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Chinese Medical Journal 2021年第12期134卷 1489-1491页

作者： Yu Shen Kak Khee Yeung Qing-Sheng Lu department of vascular Surgery Changhai HospitalSecond Military Medical UniversityShanghai 200433China department of vascular Surgery VU University Medical Center AmsterdamAmsterdamThe Netherlands

Physician-modified fenestrated stent-graft for thoracic endovascular aortic repair(TEVAR)has economic advantages and can be used in acute situations for aortic dissection and aneurysm involving aortic arch.[1]However,accurate alignment of fenestrations and branch arteries of the aortic arch is challenging,especially for multi-fenestration.[2]Once misaligned,complications such as branch occlusion or cerebral ischemia will *** about how to align fenestrations with branch arteries of the aortic arch in TEVAR with physician-modified triple fenestrated stent-graft are elaborated in this article.

关键词： aortic thoracic acute

Renal inhibition of miR-181a ameliorates 5-fluorouracil-induced mesangial cell apoptosis and nephrotoxicity

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Renal inhibition of miR-181a ameliorates 5-fluorouracil-indu...

Neurotherapeutic potential of erythropoietin after ischemic injury of the central nervous system

首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Xiao-Yun Liu Fei-Ran Zhang Jin-Yan Shang Xiao-Fei Lv Xiao-Chun Lin Xiu Liu Jia-Guo Zhou Si-Jia Liang department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-Sen University

The development of nephrotoxicity largely limits the clinical use of *** are able to target various genes and involved in the regulation of diverse cellular processes,including cell apoptosis and *** study showed that miR-181 a expression was significantly increased after 5-fluorouracil（5-FU） treatment in renal mesangial cells and kidney tissue,which was associated with decreased baculoviral inhibition of apoptosis protein repeat containing 6（BIRC6） expression and increased apoptotic *** miR-181 a expression enhanced 5-FU-induced p53-dependent mitochondrial apoptosis,including declined Bcl-2/Bax ratio,loss of mitochondrial membrane potential,cytochrome c release,and caspase-9 and caspase-3 ***,inhibition of miR-181 a was associated with reduced p53-mediated mitochondrial apoptosis induced by ***,miR-181 a increased BIRC6 downstream gene p53 protein expression and transcriptional activity by reducing ubiquitin-mediated protein *** found that miR-181 a directly targeted 3’-UTR of BIRC6 mRNA and negatively regulated BIRC6 *** vivo study,knockdown of miR-181 a with adeno-associated virus harboring miR-181 a-tough decoy attenuated 5-FU-induced renal cell apoptosis,inflammation and kidney *** conclusion,these results demonstrate that miR-181 a increases p53 protein expression and transcriptional activity by targeting BIRC6 and promotes5-FU-induced apoptosis in mesangial *** of miR-181 a ameliorates5-FU-induced nephrotoxicity,suggesting that miR-181 a may be a novel therapeutic target for nephrotoxicity treatment during chemotherapy.

关键词： BIRC6 p53 mesangialcells apoptosis nephrotoxicity 5-fluorouracil miR-181a

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Neural Regeneration Research 2019年第8期14卷 1309-1312页

作者： Florian Simon Nicolaos Floros Wiebke Ibing Hubert Schelzig Artis Knapsis department of vascular and Endovascular Surgery Heinrich-Heine-University of Düsseldorf

Erythropoietin (EPO) is one of the most successful biopharmaceuticals in history and is used for treating anemia of different origins. However, it became clear that EPO could also work in a neuroprotective, antiapoptotic, antioxidative, angiogenetic and neurotropic way. It causes stimulation of cells to delay cell apoptosis, especially in the central nervous system. In rodent models of focal cerebral ischemia, EPO showed an impressive reduction of infarct size by 30% and improvement of neurobehavioral outcome by nearly 40%. A large animal model dealing with ischemia and reperfusion of the spinal cord showed that EPO could reduce the risk of spinal cord injury significantly. In addition, some clinical studies tested whether EPO works in real live clinical settings. One of the most promising studies showed the innocuousness and improvements in follow-up, outcome scales and in infarct size, of EPO-use in humans suffering from ischemic stroke. Another study ended unfortunately in a negative outcome and an increased overall death rate in the EPO group. The most possible reason was the involvement of patients undergoing simultaneously systemic thrombolysis with recombinant tissue plasminogen activator. An experimental study on rats demonstrated that administration of EPO might exacerbate tissue plasminogen activator-induced brain hemorrhage without reducing the ischemic brain damage. This case shows clearly how useful animal models can be to check negative side effects of a treatment before going into clinical trials. Other groups looked in human trials at the effects of EPO on the outcome after ischemic stroke, relation to circulating endothelial progerdtor cells, aneurysmal subarachnoid hemorrhage, traumatic brain injury, hemoglobin transfusion thresholds and elective first-time coronary artery bypass surgery. Most of the results were pos-让ive, but are based mostly on small group sizes. However, some of the most neglected facts when focusing on experimental setups of is

关键词： erythropoietin apoptosis central nervous system cerebral ischemia animal model stroke human trials age comorbidity spinal cord ischemia

Simultaneous multi-tear exclusion:an optimal strategy for type B thoracic aortic dissection initially proved by a single center's 8 years experience

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Chinese Medical Journal 2007年第24期120卷 2210-2214页

作者： YUAN Liang-xi BAO Jun-min ZHAO Zhi-qing FENG Xiang OU Le-feng FENG Rui LU Qing-sheng MEI Zhi-jun JING Zai-ping department of vascular Surgery,Changhai Hospital,Second Military Medical University Institute of vascular Surgery of Chinese People’s Liberation Army Clinic Center of vascular Diseases of Shanghai National Key department of vascular Surgery of China Shanghai 200433,China (Yuan LX,Bao JM,Zhao ZQ,Feng X,Ou LF,Feng R,Lu QS,Mei ZJ and Jing ZP) department of vascular Surgery Changhai HospitalSecond Military Medical University

Background Endovascular stent-grafting is widely used to treat thoracic aortic dissection. However, little information is available regarding outcome following simultaneous exclusion of multiple tears. This report details eight years of experience using simultaneous multi-tear exclusion for treatment of Stanford type B thoracic aortic dissection resulting in successful aortic remodeling without adverse events. Methods From September 1998 to January 2006, 29 type B thoracic aortic dissection patients （24 men, 5 women; 27 chronic, 2 acute; mean age 58 years, range 45-77 years） were treated by simultaneous multi-tear exclusion in our center. Magnetic resonance angiography was used as the preoperative evaluation method. Different kinds of stent-grafts were used. The patients were followed up with contrast-enhanced spiral computed tomography at 6 months postoperatively and yearly thereafter. Results Twenty-nine surgeries were completed successfully using at least 2 stent-grafts per patient （range： 2-6, mean： 2.7）. No major procedure-related complications, such as rupture, paraplegia, aortic branch ischemia or cerebral infarction were observed. During follow-up, favorable remodeling of the aorta was observed. Conclusions The mid-term result of thoracic aortic dissection with simultaneous multi-tear exclusion was satisfactory. With the improvement of stent-grafts, simultaneous multi-tear exclusion should find wider application and become an optimal strategy for thoracic aortic dissection.

关键词： aortic dissection stent-graft endovascular exclusion

A Novel Porcine Model of Septic Shock Induced by Acute Respiratory Distress Syndrome due to Methicillin-resistant Staphylococcus aureus

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Chinese Medical Journal 2017年第10期130卷 1226-1235页

作者： Shuo Wang Jun-Yu Wang Tao Wang Chen-Chen Hang Rui Shao Chun-Sheng Li department of Emergency Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing 100020 China

Background： Sepsis is one of the main canses of mortality in critically ill patients following progression to septic shock. To investigate the pathophysiologic changes of sepsis, we developed a novel porcine model of septic shock induced by acute respiratory distress syndrome （ARDS） due to methicillin-resistant Staphylococcus aureus （MRSA） pneumonia. Methods： Twenty-six male Landraces （Lvyuanweiye, Beijing, China） weighing 30 - 2 kg were divided into lbur groups： sham gronp （SH： n = 5）; cotton smoke inhalation group （SM; n = 6）; MRSA pneumonia group （MR; n = 6）; and septic shock group with cotton smoke inhalation ＋ MRSA pneumonia （SS; n = 9）. Extensive hemodynamics, oxygen dynamics, and lung function were monitored for 24 11 following the injury or until death. Tissues were collected, and histopathology evaluations were carried out. Results： Blood cultures from 6 of 9 animals in the SS group were positive for MRSA. Two hours following the injury, decreased mean arterial blood pressure （60 70 mmHg） and cardiac index （〈2 L-rain -＇m --） were observed in the animals in the SS group, while systemic vascular resistance index was increased. The hemodynamic characteristics of septic shock were only observed in the SS group but not significant in the other groups, The PO_JFiO2 in the SM and SS groups decreased to 300 and 100, respectively. In the SS group, extravascular lung water index increased to 20 ml/kg, whereas thoracopulmonary compliance decreased to 10 ml/H2O after injury. deterioration of pulmonary function in the SS group was more serious than the SM and MR groups. Severe lung injury in the SS group was confinaaed by the histopathology evaluations. The lung injury confirmed by high-resolution thin-section computed tomography and histopathology in the SS group was more serious than those of other groups. Conclusions： In the present study, we developed a novel porcine model of septic shock induced by ARDS due to severe MRSA pneumonia with characteristic hyperdynamic

关键词： Acute Respiratory Distress Syndrome: Hemodynamic Methicillin-resistant Staphylococcus aureus: Oxygen Dynamic:Septic Shock

Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells

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Genes & Diseases 2023年第5期10卷 1787-1790页

作者： Yuanfa Yao Hanbing Li Xinyi Wang Yuanhai Sun Xuqin Zhao Weiwei Zha Jiaqiang Zhou derek Toomre Junfen Fu Yingke Xu department of Endocrinology Children's Hospital of Zhejiang University School of MedicineNational Clinical Research Center for Children's HealthHangzhouZhejiang 310051China department of Biomedical Engineering Key Laboratory of Biomedical Engineering of Ministry of EducationState Key Laboratory of Modern Optical InstrumentationZhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness AppraisalZhejiang UniversityHangzhouZhejiang 310027China Institute of Pharmacology College of Pharmaceutical ScienceZhejiang University of TechnologyHangzhouZhejiang 310014China department of Endocrinology The Affiliated Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310016China department of Cell Biology Yale University School of MedicineNew HavenCT 06520USA Binjiang Institute of Zhejiang University HangzhouZhejiang 310053China

Phospholipase D(PLD)and its product phosphatidic acid(PA)function as pleiotropic factors in the regulation of cancer progression,which includes the promotion of cell growth,survival,cell migration,and angiogenesis.1 Chemical inhibition of the enzymatic activity of PLD1 and PLD2,or genetic down-regulation of their expression both induce tumor suppression,1 while the compounds for PLD expression inhibition are barely ***,we astonishingly found that the anti-hyperglycemic agents biguanides decreased PLD1 protein expression in cancer cells and further investigated its underlying regulatory mechanism.

关键词： cancer function translational

The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke

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Neuroscience Bulletin 2023年第9期39卷 1375-1395页

作者： Yuxing Zhang Xin Zhao Chun Guo Ying Zhang Fukang Zeng Qian Yin Zhong Li Le Shao desheng Zhou Lijuan Liu department of Neurology The First Hospital of Hunan University of Chinese MedicineChangsha410007China Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-cerebral Diseases Changsha410208China Hunan University of Chinese Medicine Changsha410006China Laboratory of Prevention and Transformation of Major Diseases in Internal Medicine of Traditional Chinese Medicine Changsha410007China

Ischemic stroke is a major public health problem *** the circadian clock is involved in the process of ischemic stroke,the exact mechanism of the circadian clock in regulating angiogenesis after cerebral infarction remains *** the present study,we determined that environmental circadian disruption(ECD)increased the stroke severity and impaired angiogenesis in the rat middle cerebral artery occlusion model,by measuring the infarct volume,neurological tests,and angiogenesis-related *** further report that Bmal1 plays an irreplaceable role in *** of Bmal1 promoted tube-forming,migration,and wound healing,and upregulated the vascular endothelial growth factor(VEGF)and Notch pathway protein *** promoting effect was reversed by the Notch pathway inhibitor DAPT,according to the results of angiogenesis capacity and VEGF pathway protein *** conclusion,our study reveals the intervention of ECD in angiogenesis in ischemic stroke and further identifies the exact mechanism by which Bmal1 regulates angiogenesis through the VEGF-Notch1 pathway.

关键词： Circadian clock Ischemic stroke Angiogenesis VEGF Notch pathway

Metabonomics and Molecular Biology-based Effects of Sugemule-3 in an Isoproterenol-induced Cardiovascular Disease Rat Model

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Chemical Research in Chinese Universities 2018年第4期34卷 590-597页

作者： WANG Xiye WANG Yu WEI Chengxi YU Lijun Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis College of Chemistry and Chemical Engineering Inner Mongolia University for the Nationalities Tongliao 028005 P. R. China Inner Mongolia Autonomous Region Key Laboratory of Mongolian Medicine Pharmacology for Cardio-cerebral vascular System Medicinal Chemistry and Pharmacology Institute Inner Mongolia University for the Nationalities Tongliao 028005 R R. China

Cardiovascular disease（CVD） is a common and serious disease in the elderly, which has characteristically high prevalence, disability, and mortality rates. However, the etiology of CVD is still not very clear. The traditional Mongolian medicine Sugemule-3（SM） is usually used for the treatment of CVD and exhibits a good curative effect. In this study, a sentm metabolite profile analysis was used to identify potential biomarkers associated with isoprote- renol（ISO）-induced CVD and investigate the mechanism of the action of SM. Ultra-perfornlance liquid chromato- graphy coupled with quadrupole time-of-flight mass spectrometry（UPLC-Q-TOF-MS） was used for the metabono- mics analysis. Principal component analysis（PCA） was used to process the acquired data to differentiate the results of the control, CVD, and SM treatment groups. Orthogonal partial least squares discriminant analysis（OPLS-DA） enabled the identification of 21 metabolites as potential biomarkers that were relevant to phospholipid and energy metabolism. The results indicate that SM played a protective role against ISO-induced CVD in rats by regulating phospholipid and energy metabolic pathways. Fttrther, we verified the apoptotic metabolic pathway using molecular biology methods, such as terminal deoxynucleotidyl transferase（TdT） deoxyuridine 5＇-triphosphate（dUTP） nick-end labeling（TUNEL） assay and Western blot analysis. Furthermore, this study identified early biomarkers of CVD and elucidated the underlying mechanism of the therapeutic actions of SM, which is worth further to be investigated for development as a clinical therapy.

关键词： Sugemule-3 Metabonomics Molecular biology Ultra-perfbrmance liquid chromatography coupled withmass spectrometry(UPLC-MS) Cardiovascular disease Isoproterenol

Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-κB pathway activation

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Chinese Herbal Medicines 2022年第3期14卷 367-375页

作者： Shuyin Bao Xiuzhi Wang Qianqian Ma Chengxi Wei Jixing Nan Wuliji Ao Institute of Pharmaceutical Chemistry and Pharmacology Inner Mongolia Minzu UniversityTongliao 028000China Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-cerebral vascular System Tongliao 028000China department of Medicines and Foods Tongliao Vocational CollegeTongliao 028000China Jilin Key Laboratory for Traditional Chinese Korean Medicine College of PharmacyYanbian UniversityYanji 133002China Research and development center Inner Mongolia Research Institute of Traditional Mongolian Medicine Engineering TechnologyTongliao 028000China Mongolian Medicine R&D National Local Union Engineering Research Center Inner Mongolia Minzu UniversityTongliao 028000China

Type 2 diabetes mellitus(T2DM)and nonalcoholic fatty liver disease(NAFLD)are the most problematic metabolic diseases in the *** encompasses a spectrum of severity,ranging from simple steatosis to non-alcoholic steatohepatitis(NASH)and fibrosis,increasing the risk of cirrhosis and hepatocellular ***,NAFLD is closely linked to obesity and tightly interrelated with insulin resistance and T2DM.T2DM and NAFLD(T2DM-NAFLD)are called as the Xike Rixijing Disease and Tonglaga Indigestion Disease respectively,in Mongolian *** Rixijing Disease maybe develop into Tonglaga Indigestion *** many Mongolian medicines show efficient treatment of T2DM-NAFLD,such as Agriophyllum squarrosum,Haliyasu(dried powder of camel placenta),Digeda-4(herbs of Lomatogonium carinthiacum,rhizomata of Coptis chinensis,ripe fruits of Gardenia jasminoides,herbs of Dianthus superbus),Guangmingyan Siwei decoction Powder(Halite,ripe fruits of Terminalia chebula,rhizomata of Zingiber officinale,fruit clusters of Piper longum),Tonglaga-5(ripe fruits of Punica granatum,barks of Cinnamomum cassia,ripe fruits of Amomum kravanh,fruit clusters of Piper longum,fowers of Carthamus tinctorius),Tegexidegeqi(rhizomata of Inula helenium,ripe fruits of Gardenia jasminoides,rhizomata of Platycodon grandiflorum,rhizomata of Coptis chinensis,heartwood of Caesalpinia sappan),Ligan Shiliu Bawei San(ripe fruits of Punica granatum,barks of Cinnamomum cassia,ripe fruits of Amomum kravanh,fruit clusters of Piper longum,fowers of Carthamus tinctorius,ripe fruits of Amomum tsao-ko,rhizomata of Zingiber officinale),*** of Mongolian medicine in treating diseases:by balancing“three essences or roots”and“seven elements”,strengthening liver and kidney function,transporting nutrients to enhance physical strength and disease resistance,and combined with drugs for comprehensive conditioning ***,their molecular mechanisms remain *** this review,we prospect

关键词： Mongolian medicine nonalcoholic fatty liver disease type 2 diabetes mellitus Xike Rixijing Disease

Surgical treatment of brachiocephalic vessel involvement in Takayasu＇s arteritis

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Chinese Medical Journal 2010年第9期123卷 1122-1126页

作者： WU Xin DUAN Hong-yong GU Yong-quan LI Jian-xin CHEN Bing WANG Zhong-gao ZHANG Jian department of vascular Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Background Takayasu＇s arteritis （TA） is a chronic idiopathic inflammatory disease that affects large and medium size arteries. The brachiocephalic trunk is the most frequently involved site in TA, and multi-vessel lesions are common. Surgical treatment includes vessel reconstruction surgery and percutaneous transluminal angioplasty （PTA）. Herein, we report our preliminary experience with surgical treatment of cerebral ischemia caused by cervical arterial lesions due to *** From January 2000 to december 2007, 38 patients with cerebral ischemia caused by cervical arterial occlusive lesions due to TA were treated surgically. There were three males and 35 females, with an age range of 15-42 years （mean 26.5 years）. All patients had operative repairs undertaken. Twenty eight patients received bypass operation and 10 patients received percutaneous transluminal angioplasty. One case with coronary stenosis received coronary artery bypass simultaneously. Patients were followed up for 11 months to eight *** There were no peri-operative deaths in cerebrovascular reconstruction patients. Symptoms of cerebral ischemia were improved or cured in 25 of 38 patients. There was a low incidence of cerebral reperfusion syndrome. Two patients died at five and seven years after surgery due to heart failure. Another 8 patients （20%） required further surgery for stenosis （5 patients） or anastomotic aneurysms （3 patients）. Percutaneous transluminal angioplasty was performed successfully for treatment of aortic and renal lesions. Repeated angioplasty for revascularization was performed in six PTA cases with restenosis after 5-24 *** When cerebral perfusion has potential to be affected by TA, a definitive corrective procedure is advised when the patient is relatively stable. Although the recurrence rate is very high, percutaneous transluminal angioplasty is the first choice procedure. Bypass operation is optimal for brachiocephalic-vessel involvement in TA. Cere

关键词： Takayasu's arteritis brain ischemia brachiocephalic trunk surgical procedures operative reperfusion syndrome