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Food Science and Human Wellness 2024年

作者： Shuqing Zhang Wenjing Chen Chen Ma Yinghua Luo Li Dong Xiaosong Hu Fang Chen Daotong Li College of Food Science and Nutritional Engineering， National Engineering Research Centre for fruit and Vegetable processing， Key laboratory of fruits and vegetables processing， Ministry of Agriculture， Engineering Research Centre for fruits and vegetables processing， Ministry of Education， China Agricultural University

Neurodegenerative diseases (NDs)， mainly including Alzheimer’s disease， Parkinson’s disease， and Multiple sclerosis， represent a major public health challenge with the steady increase of aging population worldwide. Emerging evidence has revealed the key role of the microbiota-gut-brain axis in the pathogenesis of NDs. Diet is one of the most important environmental factors shaping the structure and function of gut microbiota. Manipulating the gut microbiota through specific diet patterns may represent a promising approach for NDs prevention. In this review， we highlight gut microbiota variations in NDs， outline several crucial signaling pathways of the gut-brain communication， and discuss the interplay of nutrients-microbes and biological effect of diet-derived microbial metabolites on neural physiology. In particular， we summarized the current knowledge about the application of dietary patterns in NDs to prevent disease progression via the modulation of the gut microbiota. Our study provides novel insights on the diet-microbiota-gut-brain axis in neurodegenerative disorders and highlights the potential of developing microbiome-targeted personalized dietary intervention for NDs management.

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Arecoline causes cognitive impairment and potential addiction via disturbing Kenyon cells in bumblebee brain

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Food Science and Human Wellness 2024年

作者： Huiling Liu Xiaohuan Mu Rongrong Fan Jieteng Chen Jie Ma Liang Meng Xiaosong Hu Hao Zheng Shanshan Liu Xiaofei Wang College of Food Science and Nutritional Engineering， National Engineering Research Center for fruit and Vegetable processing， Key laboratory of fruits and vegetables processing， Ministry of Agriculture， Engineering Research Centre for fruits and vegetables processing， Ministry of Education， China Agricultural University BGI-Qingdao

Areca nut is the basic ingredient of betel quid， which is chewed by hundreds of millions of people in south-eastern Asia. Chewing of areca nut has been associated with oral cancers potentially due to its specific alkaloids， among which arecoline constitutes about 90% of total fraction. Being the world’s fourth most commonly used psychoactive substance， arecoline evokes stimulation， addiction， and other direct neurological effects， while its misuse correlates to neurotoxic effects. However， what might underlie its neurotoxic mechanisms has been poorly documented. The brain is encoded by a complex network of neuronal and glial cell types， and neurotoxicity of hazardous compounds present transcriptional heterogeneity. Recently， the eusocial bumblebee has been used as a model for studying brain effects， with sophisticated cognitive capability and precisely measured brain architecture. Here， we decipher cell-type-specific mental risks to arecoline using bumblebees. Arecoline induced locomotor hyperactivity and cognitive impairment. Single nucleus RNA sequencing (snRNA-seq) unearthed arecoline-induced cell-specific responses， primarily targeted on Kenyon cells (KC). Moreover， high-dose arecoline induced distinctive cell responses among KC subtypes， particularly class I large Kenyon cell (lKC)， leading to DNA damage， excitatory/inhibitory (E/I) imbalance， and calcium dyshomeostasis， which potentially resulted in cognitive impairment. Given arecoline’s popularity and growing exposure risks to humans， neurological health risks of areca nut warrant serious consideration.

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Dietary lycopene mitigates nonalcoholic steatohepatitis by regulating Nrf2/PPARα-dependent ferroptosis

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Food Science and Human Wellness 2024年

作者： Xunyu Song Daotong Li Jun Sun Xiaoying Zhang Li-Shu Wang Fang Chen College of Food Science and Nutritional Engineering， National Engineering Research Centre for fruit and Vegetable processing， Key laboratory of fruits and vegetables processing， Ministry of Agriculture Engineering Research Centre for fruits and vegetables processing， Ministry of Education， China Agricultural University Department of Hematology and Hematopoietic Cell Transplantation Comprehensive Cancer Center， City of Hope National Medical Center

The global burden of non-alcoholic steatohepatitis (NASH) is on the rise. Researchers recognize inhibiting ferroptosis， a form of cell death leading to iron-dependent oxidative damage， as a promising therapy for treating NASH. Lycopene， a natural antioxidant compound， exhibits various pharmacological properties. However， the anti-NASH efficacy of the dietary recommended concentration of lycopene and the role of lycopene in combating ferroptosis in NASH have remained unclear. Our study investigated lycopene’s impact on ferroptosis in various diet-induced mouse NASH models and corresponding cellular models， unveiling its anti-inflammatory and anti-fibrotic effects. Our findings demonstrated that lycopene notably reduced ferroptosis in MCD (methionine- and choline-deficient diet)-fed mice and a normal mouse hepatocyte cell line (NCTC1469) by restoring balanced ferrous iron levels， lipid reactive oxygen species， and normal mitochondrial morphology. These effects were linked to the regulation of ferroptosis markers GPX4 and PTGS2. Additionally， lycopene’s anti-ferroptosis action was validated in mice fed a high-fat， high-cholesterol diet and HepG2 cells treated with free fatty acid. Our transcriptomic analysis highlighted PPARα as a primary target of lycopene， crucial for activating the glutathione system because GW6471， a PPARα antagonist， blocked lycopene-induced GPX4 activation. Furthermore， Nrf2 played a crucial role in lycopene’s impact on iron metabolism-related proteins (FTH1 and TFR1). Notably， when inhibiting PPARα or Nrf2 in MCD-fed mice by GW6471 or ML385， lycopene’s protective effects against ferroptosis and NASH progression diminished. These findings underscore the crucial role of PPARα-mediated glutathione system activation and Nrf2-mediated iron metabolism modulation in lycopene's anti-ferroptosis effects.

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Phenolic compounds and its antioxidant activities in ethanolic extracts from seven cultivars of Chinese jujube

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Food Science and Human Wellness 2014年第3期3卷 183-190页

作者： Huan-xia Zhao Hai-sheng Zhang Shu-fang Yang lab.of fruit and vegetables processing College of Food Engineering and Nutritional ScienceShaanxi Normal UniversityXi’an 710062China

Phenolic compounds and its antioxidant activity of extracts from seven cultivars of Chinese jujubes were investigated by high performance liquid chromatography(HPLC)with standards and different antioxidant evaluation methods,such as phosphomolybdenum assay,superoxide radical scavenging activity(SRSA),hydroxyl radical scavenging activity(HRSA),antihemolytic activity and inhibition of lipid peroxidation in rat liver homogenate,*** results showed the components of the extracts are comprised of total phenols and flavonoids,and its content ranges from 454.3 to 1298.9(GAE mg/100 g dry weight).Phlorizin,catechin,gallic acid,chlorogenic acid,caffeic acid were the predominant phenolic *** the extracts had significant antioxidant activities either in vitro or in *** analysis indicated that the antioxidant capacities of Chinese jujube extracts demonstrated a good positive relationship with some phenolic acids,which was higher in Xiao and *** results indicated that Xiao and Goutou could be attributed to a potential source of natural antioxidants for food applications.

关键词： Chinese jujube Phenolic compounds Flavonoids Antioxidant activity Phlorizin

Theoretical Investigation on the Relationship between the Structures and Antioxidant Activities of Myricetin and Dihydromyricetin

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Chinese Journal of Structural Chemistry 2017年第3期36卷 416-422页

作者：邱松山姜翠翠黄瑶周如金 Development Center of Technology for fruit & vegetables Storage and processing Engineering Guangdong University of Petrochemical Technology

The geometry of myricetin and dihydromyricetin was optimized by DMol3 program based on DFT. The optimized structures have been proved to be stable by real frequencies *** parameters of geometry optimization,vibration frequencies,atomic charges,thermodynamics,Fukui functions,and frontier molecular orbital had been obtained. The thermodynamic properties of 2 molecules were fitted and the relationship between the thermodynamic function and temperature was obtained. The correlation coefficient of the obtained equations is larger than 0.99,indicating that the function is approximately linear in the whole temperature range. The calculated results showed the O–H molecular structures were the main group affecting the antioxidant activity and the oxygen in the benzene ring is the electrophilic reaction site. Ortho-OH on the benzene formed intramolecular hydrogen bonds,which contributed to the stability of the benzene ring. It may be the active site for the occurrence of the reaction.

关键词： myricetin dihydromyricetin density functional theory antioxidation

Deciphering Ascorbic Acid Regulatory Pathways in Ripening Tomato fruit Using a Weighted Gene Correlation Network Analysis Approach

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Journal of Integrative Plant Biology 2013年第11期55卷 1080-1091页

作者： Chao Gao Zheng Ju Shan Li Jinhua Zuo Daqi Fu Huiqin Tian Yunbo Luo Benzhong Zhu laboratory of fruit Biology College of Food Science and Nutritional Engineering China Agricultural University laboratory of Postharvest Storage and processing of vegetables National Engineering Research Center for Vegetables

Genotype is generally determined by the co-expression of diverse genes and multiple regulatory pathways in plants. Gene co-expression analysis combining with physiological trait data provides very important information about the gene function and regulatory mechanism. L-Ascorbic acid （AsA）, which is an essential nutrient component for human health and plant metabolism, plays key roles in diverse biological processes such as cell cycle, cell expansion, stress resistance, hormone synthesis, and signaling. Here, we applied a weighted gene correlation network analysis approach based on gene expression values and AsA content data in ripening tomato （Solanum lycopersicum L.） fruit with different AsA content levels, which leads to identification of AsA relevant modules and vital genes in AsA regulatory pathways. Twenty- four modules were compartmentalized according to gene expression profiling. Among these modules, one negatively related module containing genes involved in redox processes and one positively related module enriched with genes involved in AsA biosynthetic and recycling pathways were further analyzed. The present work herein indicates that redox pathways as well as hormone-signal pathways are closely correlated with AsA accumulation in ripening tomato fruit, and allowed us to prioritize candidate genes for follow-up studies to dissect this interplay at the biochemical and molecular level.

关键词： Gene co-expression L-ascorbic acid network system biology weighted gene correlation network analysis approach.

Safety evaluation and whole genome sequencing for revealing the ability of Penicillium oxalicum WX-209 to safely and effectively degrade citrus segments

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Food Science and Human Wellness 2023年第6期12卷 2369-2380页

作者： Xiao Hu Yujiao Qian Zhipeng Gao Gaoyang Li Fuhua Fu Jiajing Guo Yang Shan Hunan Agriculture Product processing Institute International Joint Lab on Fruits&Vegetables ProcessingQuality and SafetyHunan Key Lab of Fruits&Vegetables StorageProcessingQuality and SafetyHunan Academy of Agricultural SciencesChangsha 410125China College of Animal Science and Technology Hunan Agricultural UniversityChangsha 410128China

The microbial potential of Penicillium has received critical *** present research aimed to elucidate the efficacy of crude enzyme secreted from Penicillium oxalicum WX-209 in degrading citrus segments and evaluate the safety of the *** showed that citrus segment membranes gradually dissolved after treatment with the crude enzyme solution,indicating good degradation *** significant differences in body weight,food ingestion rate,hematology,blood biochemistry,and weight changes of different organs were found between the enzyme intake and control *** experiments showed that the crude enzyme had high biological ***,the whole genome of *** WX-209 was sequenced by PacBio and Illumina ***-five scaffolds were assembled to generate 36 Mbp size of genome sequence comprising 11369 predicted genes modeled with a GC content of 48.33%.A total of 592 genes were annotated to encode enzymes related to carbohydrates,and some degradation enzyme genes were identified in strain *** WX-209.

关键词： Penicillium oxalicum WX-209 Crude enzyme Degradation Safety evaluation Genome sequencing

1-MCP Regulates Ethanol Fermentation and GABA Shunt Pathway Involved in Kiwifruit Quality During Postharvest Storage

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Horticultural Plant Journal 2021年第1期7卷 23-30页

作者： Maratab Ali Muhammad Ammar Raza Shenge Li Lichao Zhou Chen Huan Shen Shuling Xiaolin Zheng College of Food Science and Biotechnology Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang ProvinceZhejiang Gongshang UniversityHangzhou 310018China National Institute of Food Science and Technology Faculty of FoodNutrition and Home SciencesUniversity of AgricultureFaisalabad 38800Pakistan fruit Professional Cooperative of Huaji Shan in Linhai City LinhaiZhejiang 317000China

Kiwifruit(Actinidia deliciosa)‘Bruno’is prone to accumulate ethanol rapidly after respiratory climacteric during storage at ambient conditions without stresses,which causes quality deterioration of the fruit associated with alcohol *** maintaining the postharvest quality of kiwifruit‘Bruno’,the effects of 1.0μL•L^−11-methylcyclopropene(1-MCP)treatment on regulating the ethanol fermentation andγ-aminobutyric acid(GABA)shunt pathway associated with control of alcohol off-flavor were investigated during storage at room temperature(24±1)°C for 27 *** results showed that 1-MCP treatment significantly reduced the respiration rate,ethylene production,decay rate,ascorbic acid(AsA)loss,and delayed the decline in the firmness and titratable acidity(TA),and the increase in total soluble solid(TSS)in ***,1-MCP treatment effectively inhibited the increases in contents of acetaldehyde,ethanol,and GABA along with the suppressed activities of key enzymes involved in ethanol fermentation and GABA shunt pathway,such as pyruvate decarboxylase(PDC),alcohol dehydrogenase(ADH),glutamate decarboxylase(GAD),and GABA-transaminase(GABA-T)in kiwifruit during *** conclusion,1-MCP treatment efficiently regulated the ethanol fermentation and GABA shunt pathway by delaying the ripening process to avoid the alcohol off-flavor development,thereby contributed to maintaining the quality of the kiwifruit.

关键词： kiwifruit ethanol fermentation GABA shunt pathway 1-methylcyclopropene quality

Crude enzyme derived from Penicillium oxalicum WX-209: degrading capability of citrus segment， safety evaluation， and prediction of enzyme- producing genes by whole genome sequencing

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Food Science and Human Wellness 2022年

作者： Xiao Hu Yujiao Qian Zhipeng Gao Gaoyang Li Fuhua Fu Jiajing Guo Yang Shan Hunan Agriculture Product processing Institute， International Joint lab on fruits &vegetables processing， Quality and Safety， Hunan Key lab.of fruits &vegetables Storage， processing， Quality and Safety， Hunan Academy of Agricultural Sciences College of Animal Science and Technology， Hunan Agricultural University

The microbial potential of Penicillium has received critical attention. The present research aimed to elucidate the efficacy of crude enzyme secreted from Penicillium oxalicum WX-209 in degrading citrus segments and evaluate the safety of the process. Results showed that citrus segment membranes gradually dissolved after treatment with the crude enzyme solution， indicatinggood degradation capability. No significant differences in body weight， food ingestion rate， hematology， blood biochemistry， and weight changes of different organs were found between the enzyme intake and control groups. Serial experiments showed that the crude enzyme had high biological safety. Moreover， the whole genome of P. oxalicum WX-209 was sequenced by PacBio and Illumina platforms. 25 scaffolds were assembled to generate 36 Mbp size of genome sequence comprising 11，369 predicted genes modeled with a GC content of 48.33%. A total of 592 genes were annotated to encode enzymes related to carbohydrates， and some degradation enzyme genes were identified in strain P. oxalicum WX-209.

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Development status and prospect of cold chain logistics of fruits,vegetables,and agricultural products based on intelligent technology

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智能化农业装备学报（中英文） 2024年第3期5卷 63-74页

作者： ZHANG Ruizhi LIU Qianyuan HUANG Yuying LIU Bing CHANG Zhiguang WANG Jiaoling Zhongnong Guoke(Nanjing)Planning and Design Co.Ltd. Nanjing 210014China Nanjing Institute of Agricultural Mechanization Ministry of Agriculture and Rural AffairsNanjing 210014China Key laboratory of Agro-Products processing and Storage Ministry of Agriculture and Rural AffairsNanjing 210014China

The cold chain in the production area of fruits and vegetables is the primary link to reduce product loss and improve product quality,but it is also a weak *** the application of big data technology in cold chain logistics,intelligent devices,and technologies have become important carriers for improving the efficiency of cold chain logistics in fruit and vegetable production areas,extending the shelf life of fruits and vegetables,and reducing fruit and vegetable *** have many advantages in fruit and vegetable pre-cooling,sorting and packaging,testing,warehousing,transportation,and other *** article summarizes the rapidly developing and widely used intelligent technologies at home and abroad in recent years,including automated guided vehicle intelligent handling based on electromagnetic or optical technology,intelligent sorting based on sensors,electronic optics,and other technologies,intelligent detection based on computer vision technology,intelligent transportation based on perspective imaging technology,*** analyses and studies the innovative research and achievements of various scholars in applying intelligent technology in fruit and vegetable cold chain storage,sorting,detection,transportation,and other links,and improves the efficiency of fruit and vegetable cold chain ***,applying intelligent technology in fruit and vegetable cold chain logistics also faces many *** challenges of high cost,difficulty in technological integration,and talent shortages have limited the development of intelligent technology in the field of fruit and vegetable cold *** solve the current problems,it is proposed that costs be controlled through independent research and development,technological innovation,and other means to lower the entry threshold for small *** integrating intelligent technology and cold chain logistics systems to improve data security and system *** the same time,the government

关键词： fruits and vegetables cold chain logistics automated guided vehicle intelligent handling computer vision spectral detection