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Theranostics:纳米热疗法或可软化肿瘤,提高癌症靶向疗法的治疗效率

现代生物医学进展 2017年第3期17卷 I0003-I0003页

作者： Iris Marangon Amanda A. K. Silva Thomas Guilbert Jelena Kolosnjaj-Tabi Carmen Marchiol Sharuja Natkhunarajah Foucault Chamming’s Cécilia Ménard-Moyon Alberto Bianco Jean-Luc Gennisson Gilles Renault Florence Gazeau laboratoire Matière et Systèmes Complexes (MSC) CNRS-UMR 7057 Université Paris Diderot Sorbonne Paris Cité 10 rue Alice Domon et Léonie Duquet F-75205 Paris Cedex 13 France Plateforme Imagerie Institut Cochin Inserm U1016-CNRS UMR8104-Université Paris Descartes Sorbonne Paris Cité Paris 22 rue Méchain 75014 Paris France PARCC Inserm U970 Paris Cardiovascular Research Center-PARCC / Université Paris-Descartes Sorbonne Paris Cité 56 rue Leblanc 75015 Paris France University of Strasbourg CNRS Immunopathology and Therapeutic Chemistry UPR 3572 67000 Strasbourg France Institut Langevin CNRS-UMR 7587 1 place Jussieu 75205 Paris France.✉ Corresponding author: Florence GAZEAU rf.toredid-sirap-vinu@uaezag.ecnerolf. Tel: +33 (0)1 57 27 62 03 Fax: +33 (0)1 57 27 62 11.Competing Interests: The authors have declared that no competing interest exists.

肿瘤的机械阻力和标准疗法的附带损伤往往会阻碍抵御癌症的效果，近日，来自法国国家健康与医学研究所等机构的研究人员通过对肿瘤加热成功软化了恶性肿瘤，这种方法称之为纳米热疗法，其能够让肿瘤对治疗制剂更加敏感，相关研究刊登于... 详细信息

肿瘤的机械阻力和标准疗法的附带损伤往往会阻碍抵御癌症的效果，近日，来自法国国家健康与医学研究所等机构的研究人员通过对肿瘤加热成功软化了恶性肿瘤，这种方法称之为纳米热疗法，其能够让肿瘤对治疗制剂更加敏感，相关研究刊登于国际杂志Theranostics上。

关键词：恶性肿瘤热疗法软化纳米癌症疗效附带损伤机械阻力

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Hepatocyte apoptosis fragment product cytokeratin-18 M30 level and non-alcoholic steatohepatitis risk diagnosis:an international registry study

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Chinese Medical Journal 2023年第3期136卷 341-350页

作者： Huai Zhang Rafael S.Rios Jerome Boursier Rodolphe Anty Wah-Kheong Chan Jacob George Yusuf Yilmaz Vincent Wai-Sun Wong Jiangao Fan Jean-Francois Dufour George Papatheodoridis Li Chen Jorn M.Schattenberg Junping Shi Liang Xu Grace Lai-Hung Wong Naomi F.Lange Margarita Papatheodoridi Yuqiang Mi Yujie Zhou Christopher D.Byrne Giovanni Targher Gong Feng Minghua Zheng department of Biostatistics and Medical Record The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China department of Hepatology MAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Service d’Hépato-Gastroentérologie et Oncologie Digestive Centre Hospitalier Universitaire d’AngersAngersFrance laboratoire HIFIH UPRES EA3859SFR ICAT 4208Universitéd’AngersAngersFrance Université Cote d’Azur CHUINSERMU1065C3M06204 NiceFrance Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyNSWAustralia department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey department of Gastroenterology School of MedicineRecep Tayyip Erdogan UniversityRizeTurkey department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong 999077China department of Gastroenterology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China University Clinic for Visceral Surgery and Medicine InselspitalUniversity Hospital BernBernSwitzerland Graduate School for Health Sciences University of BernBernSwitzerland Academic department of Gastroenterology Medical School of National and Kapodistrian University of AthensGeneral Hospitalof Athens“Laiko”AthensGreece department of Gastroenterology Ruijin HospitalShanghai 200000China Metabolic Liver Research Program I Department of MedicineUniversity Medical Center MainzMainzGermany The Affiliated Hospital of Hangzhou Normal University HangzhouZhejiang 310000China Tianjin Second People’s Hospital Tianjin 300000China Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and HepatologyMinistry of HealthRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Institute of Digestive DiseaseShanghai 200000Ch

Background:Liver biopsy for the diagnosis of non-alcoholic steatohepatitis(NASH)is limited by its inherent invasiveness and possible sampling *** studies have shown that cytokeratin-18(CK-18)concentrations may be useful in diagnosing NASH,but results across studies have been *** aimed to identify the utility of CK-18 M30 concentrations as an alternative to liver biopsy for non-invasive identification of ***:Individual data were collected from 14 registry centers on patients with biopsy-proven non-alcoholic fatty liver disease(NAFLD),and in all patients,circulating CK-18 M30 levels were *** with a NAFLD activity score(NAS)≥5 with a score of≥1 for each of steatosis,ballooning,and lobular inflammation were diagnosed as having definite NASH;individuals with a NAS≤2 and no fibrosis were diagnosed as having non-alcoholic fatty liver(NAFL).Results:A total of 2571 participants were screened,and 1008(153 with NAFL and 855 with NASH)were finally *** CK-18 M30 levels were higher in patients with NASH than in those with NAFL(mean difference 177 U/L;standardized mean difference[SMD]:0.87[0.69–1.04]).There was an interaction between CK-18 M30 levels and serum alanine aminotransferase,body mass index(BMI),and hypertension(Pder the receiver operating characteristics(AUROC)for NASH was 0.750(95%confidence intervals:0.714–0.787),and CK-18 M30 at Youden’s index maximum was 275.7 U/*** sensitivity(55%[52%–59%])and positive predictive value(59%)were not ***:This large multicenter registry study shows that CK-18 M30 measurement in isolation is of limited value for non-invasively diagnosing NASH.

关键词： Apoptosis Diagnosis Cytokeratin-18 Liver histology Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease

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