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Spinal cord injury drives chronic brain changes

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Neural Regeneration Research 2017年第7期12卷 1044-1047页

作者： Ignacio Jure Florencia Labombarda laboratorio de bioquimica Neuroendocrina Instituto de Biologia y Medicina Experimental CONICET Buenos Aires Argentina departamento de bioqulmica Humana Facultad de Medicina Universidad de Buenos Aires Buenos Aires Argentina

Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury,although cognitive impairments have been reported in these *** cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in *** the hippocampus,neurogenesis is reduced and reactive gliosis *** longterm abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.

关键词： spinal cord injury brain neurodegeneration neuroinflammation

Contrasting levels of genotype by environment interaction for life history and morphological traits in invasive populations of Zaprionus indianus(Diptera:Drosophilidae)

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Insect Science 2020年第5期27卷 1090-1100页

作者： Nicolas J.Lavagnino Marcos Imberti Victoria E.Ortizj Nicolas Flaibani Juan Jose Fanara laboratorio de Evolucion Departamento de EcologiaGenetica y EvolucidnFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina IEGEBA-CONICET Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina

It has been demonstrated that phenotypic plasticity and genotype by envi-ronment interaction are important for coping with new and heterogeneous environments during *** indianus Gupta(Diptera:Drosophilidae)is an Afrotropical invasive fly species introduced to the South American continent in *** species is generalist and polyphagous,since it develops and feeds in several different fruit *** characteristics of *** suggest that phenotypic plasticity and genotype by environment interaction may be important in this species invasion *** this sense,our aim was to investigate the role of genetic variation for phenotypic plasticity(geno-type by environment interaction)in *** invasion of the South American ***,we quantified quantitative genetic variation and genotype by environment in-teractions of morphological and life history traits in different developmental environments,that is,host *** was done in different populations in the invasive range of ***-anus in *** showed that *** populations have considerable amounts of quantitative genetic ***,genotype by environment interactions was detected for the different traits analyzed in response to the different developmental ***,the amounts and patterns of these parameters differed between *** interpreled these results as the existence of diferences in evolutionary potential be-tween populations that have an important role in the short-and long-term success of the *** invasion process.

关键词： biological invasion genotype by env ironment interaction invaded range life history traits morphological traits Zaprionus indianus

Astroglial heterogeneity:merely a neurobiological question? Or an opportunity for neuroprotection and regeneration after brain injury?

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Neural Regeneration Research 2016年第11期11卷 1739-1741页

作者： Alberto Javier Ramos laboratorio de Neuropatología Molecular Instituto de Biología Celular y Neurociencia "Prof.E.De Robertis" UBA-CONICETFacultad de MedicinaUniversidad de Buenos Aires

Pioneer studies by Ramon y Cajal in the early nineteenth century evidenced that astrocytes are a heterogeneous cell population. The initial division of the glial family proposed by Rudolf Albert von Kolliker and William Lloyd Andriezen that separated glia into two groups, fibrous glia and protoplasmic glia, was further refined by Ramon y Cajal,

关键词： Or an opportunity for neuroprotection and regeneration after brain injury

Antibacterial enhancement of antibiotic activity by Enterolobium contortisiliquum(Vell.)Morong

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Asian Pacific Journal of Tropical biomedicine 2017年第10期7卷 945-949页

作者： Zildene de Sousa Silveira Nair Silva Macêdo Thiago Sampaio de Freitas Ana Raquel Pereira da Silva Joycy Francely Sampaio dos Santos Maria Flaviana Bezerra Morais-Braga José Galberto Martins da Costa Raimundo Nonato Pereira Teixeira Jean Paul Kamdem Henrique Douglas Melo Coutinho Francisco Assis Bezerra da Cunha laboratorio de bioprospeccao do Semioarido Universidade Regional do CaririCratoBrazil laboratorio de Microbiologia e biologia Molecular Universidade Regional do CaririCratoBrazil laboratorio de Pesquisas de Produtos Naturais Universidade Regional do CaririCratoBrazil departamento de Ciencias biologicas Universidade Regional do Cariri-URCACratoCEP:63105-000Brazil Programa de Pos-graduacao em bioprospeccao Molecular Universidade Regional do Cariri–URCACratoBrazil

Objective: To identify the main chemical classes of compounds from aqueous extract of Enterolobium contortisiliquum(E. contortisiliquum) seed bark and to evaluate its antibacterial activity, as well as its potential to increase the activity of antibiotics against strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia ***: Different classes of compounds in the aqueous extract of E. contortisiliquum were evaluated based on the visual changes in the coloration and the formation of precipitate after the addition of specific reagents. The antibacterial activity of the extract and its potential to increase of antibiotic activity of antibiotics drugs, gentamicin and norfloxacin was determined by using the microdilution ***: Our results demonstrated that the following secondary metabolites were presented in E. contortisiliquum seed bark: flavones, flavonols, xanthones, flavononols,chalcones, aurones, flavones and catechins. The extract itself had very low antibacterial activity against all bacterial strains tested(MIC ≥ 1024 μg/m L), but there was an increase in the antibiotic activity of gentamicin and norfloxacin when combined in the subinhibitory concentration(i.e., MIC/8).Conclusions: Our data suggests that E. contortisiliquum seed bark may be an alternative source for new drugs with the potential to increase antibiotic activity against different strains of bacteria.

关键词： Antibiotic activity Enhancement Synergism Chemical compounds bioactivity

In vitro Mutagenesis for the Improvement of Agave Genus

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Phyton-International Journal of Experimental Botany 2023年第7期92卷 2065-2078页

作者： Sugey Vásquez-Hernández Joaquín Adolfo Montes-Molina Federico Antonio Gutiérrez-Miceli Sheila Jazmín Reyes-Zambrano Carlos Alberto Lecona-Guzmán laboratorio de biotecnología Vegetal TecNM-Campus Tuxtla GutiérrezTuxtla Gutiérrez29050Mexico

biotechnological techniques provide a viable alternative to help improve and increase the production of plant species of agricultural and economic importance,which have been affected over the years by climate change,increasing their susceptibility to pests and/or diseases,generating losses in production as well as a decrease in their regenerative and genetic *** application of biotechnological techniques such as in vitro mutagenesis offers a viable option for the generation of crops that are resistant to the different factors caused by abiotic and biotic *** vitro mutagenesis has been used in an efficient way to generate genetic changes in different plant ***,these methods have not been studied thoroughly in crops of agro-industrial interest,such as agave,which represents an economic resource of national importance and are considered as endemic species of ***,this literary review aimed to focus on the studies that have been used for the genetic improvement of this species via mutagenesis techniques in plants in the agave ***,the objective was to set a precedent for future genetic studies that aim to obtain more productive regenerants for various industries,such as food and *** is also of great interest to compile information from basic research that helps understand and elucidate a model of possible defense mechanisms that are activated in the Agave genus.

关键词： biotechnology genetic variations stress mutations resistance

Microbial degradation of Organophosphate Pesticides： A Review

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Pedosphere 2018年第2期28卷 190-208页

作者： Shardendu KUMAR Garima KAUSHIK Mohd Ashraf DAR Surendra NIMESH Ulrico Javier LOPEZ-CHUKEN Juan Francisco VILLARREAL-CHIU department of Environmental Science School of Earth Sciences Central University of Rajasthan Ajmer 305817 (India) department of biotechnology School of Life Sciences Central University of Rajasthan Ajmer 305817 (India) laboratorio de InvestigaciSn en Ciencias Ambientales Facultad de Cieneias Quimicas Universidad AutSnoma de Nuevo León Nuevo LeSn 66455 (Mexico) laboratorio de biotecnologla Facultad de Ciencias Qulmicas Universidad AutSnoma de Nuevo LeSn Nuevo Ledn 66455 (Mexico)

Pesticides have become an inevitable part of the modern environment as they are widely used in agriculture,household,and public health sectors and,hence,are extensively distributed throughout most ***,organophosphate pesticides are the most commercially favored group of pesticides,with large application areas all over the *** on their fate,these organophosphorus compounds may become bioavailable for microbial *** microbes,such as Aspergillus,Pseudomonas,Chlorella,and Arthrobacter,are capable of coupling a variety of physical and biochemical mechanisms for the degradation of organophosphate pesticides,including adsorption,hydrolysis of P–O alkyl and aryl bonds,photodegradation,and enzymatic ***,such as esterase,diisopropyl fluorophosphatase,phosphotriesterase,somanase,parathion hydrolase,and paraoxonase,have been isolated from microbes to study and understand the catabolic pathways involved in the biotransformation of these xenobiotic *** review highlights various aspects of biodegradation of organophosphate pesticides along with biological and molecular characterization of some organophosphate pesticide-degrading bacteria.

关键词： biodegradation enzymes insecticide metabolic pathways pesticide-degrading bacteria organophosphorus compound xenobiotics

Socio-spatial organization reveals paternity and low kinship in the Honduran white bat(Ectophylla alba)in Costa Rica

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Integrative Zoology 2021年第5期16卷 646-658页

作者： Edgar G.GUTIÉRREZ Isabela VIVAS-TORO Daniela CARMONA-RUÍZ David VILLALOBOS-CHAVES Bernal RODRÍGUEZ-HERRERA Melina del REAL-MONROY Gloria LEÓN-AVILA Jorge ORTEGA laboratorio de bioconservación y Manejo Posgrado en Ciencias QuimicobiológicasDepartamento de ZoologíaEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico department of biology University of WashingtonSeattleWashingtonUSA Escuela de biología Universidad de Costa RicaSan JoséCosta Rica laboratorio de Genómica Evolutiva Doctorado en Ciencias BásicasUniversidad Autónoma de ZacatecasZacatecasZac.México laboratorio de Genética Posgrado en Ciencias QuimicobiológicasDepartamento de ZoologíaEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico

Ectophylla alba is a tent-making bat that roosts in mixed-sex clusters comprising adults and *** goal was to determine the genetic identity of individuals belonging to different roosting *** tested the hypothesis of kin selection as a major force structuring group *** used 9 microsatellites designed for *** to determine the genetic identity and probability of parentage of *** analyzed parentage and kinship using the software ML-Relate,GenAIEx,and *** obtained relationship probabilities(0.5)revealed a clear maternal relationship between female adults and offspring with allele compatibility,and at least 5 relationships between male adults and *** found a low degree of relatedness within roosting *** roosting groups at different sites,the mean probability of a half-sibling relationship ranged from 0.214 to 0.244 and,for full-sibling relationship,from 0.383 to ***,adult individuals were poorly related within clusters,and kinship as an evolutionary force could not explain group membership.

关键词： Ectophylla alba group composition kinship microsatellites relatedness

Communities of saprobic fungi on leaf litter of Vismia guianensis in remnants of the Brazilian Atlantic Forest

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Journal of Forestry Research 2017年第1期28卷 163-172页

作者： Loise Araujo Costa Luís Fernando Pascholati Gusmao laboratorio de Micologia Av Transnordestina Departamentode Ciências BiológicasUniversidade Estadual de Feira deSantanas/nNovo HorizonteFeira de SantanaBA 44031-460Brazil

We examined the mycobiota associated with Vismia guianensis leaf litter in three Atlantic Forest remnants of Brazil＇ s semiarid region. Among the study sites, two remnants were protected forest reserves, whereas the third was influenced by major anthropogenic activities. Eighteen litter samples were collected in wet and dry seasons and were processed by particle filtration technique. A total of 4750 fungal isolates of 142 taxa were identified. Species richness was higher in litter samples collected during wet season. Nonmetric multidimensional scaling multivariate analysis showed differences in the composition of fungal communities among the sampling sites and the seasons. Analysis of similarity showed that the differences were statistically significant （R = 0.85; P = 0.0001）. Our findings revealed that spatial and temporal heterogeneity, and human activities had significant impacts on the saprobic fungi of V. guianensis leaf litter.

关键词： biodiversity Conservation Seasonality Spatial heterogeneity Tropical fungi

HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium

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World Journal of Gastroenterology 2022年第29期28卷 3886-3902页

作者： Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García Norma Velázquez-Guadarrama laboratorio de Investigación en Enfermedades Infecciosas Hospital Infantil de México Federico GómezMexico City 06720Mexico Posgrado en biomedicina y biotecnología Molecular Laboratorio de Producción y Control de BiológicosEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico laboratorio de Adquisición de Hierro Universidad Autónoma de la Ciudad MéxicoPosgrado Ciencias GenómicaMexico City 03100Mexico laboratorio Central de Microscopía Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Centro de estudios económicos y sociales en salud Hospital Infantil de México Federico GómezMexico City 06720Mexico laboratorio de Investigación en biología del desarrollo y Teratogénesis Experimental Hospital Infantil de México Federico GómezMexico City 06720Mexico

BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence *** To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) *** Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional *** HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium *** technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS *** analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein

关键词： Hypothetical protein HP0953 Adherence Helicobacter pylori Glycocalyx Virulence factor Persistence