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Identification of adrafinil and its main metabolite modafinil in human ***-administration study and interpretation of an authentic case

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Forensic Sciences Research 2020年第4期5卷 322-326页

作者： Alice Ameline laurie Gheddar Jean-Sébastien Raul Pascal Kintz Institut de médecine légale Laboratoire de toxicologieStrasbourgFrance X-Pertise Consulting Département de toxicologieMittelhausbergenFrance

For several years,the misuse of stimulant substances is increasingly observed both in the field of sport,to improve the functions of the body and therefore to be more performant,and also by non-athletes to make life more tolerable on a daily ***,2-((diphenylmethyl)sulfinyl)-N-hydroxyacetamide,is a drug designed for the treatment of narcolepsy by promoting an awakened state,and to treat alertness and neurological symptoms in the *** is primarily metabolized in vivo to an active form,***,2-((diphenylmethyl)sulfinyl)*** World Anti-doping Agency(WAdA)banned these two drugs in sports in *** authors report an authentic case involving adrafinil and *** laboratory was requested to test for adrafinil in a hair strand collected from a woman found in posses-sion of vials of adrafinil and suspected of trafficking.A specific method was developed by liquid chromatography tandem mass spectrometry(lC-mS/mS).Unlike modafinil(varying from 6.8 to 13.9ng/mg),adrafinil was not identified in the *** interpretation of the results was difficult because this is the first case describing human hair *** order to be able to interpret the results,a self-administration study was conducted after an oral administration to a volunteer(200 mg)whose beard hair was collected 10days after *** analysis of this specimen highlighted the presence of adrafinil at 0.8ng/mg and modafinil at 0.5 ng/*** results demonstrate the dual identification of both compounds after a single consumption,even after administration of a low *** to these results,the analysis of the hair strand from the authentic case does not match with a con-sumption of adrafinil,in accordance with abuse of modafinil *** considered that this was a trafficking case of adrafinil,with no self-consumption.

关键词： Forensic sciences forensic toxicology adrafinil modafinil human hair UPlC-mS/mS stimulants

Topological Studies of Three-dimensional Flows in a High Pressure Compressor Stator Blade Row without and with Boundary layer Aspiration

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Chinese Journal of Aeronautics 2011年第5期24卷 541-549页

作者： Ankit SACHdeVA Francis lEBOEUF laboratoire de mécanique des Fluides et d'Acoustique Ecole Centrale de Lyon

This paper presents a numerical study of the flow topologies of three-dimensional （3d） flows in a high pressure compressor stator blade row without and with boundary layer aspiration on the hub wall. The stator blade is representative of the first stage operating under transonic inlet conditions and the blade design encourages development of highly complex 3d flows. The blade has a small tip clearance. The computational fluid dynamics （CFd） studies show progressive increase of hub corner stall with the increase in incidence. Aspiration is implemented on the hub wall via a slot in the comer between the hub wall and the suction surface. The CFd studies show aspiration to be sensitive to the suction flow rate; lower rate leads to very complex flow struc- tures and increased level of losses whereas higher rate renders aspiration effective for control of hub comer separation. The flow topologies are studied by trace of skin friction lines on the walls. The nature of flow can be explained by the topological rules of closed separation. Furthermore, a deeper analysis is done for a particular case with advanced criterion to test the non-degeneracy of critical points in the flow field.

关键词： high pressure compressor flow topologies three-dimensional flows boundary layer aspiration tip clearance

Psychological distress in moroccan Patients with Hematological malignancies and Its Impact on Their Quality of life

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Psycho-Oncologie 2023年第4期17卷 235-244页

作者： maha Ouazzani Zineb El Khammar Nawal Oubelkacem Youssef Aboussaleh Hajar masrour moncef maiouak Rhizlane Berrady laboratoire de Nutrition Santéet EnvironnementDépartement de BiologieFacultédes SciencesUniversitéIbn TofailKenitra14000Maroc Service de médecine Interne et d’oncohématologie CHU Hassan IIFès30050Maroc laboratoire d’épidémiologie Facultéde Médecine et de Médecine DentaireFès30050Maroc

Introduction:la qualitéde vie des patients suivis pour une hémopathie maligne dépend non seulement du type de la maladie,de ses caractéristiques cliniques,biologiques et thérapeutiques,mais aussi de la santémentale du patient.l’objectif de notreétude est d’évaluer l’état psychologique des patients au diagnostic,de rechercher les facteurs associésàson altération et de préciser son impact sur la qualitéde vie des patients.méthode:nous avons menéuneétude monocentrique transversale quiévalue la dépression,l’anxiétéet la qualitéde vie d’une population de patients atteints de syndromes lymphoprolifératifs sur une période de *** questionnaires ontétéutilisés au moment du diagnostic:le HAdS pour rechercher la dépression et l’anxiétéet le SF12échelle pourévaluer la qualitéde vie liéeàla santé.Résultat:les cent patients ont acceptéde répondre aux *** patients sont suivis pour un lymphome malin non hodgkinien,une maladie de Hodgkin,et une leucémie lymphoïde *** sex-ratio(H/F)est de 1,*** prévalence des symptômes anxieux est de 70%avec 95%CI(61,01%;78,99%)et des symptômes dépressifs de 76%avec 95%CI(49,4%;82,6%)des *** analyse univariée,le caractère féminin est associéaux symptômes anxieux(p=0,008),etàl’altération de qualitéde vie mentale(p=0,02).Alors qu’en analyse multivariée,les symptômes anxio-dépressifs sont significativement associésàun score de qualitéde vie faible aussi bien mentale que *** plus les symptômes anxieux sont corrélés au sexe féminin(ORA=20,50;95%CI[1,58–264,48]);et la douleur(ORA=12,33;95%CI[1,07–141,77]).Conclusion:la recherche de comorbidités psychologiques doit faire partie du diagnostic initial de cette population vulnérable pour une meilleure qualitéde vie.

关键词： dépression anxiété qualitéde vie liéàla santé lymphome

Rotating instability in the vaneless diffuser of a radial flow pump

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Journal of Thermal Science 2008年第4期17卷 368-374页

作者： A.dazin O.Coutier-delgosha P.dupont S.Coudert G.Caignaert G.Bois laboratoire de mécanique de lille(UmR CNRS 8107) Arts et Métiers ParisTech laboratoire de mécanique de lille Ecole Centrale de Lille laboratoire de mécanique de lille CNRS

The paper refers to the behavior of a vaneless diffuser of a radial flow pump in partial flow operating conditions. Some experimental data have been obtained using 2d/2C PIV and unsteady pressure measurements within the diffuser, in various operating conditions. The experimental results at the lower flow rate are compared with two-dimensional numerical calculations.

关键词： Vaneless diffuser Radial flow pump Instability Particle Image Velocimetry Pressure measurements 2d calculations.

Complex dynamics of an archetypal self-excited Sd oscillator driven by moving belt friction

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Chinese Physics B 2016年第1期25卷 480-488页

作者：李志新曹庆杰 léger Alain School of Astronautics Harbin Institute of Technology laboratoire de mécanique et d'Acoustique CNRS

We propose an archetypal self-excited system driven by moving belt friction, which is constructed with the smooth and discontinuous （Sd） oscillator proposed by the Cao et al. and the classical moving belt. The moving belt friction is modeled as the Coulomb friction to formulate the mathematical model of the proposed self-excited Sd oscillator. The equilibrium states of the unperturbed system are obtained to show the complex equilibrium bifurcations. Phase portraits are depicted to present the hyperbolic structure transition, the multiple stick regions, and the friction-induced asymmetry phenomena. The numerical simulations are carried out to demonstrate the friction-induced vibration of multiple stick-slip phenomena and the stick-slip chaos in the perturbed self-excited system. The results presented here provide an opportunity for us to get insight into the mechanism of the complex friction-induced nonlinear dynamics in mechanical engineering and geography.

关键词： self-excited smooth and discontinuous (Sd) oscillator multiple stick regions friction-inducedasymmetry stick-slip chaos

liver resection and metabolic disorders: An undescribed mechanism leading to postoperative mortality

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World Journal of Gastroenterology 2014年第39期20卷 14455-14462页

作者： Alban Zarzavadjian le Bian Renato Costi mohamed Said Sbai-Idrissi Claude Smadja Service de Chirurgie digestive H?pital Antoine BéclèreClamart Assistance Publique-H?pitaux de ParisUniversité Paris Sud-XI 91400 Orsay France laboratoire d’ethique médicale et de médecine légale Université Paris Descartes-V 75006 Paris France Service de Chirurgie digestive H?pital Simone Veil95600 Eaubonne France dipartimento di Scienze Chirurgiche Università degli Studi di Parma 43100 Parma Italy

AIm: To investigate the mechanism leading to perioperative mortality in patients undergoing major liver resection and presenting with metabolic disorders.

关键词： metabolic syndrome major hepatectomy liver resection Postoperative mortality Hepatorenal syndrome

modal decomposition for the Analysis of the Rotor-stator Interactions in multi-stage Compressors

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Journal of Thermal Science 2012年第3期21卷 276-285页

作者： N.Courtiade X.Ottavy N.Gourdain laboratoire de mécanique des Fluides et d'Acoustique Ecole Centrale de Lyon CERFACS CFD Team

A modal analysis method of the rotor-stator interactions in multistage compressors has been developed by lmFA. This method, based on a double modal decomposition of the flow over space and time, has been applied to nu- merical and experimental results of the high-speed 3Y2-stage compressor CREATE based at lmFA, lyon-France. It reveals the presence of a very strong rotor-stator interaction which completely drives the flow at casing behind all the rotors. This modal analysis method applied to an unsteady RANS simulation permits to calculate the en- ergy of the rotor-stator interactions and to plot energetic meridian maps to explain experimental results and to analyze the interaction in the whole machine.

关键词： rotor-stator interactions modal analysis multistage compressors numerical and experimental results

detailed Analysis of the Flow in the Inducer of a Transonic Centrifugal Compressor

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Journal of Thermal Science 2012年第1期21卷 1-12页

作者： Nicolas Buffaz Isabelle Trébinjac laboratoire de mécanique des Fluides et d'Acoustique Ecole Centrale de lyon 36 av. Guy de Collongue

Numerical and experimental investigations were conducted in a transonic centrifugal compressor stage composed of a backswept splittered unshrouded impeller and a vaned diffuser. A detailed analysis of the flow in the inducer (i.e. the entry zone of the impeller between the main blade leading edge and the splitter blade leading edge) is proposed from choke to surge. Steady and unsteady simulations were performed using the code elsA, which uses a multi-domain approach on structured meshes and solves the compressible RANS equations, associated with a two-equation turbulence model k-l in the rotating frame of reference. The 1mW lmFA-ECl test rig was used for carrying out the tests in the compressor stage. Unsteady pressure measurements up to 150 kHz and laser doppler Anemometry measurements were performed in the inducer. A good agreement is obtained between the experimental and numerical data even if an over dissipation is noticed in the numerical results. The change in flow pattern from choke to surge is mainly due to a change in the tip leakage flow trajectory which straightens, leading to a flow blockage of an individual passage near shroud. A spectral analysis shows that only the blade passing frequency and its harmonics compose the various spectra obtained from choke to surge.

关键词： transonic centrifugal compressor inducer unsteady pressure measurements

Numerical Simulation of Turbulent diffusion Flames of a Biogas Enriched with Hydrogen

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Fluid dynamics & materials Processing 2024年第1期20卷 79-96页

作者： Naima Krarraz Amina Sabeur Khadidja Safer Ahmed Ouadha laboratoire des Science et Ingénierie maritimes Facultéde Génie MécaniqueUniversitédes Sciences et de la Technologie d’Oran Mohamed BoudiafOranAlgérie laboratoire des Carburants Gazeux et de l’Environnement Facultéde Génie MécaniqueUniversitédes Sciences et de la Laboratoire des Carburants Gazeux et de l’Environneme

Any biogas produced by the anaerobic fermentation of organic materials has the advantage of being an environmentally friendly ***,the relatively low calorific value of such gases makes their effective utilization in practical applications relatively *** present study considers the addition of hydrogen as a potential solution to mitigate this *** particular,the properties of turbulent diffusion jet flames and the related pollutant emissions are investigated numerically for different operating *** related numerical simulations are conducted by solving the RANS equations in the frame of the Reynolds Stress model in combination with the flamelet *** effects are also taken into account and the combustion kinetics are described via the GRI-mech 3.0 reaction *** considered hydrogen fuel enrichment spans the range from 0%to 50%in terms of *** varies between 1 and 10 *** results show that both hydrogen addition and pressure increase lead to an improvement in terms of mixing quality and have a significant effect on flame temperature and *** also reduce CO_(2) emissions but increase NOx *** NO is shown to be the predominant NO formation mechanism.

关键词： Biogas hydrogen diffusion flame turbulence NO formation route pressure