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Aqueous Extract of Ceiba pentandra Stimulates the Production of Fetal Hemoglobin in Sickle Cell Patients

Journal of Biosciences and Medicines 2024年第8期12卷 295-306页

作者： Marie Miezi Nsimba Magain Barihuta Mihatano Blaise Maya Mbamu Aline Diza Lubongo Thoms Nzaji Kolombo Josué Matadi Mukengeshaie José Nzunzu Lami laboratoire de Recherche Bio-Organique Dpartement de Chimie Mdicinale et Pharmacognosie Facult des Sciences Pharmaceutiques Universit de Kinshasa Kinshasa Democratic Republic of the Congo laboratoire danalyse biologique Hpital Biamba Marie Mutombo Kinshasa Democratic Republic of the Congo Centre de Phytothrapie Moderne NIECA Commune de Ngaba Kinshasa Democratic Republic of the Congo Traumatology Service Department of Surgery Kinshasa University Hospital University of Kinshasa Kinshasa Democratic Republic of the Congo

Subsequent studies have demonstrated the reversed activity of the aqueous extract of Ceiba pentandra on the deformity of sickled red blood cells in hypoxia conditions. The observation which related to an in vitro study had given rise to hopes as to the management of sickle cell disease (SCD) by the use of this plant species. In this paper, the authors aimed to investigate the effect of the aqueous extract of C. pentandra on the production of fetal hemoglobin in SCD patients. The work carried out hemoglobin electrophoresis, for a period of six months, on blood samples from SCD patients who voluntarily undergone routine treatment, based on the medicinal recipe prepared from the bark of the trunk and branches of C. pentandra, in a hospital center of herbal medicines located in Kinshasa. The medicinal recipe called BEAT-SS is a patented product of the hospital center named Centre de Phytothérapie Moderne NIECA. Blood samples from patients under treatment were taken to evaluate the behavior of different forms of hemoglobin (hemoglobin S, hemoglobin F and hemoglobin A2). Agarose gel electrophoresis with integrated reading was used for the separation of the different forms of hemoglobin, as well as their dosage on each sample of sickle blood. A reduction in the proportion of hemoglobin S and an increase in the proportion of fetal hemoglobin were found in all sickle cell patients during the treatment period. This observation could affirm that the management of sickle cell patients using the recipe prepared from the aqueous extract of C. pentandra could increase the level of fetal hemoglobin in these patients.

关键词： Sickle Cell Disease Hemoglobin S Fetal Hemoglobin Ceiba pentandra

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Experimental Study of the Anti-Corrosion Performance of Montmorillonite K-10 on Rebar in HCl Environment: Application in Mortar for the Rehabilitation of Reinforced Concrete Degraded by Corrosion

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Open Journal of Civil Engineering 2024年第2期14卷 155-167页

作者： Malang Bodian Mariétou Barro Diop-Fall Dame Keinde El-Hadji Dieye Modou Gningue Diop Modou Fall laboratoire de Chimie Physique Organique et danalyse Environnementales (LCPOAE) Dpartement de Chimie Univ Cheikh Anta Diop de Dakar Dakar Senegal laboratoire de Matriaux de Gnie Civil (LMGC) Ecole Suprieure Polytechnique de Dakar Univ Cheikh Anta Diop Dakar Sngal

This work first investigates the corrosion-inhibiting behavior of montmorillonite K-10 on reinforcing steel. The corrosion-inhibiting power of the clay (Montmorillonite) is determined in a medium HCl (C = 1N) using free corrosion potential monitoring, Tafel potentiodynamic polarization curves and electrochemical impedance spectroscopy. The results of this study showed a satisfactory corrosion-inhibiting efficiency of around 72.665% for the optimum content of 1%. This is due to the presence of a stable oxide layer that protects the metal against corrosion. To validate the concept of montmorillonite as a corrosion inhibitor in repair mortar, we now turn to the influence of montmorillonite on the mechanical properties of mortars in the hardened state. In this part, montmorillonite K-10 is added to the mortar by partial substitution of the cement by 5% and 10% of the cement mass. The aim of this study is to ensure that the addition of this clay to the mortar composition will not have a negative effect on its compressive and flexural strengths. The results of the compression and flexural tests showed that the presence of montmorillonite in the mortar improved flexural and compressive strengths for the different compositions studied.

关键词： Clay Reinforced Concrete Corrosion Inhibitor Rehabilitation Electrochemical Methods

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Cameroon Climate Predictions Using the SARIMA-LSTM Machine Learning Model: Adjustment of a Climate Model for the Sudano-Sahelian Zone of Cameroon

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Open Journal of Statistics 2024年第3期14卷 394-411页

作者： Joseph Armathé Amougou Isidore Séraphin Ngongo Patrick Forghab Mbomba Romain Armand Soleil Batha Paul Ghislain Poum Bimbar Dpartement de Gographie Universit de Yaound 1 Yaound Cameroon Observatoire National sur les Changements Climatiques (ONACC) Yaound Cameroon laboratoire danalyse et Modlisation Multidisciplinaire Statistique (SAMM) Universit de Paris 1 Panthon Sorbonne Paris France Ecole Nationale Suprieure Polytechnique de Yaound 1 Yaound Cameroon Dpartement de Mathmatiques Ecole Normale Suprieure de Yaound Yaound Cameroon Dpartement dInformatique Universit de Yaound 1 Yaound Cameroon

It is acknowledged today within the scientific community that two types of actions must be considered to limit global warming: mitigation actions by reducing GHG emissions, to contain the rate of global warming, and adaptation actions to adapt societies to Climate Change, to limit losses and damages [1] [2]. As far as adaptation actions are concerned, numerical simulation, due to its results, its costs which require less investment than tests carried out on complex mechanical structures, and its implementation facilities, appears to be a major step in the design and prediction of complex mechanical systems. However, despite the quality of the results obtained, biases and inaccuracies related to the structure of the models do exist. Therefore, there is a need to validate the results of this SARIMA-LSTM-digital learning model adjusted by a matching approach, “calculating-test”, in order to assess the quality of the results and the performance of the model. The methodology consists of exploiting two climatic databases (temperature and precipitation), one of which is in-situ and the other spatial, all derived from grid points. Data from the dot grids are processed and stored in specific formats and, through machine learning approaches, complex mathematical equations are worked out and interconnections within the climate system established. Through this mathematical approach, it is possible to predict the future climate of the Sudano-Sahelian zone of Cameroon and to propose adaptation strategies.

关键词： Adjustment Calibration Climate Sudano-Sahelian Zone Numerical Model

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