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deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure

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Neural Regeneration Research 2022年第2期17卷 237-245页

作者： Jessica D.Panes Aline Wendt Oscar Ramirez-Molina Patricio A.Castro Jorge Fuentealba laboratorio de Screening de Compuestos Neuroactivos(LSCN) Departamento de FisiologiaFacultad de Ciencias BiologicasUniversidad de ConcepcionConcepcionChile Centro de Investigaciones Avanzadas en Biomedicina(CIAB-UdeC) Facultad de Ciencias BiologicasUniversidad de ConcepcionConcepcionChile departamento de Fisiologia Facultad de Ciencias BiologicasUniversidad de ConcepcionConcepcionChile

The onset and mechanisms underlying neurodegenerative diseases remain uncertain. The main features of neurodegenerative diseases have been related with cellular and molecular events like neuronal loss, mitochondrial dysfunction and aberrant accumulation of misfolded proteins or peptides in specific areas of the brain. The most prevalent neurodegenerative diseases belonging to age-related pathologies are Alzheimer's disease, Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis. Interestingly, mitochondrial dysfunction has been observed to occur during the early onset of several neuropathological events associated to neurodegenerative diseases. The master regulator of mitochondrial quality control and energetic metabolism is the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α). Additionally, it has been observed that PGC-1α appears to be a key factor in maintaining neuronal survival and synaptic transmission. In fact, PGC-1α downregulation in different brain areas(hippocampus, substantia nigra, cortex, striatum and spinal cord) that occurs in function of neurological damage including oxidative stress, neuronal loss, and motor disorders has been seen in several animal and cellular models of neurodegenerative diseases. Current evidence indicates that PGC-1α upregulation may serve as a potent therapeutic approach against development and progression of neuronal damage. Remarkably, increasing evidence shows that PGC-1α deficient mice have neurodegenerative diseases-like features, as well as neurological abnormalities. Finally, we discuss recent studies showing novel specific PGC-1α isoforms in the central nervous system that appear to exert a key role in the age of onset of neurodegenerative diseases and have a neuroprotective function in the central nervous system, thus opening a new molecular strategy for treatment of neurodegenerative diseases. The purpose of this review is to provide an up-t

关键词： Alzheimer's disease amyotrophic lateral sclerosis Huntington's disease mitochondrial dysfunction Parkinson's disease PGC-1α synaptic function vascular dementia

TMEM16A inhibits angiotensin Ⅱ-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3994-4007页

作者： Huaqing Zheng Xiaolong Li Xin Zeng Chengcui Huang Mingming Ma Xiaofei Lv Yajuan Zhang Lu Sun Guanlei Wang Yanhua Du Yongyuan Guan department of Pharmacology Cardiac&Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

vascular smooth muscle cell(VSMC) migration plays a critical role in the pathogenesis of many cardiovascular *** recently showed that TMEM16 A is involved in hypertensioninduced cerebrovascular ***,it is unclear whether this effect is related to the regulation of VSMC ***,we investigated whether and how TMEM16 A contributes to migration in basilar artery smooth muscle cells(BASMCs).We observed that AngⅡ increased the migration of cultured BASMCs,which was markedly inhibited by overexpression of TMEM16 ***16 A overexpression inhibited AngⅡ-induced RhoA/ROCK2 activation,and myosin light chain phosphatase(MLCP)and myosin light chain(MLC20) *** AnsⅡ-induced myosin light chain kinase(MLCK)activation was not affected by TMEM16 ***,a suppressed activation of integrinβ3/FAK pathway,determined by reduced integrinβ3 expression,FAK phosphorylation and F-actin rearrangement,was observed in TMEM16 A-overexpressing BASMCs upon AngⅡ *** to the results of TMEM16 A overexpression,silencing of TMEM16 A showed the opposite *** in vitro results were further demonstrated in vivo in basilar arteries from VSMC-specific TMEM10 A transgenic mice during AngⅡ-induced ***,we observed that the inhibitory effect of TMEM16 A on BASMC migration was mediated by decreasing the activation of WNK1,a Cl^(-)-sensitive serine/threonine *** conclusion,this study demonstrated that TMEM16 A suppressed AnsⅡ-induced BASMC migration,thus contributing to the protection against cerebrovascular remodeling during AngⅡ-infused ***16 A may exert this effect by suppressing the RhoA/ROCK2/MLCP/MLC20 and integrinβ3/FAK signaling pathways via inhibiting *** results suggest that TMEM16 A may serve as a novel therapeutic target for VSMC migration-related diseases,such as vascular remodeling.

关键词： TMEM16A Integrin RhoA/ROCK VSMC migration vascular remodeling WNK1 Hypertension FAK

Case Reports of a Giant Cell Reparative Granuloma and a Giant Cell Tumor on Temporal Bone

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Chinese Medical Journal 2018年第18期131卷 2254-2256页

作者： Wei-Ying Dai Chao Tian Li Liu department of Radiology Tianjin Huanhu Hospital Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases Tianjin 300350 China

To the Editor： Giant cell reparative granuloma （GCRG） is a nonneoplastic, benign lesion derived from bone tissue. The morbidity of GCRG is relatively low, comprising approximately 7% of benign bone lesions. GCRGs are mostly tbund in adolescents, and no apparent gender inclination has been identified. In addition, GCRGs are predominantly found in the mandible and maxilla; a few cases have occurred in the short bones as the hands and feet. Occasionally, GCRGs are detected in long bones and vertebrae; temporal GCRGs are rarely reported. GCRGs associated with intracranial invasion are rare. Although some cases of GCRG have been previously reported, characteristic and elaborate descriptions have not yet been clearly established for imaging diagnosis and differential diagnosis. This article reported one case of left temporal GCRG associated with cholesteatoma caused by otitis media mastoiditis and another case of temporal giant cell tumor （GCT）.

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Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress

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Neural Regeneration Research 2014年第3期9卷 260-267页

作者： Tao Lei Haifeng Li Zhen Fang Junbin Lin Shanshan Wang Lingyun Xiao Fan Yang Xin Liu Junjian Zhang Zebo Huang Weijing Liao department of Rehabilitation Medicine Zhongnan Hospital and Cerebral Vascular Diseases Research Center Zhongnan Hospital Wuhan University School of Pharmaceutical Sciences Wuhan University

Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a pre-liminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H202-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H202 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis poly-saccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress.

关键词： nerve regeneration cerebral ischemia Angelica sinensis polysaccharides antioxidation reactive oxygen species rnitochondrial membrane potential apoptosis rnicrovessels NSFC grant neural regeneration

cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava Daniel Martinez-Fong departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia department of Pharmacology Wayne State University School of MedicineDetroitMIUSA departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

Cross-Modal Interaction and Integration Through Stimulus-Specific Adaptation in the Thalamic Reticular Nucleus of Rats

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Neuroscience Bulletin 2022年第7期38卷 785-795页

作者： Yumei Gong Yuying Zhai Xinyu Du Peirun Song Haoxuan Xu Qichen Zhang Xiongjie Yu department of Neurology of the Second Affiliated Hospital of Zhejiang University School of MedicineInterdisciplinary Institute of Neuroscience and TechnologyCollege of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhou 310029China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310027China Zhejiang Provincial Key Laboratory of Cardio-cerebral vascular detection Technology and Medicinal Effectiveness Appraisal Zhejiang UniversityHangzhou 310027China

Stimulus-specific adaptation(SSA),defined as a decrease in responses to a common stimulus that only partially generalizes to other rare stimuli,is a widespread phenomenon in the brain that is believed to be related to novelty *** cross-modal sensory processing is also a widespread phenomenon,the interaction between the two phenomena is not well *** this study,the thalamic reticular nucleus(TRN),which is regarded as a hub of the attentional system that contains multi-modal neurons,was *** results showed that SSA existed in an interactive oddball stimulation,which mimics stimulation changes from one modality to *** the bimodal integration,SSA to bimodal stimulation was stronger than to visual stimulation alone but similar to auditory stimulation alone,which indicated a limited integrative ***,the present results provide evidence for independent cross-modal processing in bimodal TRN neurons.

关键词： Stimulus-specific adaptation Regularity:Novelty detection Thalamic reticular nucleus Crossmodal

Protective mechanisms of Leontopodium leontopodioides extracts on lipopolysaccharide-induced acute kidney injury via the NF-κB/NLRP3 pathway

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Chinese Journal of Natural Medicines 2023年第1期21卷 47-57页

作者： BAI Xue MA Qianqian LI Qi YIN Meizhen XIN Ying ZHEN Dong WEI Chengxi Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-cerebral vascular System Inner Mongolia Minzu UniversityTongliao 028000China College of Preventive Medicine Medical CollegeInner Mongolia Minzu UniversityTongliao 028000China Institute of Pharmaceutical Chemistry and Pharmacology Inner Mongolia Minzu UniversityTongliao 028000China College of Traditional Mongolian Medicine Inner Mongolia Minzu UniversityTongliao 028000China

Sepsis-induced uncontrolled systemic inflammatory response syndrome(SIRS)is a critical cause of multiple organ *** kidney injury(AKI)is one of the most serious complications associated with an extremely high mortality rate in SIRS,and it lacked simple,safe,and effective treatment *** leontopodioides(Willd.)Beauv(LLB)is commonly used in traditional Chinese medicine for the treatment of acute and chronic ***,it remains unclear whether lipopolysaccharide(LPS)affects LPS-induced *** identify the molecular mechanisms of LLB in LPS-induced HK-2 cells and mice,LLB was prepared by extraction with 70%methanol,while a lipopolysaccharide(LPS)-induced HK-2 cell model and an AKI model were established in this *** histopathology staining was performed to observe the morphology *** cell supernatant and kidney tissues were collected for determining the levels of inflammatory factors and protein expression by ELISA,immunofluorescence,and Western *** results indicated that LLB significantly reduced the expression of IL-6 and TNF-αin LPS-induced HK-2 cells,as well as the secretion of IL-6,TNF-α,and IL-1βin the *** same results were observed in LPS-induced AKI *** studies revealed that LLB remarkably improved oxidative stress and apoptosis based on the content of MDA,SOD,and CAT in serum and TUNEL staining ***,LLB significantly reduced the mortality due to LPS *** histopathology staining results supported these ***,immunofluorescence and Western blot results confirmed that LLB significantly reduced the expression of the protein related to the NF-κB signaling pathway and NLRP3,ASC,and Caspase-1 which were significantly increased through LPS *** findings clearly demonstrated the potential use of LLB in the treatment of AKI and the crucial role of the NF-κB/NLRP3 pathway in the process through which LLB attenuates AKI induced by LPS.

关键词： Leontopodium leontopodioides Acute kidney injury Ethnopharmacology

Participation of Auxin Transport in the Early Response of the Arabidopsis Root System to Inoculation with Azospirillum brasilense

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Phyton-International Journal of Experimental Botany 2022年第11期91卷 2383-2401页

作者： Elizabeth Carrillo-Flores Jonanci Arreola-Rivera denníMariana Pazos-Solís Moisés Bocanegra-Mondragón Grisel Fierro-Romero MaElena Mellado-Rojas Elda Beltrán-Peña laboratorio de Transducción de Señales Edificio B3Instituto de Investigaciones Químico-Biológicas de la Universidad Michoacana de San Nicolás de HidalgoCiudad UniversitariaMorelia58030México Tecnológico de Monterrey School of Engineering and SciencesCampus QuerétaroSan PabloQuerétaro76130México School of the Environment Florida A&M UniversityTallahassee32307USA

The potential of Plant Growth Promoting Rhizobacteria(PGPR)has been demonstrated in the case of plant inoculation with bacteria of the genus Azospirillum which improves *** produces a wide variety of molecules,including the natural auxin indole-3-acetic acid(IAA),as well as other ***,several studies have suggested that auxin induces changes in plant development during their interaction with the *** effects of *** Sp245 on the development of Arabidopsis thaliana root were investigated to help explain the molecular basis of the *** results obtained showed a decrease in primary root length from the first day and remained so throughout the exposure,accompanied by a stimulation of initiation and maturation of lateral root primordia and an increase of lateral *** enhanced auxin response was evident in the vascular tissue and lateral root meristems of inoculated ***,after five days of bacterization,the response disappeared in the primary root *** role of polar auxin transport(PAT)in auxins relocation involved the PGP1,AXR4-1,and BEN2 proteins,which apparently mediated ***-induced root branching of Arabidopsis seedlings.

关键词： Auxin Azopirillum brasilense Arabidopsis auxin transport lateral roots

High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4320-4337页

作者： Zhi-Wei Mo Yue-Ming Peng Yi-Xin Zhang Yan Li Bi-Ang Kang Ya-Ting Chen Le Li Mary GSorci-Thomas Yi-Jun Lin Yang Cao Si Chen Ze-Long Liu Jian-Jun Gao Zhan-Peng Huang Jia-Guo Zhou Mian Wang Guang-Qi Chang Meng-Jie deng Yu-Jia Liu Zhen-Sheng Ma Zuo-Jun Hu Yu-Gang Dong Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of vascular Diseases NHC Key Laboratory of Assisted Circulation(Sun Yat-sen University)Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular DiseasesGuangzhouChina Division of vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Hypertension and vascular Diseases Department of CardiologyHeart CenterThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Medical College of Wisconsin MilwaukeeWIUSA Center for Translational Medicine Institute of Precision MedicineThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina department of Cardiology Heart CenterThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of Medicine of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080P.R.China

Normal high-density lipoprotein(nHDL)can induce angiogenesis in healthy ***,HDL from patients with coronary artery disease undergoes various modifications,becomes dysfunctional(dHDL),and loses its ability to promote ***,we identified a long non-coding RNA,HDRACA,that is involved in the regulation of angiogenesis by *** this study,we showed that nHDL downregulates the expression of HDRACA in endothelial cells by activating WW domain-containing E3 ubiquitin protein ligase 2,which catalyzes the ubiquitination and subsequent degradation of its transcription factor,Kruppel-like factor 5,via sphingosine 1-phosphate(S1P)receptor *** contrast,dHDL with lower levels of S1P than nHDL were much less effective in decreasing the expression of *** was able to bind to Ras-interacting protein 1(RAIN)to hinder the interaction between RAIN and vigilin,which led to an increase in the binding between the vigilin protein and proliferating cell nuclear antigen(PCNA)mRNA,resulting in a decrease in the expression of PCNA and inhibition of *** expression of human HDRACA in a hindlimb ischemia mouse model inhibited the recovery of *** together,these findings suggest that HDRACA is involved in the HDL regulation of angiogenesis,which nHDL inhibits the expression of HDRACA to induce angiogenesis,and that dHDL is much less effective in inhibiting HDRACA expression,which provides an explanation for the decreased ability of dHDL to stimulate angiogenesis.

关键词： angiogenesis lipoprotein inhibited