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Solitary Endobronchial Papilloma Mimicking a Neoplastic Lesion

Open Journal of Respiratory diseases 2018年第3期8卷 38-42页

作者： Smadhi Hanen Khalfallah Ikbel diouani Mohamed Fethi Abdennadher Mahdi Attia Monia Ayadi-Kaddour Aida Megdiche Mohamed Lamine department of Pneumology Ibn Nafis Abderrahman Mami University Hospital Ariana Tunisia Faculté de Médecine de tunis Université Tunis El Manar Tunis Tunisia Faculté des Sciences de Bizerte Université de Carthage Carthage Tunisia laboratoire d’epidémiologie et de microbiologie vétérinaire institut pasteur de tunis Tunis Tunisia department of thoracic Surgery Abderrahman Mami University Hospital Ariana Tunisia department of Radiology Abderrahman Mami University Hospital Ariana Tunisia department of Pathology Abderrahman Mami University Hospital Ariana Tunisia

Papilloma is a rare benign tumor. Laryngeal location is the most frequent. the bronchial involvement remains unusual. It represents 0.38% of pulmonary tumors. We report the case of a 39-year-old, smoker man, who consulted for a cough following during six months with persistent radiological opacity despite antibiotic treatment. the physical examination was without particularities. Flexible bronchoscopy revealed a swollen endobronchial lesion completely obstructing the orifice of the intermediate trunk. Bronchial biopsies at this level showed inflammatory mucosa. the chest Ct scan objectified an endobronchial tissular mass in the intermediate trunk. Pulmonary neoplasia was suspected. diagnostic and therapeutic surgery was performed. Histopathological examination concluded to an endobronchial squamous papilloma.

关键词： Papilloma Smoking Lung Cancer Surgery

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Unusual Location of Coelomic Cysts

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Open Journal of Respiratory diseases 2018年第3期8卷 33-37页

作者： Smadhi Hanen Ben Jemai Emna diouani Mohamed Fethi Abdennadhar Mahdi Attia Monia Ayadi-Kaddour Aida Megdiche Mohamed Lamine department of Pneumology Ibn Nafis Abderrahman Mami University Hospital Ariana Tunisia Faculté de Médecine de tunis Université Tunis El Manar Tunis Tunisia. Faculté des Sciences de Bizerte Université de Carthage Carthage Tunisia. laboratoire d’epidémiologie et de microbiologie vétérinaire institut pasteur de tunis Tunis Tunisia department of thoracic Surgery Abderrahman Mami University Hospital Ariana Tunisia department of Radiology Abderrahman Mami University Hospital Ariana Tunisia department of Pathology Abderrahman Mami University Hospital Ariana Tunisia

Intrathoracic mesothelial cysts are congenital lesions due to an abnormal development of the pericardial coelom. they are generally unilocular and can develop in various sites. We describe a case of multicystic lesions in the anterior mediastinum of a 53-year-old woman discovered in a context of an encysted pleural effusion. Chest computed tomography (Ct) scan revealed multiple cystic lesions in the anterior and posterior mediastinum. Surgery was carried out and histopathology and immunohistochemistry confirmed the diagnosis of multiple coelomic cysts of the mediastinum.

关键词： Mesothelial Cysts Mediastinum Surgery Pathology

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Factors associated with dAA virological treatment failure and resistance-associated substitutions description in HIv/HCv coinfected patients

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World Journal of Hepatology 2018年第11期10卷 856-866页

作者： dominique Salmon Pascale trimoulet Camille Gilbert Caroline Solas Eva Lafourcade Julie Chas Lionel Piroth Karine Lacombe Christine Katlama Gilles Peytavin Hugues Aumaitre Laurent Alric Franoois Boué Philippe Morlat Isabelle Poizot-Martin Eric Billaud Eric Rosenthal Alissa Naqvi Patrick Miailhes Firouzé Bani-Sadr Laure Esterle Patrizia Carrieri Franoois dabis Philippe Sogni Linda Wittkop 无 Assistance Publique des Hopitaux de Paris Hopitaux Universitaires Paris CentreHopital Hotel DieuUnitédes Maladies infectieuses et tropicalesParis 75004France Université Paris descartes Sorbonne Paris CitéParis 75006France trimoulet CHU de BordeauxHopital PellegrinLaboratoire de VirologieBordeaux 33000France trimoulet CNRS-UMR 5234Microbiologie fondamentale et PathogénicitéUniversitéde BordeauxBordeaux 3000France Philippe Morlat Laure EsterleFrancois DabisLinda WittkopUniv.BordeauxISPEDInsermBordeaux Population Health Research Centerteam MORPH3EUSUMR 1219CIC-EC 1401Bordeaux F-33000France APHM Hopital La TimoneLaboratoire de Pharmacocinétique et ToxicologieMarseille 13005France Centre Hospitalier Universitaire de dijon Département d'InfectiologieDijon cedex 21079France INSERM-CIC 1342 Universitéde Bourgogne Dijon 21000France Assistance Publique des Hopitaux de Paris GHUEP site Saint-AntoineServices Maladies infectieuses et tropicalesParis 75011France UniversitéPierre et Marie Curie UMR S1136Institut Pierre Louis d' Epidémiologie et de SantéPubliqueParis 75646France UniversitéParis-Sorbonne Paris 75005France Assistance Publique des Hopitaux de Paris Hopital PitiéSalpêtrière Services Maladies infectieuses et tropicalesParis 75013France Assistance Publique des Hopitaux de Paris Hopital Bichat-Claude BernardLaboratoire de PharmacologieParis 75877France IAME UMR 1137Sorbonne Paris CitéINSERMUniversitéParis DiderotParis 75890France Centre Hospitalier de Perpignan Service Maladies infectieuses et tropicalesPerpignan 66000Franc Centre Hospitalier Universitaire de toulouse Hopital PurpanService Médecine interne-Pole DigestifToulouse 31300France UMR 152 IRd UniversitétoulouseⅢ Paul SabatierToulouse 31330France Hopital Antoine-Béclère Assistance Publique des Hopitaux de ParisUniversitéParis SudService Médecine interne et immunologieClamart 92140France Centre Hospitalier Universitaire de Bordeaux Service de médecine interneHopital Saint-AndréBordeaux 33000France Uni

AIMto describe factors associated with treatment failure and frequency of resistance-associated substitutions （RAS）.MetHOdSHuman immunodefciency virus （HIv）/hepatitis C virus （HCv） coinfected patients starting a first direct-acting antiviral （dAA） regimen before February 2016 and included in the French ANRS CO13 HEPAvIH cohort were eligible. Failure was defned as：（1） non-response [HCv-RNA remained detectable during treatment, at end of treatment （EOt）]; and （2） relapse （HCv-RNA suppressed at EOt but detectable thereafter）. Sequencing analysis was performed to describe prevalence of drug class-specifc RAS. Factors associated with failure were determined using logistic regression *** 559 patients, 77% had suppressed plasmaHIv-RNA 〈 50 copies/mL at dAA treatment initiation41% were cirrhotic, and 68% were HCv treatmentexperienced. virological treatment failures occurred in22 patients and were mainly relapses （17, 77%） thenundefined failures （3, 14%） and non-responses （29%）. Mean treatment duration was 16 wk overall. Posttreatment NS3, NS5A or NS5B RAS were detected in10/14 patients with samples available for sequencinganalysis. After adjustment for age, sex, ribavirin useHCv genotype and treatment duration, low platelecount was the only factor signifcantly associated with ahigher risk of failure （OR： 6.5; 95%CI： 1.8-22.6）. CONCLUSIONOnly 3.9% HIv-HCv coinfected patients failed dAAregimens and RAS were found in 70% of those failingLow platelet count was independently associated withvirological failure.

关键词： Human immunodeficiency virus Hepatitis C virus direct-acting antiviral treatment virological failure Resistant associated mutations

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