells,allow a specific biological process to be precisely controlled by light in a spatiotemporal manner[1].Optogenetics thus offers cell biologists an unprecedented new way to perturb cellular *** application of optogenetic approaches in cellular biology and synthetic biology research has evolved tremendously in the last few years[2–4].

关键词： development Wireless-Controlled LED Array Cellular Activities

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How to balance between carotid endarterectomy and carotid artery stenting

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Chinese Medical Journal 2013年第3期126卷 565-568页

作者： WEI Zhou Division of vascular and Endovascular Surgery Department of Surgery Stanford University 300 Pasteur Drive Suite 3640 Stanford CA 94305 USA

Stroke is one of the most common causes of permanent disability in industrialized countries and become increasingly prevalent in developing countries. Management of stroke consumes $45 billion annually, and is responsible for greater than one million hospital admissions each year in the U.S. Neurologic sequelae related to cerebral vascular accidents （CVA） severely limit a patient＇s ability to carry out activities of daily living and invariably create an enormous burden on health care costs. As a result, the prevention of CVA with safe treatment of extra-cranial carotid occlusive disease remains an important health care goal.

关键词： carotid vascular surgery endovascular

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