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Spatiotemporal oxygen dynamics in young leaves reveal cyclic hypoxia in plants

Molecular Plant 2024年第3期17卷 377-394页

作者： Paolo M.Triozzi Luca Brunello Giacomo Novi Gianmarco Ferri Francesco Cardarelli Elena Loreti Mariano Perales Pierdomenico Perata PlantLab Center of Plant SciencesSant'Anna School of Advanced Studies56010 PisaItaly Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA-CSIC)Campus de Montegancedo UPMPozuelo de Alarcon28223 MadridSpain Fondazione Pisana per la Scienza 56017 PisaItaly laboratorio NEST Scuola Normale SuperioreIstituto Nanoscienze-CNRPiazza S.Silvestro1256127 PisaItaly institute of Agricultural Biology and Biotechnology National Research Council56124 PisaItaly departamento de Biotecnologia-biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasUniversidad Politecnica de Madrid(UPM)28040 Madrid.Spain

Oxygen is essential for plant growth and development.Hypoxia occurs in plants due to limited oxygen avail-abilityfollowing adverse environmental conditions as well inhypoxic niches in otherwisenormoxic environ-ments.However,the existence and functional integration of spatiotemporal oxygen dynamics with plant development remains unknown.In animal systems dynamic fluctuations in oxygen availability are known as cyclic hypoxia.In this study,we demonstrate that cyclic fluctuations in internal oxygen levels occur in young emerging leaves of Arabidopsis plants.Cyclic hypoxia in plants is based on a mechanism requiring the ETHYLENE RESPONSE FACTORS type VII(ERFVII)that are central components of the oxygen-sensing machinery in plants.The ERFVll-dependent mechanism allows precise adjustment of leaf growth in response to carbon status and oxygen availability within plant cells.This study thus establishes a functional connection between internal spatiotemporal oxygen dynamics and developmental processes of plants.

关键词： Arabidopsis hypoxia cyclic hypoxia leaf development oxygen-sensing mechanism ERFVII

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Advances in gastric cancer research will light the way to control this cancer

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Chinese Journal of Cancer Research 2022年第6期34卷 575-578页

作者： Paulo Pimentel de Assumpcao Rommel Rodrigues Burbano Universidade Federal do Para Nucleo de Pesquisas em OncologiaBelem-Para-Brasil 66075-110Brazil Hospital Ophir Loyola Laboratorio de Biologia MoleculaBelém-Para-Brasil 66063-240Brazil

Gastric adenocarcinoma(GC)is one of the most heterogeneous cancers,posing challenges to wide applications of the discoveries when compared to other cancers.Nevertheless,the benefits of research in the fight against GC are extraordinary,and even taking in mind the immense complexity of this disease,optimism is a great message to take home.Recent advances in GC research will pave the way for GC effective control,helping to save lives,together with permitting sustainable real-life support for those needing complex and high-expense interventions.

关键词： Gastric cancer research innovations

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Diversity and host assemblage of avian haemosporidians in different terrestrial ecoregions of Peru

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Current Zoology 2022年第1期68卷 27-40页

作者： Luz GARCIA-LONGORIA Jaime MURIEL Sergio MAGALLANES Zaira Hellen VILLA-GALARCE Leonila RICOPA Wilson Giancarlo INGA-DIAZ Esteban FONG Daniel VECCO Cesar GUERRA-SALDANA Teresa SALAS-RENGIFO Wendy FLORES-SAAVEDRA Kathya ESPINOZA Carlos MENDOZA Blanca SALDANA Manuel GONZALEZ-BLAZQUEZ Henry GONZALES-PINEDO Charlene LUJAN-VEGA Carlos Alberto del AGUILA Yessica VILCA-HERRERA Carlos Alberto PINEDA Carmen REATEGUI Jorge Manuel CARdeNAS-CALLIRGOS JoseAlberto IANNACONE Jorge Luis MENDOZA Ravinder NMSEHGAL Alfonso MARZAL departamento de Anatomia Biologia Celular y ZoologiaUniversidad de ExtremaduraBadajoz E-506071Spain Molecular Ecology and Evolution Lab Department of BiologyLund UniversitySolvegatan 37SE-22362 LundSweden Instituto Pirenaico de Ecologıa-IPE(CSIC) Avda.Nuestra Senora de la Victoria 16Jaca 22700Spain DIRESA Direccion Regional de SaludLoreto 16001Peru departamento Academico de Microbiologia y Parasitologia.Facultad de Ciencias Biologicas Universidad Nacional de la Amazonia PeruanaIquitos 16001Peru Facultad de Ciencias Agropecuarias Universidad Alas PeruanasLima 15823Peru EverGreen Institute-San Rafael Distrito de IndianaLoreto 16200Peru Observatorio de Aves Loreto(LBO) Distrito de San JuanLoreto 16008Peru Centro Urku de Estudios Amazonicos Tarapoto 22200Peru Servicio Nacional de Areas Naturales Protegidas por el Estado 15036Peru Sanidad Animal-Facultad de Zootecnia Universidad Nacional Agraria La MolinaLima 15012Peru laboratorio de Microbiologia Facultad de Medicina Veterinaria y ZootecniaUniversidad CientUfica del SurLima 15067Peru laboratorio de Analisis Clinico Moraleslab SAC MoralesSan Martin 22201Peru Asociacion Ecosistemas Andinos(ECOAN) Cuzco 08002Peru Pharmacology and Toxicology Graduate Group University of CaliforniaDavisDA 95616USA Global Health Initiative Wabash CollegeCrawfordsvilleIN 47933USA Facultad de Ciencias Biologicas Universidad Nacional Mayor de San MarcosLima 15081Peru Facultad de Medicina Veterinaria Universidad Nacional Hermilio ValdizanHuanuco10160Peru Asociacion Peruana de Helmintologia e Invertebrados Afines Lima 15054Peru laboratorio de Ecologia y Biodiversidad Animal Universidad Nacional Federico VillarrealEl AgustinoLima 15007Peru laboratorio de Invertebrados Universidad Ricardo Palma-Santiago de SurcoLima 15537Peru department of Biology San Francisco State UniversitySan FranciscoCA 94132USA

Characterizing the diversity and structure of host–parasite communities is crucial to understandingtheir eco-evolutionary dynamics.Malaria and related haemosporidian parasites are responsible forfitness loss and mortality in bird species worldwide.However,despite exhibiting the greatest ornithologicalbiodiversity,avian haemosporidians from Neotropical regions are quite unexplored.Here,we analyze the genetic diversity of bird haemosporidian parasites(Plasmodium andHaemoproteus)in 1,336 individuals belonging to 206 bird species to explore for differences in diversityof parasite lineages and bird species across 5 well-differentiated Peruvian ecoregions.Wedetected 70 different haemosporidian lineages infecting 74 bird species.We showed that 25 out ofthe 70 haplotypes had not been previously recorded.Moreover,we also identified 81 new host–parasite interactions representing new host records for these haemosporidian parasites.Our outcomesrevealed that the effective diversity(as well as the richness,abundance,and Shannon–Weaver index)for both birds and parasite lineages was higher in Amazon basin ecoregions.Furthermore,we also showed that ecoregions with greater diversity of bird species also had highparasite richness,hence suggesting that host community is crucial in explaining parasite richness.Generalist parasites were found in ecoregions with lower bird diversity,implying that the abundanceand richness of hosts may shape the exploitation strategy followed by haemosporidian parasites.These outcomes reveal that Neotropical region is a major reservoir of unidentified haemosporidianlineages.Further studies analyzing host distribution and specificity of these parasites inthe tropics will provide important knowledge about phylogenetic relationships,phylogeography,and patterns of evolution and distribution of haemosporidian parasites.

关键词： Amazonia avian malaria generalist parasite habitat specificity Haemoproteus Plasmodium specialist parasite

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Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model

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World Journal of Hepatology 2019年第4期11卷 359-369页

作者： Francielle Graus-Nunes Felipe de Oliveira Santos Thatiany de Souza Marinho Carolline Santos Miranda Sandra Barbosa-da-Silva Vanessa Souza-Mello laboratorio de Morfometria Metabolismo e Doencas Cardiovasculares Departamento de Anatomia Instituto de Biologia Roberto Alcantara Gomes

BACKGROUND Obesity has been associated with hepatic overexpression of the renin-angiotensin system(RAS).AIM To evaluate the action of two angiotensin II(ANGII) receptor blockers(losartan or telmisartan) on the modulation of local hepatic RAS and the resulting metabolic effects in a diet-induced obesity murine model.METHODS Twenty C57 BL/6 mice were randomly divided into two nutritional groups for 10 wk: control group(C, n = 5, 10% of energy as fat) or high-fat group(HF, n = 15,50% of energy as fat). After treatment started, the HF group was randomly divided into three groups: untreated HF group(n = 5), HF treated with losartan(HFL, n = 5) and HF treated with telmisartan(HFT, n = 5). The treatments lasted for 5 wk, and the dose was 10 mg/kg body mass.RESULTS HF diet induced body mass gain(+28%, P demonstrated by reduced hepatic triacylglycerol levels coupled with reduced PLIN 2 expression and improved glycemic control.

关键词： Liver Telmisartan Losartan Obesity Angiotensin Ⅱ type 1 receptor C57BL/6 mouse

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Spinal cord injury drives chronic brain changes

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Neural Regeneration Research 2017年第7期12卷 1044-1047页

作者： Ignacio Jure Florencia Labombarda laboratorio de Bioquimica Neuroendocrina Instituto de Biologia y Medicina Experimental CONICET Buenos Aires Argentina departamento de Bioqulmica Humana Facultad de Medicina Universidad de Buenos Aires Buenos Aires Argentina

Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury,although cognitive impairments have been reported in these patients.Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents.Regarding the hippocampus,neurogenesis is reduced and reactive gliosis increased.These longterm abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.

关键词： spinal cord injury brain neurodegeneration neuroinflammation

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Classical olfactory conditioning promotes long-term memory and improves odor-cued flight orientation in the South American native bumblebee Bombus pauloensis

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Current Zoology 2021年第5期67卷 561-563页

作者： denise NERY Florencia PALOTTINI Walter M.FARINA laboratorio de Insectos Sociales Departamento de Biodiversidad y Biologia ExperimentalFacultad de Ciencias NaturalesUniversidad de Buenos AiresBuenos AiresArgentina Instituto de Fisiologia Biologia Molecular y Neurociencias(IFIBYNE)CONICET-Universidad de Buenos AiresBuenos AiresArgentina

When collecting a flower,bumblebees learn to associate floral features with reward,preferring,and specializing in the most profitable ones they visit(Chittka et al.1999).The proboscis extension reflex(PER)occurs naturally in the feeding context allowing individuals to access the floral nectaries.Under controlled conditions,the PER paradigm is a well-established controlled learning procedure used in honeybees(Takeda 1961),and some bumblebees of the genus Bombus(Laloi et al.1999).The assessment of cognitive capacities in an operant context has been studied mainly in B.terrestris and B.impatiens(Chittka 1998;Mirwan and Kevan 2014).However,little is known about the ability to evoke associative memories in an operant context,which had been acquired in a classical one.In turn,on the contrary,the Bombus genus also has the capacity to form longterm memories(Chittka 1998;McAulay et al.2015).In particular,the South American bumblebee B.pauloensis(sin.B.atratus)can learn a pure odor when it is presented in a paired association with a sugar reward within a PER paradigm(Palottini et al.2018).As other species,this one is a commercially reared pollinator that is increasingly managed in pollination services of some South American countries and they could be important for increasing production of crops(Palottini et al.2018).

关键词： crops sugar associative

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Abiotic and biotic drivers of struvite solubilization in contrasting soils

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Pedosphere 2023年第6期33卷 828-837页

作者： Antonio RUIZ-NAVARRO Manuel deLGADO-BAQUERIZO Concha CANO-DíAZ Carlos GARCíA Felipe BASTIDA Centro de Edafologia y biologia Aplicada del Segura Consejo Superior de Investigaciones Cientificas(CEBAS-CSIC)Department of Soil and Water ConservationEspinardoMurcia E-30100Spain ICL Specialty Fertilizers Iberia TotanaMurcia E-30850Spain laboratorio de Biodiversidad y Funcionamiento Ecosistemico Instituto de Recursos Naturales y Agrobiologia de Sevilla(IRNAS)CSICAv.Reina Mercedes 10Sevilla E-41012Spain IRNAS-CSIC Unidad Asociada Universidad Pablo de OlavideUniversidad Pablo de Olavide(UPO)Sevilla 41013Spain Centre for Research and development in Agrifood Systems and Sustainability(CISAS) Instituto Politecnico de Viana do Castelo(IPVC)Rua Escola Industrial e Comercial Nun'Alvares 34Viana do Castelo 4900-347Portugal

Phosphorus(P) limitation in the coming decades calls for the utilization of alternative fertilizers in agriculture. Struvite is a promising P source, but its potential role as a fertilizer is dependent on different physical, chemical, and biological properties, which are very heterogeneous in soil, complicating the prediction of the best soil conditions for its application. Here, we evaluated the solubility of struvite in soil, its redistribution into P fractions, and its potential abiotic and biotic drivers in 62 globally distributed soils with contrasting properties through an incubation assay. We found that after 40 d, about 35% of struvite P was redistributed into soil fractions more accessible to plants and microbes. Phosphorus redistribution from struvite was driven by a complex suite of soil physical, chemical, and microbial properties as well as environmental factors that varied across soils. Soil texture played a critical role in determining the redistribution of P in struvite-amended soils in soluble(H2O extraction), labile(NaHCO3 extraction), and moderately labile(NaOH extraction) fractions.In addition, the soil solution cation concentration was one of the most important drivers of available struvite-derived P fractions. The great importance of texture and cations in determining struvite-derived P fractions in soil was contrasted with the relatively minor role of pH. At the microbial level, the number of bacterial operational taxonomic units(OTUs) from the unfertilized soils that correlated with struvite-derived P fractions was higher than that of fungi. The number of OTUs that correlated with the struvite-derived soluble P fraction was dominated by fungi, whereas the number of OTUs that correlated with the struvite-derived labile P fraction was dominated by bacteria. Overall, this study provided a predictive framework for the potential use of struvite as a P fertilizer in contrasting soils.

关键词： bacteria fungi environmental factor operational taxonomic unit phosphorus fertilizer phosphorus fraction phosphorus solubilization soil fertility soil property

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Fruiting increases total content of flavonoids and antiproliferative effects of Cereus jamacaru D.C. cladodes in sarcoma 180 cells in vitro

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Asian Pacific Journal of Tropical Biomedicine 2019年第2期9卷 66-72页

作者： Jean Carlos Vencioneck Dutra Juda Ben-Hur de Oliveira Vanessa Silva dos Santos Paula Roberta Costalonga Pereira Jean Moises Ferreira Maria do Carmo Pimentel Batitucci laboratorio de Genetica Vegetal e Toxicologica Departamento de Ciencias BiologicasUniversidade Federal do Espirito Santo laboratorio de biologia Molecular e Expressao Genica Departamento de Ciências BiologicasUniversidade Federal de Alagoas

Objective: To evaluate the influence of fruiting phenological stage on total flavonoid content, antioxidant activity, and antiproliferative effects of Cereus jamacaru(C. jamacaru)(mandacaru) cladodes and fruit. Methods: Fruit and cladodes at vegetative and fruiting stage of C. jamacaru were collected. The fruit was dissected and bark, pulp, and seeds were separated. Vegetative and fruiting cladodes, together with bark, pulp, and seeds were used to obtain five hydroalcoholic extracts. The extracts were investigated for total flavonoid content, using AlCl3 colorimetric method, antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical scavenging capacity and Fe^(2+) ion chelating activity, and in vitro antiproliferative effects(sarcoma 180 cells) by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetrazolium bromide assay. Results: The extract of C. jamacaru cladodes at the fruiting stage showed higher flavonoid content compared to the other extracts. Seed extracts showed the highest antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) assays, and the extract of cladodes at vegetative stage showed better antioxidant activity in Fe^(2+) ion chelating activity. The extract of fruiting cladodes promoted higher antiproliferative effects compared to the other extracts. Conclusions: These findings suggest that fruiting increases the content of flavonoids and antiproliferative effects of C. jamacaru cladodes. Data reinforce the potential use of C. jamacaru cladodes and fruits as natural antioxidants and potent anticancer agent.

关键词： Mandacaru Flavonoid content DPPH ABTS Fe^(2+) ion chelating activity MTT assay Sarcoma 180 cells

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Beyond reproduction：the role of progesterone in neuropathic pain after spinal cord injury

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Neural Regeneration Research 2016年第8期11卷 1238-1240页

作者： Susana Laura González María Florencia Coronel Universidad de Buenos Aires Facultad de Medicina Departamento de Bioquimica Humana Buenos Aires Argentina laboratorio de Nocicepcion y Dolor Neuropatico Instituto de Biologia y Medicina Experimental CONICET Buenos Aires Argentina

Neuropathic pain,a type of pain arising after direct damage or disease of the nervous system,is often intractable and challenges the search of effective therapeutic strategies.In particular,neuropathic pain is a very ... 详细信息

关键词： progesterone intractable Beyond contributor reproduction neuronal NMDAR glial synaptic targeting

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A PCR and RFLP-based molecular diagnostic algorithm for visceral leishmaniasis

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Asian Pacific Journal of Tropical Medicine 2020年第2期13卷 62-70页

作者： Natalia Souza de Godoy Manoel Sebastiao da Costa Lima-Junior Jose Angelo Lauletta Lindoso Vera Lucia Pereira-Chioccola Thelma Suely Okay Lucia Maria Almeida Braz laboratorio de Parasitologia Médica Departamento de Moléstias Infecciosas e Parasitárias do Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil laboratorio de Imunopatologia e biologia Molecular-Instituto Aggeu Magalhaes/IAM-FIOCRUZ RecifeBrazil laboratorio de Soroepidemiologia e Imunobiologia-FMUSP Sao PauloBrazil laboratorio de biologia Molecular de Parasitas e Fungos-Instituto Adolfo Lutz Sao PauloBrazil laboratorio de Parasitologia-Instituto de Medicina Tropical de Sao Paulo-USP Sao PauloBrazil

Objective:To determine an algorithm for molecular diagnosis of visceral leishmaniasis(VL)by kinetoplast DNA(kDNA)(RV1/RV2)and internal transcriber spacer(ITS1)(LITSR/L5.8 S)polymerase chain reaction(PCR),complemented by ITS 1 PCR restriction fragment length polymorphism(RFLP),using peripheral blood or bone marrow aspirate from patients with suspected VL.Methods:Biological samples were submitted to the gold standard for the diagnosis of VL and molecular diagnosis represented by ITS 1 PCR,kDNA PCR,and ITS 1 PCR RFLP.The samples were obtained from seven groups:groupⅠ,82 samples from patients with confirmed VL;groupⅡ,16 samples from patients under treatment for VL;groupⅢ,14 samples from dogs with canine visceral leishmaniasis(CVL);groupⅣ,a pool of six experimentally infected sandflies(Lutzomya longipalpis);group V,18 samples from patients with confirmed tegumentary leishmaniasis(TL)and groupsⅥandⅦwere from control groups without VL.Results:The following gold standard and molecular examination results were obtained for each of the seven groups:groupⅠ:parasitologic and immunochromatographic tests showed a sensitivity of 76.3%(61 of 80)and 68.8%(55 of 80),respectively,and a sensitivity of 97.6%(80 of 82)and 92.7%(76 of 82)by ITS1 and kDNA PCR,respectively.After ITS1 PCR RFLP(HaeⅢ)analysis of the 80 positive samples,52.5%(42 of 80)generated three fragments of 180,70,and 50 bp,corresponding to the pattern of Leishmania infantum infantum;groupⅡ:negative for the parasitologic methods and positive for IrK39(100%,16 of 16),presented 12.5%(2 of 16)of positivity by ITS 1 PCR and 25.0%(4 of 16)by kDNA PCR;groupⅢ:positive in the parasitologic and serologic tests(100%,14 of 14),presented 85.7%(12 of 14)of positivity by ITS1 PCR and kDNA PCR.ITS1 PCR RFLP showed that 83.3%(10 of 12)of the canine samples contained parasites with profiles similar to L.infantum;groupⅣpresented amplifications by ITS1 PCR and kDNA PCR.ITS1 PCR products were analyzed by RFLP,generating a profile similar to that of L.infantum;groupⅤ:positive in the parasi

关键词： Leishmania infantum Molecular diagnosis Visceral leishmaniasis PCR RFLP

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