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Compact and effective photon-resolved image scanning microscope

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Advanced Photonics 2024年第1期6卷 84-95页

作者： Giorgio Tortarolo Alessandro Zunino Simonluca Piazza Mattia donato Sabrina Zappone Agnieszka Pierzyńska-Mach Marco Castello Giuseppe Vicidomini Istituto Italiano di tecnologia Molecular Microscopy and SpectroscopyGenoaItaly Genoa Instruments GenoaItaly University of Genoa Dipartimento di InformaticaBioingegneriaRobotica e Ingegneria dei SistemiGenoaItaly Istituto Italiano di tecnologia Nanoscopy and NIC@IITGenoaItaly École Polytechnique Fédérale de Lausanne Laboratory of Experimental BiophysicsLausanneSwitzerland

Fluorescence confocal laser-scanning microscopy(LSM)is one of the most popular tools for life science *** popularity is expected to grow thanks to single-photon array detectors tailored for *** detectors offer unique single-photon spatiotemporal information,opening new perspectives for gentle and quantitative superresolution ***,a flawless recording of this information poses significant challenges for the microscope data acquisition(DAQ)*** present a DAQ module based on the digital frequency domain principle,able to record essential spatial and temporal features of *** use this module to extend the capabilities of established imaging techniques based on single-photon avalanche diode(SPAD)array detectors,such as fluorescence lifetime image scanning ***,we use the module to introduce a robust multispecies approach encoding the fluorophore excitation spectra in the time ***,we combine time-resolved stimulated emission depletion microscopy with image scanning microscopy,boosting spatial *** results demonstrate how a conventional fluorescence laser scanning microscope can transform into a simple,information-rich,superresolved imaging system with the simple addition of a SPAD array detector with a tailored data acquisition *** expected a blooming of advanced single-photon imaging techniques,which effectively harness all the sample information encoded in each photon.

关键词： fluorescence lifetime image scanning microscopy digital frequency domain single photon

One-neutron stripping process in the^(209)Bi(^(6)Li,^(5)Li)^(210)Bi*reaction reaction

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Nuclear Science and Techniques 2024年第6期35卷 120-129页

作者： Gao-Long Zhang Zhen-Wei Jiao Guang-Xin Zhang e.N.Cardozo B.Paes Shi-Peng Hu Jian-Qiang Qian Daniele Mengoni Wei-Wei Qu Cong-Bo Li Yun Zheng Huan-Qiao Zhang Hui-Bin Sun Nan Wang Chun-Lei Zhang J.J.Valiente-dobón D.Testov M.Mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou M.La Commara A.Goasduff D.Bazzacco D.R.Napoli F.Galtarossa F.Recchia A.Illana S.Bakes I.Zanon S.Aydin Gde Angelis M.Siciliano R.Menegazzo S.M.Lenzi S.Akkoyun L.F.Canto J.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil laboratorio TANDAR Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina Institute for Advanced Study in Nuclear energy and Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key laboratory of Research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPaduaItaly Dipartimento di fisica Astronomia dell’Universita di padova PaduaItaly State Key laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic energy Beijing 102413China The Key laboratory of Beam Technology and Material Modification of Ministry of education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China laboratori Nazionali di Legnaro INFN35020 LegnaroItaly INFN Sezione di Napoli80126 NaplesItaly Dipartimento di Farmacia Universitàdi Napoli“Federico II”80131 NaplesItaly department of Natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics Division Argonne National LaboratoryLemontILUSA department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)Li and^(209)Bi was studied at 28,30,and 34 MeV using the in-beamγ-ray spectroscopy ***γ-γcoincident analysis clearly identified twoγ-rays feeding the ground and long-lived isomeric states,which were employed to determine the cross *** one-neutron stripping cross sections were similar to the cross sections of complete fusion in the^(6)Li+^(209)Bi system,but the one-neutron stripping cross sections decreased more gradually at the sub-barrier region.A coupled-reaction-channel calculation was performed to study the detailed reaction mechanism of the one-neutron stripping process in^(6)*** calculations indicated that the first excited state of 5 Li is critical in the actual one-neutron transfer mechanism,and the valence proton of 209Bi can be excited to the low-lying excited state in(^(6)Li,^(5)Li)reaction,unlike in the(d,p)reaction.

关键词： Transfer reaction Weakly bound nuclei Cross section

Optimization of a photovoltaic-battery system using deep reinforcement learning and load forecasting

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energy and AI 2024年第2期16卷 168-183页

作者： António Corte Real G.Pontes Luz J.M.C.Sousa M.C.Brito S.M.Vieira IDMeC Instituto Superior TécnicoUniversidade de LisboaLisboa1049-001Portugal Instituto dom Luiz Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016LisboaPortugal

Home energy Management Systems(HeMS)are increasingly relevant for demand-side management at the residential level by collecting data(energy,weather,electricity prices)and controlling home appliances or storage *** control can be performed with classical models that find optimal solutions,with high real-time computational cost,or data-driven approaches,like Reinforcement Learning,that find good and flexible solutions,but depend on the availability of load and generation data and demand high computational resources for *** this work,a novel HeMS is proposed for the optimization of an electric battery operation in a real,online and data-driven environment that integrates state-of-the-art load forecasting combining CNN and LSTM neural networks to increase the robustness of *** Reinforcement Learning agents are trained with different algorithms(double DQN,Dueling DQN,Rainbow and Proximal Policy Optimization)in order to minimize the cost of electricity purchase and to maximize photovoltaic self-consumption for a PV-Battery residential *** show that the best Reinforcement Learning agent achieves a 35%reduction in total cost when compared with an optimization-based agent.

关键词： energy management system deep reinforcement learning demand-side management Load forecasting deep learning energy storage systems

Chemical and microbiological characterization of tinctures and microcapsules loaded with Brazilian red propolis extract

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Journal of Pharmaceutical Analysis 2017年第5期7卷 280-287页

作者： erika Tayse da Cruz Almeida Maria Cristina delgado da Silva José Marcos dos Santos Oliveira Regianne Umeko Kamiya Rodolfo elleson dos Santos Arruda Danilo Abreu Vieira Valdemir da Costa Silva Pierre Barnabé escodro Irinaldo Diniz Basílio-Júnior Ticiano Gomes do Nascimento laboratório de controle de qualidade e Análise de Fármacos Medicamentos e AlimentosCurso de FarmáciaEscola de Enfermagem e FarmáciaUniversidade Federal de AlagoasCampus A.C.SimõesBR 104 Norte-Km 97MaceióAL.CEP:57072-970Brazil laboratório de controle de qualidade Microbiológico de Alimentos Faculdade de NutriçãoUniversidade Federal de AlagoasCampus A.C.SimõesBR 104 Norte/Km 97MaceióAL.CEP:57072-970Brazil

The aim of this study was to characterize tinctures and microcapsules loaded with an ethanol extract of red propolis through chemical, physicochemical and microbiological assays in order to establish quality control tools for nutraceutical preparations of red propolis. The markers(isoflavonoids, chalcones, pterocarpans,flavones, phenolic acids, terpenes and guttiferones) present in the tinctures A and B were identified and confirmed using LC/eSI/FTMS/Orbitrap. Four compositions(A, B, C and D) were prepared to contain B tincture of the red propolis with some pharmaceutical excipients and submitted to two drying processes, i. ***-drying and freeze-drying to obtain microcapsules loaded with the red propolis extract. The tinctures and microcapsules of the red propolis were submitted to the total flavonoid content and antioxidant activity *** antibacterial activity and minimum inhibitory concentration(MIC) were tested using Staphylococcus aureus ATCC 25293 and Pseudomonas aeruginosa ATCC 27853 strains. The tinctures and microcapsules presented high flavonoid quantities from 20.50 to 40.79 mg/100 mg of the microcapsules. The antioxidant activity and IC50 were determined for the tinctures A and B(IC50: 6.95 μg/m L and 7.48 μg/m L), the spray-dried microcapsules(IC50: 8.89–15.63 μg/m L) and the freeze-dried microcapsules(IC50: 11.83–23.36 μg/m L). The tinctures and microcapsules were proved to be bioactive against gram-positive and gram-negative bacteria with inhibition halos superior to 10 mm at concentration of 200 μg/m L and MIC values of 135.87–271.74 μg/m L using gram-positive strain and 271.74–543.48 μg/m L using gram-negative strain. The tinctures and microcapsules of the red propolis have a potential application for nutraceutical products.

关键词： Red propolis Tinctures Microcapsules Isoflavonoids LC/eSI/FTMS/Orbitrap Antioxidant activity Antibacterial activity

Colon and rectal cancer:An emergent public health problem

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World Journal of Gastroenterology 2024年第7期30卷 644-651页

作者： Marina Pinheiro David Nascimento Moreira Michele Ghidini LAQV REQUIMTEDepartment of ChemistryFaculty of PharmacyUniversity of Porto4050-313 PortoPortugal Unidade de Saúde Pública Unidade Local de Saúde Barcelos/EsposendeBarcelinhos 4755-069BragaPortugal Medical Oncology Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilan 20122Italy

Colorectal cancer ranks third globally,with a high mortality *** the United States,and different countries in europe,organized population screenings exist and include people between 50 and 74 years of *** screenings have allowed an early diagnosis and consequently an improvement in health *** and rectal cancer(CRC)is a disease of particular interest due to the high global burden associated with it and the role attributed to prevention and early diagnosis in reducing morbidity and *** study is a review of CRC pathology and includes the most recent scientific evidence regarding this pathology,as well as a diagnosis of the epidemiological situation of ***,the recommendation from a public health perspective will be discussed in detail taking into account the context and the most current recommendations.

关键词： Colon and rectal neoplasia Colon and rectal tumor Mortality Morbidity

Tilapia processing waste silage (TPWS): An alternative ingredient for Litopenaeus vannamei (Boone, 1931) diets in biofloc and clear-water systems

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Aquaculture and Fisheries 2019年第5期4卷 214-218页

作者： Joaquim da Rocha Soares Neto Felipe de Azevedo Silva Ribeiro Alex Augusto Gonçalves Maurício Gustavo Coelho emerenciano Universidade Federal Rural do Semi-Árido(UFeRSA) Departamento de Ciência AnimalSetor de AquiculturaMossoró59625-900Brazil UFeRSA Departamento de Ciência AnimalLaboratório de Tecnologia e Controle de Qualidade do PescadoMossoró59625-900Brazil Universidade do estado de Santa Catarina(UdeSC) Laboratório de Aquicultura(LAQ)88790-000LagunaSCBrazil and Programa de Pós-Graduação em Zootecnia(PPGZOO/UDESC)Chapecó89815-630Brazil

The aim of this study was to evaluate the growth performance of Litopenaeus vannamei juveniles reared under biofloc and clear-water conditions fed with different inclusion levels of tilapia processing waste silage(TPWS)*** experiment was performed in two individual systems:biofloc(BS)and clear-water systems(CWS).The trial used forty 40 L rectangular plastic bins(twenty per system)in a density of 63 shrimp/m^(2).The juveniles were distributed in a factorial completely randomized experimental *** treatments were based on the percentage of silage inclusion(control or 0,1.5%,3.0%,4.5%and 6.0%of inclusion)in BS or CWS,totalizing ten treatments and four *** was above 80%in all treatments and was not affected by both systems and *** final weight and SGR were statistically influenced by system(Pe diet;and presented high values in *** inclusion of TPWS in *** diets did not affect shrimp *** addition,shrimp raised in BS demonstrated better growth performance as compared to CWS.

关键词： Silage Nutrition Waste BFT Pacific white shrimp

Thermal and structural properties of Nd2O3-doped calcium boroaluminate glasses

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Journal of Rare earths 2016年第5期34卷 521-528页

作者： J.D.M.Dias G.H.A.Melo T.A.Lodi J.O.Carvalho P.F.Facanha Filho M.J.Barboza A.Steimacher F.Pedrochi Centro de Ciencias Sociais Saude e TecnologiaUniversidade Federal do Maranhao-Imperatriz MA Instituto Federal de educaceo Ciencia e tecnologia do Maranhao Campus Imperatriz-Imperatriz-MA Instituto Federal de educacao Ciencia e tecnologia do Tocantins Campus Araguaina-Araguaina-TO

Nd^3＋ doped CaO-Al2O-B2O3-CaF2 glasses were prepared by conventional melt-quenching technique,and their structural and thermal properties were *** amorphous nature of these samples was confirmed by X-ray diffraction（XRD）.The measured density showed an increase with Nd2O3 doping,at the expense of *** spectra presented changes with addition of Nd2O3,which indicated that the network structure of the glasses studied presented various borate groups,such as tetraborates,metaborates,ortho-borates and pyroborates *** N4 values calculated from FTIR spectra revealed that incorporation of Nd2O3 into glass network converted the structural units from BO4 to *** the analysis of DTA curves,we verified that Tg increased with the addition of Nd2O3;it was similar to the behavior caused by modifier oxides in the structure of borate *** that,the calculated glass stability Tx–Tg for doped samples presented a decrease if compared to the undoped *** heat and thermal conductivity did not present significant changes with Nd2O3 concentration,up to 2.30 mol.%.The results of density,DTA,Raman and FTIR reinforced the idea that Nd2O3 acted as network modifier.

关键词： Nd^3+ Nd^3+ doped glass borate glasses glass structure thermal properties rare earths

Gangliosides in nervous system development,regeneration,and pathologies

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Neural Regeneration Research 2023年第1期18卷 81-86页

作者： Juliana F.Vasques Renata Guedes de Jesus Gonçalves Almir Jordão da Silva-Junior Robertta Silva Martins Fernanda Gubert Rosalia Mendez-Otero Instituto de Ciências Biomédicas Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Programa Redes de Pesquisa em Saúde no estado do rio de Janeiro Rio de JaneiroBrazil Programa Rede NanoSaúde do estado do rio de Janeiro Rio de JaneiroBrazil Instituto Nacional de Ciência e tecnologia em Medicina Regenerativa Rio de JaneiroBrazil

Gangliosides,sialic acid-containing sphingolipids,are major constituents of neuronal *** to the number of sialic acids and the structure of the oligosaccharide chain,gangliosides can be classified as simple or complex and grouped in different *** of gangliosides have been identified in vertebrate cells,with different expression patterns during development and related to several physiological processes,especially in the nervous *** GD3 and its O-acetylated form,9acGD3,are highly expressed in early developmental stages,GM1,GD1a,GD1b,and GT1b are the most abundant ganglioside species in the mature nervous *** in enzymes involved in ganglioside metabolism can lead to the accumulation of specific species,a condition termed gangliosidosis and usually marked by severe neurological *** in ganglioside levels have also been described in several neurodegenerative diseases,such as Alzheimer’s and Parkinson’*** this review,we summarized recent information about the roles of GD3,9acGD3,GM1,GD1a,GD1b,GT1b,and other ganglioside species in nervous system development and regeneration,as well as clinical trials evaluating possible therapeutic applications of these molecules.

关键词： 9acGD3 gangliosides GD1a GD1b GD3 glycolipids GM1 GM2 GM3 GM4 GT1b

A review on the scale-up of high-shear wet granulation processes and the impact of process parameters

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Particuology 2024年第9期92卷 180-195页

作者： Ana Rita Alves Marta Filipe Simões Sérgio Simões João Gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty of Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HSG)one of the most employed technologies in the pharmaceutical *** most critical process parameters of HSG are discussed in this *** main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all *** scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based *** engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule *** work presents the effect of different HSG process parameters on the scale-up,as well as the use of process analytical tools(PAT)and modelling *** aim is to review applied scale-up approaches in HSG and discuss benefits and *** is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.

关键词： High-shear wetgranulation Parametric-based Attribute-based Physics-based modelling Impeller design Scale-up