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Plasma Science and Technology 2014年第11期16卷 1013-1019页

作者： Raja DHOUIOUI Philippe TEULET Yann CRESSAULT Hassen GHALILA Riadh RIAHI Nejm Eddine JAIDANE Zohra BEN LAKHDAR Université de Toulouse UPSINPTLAPLACE(Laboratoire Plasma et Conversion d'Energie)118 route de NarbonneF-31062 Toulouse cedex 9France laboratoire de spectroscopic atomique Moléculaire et Applications(LSAMA)Faculté des Sciences de TunisUniversité de Tunis el Manar1060 TunisTunisia

A method based upon the weighted total cross section （WTCS） theory is proposed to calculate the photo-ionisation cross sections and the radiative recombination rate coefficients between the fundamental level of CO and the main electronic states of its corresponding ion. Total photo-ionisation cross sections and radiative recombination rate coefficients are determined from the calculation of elementary vibrational photo-ionisation cross sections. Transitions be- tween CO＋（X, A and B） and CO（X） are considered. Total photo-ionisation cross sections and recombination coefficients are computed in the temperature interval 500-15000 K.

关键词： CO photo-ionisation cross sections radiative recombination rate coefficients

New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and in Silico ADMET Properties

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International Journal of Organic Chemistry 2024年第3期14卷 107-122页

作者： Marwa Dhiabi Sirine Karoui Mehdi Fakhfakh Souhir Abid Emmanuelle Limanton Rémy Le Guével Thierry Charlier Ludovic Paquin Jean-Pierre Bazureau Houcine Ammar laboratoire de Chimie Applique: Htrocycles Corps et Polymres Facult des Sciences de Sfax Universit de Sfax Sfax Tunisie Institut des Sciences Chimiques de Rennes Universit de Rennes Campus de Beaulieu Rennes Cedex France department of Chemistry (Science and Arts): Al Qurayat Al-Jouf University Al Jawf Saudi Arabia S2Wave Platform ScanMAT UAR CNRS Universit de Rennes Campus de Beaulieu Rennes Cedex France ImPACcell Platform Biosit SFR UMS CNRS Inserm Campus de Villejean Rennes France Institut de Recherche en Sant Environnement et Travail IRSET Inserm UMR_S Rennes France

The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.

关键词： 2-Amino-4H-Chromene 4H-Chromeno[2 3-d]Pyrimidin-3(5H)-Amine Microwave Irradiation Tumoral Cell Line in Silico ADMET

Isovector pairing and particle-number fluctuation effects on the spectroscopic factors of one-proton stripping and one-neutron pick-up reactions in proton-rich nuclei

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Chinese Physics C 2018年第8期42卷 137-158页

作者： Y.Benbouzid N.H.Allal M.Fellah M.R.Oudih laboratoire de Physique Theorique-Facultéde Physique-USTHB BP32 El-Alia16111 Bab-Ezzouar-Alger-Algeria

Expressions of the spectroscopic factors（SFs） corresponding to one-particle transfer reactions have been established using a schematic *** expressions have been derived by taking into account the isovector neutron-proton（np） pairing correlations and a particle-number projection in the framework of the generalized SharpBCS（SBCS） *** proposed expressions of the projected wave-functions of odd-mass nuclei have been used for this *** formalism has first been tested using the single-particle energies of the schematic picketfence *** is shown that the np pairing and particle-number fluctuation effects are far from negligible and they depend on the pairing gap parameter *** behavior is not the same when the parent nuclei are even-even or *** dealing with the SFs corresponding to one-proton stripping and one-neutron pick-up reactions in proton-rich nuclei have then been established within the framework of the realistic Woods-Saxon *** is shown that the np pairing effect as well as the particle-number projection effect are important and thus have to be included in future calculations of the SF corresponding to these kinds of reactions.

关键词： neutron-proton pairing particle-number projection spectroscopic factor

Influence of isovector pairing and particle-number projection effects on spectroscopic factors for one-pair like-particle transfer reactions in proton-rich even-even nuclei

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Chinese Physics C 2018年第4期42卷 171-187页

作者： Y.Benbouzid N.H.Allal M.Fellah M.R.Oudih laboratoire de Physique Theorique-Faculte de Physique-USTHB BP32 El-Alia16111 Bab-EzzouarAlgerAlgeria

Isovector neutron-proton（np） pairing and particle-number fluctuation effects on the spectroscopic factors（SF） corresponding to one-pair like-particle transfer reactions in proton-rich even-even nuclei are studied. With this aim, expressions of the SF corresponding to two-neutron stripping and two-proton pick-up reactions, which take into account the isovector np pairing effect, are established within the generalized BCS approach, using a schematic definition proposed by Chasman. Expressions of the same SF which strictly conserve the particle number are also established within the Sharp-BCS（SBCS） discrete projection method. In both cases, it is shown that these expressions generalize those obtained when only the pairing between like particles is considered. First, the formalism is tested within the Richardson schematic model. Second, it is applied to study even-even proton-rich nuclei using the single-particle energies of a Woods-Saxon mean-field. In both cases, it is shown that the np pairing effect and the particle-number projection effect on the SF values are important, particularly in N =Z nuclei, and must then be taken into account.

关键词： neutron-proton pairing particle-number fluctuations spectroscopic factor

Optical response and SERS properties of individual large scale supracrystals made of small silver nanocrystals

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Nano Research 2015年第5期8卷 1615-1626页

作者： Pierre Aubertin Mohamed Ali Ben Aissa Noureddine Raouafi Suzanne Joiret Alexa Courty Emmanuel Maisonhaute Sorbonne Universites UPMC Univ Paris 06 UMR 8235 Laboratoire Interfaces et Systemes Electrochimiques F-75005 Paris France CNRS UMR 8235 LISE F-75005 Paris France Sorbonne Universites UPMC Univ Paris 06 UMR 8233 Laboratoire MONARIS F-75005 Paris France CNRS UMR 8233 Laboratoire MONARIS F-75005 Paris France laboratoire de Chimie Analytique et Electrochimie Departement de Chimie Faculte des Sciences de Tunis Universite de Tunis El Manar Campus universitaire de Tunis EI-Manar 2092 Tunis El Manar Tunisie

There is a considerable interest in producing and understanding the optical and spectroscopic properties of ordered nanoparticle assemblies. Herein, we describe and interpret the optical absorbance and Raman properties of 5.9 nm ± 0.3 nm diameter silver nanocrystals coated with dodecanethiol and organized in highly ordered 3D superlattices of different heights. Each superlattice was studied individually, which allowed to elaborate a model based on Maxwell-Garnett theory to reproduce qualitatively the height and wavelength dependence of the absorbance. Importantly, because of their small size compared to that of traditional nanoparticles used in Surface Enhanced Raman Spectroscopy （SERS）, the large 3D distribution of hot spots generated by the silver superlattices allowed to easily obtain SERS spectra of the surrounding ligands despite their intrinsic low Raman cross section. Accordingly, traces of thiophenol could be detected very easily.

关键词： nanoparticles nanocrystals superlatfices supracrystals surface enhanced Raman spectroscopy (SERS) plasmonic properties organization

Different Thermostability of Skeletal Muscle Glyceraldehyde-3-phosphate dehydrogenase from Hibernating and Euthermic Jerboa (Jaculus orientalis)

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Acta Biochimica et Biophysica Sinica 2003年第10期35卷 891-896页

作者： IDDAR Abdelghani,CAMPOS Luis A.,SANCHO Javier,SERRANO Aurelio,SOUKRI Abdelaziz laboratoire de Biochimie departamento de Bioquímica y Biología Molecular y Celular departamento de Bioquímica y Biología Molecular y Celular Instituto de Bioquímica Vegetal y Fotosíntesis laboratoire de Biochimie Unitè de Gènie Enzymatique et Biologie Molèculaire Facultè des Sciences-Ain Chock Casablanca Morocco Universidad de Zaragoza Zaragoza Spain Universidad de Zaragoza Zaragoza Spain CSIC-Universidad de Sevilla Sevilla Spain Unitè de Gènie Enzymatique et Biologie Molèculaire Facultè des Sciences-Ain Chock Casablanca Morocco

In previous study, we demonstrated that the specific activity of D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH, EC 1.***.1.12) in skeletal muscle of induced hibernating jerboa (hibernating GAPDH) was 3-4 folds lower than that of the one in the skeletal muscle of the euthermic jerboa (euthermic GAPDH). A significant decrease in both GAPDH protein and GapC mRNA levels occurs when hibernating, but the purified hibernating GAPDH is less active than the euthermic GAPDH. To investigate the physico-chemical basis of this lower activity, the behaviour during thermal inactivation of skeletal muscle GAPDH from hibernating and euthermic tissues was examined by a variety of spectroscopic techniques, including fluorescence emission, circular dichroism and ultraviolet absorption. A clear resistance to thermal denaturation was observed in the hibernating GAPDH compared with the euthermic GAPDH. The different temperature of denaturation found in these proteins by both fluorimetry and circular dichroism indicates that there might exist conformational changes of GAPDH upon hibernation that could affect the stability of this enzyme.

关键词： glyceraldehyde-3-phosphate dehydrogenase hibernation thermal denaturation circular dichroism spectroscopy protein stability

New flavan and unusual chalcone glycosides from Drypetes parvifolia

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Chinese Chemical Letters 2008年第8期19卷 943-946页

作者： Viviane Nadège Nenkep Jovita Chi Shirri Hanh Trinh Van-Dufat Falindor Sipepnou Philippe Vérité Elisabeth Seguin Francois Tillequin Jean Wandji department of Organic Chemistry University of Yaounde-1Faculty of ScienceP.O.Box 812YaoundeCameroon laboratoire de Pharmacognosie de l'Université Paris descartes UMR/CNRS N 8638Faculté des Sciences Biologiques et Pharmaceutiques4-Avenue de l'Observatoire75006 ParisFrance laboratoire de Chimie Analytique UFR de Médecine Pharmacie Rouen22-Bid Gambetta76183 Rouen Cedex 1France laboratoire de Pharmacognosie UFR de Médecine Pharmacie Rouen22-Bld Gambetta76183 Rouen Cedex 1France

Two new compounds 7-hydroxy-5-O-（β-D-glucopyranoside） flavan （1） and （Z）-4＇,6＇-dihydroxy-2＇-O-（β-D-glucopyranoside） chalcone （2）, along with eight known compounds, were isolated from the stem bark of Drypetes parvifolia （Euphorbiaceae）. Their structures were established on the basis of spectroscopic analysis and chemical evidence.

关键词： Drypetes parvifolia Flavonoid glycosides 7-Hydroxy-5-O-(β-D-glucopyranoside) flavan (Z)-4',6'-Dihydroxy-2'-O-(β-D-glucopyr-anoside) chalcone

A new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata

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Chinese Chemical Letters 2011年第2期22卷 171-174页

作者： Simone Veronique Fannang Victor Kuete Celine Mbazoa Djama Marlise Diane J.Dongfack Jean Duplex Wansi Francois Tillequin Elisabeth Seguin Elizabeth Chosson Jean Wandji laboratoire de Synthese et de Produits Naturels Departement de Chimie Organique de l'Universite de Yaounde-1Faculte des SciencesP.O.Box 812 YaoundeCameroon department of Biochemistry University of DschangFaculty of ScienceP.O.Box 67 DschangCameroon laboratoire de Pharmacognosie de l'Universite Paris descartes UMR/CNRS No.8638Faculte des Sciences Biologiques et Pharmaceutiques4-Avenue de l'Observatoire75006 ParisFrance department of Chemistry University of DoualaFaculty of ScienceP.O.Box 24157 DoualaCameroon laboratoire de Pharmacognosie UFR de Medecine Pharmacie Rouen22-Bld Gambetta76183 Rouen Cedex 1France

A new friedelane-type triterpene named 3β-hydroxyfriedelane-7,12,22-trione,as well as nine known compounds were isolated from the whole stems of Drypetes laciniata Hutch.（Euphorbiaceae）.Their structures were established on the basis of spectroscopic *** new triterpene derivative and a known saponin were tested for antimicrobial and antifungal activities and they appeared to be moderate active.

关键词： Drypetes laciniata Euphorbiaceae Stem Friedelane-type triterpenoid Antimicrobial activity

Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 598-603页

作者： Monia deghrigue Carmen Festa Lotfi Ghribi Maria Valeria D’Auria Simona de Marino Hichem Ben Jannet Abderrahman Bouraoui laboratoire de développement chimique galénique et pharmacologique des médicaments (LR12ES09).Equipe de Pharmacologie marineFaculté de pharmacie de MonastirUniversité de Monastir department of Pharmacy University of Naples "Federico II" laboratoire de chimie hétérocyclique produits naturels et réactivité. Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir laboratoire de chimie hétérocyclique produits naturels et réactivité.Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir

Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions(ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/Et OH induced gastric ulcers in rats. The purification and structure elucidation of compound(s) from the more effective fraction were determined by chromatographic and spectroscopic methods and in comparison with data reported in the literature. Results: The fraction F-Et OH showed an important antiinflammatory activity associated with significant analgesic and gastroprotective properties. The purification and structure elucidation of compound(s) from this fraction lead to the identification of one diterpenoid and four sterols. Conclusions: These results suggested that components from the active fraction can be used to treat various anti-inflammatory diseases.

关键词： Eunicella singularis Anti-inflammatory activity Analgesic activity Gastroprotective effect Diterpenoid Sterols

Evaluation of in vitro antioxidant and apoptotic activities of Cyperus rotundus

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Asian Pacific Journal of Tropical Medicine 2014年第2期7卷 105-112页

作者： Kilani-Jaziri Soumaya Ghedira Zied Nasr Nouha Krifa Mounira Ghedira Kamel Franca Dijoux Marie Genviève Ghedira Chekir Leila Unité de Substances Naturelles Bioactives et Biotechnologies UR12ES12.Universite de Monastic Faculte de Pharmacie de Monastir laboratoire de Biologie Moleculaire et Cellulaire Faculté de Medecine Dentaire de MonastirUniversite de MonastirRue Aricenne5019 MonastirTunisie laboratoire de Botanique.Pharmacognosie et Phytothérapie UMR CNRS 5557 Ecologie Microbienne Institut des Sciences Pharmaceutiques et Biologiques-Faculte de Pharmacie Université Claude Bernard Btiment Netien-8 Avenue Rockefeller-69373 Lyon cedex 08France

Objective:To evaluate in vitro antioxidant and apoptotic activities of Crperus rotundas(***).Methods:The phytochemical study and the antioxidant activities of both methanol and aqueous extracts from *** aerial part were *** addition,these extracts were also investigated for their cytotoxic and apoptotic *** major compound of the methanol extract was *** metlianol and aqueous extracts(300,150,and 50μg/mL)were evaluated for their antioxidant activity by the xanthine/xanthine oxidase assay ***,16,8,and 4 mg/mL of each extract were tested to investigate their *** scavenging *** extract(800,*** 200μg/mL)and melhunol extract(350,175,and 88μg/mL)were tested against lipid peroxidation,induced by 75μM H_2O_2,The cytotoxicity(by MTT assay)and cell DNA fragmentation of both extracts were evaluated Inwards K562 and L1210 cell *** major compound was obtained from the butanol fraction of methanol extract and its structure was determined by KMN spectroscopic ***:The methanol and aqueous extracts showed respectively,88%and 19%inhibition of xanthine oxidase *** same extracts inhibited lipid peroxidation by 61.5%and 42.0%.*** extracts inhibited *** by 27.1%and 25.3%,*** methanol cxtract induced DNA *** was determined as the major compound isolated from the butanol fraction of metlianol ***:It appears that *** extracts exhibit a potential use as a natural antioxidant and an apoptosis inducer.

关键词： Polyphenols Orientin Xanthine/Xanthine oxidase assay Lipid peroxidation assay deoxyribose assay DNA fragmentation