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health Risk Assessment of Employees Exposed to Chlorination By-products of Recreational Water in Large Amusement Parks in Shanghai

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Biomedical and Environmental Sciences 2024年第8期37卷 865-875页

作者： Weizhao Cao Yiming Zheng Wenxuan Zhao Lisha Shi Yunhui Zhang Lijun Zhang Jian Chen Key lab.of health Technology Assessment National Health Commission of the People’s Republic of China(Fudan University)Shanghai 200032China Key lab.ratory of Public health Safety Ministry of EducationSchool of Public HealthFudan UniversityShanghai 200032China Division of Public health Service and Safety Assessment Shanghai Municipal Center for Disease Control and PreventionShanghai 200336China Shanghai Institute of Preventive Medicine Shanghai 200336China

Objective Chlorination is often used to disinfect recreational water in large amusement parks;however,the health hazards of chlorination disinfection by-products(DBPs)to occupational populations are *** study aimed to assess the exposure status of chlorinated DBPs in recreational water and the health risks to employees of large amusement *** Exposure parameters of employees of three large amusement parks in Shanghai were investigated using a *** typical chlorinated DBPs in recreational water and spray samples were quantified by gas chromatography,and the health risks to amusement park employees exposed to chlorinated DBPs were evaluated according to the WHO's risk assessment *** Trichloroacetic acid,dibromochloromethane,bromodichloromethane,and dichloroacetic acid were detected predominantly in recreational *** carcinogenic and non-carcinogenic risks of the five DBPs did not exceed the risk *** addition,the carcinogenic and non-carcinogenic risks of mixed exposure to DBPs were within the acceptable risk *** Typical DBPs were widely detected in recreational water collected from three large amusement parks in Shanghai;however,the health risks of DBPs and their mixtures were within acceptable limits.

关键词： Risk assessment Water Environmental health Occupational exposure Chlorinated disinfection by-product

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The role of inflammasomes in human diseases and their potential as therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 479-508页

作者： Jing Yao Keenan Sterling Zhe Wang Yun Zhang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053China Townsend Family lab.ratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Key lab.ratory of Neurodegenerative Diseases Ministry of EducationBeijingP.R.China Zhejiang Clinical Research Center for mental Disorders Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and The Affiliated Kangning HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325000China Oujiang lab.ratory(Zhejiang lab.for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000China

Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune *** inflammasome complex has three major components:an upstream sensor molecule that is connected to a downstream effector protein such as caspase-1 through the adapter protein *** formation typically occurs in response to infectious agents or cellular *** active inflammasome then triggers caspase-1 activation,followed by the secretion of pro-inflammatory cytokines and pyroptotic cell *** inflammasome activation and activity contribute to the development of diabetes,cancer,and several cardiovascular and neurodegenerative *** a result,recent research has increasingly focused on investigating the mechanisms that regulate inflammasome assembly and activation,as well as the potential of targeting inflammasomes to treat various *** clinical trials are currently underway to evaluate the therapeutic potential of several distinct inflammasome-targeting ***,understanding how different inflammasomes contribute to disease pathology may have significant implications for developing novel therapeutic *** this article,we provide a summary of the biological and pathological roles of inflammasomes in health and *** also highlight key evidence that suggests targeting inflammasomes could be a novel strategy for developing new disease-modifying therapies that may be effective in several conditions.

关键词： inflam therapeutic potential

Early-life exposure to per-and polyfluoroalkyl substances:Analysis of levels,health risk and binding abilities to transport proteins

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Eco-Environment & health 2024年第3期3卷 308-316页

作者： Yaqi Xu Xinyao Sui Jinhong Li Liyi Zhang Pengpeng Wang Yang Liu Huijing Shi Yunhui Zhang Key lab.of health Technology Assessment National Health Commission of the People's Republic of ChinaFudan UniversityShanghai 200032China Key lab.ratory of Public health Safety Ministry of EducationSchool of Public HealthFudan UniversityShanghai 200032China

Per-and polyfluoroalkyl substances(PFAS)can pass through the placenta and adversely affect fetal ***,there is a lack of comparison of legacy and emerging PFAS levels among different biosamples in pregnant women and their *** study,based on the Shanghai Maternal–Child Pairs Cohort,analyzed the concentrations of 16 PFAS in the maternal serum,cord serum,and breast milk samples from 1,076 motherchild *** placental and breastfeeding transfer efficiencies of PFAS were determined in maternal-cord and maternal-milk pairs,*** binding affinities of PFAS to five transporters were simulated using molecular *** results suggested that PFAS were frequently detected in different *** median concentration of perfluorooctane sulfonate(PFOS)was the highest at 8.85 ng/mL,followed by perfluorooctanoic acid(PFOA)at 7.13 ng/mL and 6:2 chlorinated polyfluorinated ether sulfonate at 5.59 ng/mL in maternal *** median concentrations of PFOA were highest in cord serum(4.23 ng/mL)and breast milk(1.08 ng/mL).PFAS demonstrated higher placental than breastfeeding transfer *** transfer efficiencies and the binding affinities of most PFAS to proteins exhibited alkyl chain length-dependent ***,we comprehensively assessed the estimated daily intakes(EDIs)of PFAS in breastfeeding infants of different age groups and used the hazard quotient(HQ)to characterize the potential health *** decreased with infant age,and PFOS had higher HQs than *** findings highlight the significance of considering PFAS exposure,transfer mechanism,and health risks resulting from breast milk intake in early life.

关键词： Emerging PFAS Placental transfer Breast milk health risk Binding affinity

Higher ambient temperatures may worsen obstructive sleep apnea:A nationwide smartwatch-based analysis of 6.2 million person-days

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Science Bulletin 2024年第13期69卷 2114-2121页

作者： Anni Li Qingli Zhang Yuan Yao Xinlei Zhu Cong Liu Yutao Guo Haidong Kan Renjie Chen School of Public health Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology AssessmentFudan UniversityShanghai 200032China Ministry of Education-Shanghai Key lab.ratory of Children’s Environmental health Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pulmonary Vessel and Thrombotic Disease Sixth Medical CenterChinese PLA General HospitalBeijing 100048China Institute for Hospital Management Research Chinese PLA General HospitalBeijing 100048China Children’s Hospital of Fudan University National Children’s Medical CenterShanghai 201102China School of Public health Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Obstructive sleep apnea(OSA)is a serious type of sleep disorder that can lead to cardiometabolic and neurocognitive *** utilized smart device-based photoplethysmography technology to collect sleep data from the Chinese population from 2019 to *** lag nonlinear models combined with a generalized nonlinear model or a linear mixed effects model were used to investigate the shortterm associations between daily temperature and indicators of OSA *** included a total of 6,232,056 d of sleep monitoring data from 51,842 participants with moderate to severe risk of OSA from 313 Chinese *** relationships between ambient temperature and OSA exacerbation,apneahypopnea index(AHI),and minimum oxygen saturation(MinSpO_(2))were almost linear and present only on the same *** temperatures were associated with a greater risk of OSA exacerbation,with an 8.4%(95%confidence interval(CI):7.6%–9.3%)increase per 10℃increase in temperature.A 10℃increase in daily temperature corresponded to an AHI increase of 0.70 events/h(95%CI:0.65–0.76)and a MinSpO_(2)decrease of 0.18%(95%CI:0.16%–0.19%).Exposure to elevated temperatures during the night can also lead to adverse *** effects of higher temperatures on OSA severity were stronger among men,participants with a body mass index24 kg/m2,those aged 45 years and older,individuals with a history of hypertension and diabetes,and during the cold *** large-scale,nationwide,longitudinal study provides robust evidence suggesting that higher ambient temperatures may immediately worsen OSA.

关键词： Obstructive sleep apnea Temperature Apnea-hypopnea index Oxygen saturation Smart device

应用欧拉-拉格朗日方法分析动脉粥样硬化性颈动脉血流的流-固相互作用

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Journal of Central South University 2024年第1期31卷 151-168页

作者： Majid SIAVASHI Ava BINA Mojtaba SAYADNEJAD Borhan BEIGZADEH Applied Multi-Phase Fluid Dynamics lab. School of Mechanical EngineeringIran University of Science and TechnologyTehranIran Biomechatronics and Cognitive Engineering Research lab. School of Mechanical EngineeringIran University of Science and TechnologyTehranIran

本研究旨在模拟不同狭窄程度和脉搏率的颈动脉搏动血流。采用流-固耦合(FSI)和任意拉格朗日-欧拉(ALE)方法研究了不同狭窄程度、脉搏率和动脉壁性质对周围流体的影响。分别应用Carreau-Yasuda非牛顿超弹性模型和修正Mooney-Rivin超弹性... 详细信息

本研究旨在模拟不同狭窄程度和脉搏率的颈动脉搏动血流。采用流-固耦合(FSI)和任意拉格朗日-欧拉(ALE)方法研究了不同狭窄程度、脉搏率和动脉壁性质对周围流体的影响。分别应用Carreau-Yasuda非牛顿超弹性模型和修正Mooney-Rivin超弹性模型于具有非牛顿行为的血液和超弹性血管壁。结果得到血液的壁面径向位移、压力分布、轴向速度分布和壁面剪切应力。通过增加狭窄的严重程度,轴向速度、血压变化、最大壁面剪切应力和壁面径向位移均呈增长趋势。当脉率在狭窄程度为75%时,最大流量矩、壁面径向位移、压力、轴向速度和壁面剪应力的最大值均增大。此外,与弹性和刚性模型相比,将动脉壁视为超弹性模型,将其周围流体视为非牛顿和非定常,可以使模拟更加真实。在严重程度高达50%的狭窄中,红细胞受到轻微损害,而在严重程度为75%的狭窄中观察到溶血。通过改善动脉粥样硬化,弹性模量从500 k Pa提高到2 MPa,在60 bpm脉率和狭窄程度75%下,剪切应力最大值增长65%。与刚性和弹性动脉壁相比,动脉壁的超弹性模型导致较低的轴向速度、较低的血压、较低的剪切应力和较高的径向位移。

关键词：流-固耦合狭窄严重程度脉率变化超弹性的动脉动脉粥样硬化

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XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation

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Genes & Diseases 2024年第5期11卷 350-359页

作者： Yun Zhang Susan Lin Jing Yao Wantong Cai Huaqiu Chen Ailikemu Aierken Zhe Wang Weihong Song National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijing 100053China Townsend Family lab.ratories Department of PsychiatryThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Institute of Aging Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and the Affiliated Kangning HospitalWenzhou Medical UniversityWenzhouZhejiang 325000China Oujiang lab.ratory(Zhejiang lab.for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325001China

As a pathological hallmark of type 2 diabetes mellitus(T2DM),islet amyloid is formed by the aggregation of islet amyloid polypeptide(IAPP).Endoplasmic reticulum(ER)stress interacts with IAPP aggregates and has been implicated in the pathogenesis of *** examine the role of ER stress in T2DM,we cloned the hIAPP promoter and analyzed its promoter activity in human *** found that ER stress significantly enhanced hIAPP promoter activity and expression in human b-cells via triggering X-box binding protein 1(XBP1)*** identified a binding site of XBP1 in the hIAPP *** of this binding site by substitution or deletion mutagenesis significantly diminished the effects of ER stress on hIAPP promoter *** of XBP splicing by MKC3946 treatment inhibited ER stress-induced hIAPP up-regulation and improved human b-cell survival and *** study uncovers a link between ER stress and IAPP at the transcriptional level and may provide novel insights into the role of ER stress in IAPP cytotoxicity and the pathogenesis of T2DM.

关键词： b-cell function Endoplasmic reticulum stress Islet amyloid polypeptide Type 2 diabetes mellitus XBP1

Digital twin driven and intelligence enabled content delivery in end-edge-cloud collab.rative 5G networks

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Digital Communications and Networks 2024年第2期10卷 328-336页

作者： Bo Yi Jianhui Lv Xingwei Wang Lianbo Ma Min Huang College of Computer Science and Engineering Northeastern UniversityShenyang110169China Pengcheng lab. Shenzhen518055China College of Software Northeastern UniversityShenyang110819China College of Information Science and Engineering Northeastern UniversityShenyang110819China

The rapid development of 5G/6G and AI enables an environment of Internet of Everything(IoE)which can support millions of connected mobile devices and applications to operate smoothly at high speed and low ***,these massive devices will lead to explosive traffic growth,which in turn cause great burden for the data transmission and content *** challenge can be eased by sinking some critical content from cloud to *** this case,how to determine the critical content,where to sink and how to access the content correctly and efficiently become new *** work focuses on establishing a highly efficient content delivery framework in the IoE *** particular,the IoE environment is re-constructed as an end-edge-cloud collab.rative system,in which the concept of digital twin is applied to promote the *** on the digital asset obtained by digital twin from end users,a content popularity prediction scheme is firstly proposed to decide the critical content by using the Temporal Pattern Attention(TPA)enabled Long Short-Term Memory(LSTM)***,the prediction results are input for the proposed caching scheme to decide where to sink the critical content by using the Reinforce Learning(RL)***,a collab.rative routing scheme is proposed to determine the way to access the content with the objective of minimizing *** experimental results indicate that the proposed schemes outperform the state-of-the-art benchmarks in terms of the caching hit rate,the average throughput,the successful content delivery rate and the average routing overhead.

关键词： Digital twin IoE Content delivery Caching Routing

FIFAWC: a dataset with detailed annotation and rich semantics for group activity recognition

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Frontiers of Computer Science 2024年第6期18卷 1-2页

作者： PEI Duoxuan HUANG Di WANG Yunhong State Key lab.ratory of Software Development Environment School of Computer Science and Engineering Beihang University Intelligent Recognition and Image Processing lab. School of Computer Science and Engineering Beihang University

In this letter, we propose the FIFAWC dataset for GAR, offering unique features compared to existing ones. FIFAWC is meticulously annotated with all included GAs per sample augmenting both practicality and challenge. ... 详细信息

关键词： Semantics

Cheyne-Stokes Respiration in Heart Failure Is Not a Therapeutic Target: A Lesson from CANPAP, SERVE-HF and ADVENT-HF Trials (Letter to the Editor)

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health 2024年第6期16卷 561-564页

作者： Fumihiko Yasuma Junichiro Hayano Department of Biomedical Sciences College of Life and Health Sciences Chubu University Kasugai Japan Heart Beat Science lab. Co. Nagoya Japan

Letter to the Editor.

关键词： Letter to the Editor