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Regulation of pseudographitic carbon domain to boost sodium energy storage

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Nano Research 2024年第6期17卷 5188-5196页

作者： Zhidong Hou Mingwei Jiang Da Lei Xiang Zhang Yuyang Gao Jian-Gan Wang State Key lab.ratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Lab of Graphene(NPU)Xi’an 710072China

Hard carbon anode has shown extraordinary potentials for sodium-ion batteries(SIBs)owing to the cost-effectiveness and advantaged ***,the widespread application of hard carbon is still hindered by the insufficient sodium storage capacity and depressed rate property,which are mainly induced by the undesirable pseudographitic ***,we develop a molten-salt-mediated strategy to regulate the pseudographitic structure of hard carbon with suitable interlayer spacing and enlarged pseudographitic domain,which is conducive to the intercalation capacity and diffusion kinetics of sodium ***,the optimized hard carbon anode delivers a high reversible capacity of 320 mAh·g^(−1),along with superior rate property(138 mAh·g−1 at 2 A·g^(−1))and stable cyclab.lity over 1800 ***,the in situ Raman spectroscopic study and full-cell assembly further investigate the sodium storage mechanism and practical implement of obtained hard *** work pioneers a low-cost and effective route to regulate the pseudographitic structure of hard carbon materials for advanced SIBs.

关键词： pseudographitic structure molten salt hard carbon anode sodium-ion batteries

Immunohistochemical localization of dopamine and norepinephrine receptors in human early placental villi

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Chinese Science Bulletin 1996年第14期41卷 1203-1206页

作者：张荣庆黄威权张崇理 State Key lab. of Repro. biol.gy Institute of Zoology Chinese Academy of Sciences Beijing 100080 China Dept. of biol. Sci. and Biotech. Tsinghua University Beijing 100084 China Dept. of Histology and Embryology Fourth Military Medical College Xi'an 710032 China

Evidence so far accumulated suggests that the human early placenta can be considered as a complicated neuroendocrine organt. Our previous reports have demonstrated that the human early placenta presents not only a variety of neuropeptides but also neurotransmitters such as 5-hydroxytryptamine (5-HT), dopamine (DA) and norepinephrine (NE). It has been shown that these neurotransmitters in human placenta may play an important role in the process of blastocyst implantation and maintenance of normal pregnancy. As far as we are aware, no information concerning the DA and/or NE receptors localized in

关键词： human placental villi norepinephrine receptor dopamine receptor anti-idiotypic antibody immunohistochemistry.

Enhanced wear resistance, antibacterial performance, and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro

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BIO-DESIGN AND MANUFACTURING 2024年第5期7卷 670-686页

作者： Wang, Qingge Liu, Jia Wu, Hong Liu, Jingbo Ren, Yaojia Liang, Luxin Yan, Xinxin Baker, Ian Liu, Shifeng Uglov, V. V. Yang, Chengliang Wang, Liqiang Cent South Univ State Key Lab Powder Met Changsha 410083 Peoples R China Youjiang Med Univ Nationalities Guangxi Zhuang Autonomous Reg Engn Res Ctr Biomat Guangxi Key Lab Preclin & Translat Res Bone & Join Guangxi Key Lab Biomed Mat ResAffiliated Hosp Baise 533000 Peoples R China Cent South Univ Xiangya Hosp 2 Dept Orthoped Changsha 410011 Peoples R China Wuhan Univ Renmin Hosp Dept Orthoped Wuhan 430060 Peoples R China Dartmouth Coll Thayer Sch Engn Hanover NH 03755 USA Xian Univ Architecture & Technol Sch Met Engn Xian 710055 Peoples R China Belarusian State Univ Minsk 220030 BELARUS Shanghai Jiao Tong Univ Sch Mat Sci & Engn State Key Lab Met Matrix Composites Shanghai 200240 Peoples R China

A good Ti-based joint implant should prevent stress shielding and achieve good bioactivity and anti-infection performance. To meet these requirements, the low-elastic-modulus alloy-Ti-35Nb-2Ta-3Zr-was used as the substrate, and functional coatings that contained bioceramics and Ag ions were prepared for coating on TiO2 nanotubes (diameter: (80 +/- 20) nm and (150 +/- 40) nm) using anodization, deposition, and spin-coating methods. The effects of the bioceramics (nano-beta-tricalcium phosphate, microhydroxyapatite (micro-HA), and meso-CaSiO3) and Ag nanoparticles (size: (50 +/- 20) nm) on the antibacterial activity and the tribocorrosion, corrosion, and early in vitro osteogenic behaviors of the nanotubes were investigated. The tribocorrosion and corrosion results showed that the wear rate and corrosive rate were highly dependent on the features of the nanotube surface. Micro-HA showed great wear resistance with a wear rate of (1.26 +/- 0.06)x10-3 mm3/(N center dot m) due to adhesive and abrasive wear. Meso-CaSiO3 showed enhanced cell adhesion, proliferation, and alkaline phosphatase activity. The coatings that contained nano-Ag exhibited good antibacterial activity with an antibacterial rate of >= 89.5% against Escherichia coli. These findings indicate that hybrid coatings may have the potential to accelerate osteogenesis. [GRAPHICS] .

关键词： beta Ti alloy Surface modification Wear resistance Corrosion resistance Osteogenic behavior Antibacterial activity TITANIUM SURFACES DOPED HYDROXYAPATITE SILVER NANOPARTICLES TIO2 NANOTUBES BEHAVIOR ALLOY DIFFERENTIATION MICROSTRUCTURES POLARIZATION COATINGS

Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 4149-4163页

作者： Jian, Xinyun Wang, Cheng Wu, Shijuan Sun, Guo Huang, Chuan Qiu, Chengbing Liu, Yuanzheng Leadlay, Peter F. Liu, Dong Deng, Zixin Zhou, Fuling Sun, Yuhui Wuhan Univ Zhongnan Hosp Sch Pharmaceut Sci Dept Hematol Wuhan 430071 Peoples R China Wuhan Univ Key Lab Combinatorial Biosynth & Drug Discovery Minist Educ Wuhan 430071 Peoples R China Monash Univ Biomed Discovery Inst Dept Biochem & Mol Biol Clayton Vic 3800 Australia Monash Univ ARC Ctr Excellence Innovat Prot & Peptide Sci Clayton Vic 3800 Australia Huazhong Univ Sci & Technol Sch Pharm Wuhan 430030 Peoples R China Nantong Univ Coinnovat Ctr Neuroregenerat Sch Life Sci Nantong Lab Dev & Dis Nantong 226019 Peoples R China Univ Cambridge Dept Biochem Cambridge CB2 1GA England

Aminoglycosides (AGs) are a class of antibiotics with a broad spectrum of activity. However, their use is limited by safety concerns associated with nephrotoxicity and ototoxicity, as well as drug resistance. To address these issues, semi-synthetic approaches for modifying natural AGs have generated new generations of AGs, however, with limited types of modification due to significant challenges in synthesis. This study explores a novel approach that harness the bacterial biosynthetic machinery of gentamicins and kanamycins to create hybrid AGs. This was achieved by glycodiversification of gentamicins via swapping the glycosyltransferase (GT) in their producer with the GT from kanamycins biosynthetic pathway and resulted in the creation of a series of novel AGs, therefore referred to as genkamicins (GKs). The manipulation of the hybrid biosynthetic pathway enabled the targeted accumulation of different GK species and the isolation and characterization of six GK components. These compounds display retained antimicrobial activity against a panel of World Health Organization (WHO) critical priority pathogens, and GK-C2a, in particular, demonstrates low ototoxicity compared to clinical drugs in zebrafish embryos. This study provides a new strategy for diversifying the structure of AGs and a potential avenue for developing less toxic AG drugs to combat infectious diseases.

关键词： Aminoglycoside Biosynthetic engineering Ototoxicity BIOSYNTHESIS ZEBRAFISH GENE

Compressive strain in Cu catalysts: Enhancing generation of C2+ products in electrochemical CO2 reduction

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SCIENCE BULLETIN 2024年第18期69卷 2881-2891页

作者： Fan, Qikui Yan, Pengxu Liu, Fuzhu Xu, Zhongshuang Liang, Pengfei Cao, Xi Ye, Chenliang Liu, Moxuan Zhao, Lingyi Ren, Shan Miao, Huanran Zhang, Xiai Yang, Zhimao Ding, Xiangdong Yang, Jian Kong, Chuncai Wu, Yuen Xi An Jiao Tong Univ Sch Phys MOE Key Lab Nonequilibrium Synth & Modulat Condens Key Lab Adv Mat & Mesoscop Phys Shaanxi Prov Xian 710049 Peoples R China Xi An Jiao Tong Univ State Key Lab Mech Behav Mat Xian 710049 Peoples R China Anhui Normal Univ Coll Chem & Mat Sci Wuhu 241002 Peoples R China North China Elect Power Univ Dept Power Engn Beijing 102206 Peoples R China Xian Univ Sci & Technol Coll Chem & Chem Engn Xian 710054 Peoples R China Chinese Acad Sci Shenzhen Inst Adv Technol Ctr Mat & Interfaces Shenzhen 518055 Peoples R China Univ Sci & Technol China Collaborat Innovat Ctr Chem Energy Mat iChEM Sch Chem & Mat Sci Hefei Natl Lab Phys Sci Microscale Hefei 230026 Peoples R China Univ Sci & Technol China Natl Synchrotron Radiat Lab Hefei 230026 Peoples R China

Elastic strain in Cu catalysts enhances their selectivity for the electrochemical CO2 reduction reaction (eCO(2)RR), particularly toward the formation of multicarbon (C2+) products. However, the reasons for this selectivity and the effect of catalyst precursors have not yet been clarified. Hence, we employed a redox strategy to induce strain on the surface of Cu nanocrystals. Oxidative transformation was employed to convert Cu nanocrystals to CuxO nanocrystals; these were subsequently electrochemically reduced to form Cu catalysts, while maintaining their compressive strain. Using a flow cell configuration, a current density of 1 A/cm(2) and Faradaic efficiency exceeding 80% were realized for the C2+ products. The selectivity ratio of C2+/C1 was also remarkable at 9.9, surpassing that observed for the Cu catalyst under tensile strain by approximately 7.6 times. In-situ Raman and infrared spectroscopy revealed a decrease in the coverage of K+ ion-hydrated water (KH2O) on the compressively strained Cu catalysts, consistent with molecular dynamics simulations and density functional theory calculations. Finite element method simulations confirmed that reducing the coverage of coordinated KH2O water increased the probability of intermediate reactants interacting with the surface, thereby promoting efficient C-C coupling and enhancing the yield of C2+ products. These findings provide valuable insights into targeted design strategies for Cu catalysts used in the eCO(2)RR. (c) 2024 Science China Press. Published by Elsevier B.V. and Science China Press. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Strain effect CO2 electroreduction to C2+ Catalytic selectivity Copper catalyst Water coverage SPECTROSCOPY REVEALS CARBON-MONOXIDE COPPER SELECTIVITY ETHYLENE OPERANDO

Plasma-Sprayed Coating of an Apatite-Type Lanthanum Silicate Electrolyte for Intermediate Temperature Solid Oxide Fuel cells (IT-SOFCs)

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Plasma Science and Technology 2013年第7期15卷 673-676页

作者：陈军黄建军李信军刘英齐冰江石寿王喜省 SZU-ASIPP Joint lab. for Applied Plasma Shenzhen University

Apatite-type lanthanum silicate was successfully synthesized via a solid state re- action protocol at 1400~C in a vacuum for 4 hours. The powder was synthesized faster and at a lower reaction temperature than by conventional solid state reaction methods. The resulting powder was used in the fabrication of a coating deposited by atmospheric plasma spray （APS） technology. The microstructure of the coating was analyzed by X-ray diffraction and scanning electron microscopy. Heat treatment was found to fully crystallize the coating, increasing its den-sity. The ionic conductivity of the apatite coating was 0.39 （0.054） mS/cm at 850 （700） ℃, and its activation energy was 0.67 eV.

关键词： lanthanum silicate solid oxide fuel cell atmospheric plasma spraying ionicconductivity activation energy

A growth-regulating factor 7(GRF7)-mediated gene regulatory network promotes leaf growth and expansion in sugarcane

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The Crop Journal 2024年第2期12卷 422-431页

作者： Qiaoyu Wang Yihan Li Dadong Lin Xiaoxi Feng Yongjun Wang Tianyou Wang Hongyan Ding Jisen Zhang State Key lab.for Conservation and Utilization of Subtropical Agrobiol.gical Resources and Guangxi Key lab.for Saccharum biol.gy Guangxi UniversityNanning 530005GuangxiChina Center for Genomics and Biotechnology/Fujian Provincial Key lab.ratory of Haixia Applied Plant Systems biol.gy/Key lab.ratory of Saccharum biol.gy and Genetic Breeding/National Engineering Research Center for Saccharum Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Knowledge of the function of growth-regulating factors(GRFs)in sugarcane(Saccharum officinarum and ***)growth and development could assist breeders in selecting desirable plant ***,limited information about GRFs is availab.e in Saccharum due to their *** this study,22 GRFs were identified in the two species and their conserved domains,gene structures,chromosome location,and synteny were ***7 expression varied among tissues and responded to diurnal ***7-YFP was localized preferentially in the nucleus and appears to act as a transcriptional ***7 positively regulated the size and length of rice leaves,possibly by regulating cell size and plant *** seven potential transcription factors binding to the SsGRF7 promoter in ***,four showed positive expression patterns,and two showed negative expression patterns relative to SsGRF7.

关键词： Expression analysis Growth-regulating factor Leaf development Sugarcane Transcription factors

Lignin‐derived carbon with pyridine N‐B doping and a nanosandwich structure for high and stable lithium storage

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Carbon Energy 2024年第8期6卷 232-247页

作者： Dichao Wu Jiayuan Li Yuying Zhao Ao Wang Gaoyue Zhang Jianchun Jiang Mengmeng Fan Kang Sun Key lab.of Biomass Energy and Material Jiangsu ProvinceNational Engineering Lab for Biomass Chemical UtilizationKey and Open Lab on Forest Chemical EngineeringSFAInstitute of Chemical Industry of Forest ProductsChinese Academy of ForestryNanjingChina Jiangsu Co‐Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjingChina School of Energy and Environment Southeast UniversityNanjingChina Department of Chemistry Tsinghua UniversityBeijingChina Fujian Provincial Key lab.ratory of Biomass Low‐Carbon Conversion Academy of Advanced Carbon Conversion TechnologyHuaqiao UniversityXiamenChina Chinese Academy of Sciences Xinjiang Lihua Institute of Technology UrumqiChina

Biomass‐derived carbon is a promising electrode material in energy storage ***,how to improve its low capacity and stability,and slow diffusion kinetics during lithium storage remains a *** this research,we propose a“self‐assembly‐template”method to prepare B,N codoped porous carbon(BN‐C)with a nanosandwich structure and abundant pyridinic N‐B *** nanosandwich structure can increase powder density and cycle stability by constructing a stable solid electrolyte interphase film,shortening the Li^(+)diffusion pathway,and accommodating volume expansion during repeated charging/*** abundant pyridinic N‐B species can simultaneously promote the adsorption/desorption of Li^(+)/PF_(6)^(−)and reduce the diffusion *** BN‐C electrode showed a high lithium‐ion storage capacity of above 1140 mAh g^(−1)at 0.05 A g^(−1)and superior stability(96.5%retained after 2000 cycles).Moreover,owing to the synergistic effect of the nanosandwich structure and pyridinic N‐B species,the assembled symmetrical BN‐C//BN‐C full cell shows a high energy density of 234.7Wh kg^(−1),high power density of 39.38 kW kg−1,and excellent cycling stability,superior to most of the other cells reported in the *** the density functional theory simulation demonstrated,pyridinic N‐B shows enhanced adsorption activity for Li^(+)and PF_(6)^(−),which promotes an increase in the capacity of the anode and cathode,***,the relatively lower diffusion barrier of pyridinic N‐B promotes Li^(+)migration,resulting in good rate ***,this study provides a new approach for the synergistic modulation of a nanostructure and an active site simultaneously to fabricate the carbon electrode material in energy storage devices.

关键词： high cycling stability high energy density lithium‐ion batteries pyridinic N‐B species sandwich structure carbon nanosheet

HBV resistant to lamivudine: experimental and clinical studies

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Hepatobiliary & Pancreatic Diseases International 2002年第4期1卷 519-522页

作者： Dong-Yao Zhou Yong-Jian Cao Lian-Ying Lin Hong Wang Jian-Sheng Huang the Department of Clinical lab.ratory Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China Institution of Molecular biol.gy Diagnostic Center, First Military Medical University, Guangzhou 510515, China Department of Clinical lab. Medicine Guangdong Prov. Hosp. Trad. Chinese Guangzhou 510120 China Inst. of Molec. biol. Diagnost. Ctr. First Military Medical University Guangzhou 510515 China

Objective: To identify the impact of lamivudine on HBV e antigen (HBeAg) seroconversion and HBV DNA level, and the appearance of Tyr-Met-Asn-Asp (YMDD) resistants. Methods: Forty-seven hepatitis B patients were trea- ted with oral lamivudine. ALT level and HBeAg were detected in the treatment on the zero, 3rd, 6th and 9th month respectively. The levels of HBV DNA and YMDD resistants were analyzed with PCR mi- croplate hybridization-ELISA. Results: After 9 months of treatment, HBV DNA be- came negative and ALT level was normal in 74% pa- tients. Among these patients, 17% patients had HBeAg converted to negative and anti-HBe antibody positive, whereas another 15% patients showed HBeAg negative. YMDD resistants appeared in 19 % patients (9/47). One, three and five resistants were detected in the treatment on the 3rd, 6th and 9th month respectively. Conclusions: Most HBV DNA in serum became nega- tive after 9 months of treatment, and the rate of HBeAg seroconversion was 17% (HBV DNA level was lower than 100 pg/ml before treatment). YMDD resistants appeared in 19% patients.

关键词： lamivudine Tyr-Met-Asn-Asp mutants microplate hybridization HBeAg seroconversion