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Garcinia spp:Products and by-products with potential pharmacological application in cancer

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Food Bioscience 2022年第6期50卷 2138-2151页

作者： Lavínia de C.Brito André Mesquita Marques Flávia da Cunha Camillo Maria Raquel Figueiredo laboratório de produtos naturais (TecBio) Instituto de Tecnologia em FármacosFIOCRUZRua Sizenando Nabuco100Rio de JaneiroRJ21041-250Brazil

The Garcinia genus belongs to the Clusiaceae family and is composed of approximately 240 species,distributed throughout the tropical regions,with a significant representation in *** edible fruits have a high dietary value and have been recognized for their economic value as food and ***-products of Garcinia fruits,such as the peel and seed of Garcinia brasiliensis,are a rich source of fibers,proteins,and bioactive metabolites,producing flour with an energetic value near wheat flour and antioxidant *** waste of ***(mangosteen)has been used as a green absorbent to recover valuable metals such as gold and silver from electronic *** Garcinia species have obtained great prominence for extracts and isolated compounds,such as polyphenols,bioflavonoids,anthocyanins,benzophenones,and xanthones in the treatment of various ***,natural products isolated from Garcinia species have been described as having a chemical diversity and potential for medicinal uses with emphasizing adipogenesis,diabetes,cardiovascular illness,and *** review comprises works published from January 2017 to March 2022 and highlights the promising anticancer activity and potential use of natural compounds from Garcinia species and fruit wastes.

关键词： Clusiaceae Anticarcinogenic Antiproliferative Cytotoxic

Bioactive extracts of red seaweeds Pterocladiella capillacea and Osmundaria obtusiloba(Floridophyceae:Rhodophyta) with antioxidant and bacterial agglutination potential

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 363-370页

作者： Daniel Barroso de Alencar Fátima Cristiane Teles de Carvalho Rosa Helena Rebouas Daniel Rodrigues dos Santos Kelma Maria dos Santos Pires-Cavalcante Rebeca Larangeira de Lima Bárbara Mendes Baracho Rayssa Mendes Bezerra Francisco Arnaldo Viana Regine Helena Silva dos Fernandes Vieira Alexandre Holanda Sampaio Oscarina Viana de Sousa Silvana Saker-Sampaio laboratrio de produtos naturais Marinhos.departamento de Engenharia de Pesca Universidade Federal do Ceará.Campus do Pici.Ar.Mister Hull.s/nCaixa Postal 6043 laboratrio de Microbiologia Ambiental e do Pescado.Instituto de Ciências do Mar.Universidade Federal do Ceará.Av.da Abolicao 3207 laboratrio de Microbiologia Ambiental e do Pescado.Instituto de Ciências do Mar.Universidade Federal do Ceará laboratrio de produtos naturais Marinhos.departamento de Engenharia de Pesca Universidade Federal do Ceará laboratrio de Cromatografia Departamento de QuimicaUniversidade do Estado do Rio Grande do NorteCampus Universitário Central

Objective:To evaluate the antioxidant,antibacterial and bacterial cell agglutination activities of the hexane(Hex) and 70%ethanol(70%EtOH) extracts of two species of red seaweeds Pterocladiella capillacea(***) and Osmundaria ***:In vitro antioxidant activity was determined by DPPH radical scavenging assay,ferric-reducing antioxidant power assay,ferrous ion chelating assay,β-carotene bleaching assay and total phenolic content *** activity was tested using the method of disc diffusion on Mueller-Hinton *** ability of algal extracts to agglutinate bacterial cells was also ***:The 70%EtOH extract of the two algae showed the highest values of total phenolic content compared to the Hex *** results of DPPH for both extracts(Hex,70%EtOH) of Osmundaria obtusiloba(43.46%and 99.47%) were higher than those of ***(33.04%and 40.81%) at a concentration of 1 000 μg/*** for the ferrous ion chelating,there was an opposite behavior,extracts of *** had a higher *** extracts showed a low ferric-reducing antioxidant power,with optical density ranging from0.054 to *** activities of all extracts evaluated for β-carotene bleaching were above 40%.There was no antibacterial activity against bacterial strains ***,the extracts of both species were able to agglutinate bacterial Gram positive cells of Staphylococcus aureus and Gram negative cells of Escherichia coli,multidrug-resistant Salmonella and Vibrio *** This is the first report of the interaction between these algal extracts,rich in natural compounds with antioxidant potential,and Gram positive and Gram negative bacterial cells.

关键词： Bioactive compounds Antioxidant Bacterial agglutination Rhodophyta

LC–MS characterization, anti-kinetoplastide and cytotoxic activities of natural products from Eugenia jambolana Lam. and Eugenia uniflora

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 836-841页

作者： Celestina Elba Sobral de Souza Ana Raquel Pereira da Silva Janaina Esmeraldo Rocha Maria Celeste Vega Gomez Míriam Rolóm Cathia Coronel José Galberto Martins da Costa Manoel L.C.Netto Larissa A.Rolim Henrique Douglas Melo Coutinho laboratório de Microbiologia e Biologia Molecular Universidade Regional do Cariri Center for the development of Scientific Research Moisés Bertoni Foundation/Díaz Gill Laboratories laboratório de pesquisa de produtos naturais Universidade Regional do Cariri Centro Universitário Dr.Leao Sampaio–UNILEAO Universidade Federal do Vale do Sao Francisco–UNIVASF

Objective: To evaluate the trypanocidal, leishmanicidal and cytotoxic activity of Eugenia jambolana(E. jambolana) and Eugenia uniflora(E. uniflora) extracts and ***: The products were characterized by LC–MS. Antiparasitic assays were performed and cytotoxicity was evaluated in fibroblastos. In vitro assays were performed using spectrophotometric evaluation. All assays were performed in ***: The results showed that the extracts and the tannic fraction from E. jambolana inhibited 100% of the epimastigote lines. The ethanolic extract was the most efficient in all concentrations tested against the three parasite strains. In the cytotoxicity assay the flavonoid fraction showed low toxicity. All E. uniflora samples showed cytotoxicity at the highest concentration tested, but the extract showed no toxic effect on the fibroblasts at the lowest concentration. The flavonoid and tannic fractions were more efficient against Leishmania braziliensis promastigotes compared to the extract. However, the extracts and the tannic fraction were more effective against Leishmania infantum strains. The effect on epimastigote cells was observed at all concentrations tested, with all E. uniflora samples. However, the samples were more effective at the highest concentration, where there was inhibition in 100% of the Trypanosoma cruzi ***: The species E. jambolana and E. uniflora presented antiparasitic activity against all tested parasite strains, indicating that these species can serve as an alternative therapy as they were efficient in the tests performed. The E. uniflora extract and the E. jambolana flavonoid fraction presented a low cytotoxicity, opening the floor for new biological studies.

关键词： Antiparasitic effect Cytotoxicity Eugenia jambolana Eugenia uniflora

Chemical profile and antimicrobial activity of Secondatia floribunda A. DC(Apocynaceae)

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Asian Pacific Journal of Tropical Biomedicine 2017年第8期7卷 739-749页

作者： Daiany Alves Ribeiro Sarah Soares Damasceno Aline Augusti Boligon Irwin Rose Alencar de Menezes Marta Maria de Almeida Souza JoséGalberto Martins da Costa Programa de Pós-Graduacao em Etnobiologia e Conservacao da Natureza Universidade Regional do Cariri departamento de Química Biológica Laboratório de Pesquisas de Produtos NaturaisUniversidade Regional do Cariri laboratório de Fitoquímica Universidade Federal de Santa Maria departamento de Química Biológica Laboratório de Farmacologia e Química MolecularUniversidade Regional do Cariri departamento de Ciências Biológicas Laboratório de Ecologia VegetalUniversidade Regional do Cariri

To establish the chemical profile, and to evaluate the antibacterial and modulatory activity of the ethanolic extracts of the stalk’s inner bark and heartwood of Secondatia *** of total phenols and flavonoids was determined by the Folin-Ciocalteu method and aluminum chloride, respectively. Phenolic compounds were identified and quantified by HPLC-DAD (High Performance Liquid Chromatography-Diodearray detector) and the Infrared Spectroscopy was performed using the measure by Attenuated Total Reflectance with Fourier Transform (ATR-FTIR). Antibacterial assays for determination of the Minimum Inhibitory Concentration (MIC) and modification of aminoglycosides were performed by *** spectra showed similar characteristics, having among its main absorption bands hydroxyl group (OH). The antibacterial activity showed clinically significant results for the strains of Staphylococcus aureus and Escherichia coli. In modulation assay, synergic and antagonistic effect for both extracts was observed. Heartwood extract in combination with antibiotics showed a significant MIC reduction at 19.8% (P < 0.000 1)-79.3% (P < 0.01).ConclusionsThis study is the first report of chemical and biological information of Secondatia floribunda suggesting that it is clinically relevant source of a new antibacterial therapy, especially due to the presence of significant levels of phenolic compounds.

关键词： Chemical composition HPLC Cinchonain Natural product Modification resistance

Comparison of morphological and functional outcomes of mouse sciatic nerve repair with three biodegradable polymer conduits containing poly (lactic acid)

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Neural Regeneration Research 2018年第10期13卷 1811-1819页

作者： Fernanda Marques Pestana Rui C.C.Domingues Júlia Teixeira Oliveira Daniela F.P.A.Durco Camila Oliveira Goulart Henrique Rocha Mendonca Anne Caroline Rodrigues dos Santos Natália Tavares de Campos Beatriz Theodoro da Silva Cristina Cardoso Pereira Cristiano Piacsek Borges Ana Maria Blanco Martinez Pós Graduacao em Ciências Morfológicas Instituto de Ciências Biomédicas-UFRJRio de Janeiro RJ Brazil Anatomia Patológica-Faculdade de Medicina-HUCFF-UFRJ Rio de Janeiro RJ Brazil laboratório de Neurodegeneracao e Reparo-Faculdade de Medicina-HUCFF-UFRJ Rio de Janeiro RJ Brazil Programa de Eng. Química COPPE-UFRJRio de Janeiro Brazil Polo Universitário de Macaé Laboratório Integrado de Produtos Bioativos e BiociênciasMacaê UFRJ Brazil

Poly（lactic acid）（PLA）-containing nerve guidance conduits（NGCs） are currently being investigated for nerve repair as an alternative to autograft, which leads to permanent functional impairment in the territory innervated by the removed nerve. Combination of polymers modifies the physical properties of the conduits, altering their nerve-guidance properties. Conduits made from PLA-only or combined with other polymers have been used successfully for nerve repair, but their efficiency has not been compared. We compared the morphological and functional outcomes of peripheral nerve repair by using NGCs made of poly（lactic acid） and combined or not with polycaprolactone（PLA/PCL） or polyvinylpyrrolidone（PLA/PVP）. To assess the functional recovery, we employed a mechanical hyperalgesia analysis, sciatic functional index（SFI）, and electroneuromyography. The mechanical hyperalgesia analysis showed that the PLA group improved more rapidly than the PLA/PVP and PLA/PCL groups; similarly, in the electroneuromyography assay, the PLA group exhibited higher amplitude than the PLA/PCL and PLA/PVP groups. However, the SFI improvement rates did not differ among the groups. Morphologically, the PLA group showed more vascularization, while the nerve fiber regeneration did not differ among the groups. In conclusion, the PLA-only conduits were superior to the other NGCs tested for nerve repair.

关键词： sciatic nerve tubulization biodegradable conduit poly(lactic acid) regeneration

Clusia nemorosa的叶提取物通过肾上腺素系统依赖机制对大鼠的镇痛作用(英文)

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中国天然药物 2013年第4期11卷 385-390页

作者： Jamylle Nunes de Souza Ferro Juliane Pereira da Silva Lucia Maria Conserva Emiliano Barreto laboratório de Biologia Celular Universidade Federal de AlagoasMaceió 57072-970ALBrazil laboratório de pesquisa em Química dos produtos naturais Universidade Federal de AlagoasMaceió 57072-970ALBrazil

Previous studies on the genus Clusia have shown anti-inflammatory and antiproliferative effects of the leaf extracts,but its antinociceptive activity has never been *** the present study,the antinociceptive activity of the hexane extract of the leaves of Clusia nemorosa ***,called HECn,was *** activity was evaluated using acetic acid-induced writhing,formalin,and hot-plate *** experiments were carried out on male Swiss *** extract(1 400 mg kg 1),given by intraperitoneal route(i.p.) 1 h prior to testing,produced a dose-dependent inhibition on the number of abdominal writhings,with an ID50 of 62 mg kg *** addition,HECn was able to prevent the visceral pain induced by acetic acid in mice for at least 2 *** the formalin test,HECn had no effect in the first phase,but produced an analgesic effect on the second phase with the inhibition of licking *** HECn did not show a significant analgesic effect in the hot plate *** with yohimbine attenuated the antinociceptive effect induced by HECn in the writhing ***,naloxone,atropine,or haloperidol did not affect antinociception induced by HECn in the writhing ***,these results indicate that the extract from the leaves of Clusia nemorosa produces antinociception in models of chemical pain through mechanisms that suggest participation of the adrenergic systems pathway.

关键词：实验药理学药理病理作用天然药物

Asymmetric hydrogenation and transfer hydrogenation in the enantioselective synthesis of flavonoids

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Organic Chemistry Frontiers 2022年第4期9卷 1165-1194页

作者： Guilherme S.Caleffi Felipe C.demidoff Carmen Najera Paulo R.R.Costa laboratorio de Quimica Bioorganica(LQB) Instituto de Pesquisas de Produtos NaturaisUniversidade Federal do Rio de JaneiroAv.Carlos Chagas Filho 373Bloco HCidade Universitaria21941-902 Rio de Janeiro Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA) Universidad de AlicanteApdo.99E-03080 AlicanteSpain

Asymmetric hydrogenation(AH)and asymmetric transfer hydrogenation(ATH)are versatile synthetic methodologies widely employed in the preparation of chiral *** this review,we explore the applications of AH and ATH in the total synthesis of natural flavonoids and their analogues,highlighting the limitations and opportunities in the field.

关键词： compounds field hydrogenation

Antioxidant effects of Phyllanthus niruri tea on healthy subjects

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Asian Pacific Journal of Tropical Medicine 2014年第2期7卷 113-118页

作者： Elisngela Colpo Carlos D.D.A.Vilanova Romaiana P.Pereira Luis Gustavo B.Reetz Liline Oliveira Iria L.G.Farias Aline A.Boligon Margareth L.Athayde Joo Batista T.Rocha departamento de Química Centro de Ciências Naturais e ExatasUniversidade Federal de Santa Maria(UFSM) laboratrio de Anlises Clínicas Hospital UniversitrioUniversidade Federal de Santa Maria(UFSM) departamento de Farmcia Industrial Universidade Federal de Santa Maria(UFSM)

Objective:To investigate the potential antioxidant effects of Phyllanthus niruri(***)tea on healthy ***:Five non-smoking,male healthy volunteers,20 to 31 years *** *** subject was treated twice,following a randomized crossover fashion regarding the ingestion of *** infusion(5 g/750 mL)(tea group)or 750 mL of water(control group).Fasting venous blood samples were collected prior to and at 1.2 and 4 h after infusion *** were tested for plasmatic gallic acid and ascorbic acid levels,erythrocytic catalase and superoxide dismutase activities,and intracellular DCFH fluorescence in granulocytes,monocytes and ***:Catalase and superoxide dismutase activities were not altered by tea *** levels of gallic acid were significantly increased at1,2 and 4 h after *** ingestion and plasma ascorbic acid at 1 h after *** ***:Ingestion of *** tea is associated with a slight increase in antioxidant markers in human blood(ascorbic acid and gallic acid),which may contribute to its pharmacological effects.

关键词： Antioxidants Polyphenols Phyllanthus niruri Human Ascorbic acid Gallic acid

Medicinal properties of Angelica archangelica root extract: Cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development

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Journal of Integrative Medicine 2019年第2期17卷 132-140页

作者： Carlos R.Oliveira Daniel G.Spindola Daniel M.Garcia Adolfo Erustes Alexandre Bechara Caroline Palmeira-dos-Santos Soraya S.Smaili Gustavo J.S.Pereira André Hinsberger Ezequiel P.Viriato Maria Cristina Marcucci Alexandra C.H.F.Sawaya Samantha L.Tomaz Elaine G.Rodrigues Claudia Bincoletto departamento de Farmacologia Escola Paulista de Medicina (EPM) Universidade Federal de Sao Paulo (UNIFESP) Grupo de Fitocomplexos e Sinalizacao Celular Escola de Ciências da Saúde Universidade Anhembi Morumbi Faculdade de Ciências Farmacêuticas e Bioquímicas Oswaldo Cruz laboratório de produtos naturais e Quimiometria Programa de pós-graduacao em Farmácia e Biotecnologia Universidade Anhanguera de Sao Paulo Faculdade de Ciências Farmacêuticas Universidade Estadual de Campinas (UNICAMP) Unidade de Oncologia Experimental EPM Universidade Federal de Sao Paulo (UNIFESP)

Objective: Although Angelica archangelica is a medicinal and aromatic plant with a long history of use for both medicinal and food purposes, there are no studies regarding the antineoplastic activity of its *** study aimed to evaluate the cytotoxicity and antitumor effects of the crude extract of A. archangelica root(CEAA) on breast ***: The cytotoxicity of CEAA against breast adenocarcinoma cells(4T1 and MCF-7) was evaluated by a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide(MTT) assay. Morphological and biochemical changes were detected by Hoechst 33342/propidium iodide(PI) and annexin V/PI staining. Cytosolic calcium mobilization was evaluated in cells staining with FURA-4 NW. Immunoblotting was used to determine the effect of CEAA on anti-and pro-apoptotic proteins(Bcl-2 and Bax, respectively).The 4 T1 cell-challenged mice were used for in vivo ***: Using ultra-high-performance liquid chromatography–mass spectrometry analysis, angelicin, a constituent of the roots and leaves of A. archangelica, was found to be the major constituent of the CEAA evaluated in this study(73 mg/mL). The CEAA was cytotoxic for both breast cancer cell lines studied but not for human fibroblasts. Treatment of 4 T1 cells with the CEAA increased Bax protein levels accompanied by decreased Bcl-2 expression, in the presence of cleaved caspase-3 and cytosolic calcium mobilization, suggesting mitochondrial involvement in breast cancer cell death induced by the CEAA in this cell line. No changes on the Bcl-2/Bax ratio were observed in CEAA-treated MCF7 cells. Gavage administration of the CEAA(500 mg/kg) to 4T1 cell-challenged mice significantly decreased tumor growth when compared with untreated ***: Altogether, our data show the antitumor potential of the CEAA against breast cancer cells in vitro and in vivo. Further research is necessary to better elucidate the pharmacological application of the CEAA in breast cancer therapy.

关键词： Angelica archangelica Umbelliferae Apoptosis Cell death Breast cancer Angelicin