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Highly Angular Tolerant Transmission Filters for Narrow-Band Image Sensors

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Optics and Photonics Journal 2021年第6期11卷 140-151页

作者： Fatima Omeis Mondher Besbes Christophe Sauvan Henri Benisty laboratoire charles fabry Institut d’Optique Graduate School Universit&#233 Paris Saclay CNRS Palaiseau France

A dielectric transmittance filter composed of subwavelength grating sandwiched between two few-layers distributed Bragg reflectors (DBRs) is proposed with the aim of being compatible with CMOS technology and to be tunable by lithographic means of the grating pattern without the need of thickness changes, in the broad spirit of metamaterials. The DBR mirrors form a fabry-Perot (FP) cavity whose resonant frequency can be tuned by changing the effective refractive index of the cavity, here, by tailoring the in-plane filling factor of the grating. The structure has been studied and designed by performing numerical simulations using Fourier Modal Method (FMM). This filter proves to have high broad angular tolerance up to ±30˚. This feature is crucial for evaluating the spectral performance of narrow-band filters especially the so-called Ambient light sensors (ALS). By analyzing the transmittance spectral distributions in the band diagram, it is found that the angular tolerance is due to coupling between the FP and the guided mode inside the cavity in analogy to resonances occurring within multimode periodic waveguides in a different context.

关键词： Narrow-Band Filters Transmission CMOS Angular Tolerant Subwavelength Grating Distributed Bragg Reflectors (DBR) fabry-Perot Cavity

Design and current progress of the Apollon 10 PW project

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High Power Laser Science and Engineering 2015年第1期3卷 32-35页

作者： J.P.Zou C.Le Blanc D.N.Papadopoulos G.Chériaux P.Georges G.Mennerat F.Druon L.Lecherbourg A.Pellegrina P.Ramirez F.Giambruno A.Fréneaux F.Leconte D.Badarau J.M.Boudenne *** T.Valloton J.L.Paillard J.L.Veray M.Pina P.Monot J.P.Chambaret P.Martin F.Mathieu P.Audebert F.Amiranoff laboratoire pour l’Utilisation des Lasers Intenses CNRSEcole Polytechnique laboratoire d’Optique Appliquée ENSTA Paris TechCNRS laboratoire charles fabry UMR 8501Institut d’OptiqueCNRSUniversité Paris Sud CEA IramisSPAM

The objective of the Apollon project is the generation of 10 PW peak power pulses of 15 fs at 1 shot/minute. In this paper the Apollon facility design, the technological challenges and the current progress of the proj... 详细信息

关键词： titanium lasers PW class facilities

Natural evolution of hepatitis C virus infection in hemodialysis Tunisian patients and CTLA-4 SNP's

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World Journal of Gastroenterology 2015年第35期21卷 10150-10158页

作者： Leila Ksiaa Cheikhrouhou Yousr Lakhoua-Gorgi Imen Sfar Salwa Jendoubi-Ayed Houda Aouadi Mouna Makhlouf Khaled Ayed Taieb Ben Abdallah Immunology Research Laboratory of Kidney Transplantation and Immunopathology Laboratoire de Recherche Laboratory of Immunology Charles Nicolle Hospital

AIM: To analyze the polymorphisms of CTLA-4 gene involved in the response against hepatitis C virus(HCV) ***: We recruited 500 hemodialysed patients from several hemodialysis centers, all HCV-antibody positive, spread over different regions of Tunisia, as part of a national survey in 2008 conducted in the laboratory of immunology at the charles Nicolle hospital Tunisia, classified into two groups G1(PCR+) and G2(PCR-) according to the presence or absence of viral RNA. Of these patients, 307 were followed prospectively on a viral molecular level over a period from 2002 to 2008, divided into two groups based on the persistence and viral clearance. PCR-RFLP was performed for the analysis of SNPs(+49) A/G and(+6230) G/A CTLA-4 for these 500 patients and 358 healthy ***: Analysis of clinical and virological charac-teristics of our cohort suggests a nosocomial infection in our hemodialysed patients with transfusion history as a primary risk factor and a predominance of genotype 1b. The haplotype analysis revealed an increase of frequencies of GG(+49)/(CT60) CTLA-4 in the entire patients group compared to controls(P = 0.0036 and OR = 1.42; 95%CI: 1.12-1.79, respectively). This haplotype is therefore associated with susceptibility to HCV infection. CONCLUSION: Our study suggests a possible role of CTLA-4 polymorphisms in the outcome of HCV infection in the Tunisian hemodialysed population.

关键词： Hepatitis C virus Hemodialysis Natural evolution C

Hybrid silicon slotted photonic crystal waveguides:how does third order nonlinear performance scale with slow light?

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Photonics Research 2016年第6期4卷 257-261页

作者： Junfei Xia Samuel Serna Weiwei Zhang Laurent Vivien éric Cassan Centre de Nanosciences et de Nanotechnologies UMR 9001 (CNRS/Université Paris-Sud)Université Paris-Saclay laboratoire charles fabry Institut d’Optique CNRS Université Paris-Sud

We investigate in this paper the influence of slow light on the balance between the Kerr and two-photon absorption(TPA) processes in silicon slotted hybrid nonlinear waveguides. Three typical silicon photonic waveguide geometries are studied to estimate the influence of the light slow-down factor on the mode field overlap with the silicon region, as well as on the complex effective nonlinear susceptibility. It is found that slotted photonic crystal modes tend to focalize in their hollow core with increasing group index(n_G) values. Considering a hybrid integration of nonlinear polymers in such slotted waveguides, a relative decrease of the TPA process by more factor of 2 is predicted from n_G=10 to n_G=50. As a whole, this work shows that the relative influence of TPA decreases for slotted waveguides operating in the slow light regime, making them a suitable platform for third-order nonlinear optics.

关键词： mode Hybrid silicon slotted photonic crystal waveguides:how does third order nonlinear performance scale with slow light

Line-field confocal optical coherence tomography for three-dimensional skin imaging

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Frontiers of Optoelectronics 2020年第4期13卷 381-392页

作者： Jonas OGIEN Anthony DAURES Maxime CAZALAS Jean-Luc PERROT Arnaud DUBOIS DAMAE Medical Paris 75013.France CHU St-Etienne Service DermatologieSaint-Etienne 42055France Universite Paris-Saclay Institut d'Optique Graduate SchoolCNRSLaboratoire Charles FabryPalaiseau 91127France

This paper reports on the latest advances in line-field confocal optical cohere nee tomography(LC-OCT),a recently invented imaging technology that now allows the generation of either horizontal(x×y)section images at an adjustable depth or vertical(x×z)section images at an adjustable lateral position,as well as thre dimensional *** both two-dimensional imaging modes,images are acquired in real-time,with real-time control of the depth and lateral ***-dimensional(x×y×z)images are acquired from a stack of horizontal section *** device is in the form of a portable *** handle of the probe has a button and a scroll wheel allowing the user to control the imaging *** a supercontinuum laser as a broadband light source and a high numerical microscope objective,an isotropic spatial resolution of^1|im is *** field of view of the three-dimensional images is 1.2 mm×0.5 mm×0.5 mm(x×y×z).Images of skin tissues are presented to demonstrate the potential of the technology in dermatology.

关键词： optical coherence tomography(OCT) microscopy three-dimensional imaging dennatology

Cytokine and apoptosis gene polymorphisms influence the outcome of hepatitis C virus infection

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Hepatobiliary & Pancreatic Diseases International 2011年第3期10卷 280-288页

作者： Leila Ksiaa Cheikhrouhou Imen Sfar Hajer Aounallah-Skhiri Houda Aouadi Salwa Jendoubi-Ayed Taieb Ben Abdallah Khaled Ayed Yousr Lakhoua-Gorgi Immunology Research Laboratory of Kidney Transplantation and Immunopathology (laboratoire de Recherche:LR03SP01) Charles Nicolle Hospital National Health Institute

BACKGROUND:Hepatitis C virus (HCV) infection is thought to be chronic and the factors leading to viral clearance or persistence are poorly *** study was undertaken to investigate the possibility of a significant relationship between the spontaneous clearance or the persistence of hepatitis C virus (HCV) infection and cytokine and apoptosis gene polymorphisms in Tunisian patients on ***:Polymorphisms of the genes IL-1 (-889 IL-1α,-511 and +3954 IL-1β,IL-1Ra),IL-18 (-137 and-607),IL-12 (-1188) and Apo1/Fas (-670) were determined by PCR-RFLP,PCR-SSP and PCR-VNTR in 100 healthy blood donors and 100 patients infected with HCV and undergoing *** patients were classified into two groups:G1 consisted of 76 active chronic hepatitis patients (positive for HCV RNA) and G2 consisted of 24 hemodialysed patients who spontaneously eliminated the virus (negative for HCV RNA).RESULTS:The frequency of genotype association [-137GC/-607CA] IL-18 was higher in G2 (41.7%) than in G1 (15.8%) (P=0.008;OR=0.26;95% CI,0.10-0.73).We also found a higher frequency of the AA genotype of the Apo1/Fas gene in G2 (41.6%) than in G1 (17.5%) (P=0.026;OR=3.49;95% CI,1.13-10.69).Adjustment for known covariate factors (age,gender and genotype) confirmed these univariate findings and revealed that the genotype association GC-CA of the (-137 and-607) IL-18 gene and the AA genotype of the Apo1/Fas gene were associated with the clearance of HCV (P=0.041 and 0.017,respectively).CONCLUSION:The two genotypes GC-CA of the (-137 and-607) IL-18 polymorphism and the AA genotype of the Apo1/Fas gene influence the outcome of HCV infection in Tunisian patients on hemodialysis.

关键词： hepatitis C virus spontaneous clearance cytokine gene polymorphisms Apo1/Fas gene polymorphisms

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贝尔定理:一位实验学家的朴素观点

物理 2022年第12期51卷 827-843页

作者： Alain Aspect 陈徐宗陈佐尧(译) 俞旭东(校) laboratoire charles fabry Institut d’OptiqueUniversitéParis-SaclayPalaiseau Cedex 91127France 北京大学电子学院北京100871

译者的话双光子纠缠实验,是自20世纪70年代开展以来,验证贝尔不等式、证明量子力学非局域性的主要实验。法国科学家阿兰·阿斯佩(Alain Aspect)在20世纪80年代做了第一个数据令人信服的实验,获得了2022年诺贝尔物理学奖。

关键词：诺贝尔物理学奖贝尔不等式非局域性量子力学

用于评价小球隐孢子虫卵囊感染力的NMRI乳鼠模型(英文)

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中国寄生虫学与寄生虫病杂志 2000年第2期18卷 94-96页

作者： Xunde LI Philippe Brasseur laboratoire de Parasitologie Hospital Charles NicolleCHU76031RouenFrancLaboratoire de ParasitologieHospital Charles NicolleCHU76031RouenFrance

[目的 ]评价一定数量的小球隐孢子虫卵囊的感染力。 [方法 ]4日龄 NMRI乳鼠经口腔管饲法接种不同数量的卵囊 ,7d后处死乳鼠 ,取消化道幽门至肛门段并匀成悬液 ,取此悬液置载玻片上 ,石碳酸品红染色 ,相差显微镜查见卵囊的为被感染乳鼠... 详细信息

[目的 ]评价一定数量的小球隐孢子虫卵囊的感染力。 [方法 ]4日龄 NMRI乳鼠经口腔管饲法接种不同数量的卵囊 ,7d后处死乳鼠 ,取消化道幽门至肛门段并匀成悬液 ,取此悬液置载玻片上 ,石碳酸品红染色 ,相差显微镜查见卵囊的为被感染乳鼠。以各组被感染乳鼠百分率评价卵囊的感染力。 [结果 ]接种 15 0 0或 2 0 0 0的乳鼠均被感染 ;接种 10 0 0、 5 0 0、2 5 0、 10 0和 5 0个卵囊的乳鼠 ,感染率分别为 88%、 74%、 5 1%、 2 8%和 9.5 %。 [结论 ]NMRI乳鼠模型接种卵囊数在 15 0 0～5 0范围内 ,其接种量与感染率呈正相关。该模型可用于评价一定数量小球隐孢子虫卵囊的感染力。

关键词：隐孢子虫卵囊感染力

Determination of Evanescent Electric Field Decay Length of Metallic Nanodisks by Using Localized Surface Plasmon Spectroscopy

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材料科学与工程（中英文版） 2010年第11期4卷 69-74页

作者： Gregory Barbillon Laboratory charles fabry of the Institute of Optics CNRS UMR 8501 Institut d＇Optique Graduate School Palaiseau cedex 91127France