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Psycho-Oncologie 2024年第2期18卷 137-146页

作者： Laure Salomé Jérémy Martin Camille Baussant-Crenn Cécile Flahault Institut de psychologie UniversitéParis CitéBouologne-Billancourt92774France Fondation Oeuvre de la Croix Saint-Simon Service d’hospitalisationàdomicileParis75019France laboratoire de psychopathologie et processus de santéur4057 UniversitéParis CitéBoulogne-Billancourt92774France

Aim:To investigate parents’experience of home care for children in oncology in order to identify the benefits,expectations,and possible difficulties *** and methods:A qualitative method was adopted,with non-directive interviews conducted with nine participants,then analyzed using thematic content ***:The main recurring themes in the discourse include:(1)relief,(2)positive representation of home,(3)positive representation of home care,and(4)negative representation of home *** these parents,home care appears to be positive overall,even though the introduction of home care is often reported as a source of stress for ***:These results must be interpreted with caution,but they do support previous research and highlight certain recommendations for further improving this experience,particularly for parents,but also for the sick child and the family.

关键词： Home care parents oncology pediatric children

Assessment of a Multimodal Strategy for Information and Collection of Advance Directives in a Comprehensive Cancer Center:description of the Study Protocol

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Psycho-Oncologie 2024年第4期18卷 367-375页

作者： Léonor Fasse François Blot laboratoire psychopathologie et processus de santé(ur 4057) Institut de PsychologieUniversitéParis CitéBoulogne92100France Département Interdisciplinaire d’Organisation du Parcours Patient Institut Gustave RoussyUniversitéParis SaclayVillejuif94805France

Background:Information on the possibility of drawing up Advance Directives(AD)is a necessity,and represents a major medical,ethical,and legal *** difficulties are numerous,both organizational and cultural,and this is also true in the context of oncology,where ADs(and more broadly,advanced palliative care)are of critical *** an eminently sensitive subject,dealing with ADs(and therefore with end-of-life issues)requires both societal and medical/health-care *** institutional approach has therefore been developed,to deploy information tools,training professionals,and formalize the collection of *** an approach cannot be implemented without an assessment not only of its objective results but also above all of its psychological effects,on both users(patients,family caregivers)and ***:This longitudinal study,based on a mixed-method,interdisciplinary approach,will assess the impact of this information dissemination on AD,in terms of both potential positive and negative effects,using validated measurement ***,this study follows the 5 criteria of the RE-AIM model,designed to analyze the interest and impact of a device intended for users of the healthcare system;we will use a mixed methodology,relying on both a quantitative component(counting the number of people benefiting from the scheme,and those requesting support in drawing up their DA...,administering questionnaires),as well as a qualitative component(focus groups)which will enable us to study the subjective experiences of users,their relatives and the professionals involved in the ***:The results of this study will make it possible to determine the effects of this system of assistance in the drafting of ADs,which is currently being promoted by the legislator,but which is struggling to be implemented.

关键词： Advance directive cancer palliative care living wills end of life shared-decision making

Conducting Multi-Inter or Transdisciplinary Research in Oncology:What to Expect?How to Prepare?

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Psycho-Oncologie 2024年第4期18卷 377-379页

作者： Cassandra Patinet Diane Boinon Sylvie Dolbeault UnitéTransversale de Recherche en Psychogénèse et psychopathologie UniversitéSorbonne Paris NordVilletaneuse93430France Centre Hospitalier Intercommunal de Créteil Unitéde médecine de l’adolescentCréteil94000France laboratoire UTRPP UniversitéSorbonne Paris NordVilletaneuse93430France Gustave-Roussy Unitéde psycho-oncologieVillejuifF-94805France laboratoire de psychopathologie et processus de santé UniversitéParis CitéBoulogne-BillancourtF-92100France Psycho-Oncology and Social Service Supportive Care DepartmentInstitut CurieParis75005France

Introduction La modification du regard portésur l’objet«soin»affecte les pratiques de soin,dans une réflexion non plus uniquement centrée sur le remède,sur le soin en tant que«cure»,mais sur«la façon dont on donne le soin»[1]au sens oùWinnicott entend le《care-cure》[2];favorisant ainsi le développement de pratiques de soin innovantes,portée par une réflexion collective et pluridisciplinaire autour des *** le soin en oncologie ne peut plus se penser ni se pratiquer en dehors d’une rencontre pluridisciplinaire autour du patient,il en va de même pour la recherche dans le domaine du cancer.

关键词： naire des collective

Mener des recherches pluridisciplinaires en SHS dans le domaine du cancer:quels leviers,quels freins?Conducting Multidisciplinary SHS Research in the Field of Cancer:Strengths and Barriers?

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Psycho-Oncologie 2024年第2期18卷 101-107页

作者： Sylvie Dolbeault Manon Fontaine Diane Boinon Service Psycho-Oncologie et Social Département de Soins de SupportInstitut CurieParis75005France SHARE PSL UniversityParis75005France CESP UniversitéParis SaclayVillejuif91190France Institut la Personne en Médecine Institut de Recherche Saint LouisUniversitéParis CitéParis75013France Institut de Psycho-Oncologie Gustave RoussyVillejuif94805France laboratoire de psychopathologie et processus de santé UniversitéParis CitéBoulogne-Billancourt92100France

This paper summarizes the work held at the Cancéropôle Ile-de-France's annual SHS research seminar on the theme:Pluridisciplinarity and methods for SHS research in thefield of *** clarifying the concepts of pluri-,inter-,and transdisciplinarité,it aimed to describe how this type of research is carried out in practice,addressing successively:the role of stakeholders and their respective positions,the need for a shared language,the various temporalities involved and task sharing,the interview and analysis methods as well as the implication of *** highlighted the personal qualities required to practice this type of research,such as psychologicalﬂexibility and adaptability,a strong desire for collaborative work,acceptance of risk,and a humble stance.

关键词： SHS research interdisciplinarity pluridisciplinarity strengths and barriers oncology

Orf1/SpcS Chaperones ExoS for Type Three Secretion by Pseudomonas aeruginosa

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Biomedical and Environmental Sciences 2008年第2期21卷 103-109页

作者： DA-KANG SHEN LAurIANE QUENEE MARIetTE BONNet LAurIANE KUHN MADIHA deROUAZI DANIELE LAMOTTE BERTRAND TOUSSAINT BENOIT POLACK Groupe de Recherche et d'etude du processus Inflammatoire (GREPI) MENRT EA 2938 Centre Hospitalier Universitaire de Grenoble BP 217 38043 Grenoble Cedex 9 France laboratoire de Chimie des Protéines DRDC CEA Grenoble 38054 Grenoble France

Objective Pseudomonas aeruginosa is a ubiquitous and opportunistic pathogen that uses the type Ⅲ secretion system （TTSS） to inject effector proteins directly into the cytosol of target cells to subvert the host cell＇s functions. Specialized bacterial chaperones are required for effective secretion of some effectors. To identify the chaperone of ExoS, the representative effector secreted by the TTSS of P aeruginosa, we analyzed the role of a postulated chaperone termed Orfl. Methods By allelic exchange, we constructed the mutant with the deletion of gene Orfl. Analysis of secreted and cell-associated fractions was performed by SDS-PAGE and Western blotting. Using strain expressing in trans Orfl, tagged by V5 polypeptide and histidine, protein-protein interaction was determined by affinity resin pull-down assay in combination with MALDI-TOF The role of Orfl in the expression of exoS was evaluated by gene reporter analysis. Results Pull-down assay showed that Orfl binds to ExoS and ExoT. Secretion profile analysis showed that Orfl was necessary for the optimal secretion of ExoS and ExoT. However, Orfl had no effect on the expression of exoS. Conclusion Orfl is important for the secretion of ExoS probably by maintaining ExoS in a secretion-competent conformation. We propose to name Orfl as SpcS for ＂specific Pseudomonas chaperone for ExoS＂.

关键词： Type Ⅲ secretion system Pseudomonas aeruginosa Chaperone

Pour un accompagnement des familles endeuillées avec un enfant en basâge Supporting Bereaved Families with Young Children

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Psycho-Oncologie 2024年第3期18卷 201-211页

作者： Marthe Ducos Voskan Kirakosyan Nathalie Duriez Centre de Lutte Contre le Cancer Institut BergoniéBordeaux33063France CAPS Composante urm RPpsy—15297 Universitéde PoitiersPoitiers86000France laboratoire psychopathologie et processus de changement(LPPC)—UniversitéParis 8 Paris75001France Groupe SOS Solidarité Pôle Addiction IDFCSAPA SOS 75 Site MonceauParis75001France

Objective:The violent death of a young parent from cancer has a profound effect on both spouse and *** family must adapt to the absence of the bereaved and reorganize to raise the children as best they *** young children are particularly vulnerable,as they are generally unable to express their *** give them a voice,we have designed an innovative system,The Little Match Girl,as part of a health democracy ***:We assessed the effects of their participation in the group for a population of eight children and their *** six parents assessed their child(ren)’s emotion regulation before and after therapy using the ERC-vf *** FACES IV enabled us to assess the cohesion and adaptability of each ***:All eight children showed improved emotion *** program promotes family ***,difficulties persist in rigid or disengaged ***:We hope that other cancer centers will follow our model to give a place to very young children dealing with the death of a parent from cancer,and to encourage family empowerment.

关键词： Cancer bereavement in young children emotion regulation health democracy discussion group

Electrochemical synthesis and the functionalization of few layer graphene in ionic liquid and redox ionic liquid

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Science China Chemistry 2018年第5期61卷 598-603页

作者： Maria Gómez-Mingot Amarnath Chellachamy Anbalagan Hyacinthe Randriamahazaka Jalal Ghilane Universite Paris Diderot Sorbonne Paris Cite ITODYS UMR 7086 CNRS SIELE group Paris 75013 France laboratoire de Chimie des processus Biologiques UMR 8229 CNRS University Pierre et Marie Curie College de France Paris 75231 France Chemistry Division Bhabha Atomic Research Centre Trombay Mumbai 400085 India

Electrochemical reductive exfoliation of graphite to few layered graphene(FLG) in presence of 1-ethyl-2,3-dimethyl imidazolium bis(trifluoromethylsulfonyl) imide ionic liquid and redox ionic liquid based ferrocene has been investigated. Thus, by applying a mild negative potential(-2.7 V vs. Fc/Fc^+) to carbon electrode in ionic liquid graphene flakes could be generated. The generated materials have been characterized by X-ray photoelectron spectroscopy, Raman spectroscopy, high resolution transmission electron microscopy and atomic force microscopy. XPS and Raman analysis show that the electrochemical reductive exfoliation provides the formation of FLG. The thickness of the resulting FLG was found to be ranged between 4 and1 nm. HR-TEM images reveal the formation of few graphene layers and in some cases single graphene layer was ***, this electrochemical route conduces to the formation of ionic liquid functionalized FLG. Finally, the reductive exfoliation was further investigated in the presence of redox ionic liquid. XPS and electrochemical measurements confirm the presence of ferrocene.

关键词： electrochemistry reductive exfoliation ionic liquid graphene

The Impact of Adolescent and Young Adult Cancer-AJA-on Family *** of Family Relationships in Terms of Adaptability and Cohesion

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Psycho-Oncologie 2024年第4期18卷 337-347页

作者： Voskan Kirakosyan Manon Arnoult Maître de conférences en psychologie clinique et psychopathologie UniversitéParis NanterreParis92001France

Objectives:The arrival of cancer in adolescents and young adults(aged 15 to 24 years)-Adolescents and young adults(AJA)-corresponds to a fragile period during which the adulthood of the young person and the evolution of family ties mobilize the family as a ***,cancer,beyond its individual traumatic dimension,affects the whole family,which can modify family ties and family *** objective is to evaluate family functioning from the complex model evaluating cohesion and adaptability when an adolescent or young adult has ***:Adolescents and young adults with cancer(n=41),mothers(n=41),and fathers(n=13)participated in this *** completed the Family Adaptation and Cohesion Scales(FACES Ⅲ)*** functioning when an aya is ill has been compared to that of families without any ***:a comparison of the mean scores of perceived cohesion and adaptability of face Ⅲ indicates no significant difference for *** contrast,the averages of the adaptability scores of our sample with those of the general population indicate that families with cancer hais generally feel more“adaptable”than the non-clinical *** results are statistically significant for AJA,but also for mothers and *** the mean scores of ideal cohesion and ideal adaptability,there are no significant differences between fathers in our sample and fathers in the general *** contrast,mothers in our sample had less ideal adaptability than those in the general *** aya patients with cancer,the scores of both adaptability and cohesion were significantly different from those of non-diseased ***:Cancer leads to many changes in family relationships,making it difficult to empower the young patient and latent the evolution of the relationship.

关键词： Adolescent and young adult cancer and family and family functioning family relations relations

Comparative Study between Different Modulation Strategies for Five Levels NPC Topology Inverter

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Energy and Power Engineering 2011年第3期3卷 276-284页

作者： Noureddine Ould Cherchali Abdelhalim Tlemcani Mohemed Seghire Boucherit Linda Barazane laboratoire de Recherche en Electrotechnique et Automatique Universite de MedeaMedeaAlger laboratoire de Commande des processus Ecole Nationale PolytechniqueAlgiersAlger Faculte d’Electronique Universite des Sciences et de la Technologie Houari BoumedieneAlgiersAlger

The object of this paper is the study of various modulation strategies applied to the five-level inverter neutral-point-clamped NPC topology. Firstly we presented the structure of the voltage inverter three-phase five-level NPC topology. After that we model the inverter and the inverter are controlled by different strategies and then we made a comparative study between the results given by different strategies.

关键词： Multilevel Five Levels NPC SHEPWM SPWM Hysteresis Control

The multifaceted question of the prescription of antidepressants during pregnancy

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上海精神医学 2013年第5期25卷 317-318页

作者： Gisèle Apter Emmanuel devouche Erasme Hospital Psychiatry and Psychopathology Research Institute Paris France University Paris Diderot Paris France. Erasme Hospital Psychiatry and Psychopathology Research Institute Paris France University Paris Descartes Laboratoire Psychopathologie et Processus de Santé Paris France.

Pregnancy has long been considered a period of bliss,free of psychiatric *** was even supposed that if such conditions preexisted,they would momentarily be miraculously suspended.[1]Numerous studies have now shown tha... 详细信息

关键词：怀孕期间抗抑郁药处方精神障碍精神分裂症抑郁症 TSL