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Protective behaviors regarding coastal flooding risk in a context of climate change

Advances in Climate Change Research 2020年第4期11卷 310-316页

作者： Colin LEMEE Oscar NAVARRO Diego RESTREPO-OCHOA denis MERCIER Ghozlane FLEURY-BAHI University of Brest Brest29200France laboratoire de psychologie des pays de la loire University of NantesNantes44312France CES University Medellin050022Colombia laboratoire de Geographie Physique(UMR 8591-CNRS) Sorbonne UniversiteParis75000France

The physical vulnerability of coastal areas due to rising sea level and the flooding risk consequent,does not guarantee the implementation of protective behaviors by these risk zones’*** study aims to establish the link between the willingness to carry out protective behaviors and physical and perceived indicators of vulnerability.A typology of coastal flooding vulnerability,uses various physical indicators and their perceived counterparts which have been collected from 490 inhabitants of Cartagena(Colombia,declared world heritage of humanity by UNESCO in 1984),resident in areas of coastal flooding *** item-response theory(IRT)approach has been *** results reveal that the implementation of protective behaviors is more related to perceived indicators,such as distance to the sea,than to actual physical *** observe that physical vulnerability is linked to the intention to carry out protective *** presence of a defensive structure against coastal flooding could be considered as a visual cue and be a good predictor of the willingness to carry out protective *** the contrary,people in the most vulnerable situation(single-storey house)do not demonstrate a higher level of willingness to carry out protective behavior,as well of participants who lived in residential buildings which have demonstrated lower level of willingness to carry out such ***,vulnerability of the house is not seen as a criterion that encourages participants to better protect themselves.

关键词： Coastal flooding risk Protective behaviors Climate change Vulnerability Item response theory

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Effect of Geogenic Lead on Fungal and Collembolan Communities in Garden Topsoil

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土壤圈：英文版 2018年第2期28卷 215-226页

作者： Sophie JOIMEL Hervé CAPIAUX Christophe SCHWARTZ Mickael HEDde Thierry LEBEAU Cécile LE GUERN Johanne NAHMANI Céline PERNIN Sandrine SALMON Lucia SANTORUFO Béatrice BECHET Jérome CORTET Université de Lorraine Laboratoire Sols et Environnement UMR 1120 Vandceuvre-lès-Nancy 54500 (France) INRA Laboratoire Sols et Environnement UMR 1120 Vandceuvre-lès-Naney 54500 (France) UMR ECOSYS INRA AgroParisTech Universitè Paris-Saclay Thiverval-Grignon 78850 (France) Plateforme d'Analyse Moléculaire Biodiversitg-Environnement IUT Ggnie Biologique La Roche sur Yon 85035 (France) Institut de Recherche sur les Sciences et Techniques de la Ville (IRSTV) CNRff 2488 Ecole Centrale de Nantes 1 rue de la Noē Nantes 44321 (France) laboratoire Plandtologie & Gdodynamique Nantes Faculté des Sciences et des Techniques 2 rue de la Houssinière Nantes 44322 (Franee) Bureau de Reeherches Gdologiques et Minières (BRGM) Regional Geological Survey Direction Régionale des Pays de la Loire 1 rue des Saumonières Nantes 44000 (France) UMR CEFE 5175 Universitd de Montpellier EPHE Université Paul-Valdry Montpellier Montpellier 34199 (France) Université Lille 1 EA 4515 Laboratoire Gdnie Civil & Géo Environnement Villeneuve D'Ascq 59655 (France) Musdum National d'Histoire Naturelle CNRS UMR 7179 4 Avenue du Petit-Chateau Brunoy 91800 (France) department of Biology University of Naples Federico Ⅱ Via Cinthia Naples 80126 (Italy) French Institut of Science and Technology for Transport Development and Networks Water and Environment Laboratory Route de Bouaye Bouguenais 44344 (France)

Geogenic lead (Pb) is considered to be less bioavailable than anthropogenic Pb and exerts less effect on the soil fauna. However,Pb contamination in vegetables has been reported in the case of geogenic anomalies, even at moderate concentrations (around 170 mgkg^(-1)). In this study, we investigated collembolan communities using both taxonomic- and trait-based approaches and observed fungal communities to assess the effects of a moderate geogenic Pb anomaly on collembolans and fungi in an urban vegetable garden *** indicated that geogenic Pb indeed modified fungi communities and altered the functional structure of collembolan communities in garden soils. Although geogenic Pb presented low bioavailability, it affected soil fauna and vegetables similar to anthropogenic Pb.

关键词： functional diversity functional trait soil fauna soil food web vegetable garden urban soil

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NumericalMethods for Balance laws with Space dependent Flux:Application to Radiotherapy Dose Calculation

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Communications in Computational Physics 2011年第10期10卷 1184-1210页

作者： Christophe Berthon Martin Frank Celine Sarazin Rodolphe Turpault Universite de Nantes Laboratoire de Mathematiques Jean LerayUMR66292 rue de la HoussiniereBP 9220844322 Nantes Cedex 3France RWTH Aachen University MathematicsCenter for Computational Engineering ScienceSchinkelstrasse 252062 AachenGermany

The present work is concerned with the derivation of numerical methods to approximate the radiation dose in external beam *** address this issue,we consider a moment approximation of radiative transfer,closed by an entropy minimization *** model under consideration is governed by a system of hyperbolic equations in conservation form supplemented by source *** main difficulty coming from the numerical approximation of this system is an explicit space dependence in the flux ***,this dependence will be seen to be stiff and specific numerical strategiesmust be derived in order to obtain the needed accuracy.A first approach is developed considering the 1D case,where a judicious change of variables allows to eliminate the space dependence in the flux *** is not possible in *** therefore reinterpret the 1D scheme as a scheme on two meshes,and generalize this to 2D by alternating transformations between separate *** call this procedure projection *** numerical experiments,coming from medical physics,illustrate the potential applicability of the developed method.

关键词： Radiotherapy hyperbolic system of conservation laws source term approximations finite volume methods

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ABA-Mediated Inhibition of Germination Is Related to the Inhibition of Genes Encoding Cell-Wall Biosynthetic and Architecture： Modifying Enzymes and Structural Proteins in Medicago truncatula Embryo Axis

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Molecular Plant 2009年第1期2卷 108-119页

作者： Christine Gimeno-Gilles Eric Lelievre laure Viau Mustafa Malik-Ghulam Claudie Ricoult Andreas Niebel Nathalie Leduc Anis M. Limami University of Angers UMR_A 1191 Physiologie Moleculaire des Semences (PMS) 2 Bd Lavoisier F-49045 Angers France UMR 441 CNRs-INRA Laboratoire de Biologie Moleculaire des Relations Plantes Micro-organismes (LIPM) Castanet-Tolosan 31326 cedex France University of Angers UMR Sciences Agronomiques Appliques a I'Horticulture (SAGAH) 2 Bd Lavoisier F-49045 Angers France

Radicle emergence and reserves mobilization are two distinct programmes that are thought to control germination. Both programs are influenced by abscissic acid （ABA） but how this hormone controls seed germination is still poorly known. Phenotypic and microscopic observations of the embryo axis of Medicago truncatula during germination in mitotic inhibition condition triggered by 10 μM oryzalin showed that cell division was not required to allow radicle emergence. A suppressive subtractive hybridization showed that more than 10% of up-regulated genes in the embryo axis encoded proteins related to cell-wall biosynthesis. The expression of α-expansins, pectin-esterase, xylogucan-endotransglycosidase, cellulose synthase, and extensins was monitored in the embryo axis of seeds germinated on water, constant and transitory ABA. These genes were overexpressed before completion of germination in the control and strongly inhibited by ABA. The expression was re-established in the ABA transitory-treatment after the seeds were transferred back on water and proceeded to germination. This proves these genes as contributors to the completion of germination and strengthen the idea that cell-wall loosening and remodeling in relation to cell expansion in the embryo axis is a determinant feature in germination. Our results also showed that ABA controls germination through the control of radicle emergence, namely by inhibiting cell-wall loosening and expansion.

关键词： ABA cell-wall expansion germination Medicago truncatula radicle emergence XET.

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EGFR Expression Is Unreliable to decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Philippe deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi de Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian laboisse Eric lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda delphine Déniel lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et pays de la loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH laval France Polyclinique Cesson Sévigné France laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France laboratoire d’anatomie et de cytologie pathologiques Rennes France laboratoire d’anatomie et de cytologie pathologiques Angers France laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

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Path probability for a Brownian motion

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Chinese Science Bulletin 2011年第34期56卷 3736-3740页

作者： LIN TongLing PUJOS Cyril OU CongJie BI WenPing CALVAYRAC Florent WANG Qiuping Alexandre LUNAM Universite ISMANS Laboratoire de Physique Statistique et Systemes Complexes 44 Avenue F.A. Bartholdi 72000 Le Mans France LPEC Universite du Maine Ave. O. Messiaen 72035 Le Mans France College of Information Science and Engineering Huaqiao University Quanzhou 362021 China laboratoire d＇Acoustique Universite du Maine Ave. O. Messiaen 72085 Le Mans Cedex 9 France

This work reports on numerical simulations of Brownian motion in the non-dissipative limit. The objective was to prove the existence of path probability and to compute probability values for some sample paths. By simulating a large number of particles moving from point to point under Gaussian noise and conservative forces, we numerically determine that the path probability decreases exponentially with increasing lagrangian action of the paths.

关键词：样本路径布朗运动概率值数值模拟高斯噪声拉格朗日非耗散点对点

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