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Development of an orally bioavailab.e selective inhibitor of the menin-MLL

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Genes & Diseases 2023年第5期10卷 1735-1738页

作者： Hai-Jing Zhong Wanhe Wang Wei Zhou Jia-Xin Liang Yung-Chi Cheng Dik-Lung Ma Chung-Hang Leung State Key lab.ratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Department of chemistry Hong Kong Baptist UniversityKowloon TongHong Kong SARChina Department of Pharmacology Yale University School of MedicineNew HavenCT 06520USA Department of Biomedical Sciences Faculty of Health SciencesUniversity of MacaoMacao SARChina International Cooperative lab.ratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) College of PharmacyJinan UniversityGuangzhouGuangdong 510632China

The protein–protein interaction between menin and mixed lineage leukemia(MLL)plays an important role in the development of human hepatocellular carcinogenesis(HCC)and is associated with poor prognosis of HCC patients.1,2 Hence,interrupting the menin-MLL interaction is an attractive strategy in cancer treatment,particularly for liver cancer.3,4 In this study,we identified complex C1 as the first rhodium(III)-based orally bioavailab.e selective inhibitor of the menin-MLL interaction for HCC.

关键词： MLL prognosis carcinogenesis

On the accurate characterization of quantum-dot light-emitting diodes for display applications

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npj Flexible Electronics 2022年第1期6卷 351-362页

作者： Wangxiao Jin Yunzhou Deng Bingbing Guo Yaxiao Lian Baodan Zhao Dawei Di Xiaowei Sun Kai Wang Shuming Chen Yixing Yang Weiran Cao Song Chen Wenyu Ji Xuyong Yang Yuan Gao Shuangpeng Wang Huaibin Shen Jialong Zhao Lei Qian Fushan Li Yizheng Jin Key lab.ratory of Excited-State Materials of Zhejiang Province State Key Laboratory of Silicon MaterialsDepartment of ChemistryZhejiang University310027 HangzhouChina State Key lab.ratory of Modern Optical Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang University310027 HangzhouChina Department of Electronic and Electrical Engineering Southern University of Science and Technology518055 ShenzhenChina TCL Research ShenzhenGuangdongChina Shenzhen China Star Optoelectronics Semiconductor Display Technology Co. LtdShenzhenGuangdongChina College of chemistry Chemical Engineering and Materials ScienceSoochow University199 Ren’ai Rd215123 SuzhouJiangsuChina Key lab.of Physics and Technology for Advanced Batteries(Ministry of Education) College of PhysicsJilin University130023 ChangchunChina Key lab.ratory of Advanced Display and System Applications of Ministry of Education Shanghai University149 Yanchang RoadShanghai 200072China Najing Technology Corporation Ltd Hangzhou 310052China Institute of Applied Physics and Materials Engineering University of MacaoTaipaMacaoSAR 999078China Key lab.ratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-Efficiency Display and Lighting Technologyand Collaborative Innovation Center of Nano Functional Materials and ApplicationsHenan UniversityKaifeng 475004China School of Physical Science and Technology MOE Key Laboratory of New Processing Technology for Non-ferrous Metals and MaterialsGuangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsGuangxi UniversityNanning 530004China Division of Functional Materials and Nanodevices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China College of Physics and Information Engineering Fuzhou UniversityFuzhou 350108China

Quantum dot light-emitting diodes(QLEDs)are a class of high-performance solution-processed electroluminescent(EL)devices highly attractive for next-generation display *** the encouraging advances in the mechanism investigation,material chemistry,and device engineering of QLEDs,the lack of standard protocols for the characterization of QLEDs may cause inaccurate measurements of device parameters and invalid comparison of different ***,we report a comprehensive study on the characterizations of QLEDs using various *** show that the emission non-uniformity across the active area,nonLambertian angular distributions of EL intensity,and discrepancies in the adopted spectral luminous efficiency functions could introduce significant errors in the device *** errors in the operational-lifetime measurements may arise from the inaccurate determination of the initial luminance and inconsistent methods for analyzing the luminance-decay ***,we suggest a set of recommended practices and a checklist for device characterizations,aiming to help the researchers in the QLED field to achieve accurate and reliable measurements.

关键词： diodes characterization luminous

Adjusting the SnZn defects in Cu_(2)ZnSn(S,Se)_(4) absorber layer via Ge^(4+) implanting for efficient kesterite solar cells

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Journal of Energy chemistry 2021年第10期30卷 1-7,I0001页

作者： Yueqing Deng Zhengji Zhou Xin Zhang Lei Cao Wenhui Zhou Dongxing Kou Yafang Qi Shengjie Yuan Zhi Zheng Sixin Wu Key lab.for Special Functional Materials Ministry of EducationNational and Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologyAnd School of MaterialsHenan UniversityKaifeng 475004HenanChina Collab.rative Innovation Centre of Nano Functional Materials and Applications HenanChina Key lab.ratory for Micro-Nano Energy Storage and Conversion Materials of Henan Province College of Advanced Materials and EnergyInstitute of Surface Micro and Nano MaterialsXuchang UniversityXuchang 461000HenanChina

The development of kesterite photovoltaic solar cells has been hindered by large open-circuit voltage(V_(oc))***,Snzn deep point defect and associative defect cluster have been recognized as the main culprit for the Voc ***,manipulating the deep-level donor of Snzn antisite defects is crucial for breaking through the bottleneck of present Cu_(2) ZnSn(S,Se)_(4)(CZTSSe)photovoltaic *** this study,the Snzn deep traps in CZTSSe absorber layer are suppressed by incorporation of *** energy levels and concentration of Snzn defects measured by deep-level transient spectroscopy(DLTS)decrease *** addition,the grain growth of CZTSSe films is also promoted due to Ge implantation,yielding the high quality absorber ***,the efficiency of CZTSSe solar cells increases from 9.15%to 11.48%,largely attributed to the 41 mV Voc increment.

关键词： CZTSSe Defect Absorber layer Solar cells V_(oc)

Synthesis of a Novel High Solid Coating Used in Automobile

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合成化学 2004年第Z1期12卷 96-96页

作者： LIANG Lu CHEN Hua-lin LIANG Shou-tian LIU Bai-ling Chengdu Institute of Organic chemistry Chinese Academy of Sciences Chengdu 610041 China Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China

High solid coating is one of the most important environmental friendly coatings, and has been obtained great attention since 70s' last century. For there are high volatile organic compounds(VOCs) in the conventional coatings, which cause both a serious pollution and consume of a plentiful of natural resource, such as petroleum. The development and production of high solid coatings is pressing target for all the countries, especially for China due to our heavy population and short of resources. Based on the requirement, a novel coating with high solid content has been developed in our lab. The solid content of the resin is 80%, compared to the 55% of conversional resin. This coating is characterized by its unique molecular architecture, it is a kind of hyper-branched polymer with uniform distribution of the reactive groups along the molecular backbone, which can react with other chemicals to form a cross-linking structure at high *** coating has a lower viscosity and lower Tg corresponding to its branched structure( scheme 1).This coating has been applied in the automobile finishing. The experimental results indicated that the developed coating presented high performance properties in fastness, mar resistance, and hardness, it also reduced the baking temperature, resulting in a energy saving.

关键词： High solid coatings, hyper-branched polymers, automobile, low VOC.

Electrospinning as a route to advanced carbon fibre materials for selected low-temperature electrochemical devices:A review

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Journal of Energy chemistry 2021年第8期30卷 492-529,I0011页

作者： Yue Wen Matt D.R.Kok Jorge Pavel Victoria Tafoya Ana BJorge Sobrido Ellsworth Bell Jeff T.Gostick Servann Herou Philipp Schlee Maria-Magdalena Titirici Dan J.L.Brett Paul R.Shearing Rhodri Jervis The Electrochemical Innovation lab Dept.of Chemical EngineeringUniversity College LondonTorrington PlaceWC1E 7JE LondonUK Queen Mary University of London School of Engineering and Materials ScienceMile End RoadE14NS LondonUK Department of Chemical Engineering University of WaterlooWaterlooCanada Department of Chemical Engineering Imperial College LondonSouth Kensington CampusSW72AZ LondonUK

Electrospinning has been proven as a highly versatile fabrication method for producing nano-structured fibres with controllab.e morphology,of both the fibres themselves and the void structure of the ***,it is possible to use heteroatom doped polymers or to include catalytic precursors in the electrospinning solution to control the surface properties of the *** factors make it an ideal method for the production of electrodes and flow media for a variety of electrochemical devices,enabling reduction in mass transport and activation overpotentials and therefore increasing ***,the use of biomass as a polymer source has recently gained attention for the ability to embed sustainable principles in the materials of electrochemical devices,complementing their ability to allow an increase in the use of renewable electricity via their *** this review,the historical and recent developments of electrospun materials for application in redox flow batteries,fuel cells,metal air batteries and supercapacitors are thoroughly reviewed,including an overview of the electrospinning process and a guide to best ***,we provide an outlook for the emerging use of this process in the field of electrochemical energy devices with the hope that the combination of tailored microstructure,surface functionality and computer modelling will herald a new era of bespoke functional materials that can significantly improve the performance of the devices in which they are used.

关键词： Electrospinning Redox flow batteries Fuel cells Metal-air batteries Supercapacitors

Deep learning enhanced lithium-ion battery nonlinear fading prognosis

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Journal of Energy chemistry 2023年第3期78卷 565-573,I0015页

作者： Shanling Ji Jianxiong Zhu Zhiyang Lyu Heze You Yifan Zhou Liudong Gu Jinqing Qu Zhijie Xia Zhisheng Zhang Haifeng Dai School of Mechanical Engineering Southeast UniversityNanjing 211189JiangsuChina Guangdong Provincial Key lab.of Green Chemical Product Technology South China University of TechnologyGuangzhou 510006GuangdongChina Engineering Research Center of New Light Sources Technology and Equipment Ministry of EducationNanjing 211189JiangsuChina Clean Energy Automotive Engineering Center School of Automotive EngineeringTongji UniversityShanghai 201804China School of Mathematics Southeast UniversityNanjing 211189JiangsuChina

With the assistance of artificial intelligence,advanced health prognosis technique plays a critical role in the lithium-ion(Li-ion) batteries management ***,conventional data-driven early aging prediction exhibited dramatic drawbacks,i.e.,volatile capacity nonlinear fading trajectories create obstacles to the accurate multistep ahead prediction due to the complex working conditions of ***,a novel deep learning model is proposed to achieve a universal and accurate Li-ion battery aging *** battery datasets with various electrode types and cycling conditions are developed to validate the proposed ***-point probability(KPP),extracted from the capacity loss curve,is first proposed to detect knee points and improve state-of-health(SOH) predictive accuracy,especially during periods of rapid capacity *** one-cycle data of partial raw voltage as the model input,the SOH and KPP can be simultaneously predicted at multistep ahead,whereas the conventional method showed worse ***,to explore the underlying characteristics among various degradation tendencies,an online model update strategy is developed by leveraging the adversarial adaptationinduced transfer learning *** work gains new sights into the comprehensive Li-ion battery management and prognosis framework through decomposing capacity degradation trajectories and adversarial learning on the unlab.led samples.

关键词： Battery aging prognosis Deep learning Knee-point probability Sate-of-health

Recent progress in perovskite solar cells:from device to commercialization

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Science China chemistry 2022年第12期65卷 2369-2416页

作者： Xinhui Luo Xuesong Lin Feng Gao Yang Zhao Xiaodong Li Liqing Zhan Zexiong Qiu Jin Wang Cong Chen Lei Meng Xiaofeng Gao Yu Zhang Zijian Huang Rundong Fan Huifen Liu Yanrun Chen Xiaoxue Ren Jiahong Tang Chun-Hao Chen Dong Yang Yongguang Tu Xiao Liu Dongxue Liu Qing Zhao Jingbi You Junfeng Fang Yongzhen Wu Hongwei Han Xiaodan Zhang Dewei Zhao Fuzhi Huang Huanping Zhou Yongbo Yuan Qi Chen Zhaokui Wang Shengzhong(Frank)Liu Rui Zhu Jotaro Nakazaki Yongfang Li Liyuan Han State Key lab.ratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key lab.for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Key lab.ratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Physics and Electronic Science Engineering Research Center of Nanophotonics&Advanced InstrumentMinistry of EducationEast China Normal UniversityShanghai 200241China Key lab.ratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Wuhan National lab.ratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage CenterSolar Energy Research CenterNankai UniversityTianjin 300350China College of Materials Science and Engineering&Engineering Research Center of Alternative Energy Materials&Devices Ministry of EducationSichuan UniversityChengdu 610065China Beijing National lab.ratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China State Key lab.ratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Beijing Key lab.ratory for Theory and Technology of Advanced Battery Materials Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationSchool of Materials Science and EngineeringPeking UniversityBeijing 100871China School of Physics and Electronics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangsha 410083China Experimental Center for Advanced Materials School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Jia

Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization *** this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and ***,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future.

关键词： perovskite solar cells device engineering stability application

Characteristics of the gene encoding pyrroline-5-carboxylate synthase(P5CS) in Vietnamese soybean cultivars(Glycine max ***)

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Characteristics of the gene encoding pyrroline-5-carboxylate...

The acceleration degradation processes of different aged refuses with the forced aeration for landfill reclamation

International Conference on Biology, Environment and chemistry（ICBEC 2010）

作者： Chu Hoang Mau Nguyen Thi Thuy Huong Chu Hoang Lan Nguyen Tuan Anh Le Van Son Chu Hoang Ha Dept.of Genetics Faculty of Biology Thainguyen University Dept.of Genetics Faculty of Biology Vietnam National University of Science Dept.of Environment Faculty of Agricultural Environment Thainguyen University lab.of Plant Cell Biotechnology Institute of Biotechnology

ISBN: (纸本)9789810886424

This research evaluates the ability of six soybean local cultivars and a control cultivar(DT84) to tolerate severe *** this research,SL5 and SL6 have the most stress tolerance while DT84 and SL1 have the least stress *** have isolated P5CS gene as it relates to stress tolerance by using PCR with *** results show that the size of the P5CS gene of the studied cultivars is 2,148 bp,which encodes for 715 amino *** these proteins are compared with the P5CS proteins of the other species,the result shows that the isolated P5CS proteins have a higher identity than other bean *** are located on the same branch of the phylogenetic ***(Pro) is one of the most accumulated osmolytes in salinity and water deficit conditions in plants.P5CS is a key regulatory enzyme involved in prolin biosynthesis in plants and is subject to feedback inhibition by *** conserved aspartate residue at 126 and the phenylalanine at 129 are involved in the feedback inhibition by Pro binding.A gene encoding a feedback insensitive P5CS enzyme was obtained by mutating the P5CS *** mutation was due to a change of an aspartate at position 125 to alanine in the *** mutated gene was cloned in pBT vector and *** gene will be transfered to plants to increase the level of proline overproduction and to enhance the drought tolerance ability.

关键词： drought,Glycine max,point mutation,P5CS,proline.

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Waste Disposal and Sustainable Energy 2023年第3期5卷 407-416页

作者： Yihang Liu Chengqi Ning Qiujie Huang Zhaowen Cheng Weihua Cao Xianghui Wang Changfu Yang Hui Liu Jia Song Luochun Wang Ziyang Lou College of Environmental and chemistry Engineering Shanghai University of Electric PowerShanghai200090China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China Shanghai Municipal Engineering Design Institute(Group)Co. Ltd.Shanghai200092China Shanghai SUS Environmental Remediation Co. Ltd.Shanghai201799China Shanghai Environmental Sanitary Engineering Design Institute Co. Ltd.Shanghai200030China Shanghai Institute of Pollution Control and Ecological Security Shanghai200092China Institute for Urban Governance Shanghai Jiao Tong UniversityShanghai200240China

Forced aeration is one of the promising ways to accelerate landfill reclamation,and understanding the relation between aeration rates and waste properties is the prerequisite to implementing forced aeration under the target of energy saving and carbon *** this work,landfill reclamation processes with forced aeration were simulated using aged refuses(ARs)of 1,4,7,10,and 13 disposal years,and the potential of field application was also investigated based on a field project,to identify the degradation rate of organic components,the O_(2)consumption efficiency and their correlations to *** was found that the removal rate of organic matter declined from 20.3%(AR_(1))to 12.6%(AR_(13)),and that biodegradable matter(BDM)decreased from 5.2%to 2.4%at the set aeration rate of 0.12 L O_(2)/kg waste(Dry Matter,DM)/day.A linear relationship between the degradation rate constant(K)of BDM and disposal age(x)was established:K=−0.0002193x+0.0091(R^(2)=0.854),suggesting that BDM might be a suitable indicator to reflect the stabilization of *** cellulose/lignin ratio decrease rate for AR1(18.3%)was much higher than that for AR13(3.1%),while the corresponding humic-acid/fulvic-acid ratio increased from 1.44 to *** dominant bacteria shifted from Corynebacterium(9.2%),Acinetobacter(6.6%),and Fermentimonas(6.5%),genes related to the decompose of biodegradable organics,to Stenotrophomonas(10.2%)and Clostridiales(3.7%),which were associated with *** aeration efficiencies of lab.scale tests were in the range of 5.4–11.8 g BDM/L O_(2)for ARs with disposal ages of 1–13 years,and in situ landfill reclamation,ARs with disposal ages of 10–18 years were around 1.9–8.8 g BDM/L O_(2),as the disposal age *** increased discrepancy was observed in ARs at the lab.scale and field scale,indicating that the forced aeration rate should be adjusted based on ARs and the unit compartment combined,to reduce the operation cost.

关键词： Forced aeration Aged refuses Landfill reclamation Biodegradable matter Acceleration rate Aeration efficiencies