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Biorefinery of Rice Husk to Obtain Functionalized Bioactive Compounds

Journal of Renewable Materials 2019年第4期7卷 313-324页

作者： M.Lopretti N.Lecot A.Rodriguez G.Lluberas F.Orozco L.Bolaños G.Montes de Oca H.Cerecetto J.Vega-Baudrit laboratorio de Técnicas Nucleares Aplicadas a Bioquímica y Biotecnología Centro de Investigaciones Nucleares-Facultad de CienciasMataojo 2055Montevideo CP 11400Uruguay Área de Radiofarmacia Centro de Investigaciones Nucleares-Facultad de CienciasMataojo 2055Montevideo CP 11400Uruguay Química Bioanalítica Instituto Polo Tecnológico de Pando-Facultad de QuímicaUdelaRBy Pass de Pando y Ruta 8Pando-Canelones CP 91000Uruguay laboratorio de nacional de nanotecnología-cenat-conare Costa Rica 1174-1200San JoséCP 10109Costa Rica laboratorio de Polímeros POLIUNA-Escuela de Química Universidad NacionalHerediaSan JoséCP 86-3000Costa Rica

The biomass industrialization valorisation of grains and cereals is considered an opportunity for the countries where agro-industrial activity is one of its main economic activities,rendering new higher-value products with a concomitant solution to waste accumulation *** that end,in this work we describe and characterise bioactive compounds generation from rice husk by semisolid fermentation,obtained from 500 g of the material at room temperature and 60%humidity with mixed cultures of Phanerochaete chrysosporium and Gloeophyllum *** extract was evaluated in different situations:murine mammary tumour cells(4T1),normal cells(NIH 3T3)and in Lactobacillus acidophilus,and Trichoderma *** results exhibited that the extract inhibited 4T1 cells at concentrations higher than 20μg/mL,but did not inhibit normal cells,and displayed germicide activity after 3 days *** propose that these functionalized compounds have a potential application in industry/agriculture/medicine obtained from rice husk waste.

关键词： Biorefinery rice husk bioactive compounds valorisation of biomass veratryl alcohol

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Irbesartan desmotropes:Solid-state characterization,thermodynamic study and dissolution properties

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Journal of Pharmaceutical Analysis 2019年第5期9卷 339-346页

作者： Andrea Mariela Araya-Sibaja Carlos Eduardo Maduro de Campos Cinira Fandaruff Jose Roberto Vega-Baudrit Teodolito Guillen-Giron Mirtha Navarro-Hoyos Silvia Lucía Cuffini laboratorio nacional de nanotecnología lanotec-cenat-conare 1174-1200 Pavas San Jose Costa Rica Escuela de Ciencia e Ingeniería de los Materiales Tecnologico de Costa Rica Cartago 159-7050 Costa Rica Escuela de Química Universidad de Costa Rica San Pedro de Montes de Oca 2060 San Jose Costa Rica Programa de Pos-Graduacao em Física Universidade Federal de Santa Catarina Florianopolis Brazil Independent Researcher 06472-005 Barueri Sao Paulo Brazil laboratorio de Investigacion y Tecnología de Polímeros POLIUNA Escuela de Química Universidad Nacional de Costa Rica Heredia 86-3000 Costa Rica Instituto de Ciencia e Tecnica Universidade Federal de Sao Paulo Sao Jose dos Campos Sao Paulo Brazil

Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) and B (2H-tautomer). Studies have reported that IBS is a polymorphic system and its forms A and B are related monotropically. These reports indicate form B as the most stable and less soluble form. Therefore, the goal of this contribution is to demonstrate through a complete solid-state characterization, thermodynamic study and dissolution properties that the IBS forms are desmotropes that are not related monotropically. However, the intention is also to call attention to the importance of conducting strict chemical and in solid-state quality controls on the IBS raw materials. Hence, powder X-ray diffraction (PXRD) and Raman spectroscopy (RS) at ambient and non-ambient conditions, differential scanning calorimetry (DSC), hot stage microscopy (HSM), Fourier transform infrared (FT-IR) and scanning electron microscopy (SEM) techniques were applied. Furthermore, intrinsic dissolution rate (IDR) and structural stability studies at 98% relative humidity (RH), 25℃ and 40 ℃ were conducted as well. The results show that in fact, form A is approximately four-fold more soluble than form B. In addition, both IBS forms are stable at ambient conditions. Nevertheless, structural and/or chemical instability was observed in form B at 40℃ and 98% RH. IBS has been confirmed as a desmotropic system rather than a polymorphic one. Consequently, forms A and B are not related monotropically.

关键词： Irbesartan Solid-state characterization Intrinsic dissolution rate Tautomerism desmotropic forms

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Statistical Approach to Regulation of Nanotechnology:Need,Advantages and Disadvantages

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Journal of Biomaterials and Nanobiotechnology 2020年第1期11卷 14-32页

作者： Ricardo Santana Cabello Jose Vega-Baudrit Robin Zuluaga Piedad Ganan deusto Institute of Technology(deusto Tech) University of DeustoBilbaoSpain New Materials Research Group Universidad Pontificia BolivarianaMedellinColombia National Laboratory of Nanotechnology lanotec-cenat-conare PavasSan JoseCosta Rica POLIUNA Chemistry SchoolNational UniversityHerediaCosta Rica Faculty of Agro-Industrial Engineering Universidad Pontificia BolivarianaMedellinColombia Faculty of Chemical Engineering Universidad Pontificia BolivarianaMedellinColombia

The need to have an express regulation covering nanotechnology has been the subject of debate in the scientific literature and identified as one of the main subsets of nanotechnology field research. However, most countries still do not have regulatory framework in order to guarantee consumer safety. This is the case of Costa Rica, one of the most promising countries in Latin America in terms of biotechnology and nanotechnology. This article presents a statistical study about the position of industry, academia and government institutions on the need to expressly regulate nanotechnology in Costa Rica. A qualitative study consisting of a survey of 79 forms was done to individuals representing the community involved with nanotechnology and institutions responsible for ensuring the safety of the citizen’s health, to conclude that the nanotechnology regulation should be created to protect the consumer in Costa Rica. The research also proposes aspects that should be taken into account in its drafting as well as the variables on which decisions should be made to authorize the commercialization of nanomaterials based on the findings of the literature.

关键词： Nanotechnology Regulation Security Consumer

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