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Immunovirological Discordance and Associated Factors among People Living with HIV under Antiretroviral Treatment at Hôpital de Jour de Donka, Guinea

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Open Journal of Medical Microbiology 2024年第2期14卷 93-104页

作者： Mariama Sadjo Diallo Djiba Kaba Charles Tchibinda delicat Issiaga Diallo Boh Fanta Diane Doufin Traore Ousmane Niabaly Oumar Mouctar Diallo Ouo-Ouo Yaramon Kolie Aly Patrice Kamano Pascal Koivogui Ahmed Sékou Keita Mohamed Macire Soumah Thierno Mamadou Tounkara Mohamed Cisse Facult des Sciences et Techniques de la Sant Universit Gamal Abdel Nasser de Conakry Conakry Guine laboratoire de biologie molculaire nestor bangoura/helene labrousse Hpital de Jour Donka CHU Donka Conakry Guine Centre dexcellence Africain Pour la Prvention et le Contrle des Maladies Transmissibles Conakry Guine Service de dermatologie-Vnrologie CHU Donka Conakry Guine

The antiretroviral treatment (ART) has significantly reduced the number of new HIV/AIDS infections and related deaths. However, cases of immunovirological discordance (IVD) are found in various locations. The objective of this study was to determine the profile of People living with HIV (PLHIV) with IVD and to identify associated factors. We conducted a cross-sectional study based on the records of PLHIV under ART for at least 6 months, followed at Hpital de Jour Donka from 2015 to 2017, and having both viral load (CV) and CD4 T-cell count. Prevalence of IVD was 34.57%, with 23.87% for immunological discordance (ID) and 10.7% for virological discordance (VD). Females were predominant (66.26%), and male gender influenced IVD with a statistically significant difference (p = 0.006) and was associated with VD (p = 0.007). The average age was 38.77 11.30 years. PLHIV were classified at WHO stages 3 and 4 (86.01%). The median initial haemoglobin level was 11.5 g/L [3.2 - 12]. The mean initial CD4 T-cell count was 272.84 cells/mm3 201.6. The median initial viral load (VL) was 147,337 copies/mL [1092 - 31,675,000]. The initial CD4 T-cell count 3 was associated with IVD with a statistically significant difference (p = 0.0009) and correlated with ID (p = 0.000). Prurigo was associated with IVD with a statistically significant difference (p = 0.003). Cerebral toxoplasmosis was not associated with IVD but was associated with ID (p = 0.04). This study allowed us to describe the profile of PLHIV with IVD. The main associated factors were male gender, initial CD4 T-cell count 3, toxoplasmosis, prurigo, and herpes zoster.

关键词： HIV Antiretroviral Treatment (ART) Immunovirological Discordance Donka Guinea

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Nutritional and Sanitary Quality of Infant Flours Produced in Ouagadougou, Burkina Faso

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Food and Nutrition Sciences 2024年第8期15卷 727-743页

作者： Léa Kilô Adam Bayala-Yaï Philippe Augustin Nikièma Hassane Sangaré Fabrice Bationo Imael Henri nestor Bassolé Jacques Simpore laboratoire de biologie molculaire et de Gntique (LABIOGENE) Universit Joseph KI-ZERBO Ouagadougou Burkina Faso laboratoire de biologie molculaire dEpidmiologie et Surveillance des Agents Transmissibles par les Aliments (LaBESTA) Universit Joseph KI-ZERBO Ouagadougou Burkina Faso laboratoire de Microbiologie et de Physicochimie du Dpartement de Technologie Alimentaire (DTA) Institut de Recherche en Sciences Appliques et Technologies (IRSAT) Ouagadougou Burkina Faso

The quality of infant flours used during the weaning age is of great importance in that it conditions the nutritional health of infants and young children. This study aimed to assess the nutritional and sanitary quality of infant flours produced in the city of Ouagadougou. This was a cross-sectional study including 11 out of 25 infant flour production units that gave their consent to partake in the study. In total, 25 infant flour samples have been collected from July to September 2021. The physicochemical and microbiological parameters were determined according to standard methods. The ANOVA analysis of variance showed significant differences between the means of the physico-chemical and the means of the microbiological parameters respectively. The results showed that 60% of proteins and 80% of lipid and total carbohydrate contents were below the authorised limits. The energy values were below the authorised limit in 88% of the cases. All instant infant flours had microbiological loads compliant with Burkinabè standards. As for infant flour to be cooked, 63.64% and 81.82% had satisfactory numbers of total coliforms and faecal coliforms respectively. Staphylococcus aureus and Escherichia coli were detected in these samples with 86.36% of infant formulae having results below the recommended limit. These results show that the infant flours produced in Ouagadougou were somehow of acceptable quality. However, there is a need to improve the formulae for macronutrient contents, energy values and sanitary quality to comply with the recommendations.

关键词： Nutritional and Sanitary Quality Infant Flours Ouagadougou Burkina Faso

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Profile of Autoantibodies and Clinical Symptoms in Guinean Patients with Connective Tissue Diseases

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Open Journal of Immunology 2024年第1期14卷 1-10页

作者： Mariama Sadjo Diallo Doufin Traore Adame Diouf Djiba Kaba Issiaga Diallo Doudou Georges Massar Niang Alimou Camara Oumar Mouctar Diallo Boh Fanta Diane Abdoulaye Barry Ouo-Ouo Yaramon Kolie Moustapha Mbow Aly Badra Kamissoko Djibril Sylla Babacar Mbengue Mohamed Cisse Faculté des Sciences et Techniques de la Santé Université Gamal Abdel Nasser de Conakry Conakry Guinée laboratoire de biologie Moléculaire nestor bangoura/helene labrousse H&#244pital de jour Donka CHU Donka Conakry Guinée Centre d’Excellence Africain Pour la Prévention et le Contrô le des Maladies Transmissibles Conakry Guinée laboratoire d’Immunologie Université Cheikh Anta Diop Dakar Sénégal Service de dermatologie-Vénérologie CHU Donka Conakry Guinée Service de Rhumatologie H&#244pital National Ignace Deen Conakry Guinée Service de Médecine Interne CHU Donka Conakry Guinée

Connective tissue diseases (CTDs) are Autoimmune diseases (AIDs) characterized by the appearance of autoantibodies, which are diagnostic markers. Investigations of these autoantibodies play a major role in the management of several autoimmune diseases. The objective of this study was to describe the profile of anti-ENA antibodies according to the clinical symptoms of mixed CTDs in Conakry teaching Hospital. We performed a cross-sectional study during six months. A total of 20 patients was recruited and we measured antibodies using the ELISA technique. The mean age of our patients was 36.5 years, with a predominance of females. Cutaneous and rheumatological signs were the main clinical manifestations. SLP was the most frequent CTDs;the threshold of ENA antibodies positivity was higher in scleroderma with and SLP. Anti-ENA identification reveals the frequency of anti-SSA (83.33%), anti-U1RNP (66.66%) and anti-histone (50%) antibodies. Antinuclear antibodies (ANA) react with various components of the cell nucleus. Their detection is of major interest in the diagnosis of CTDs. Our results highlight the importance of determining the specificity of these antibodies to guide differential diagnosis.

关键词： Autoantibodies Extractible Nuclear Antigen (ENA) Connective Tissue Diseases ELISA

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