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aBIOTECH 2024年第1期5卷 1-16页

作者： Mengting Xu Ziyue Sun Huanbin Shi Jiangnan Yue Xiaohui Xiong Zhongling Wu Yanjun Kou Zeng Tao Ministry of Agriculture Key laboratory of molecular biology of Crop Pathogens and Insects Institute of BiotechnologyZhejiang UniversityHangzhou 310058China State Key lab of Rice biology and Breeding China National Rice Research InstituteHangzhou 310021China

Di-and tri-methylation of lysine 36 on histone H3(H3K36me2/3)is catalysed by histone methyltransferase Set2,which plays an essential role in transcriptional *** there is a single H3K36 methyltransferase in yeast and higher eukaryotes,two H3K36 methyltransferases,Ash1 and Set2,were present in many filamentous ***,their roles in H3K36 methylation and transcriptional regulation remained *** with methods of RNA-seq and ChIP-seq,we revealed that both Ash1 and Set2 are redundantly required for the full H3K36me2/3 activity in Magnaporthe oryzae,which causes the devastating worldwide rice blast ***1 and Set2 distinguish genomic H3K36me2/3-marked regions and are differentially associated with repressed and activated transcription,***,Ash1-catalysed H3K36me2 was co-localized with H3K27me3 at the chromatin,and Ash1 was required for the enrichment and transcriptional silencing of H3K27me3-occupied *** the different roles of Ash1 and Set2,in H3K36me2/3 enrichment and transcriptional regulation on the stress-responsive genes,they differentially respond to various stresses in ***,we reveal a novel mechanism by which two H3K36 methyltransferases catalyze H3K36me2/3 that differentially associate with transcriptional activities and contribute to enrichment of facultative heterochromatin in eukaryotes.

关键词： Ash1 Facultative heterochromatin H3K36me2/3 Magnaporthe oryzae Set2 Transcriptional regulation

Multi-omics:Powerful accelerator for uncovering plant specialized metabolic pathways:The case of leonurine

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molecular Plant 2024年第1期17卷 13-15页

作者： Priyanka Gupta Anuj Sharma Dinesh A.Nagegowda molecular Plant biology and Biotechnology lab CSIR-Central Institute of Medicinal and Aromatic PlantsResearch CentreBengaluru 560065India Academy of Scientific and Innovative Research Ghaziabad 201002India

As sessile organisms,plants employ a unique adaptive strategy to survive harsh terrestrial environments and defend against or interact with coevolving animals and *** strategy involves expanding their metabolic systems,resulting in the production of plant specialized metabolites(PSMs)or natural ***,PSMs constitute a highly diverse group of compounds based on their common core structure,comprising terpenoids,phenylpropanoids,benzenoids,alkaloids and nitrogen-containing compounds,glucosinolates,indoles and sulfur-containing indole compounds,phenolics,and fatty acid derivatives(Garagounis et al.,2021).

关键词： expanding alkaloids sulfur

Deer antler stem cell niche: An interesting perspective

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World Journal of Stem Cells 2024年第5期16卷 479-485页

作者： Claudia Cavallini Elena Olivi Riccardo Tassinari Chiara Zannini Gregorio Ragazzini Martina Marcuzzi Valentina Taglioli Carlo Ventura National laboratory of molecular biology and Stem Cell Engineering National Institute of Biostructures and Biosystems-Eldor LabBologna 40128Italy Eldor lab Bologna 40128Italy Department of Medical and Surgical Sciences(DIMEC) University of BolognaBologna 40138Italy

In recent years,there has been considerable exploration into methods aimed at enhancing the regenerative capacity of transplanted and/or tissue-resident ***,in particular,have garnered significant interest for their potential to serve as natural scaffolds for *** this editorial,we provide commentary on the study by Wang et al,in a recently published issue of World J Stem Cells,which investigates the use of a decellularized xenogeneic extracellular matrix(ECM)derived from antler stem cells for repairing osteochondral defects in rat knee *** focus lies specifically on the crucial role of biological scaffolds as a strategy for augmenting stem cell potential and regenerative capabilities,thanks to the establishment of a favorable microenvironment(niche).Stem cell differen-tiation heavily depends on exposure to intrinsic properties of the ECM,including its chemical and protein composition,as well as the mechanical forces it can ***,these physicochemical cues contribute to a bio-instructive signaling environment that offers tissue-specific guidance for achieving effective repair and *** interest in mechanobiology,often conceptualized as a form of“structural memory”,is steadily gaining more validation and momen-tum,especially in light of findings such as these.

关键词： Extracellular matrix Antler stem cells Stem cell niche Regenerative medicine Decellularized scaffolds Cell memory

Flower morphology of Allium(Amaryllidaceae)and its systematic significance

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Plant Diversity 2024年第1期46卷 3-27页

作者： Ju Eun Jang Shukherdorj Baasanmunkh Nudkhuu Nyamgerel Seung-Yoon Oh Jun-Ho Song Ziyoviddin Yusupov Komijlon Tojibaev Hyeok Jae Choi Department of biology and Chemistry Changwon National UniversityChangwon51140Republic of Korea Department of Forest Biodiversity and Herbarium Korea National ArboretumPocheon11186Republic of Korea Department of biology Chungbuk National UniversityCheongju28644Republic of Korea International Joint lab for molecular Phylogeny and Biogeography Institute of BotanyAcademy of Sciences of UzbekistanTashkent100125Uzbekistan

Allium is a complicated genus that includes approximately 1000 *** its morphology is well studied,the taxonomic importance of many morphological traits,including floral traits,are poorly ***,we examined and measured the floral characteristics of 87 accessions of 74 Allium taxa(belonging to 30 sections and nine subgenera)from Central to Eastern Asian *** then examined the taxonomic relationships between select flower characteristics and a phylogenetic tree based on ITS *** results confirm that floral morphology provides key taxonomic information to assess species delimitation in *** found that perianth color is an important characteristic within the ***,Polyprason,and *** ***,Cepa,and Rhizirideum,significant characteristics include ovary shape,perianth shape,and inner tepal *** species in ***,the key taxonomic character is ovule number(only one ovule in per locule).In the ***,Cepa,Polyprason,and Reticulatobulbosa,which belong to the third evolutionary line of Allium,hood-like appendages occur in the ovary,although these do not occur in *** results also indicated that the flower morphology of several species in some sections are not clearly distinguished,e.g.,***(***)and ***(***).This study provides detailed photographs and descriptions of floral characteristics and information on general distributions,habitats,and phenology of the studied taxa.

关键词： Allium Flower morphology Pistil character Statistical analysis Significant characteristic Species level

Stereoselective recognition of morphine enantiomers by μ-opioid receptor

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National Science Review 2024年第3期11卷 183-191页

作者： Yibo Wang Van A.Ngo Xiaohui Wang laboratory of Chemical biology Changchun Institute of Applied ChemistryChinese Academy of Sciences Advanced Computing for Life Sciences and Engineering Group Science Engagement Section National Center for Computational Sciences Oak Ridge National Lab School of Applied Chemistry and Engineering University of Science and Technology of China Beijing National laboratory for molecular Sciences

Stereospecific recognition of chiral molecules plays a crucial role in biological systems. The μ-opioid receptor（MOR） exhibits binding affinity towards（-）-morphine, a well-established gold standard in pain management, while it shows minimal binding affinity for the（+）-morphine enantiomer, resulting in a lack of analgesic activity. Understanding how MOR stereoselectively recognizes morphine enantiomers has remained a puzzle in neuroscience and pharmacology for over half-a-century due to the lack of direct observation techniques. To unravel this mystery, we constructed the binding and unbinding processes of morphine enantiomers with MOR via molecular dynamics simulations to investigate the thermodynamics and kinetics governing MOR's stereoselective recognition of morphine enantiomers. Our findings reveal that the binding of（-）-morphine stabilizes MOR in its activated state, exhibiting a deep energy well and a prolonged residence time. In contrast,（+）-morphine fails to sustain the activation state of ***, the results suggest that specific residues, namely D1142.50and D1473.32, are deprotonated in the active state of MOR bound to（-）-morphine. This work highlights that the selectivity in molecular recognition goes beyond binding affinities, extending into the realm of residence time.

关键词： stereoselective recognition thermodynamics and kinetics residence time morphine enantiomers μ-opioid receptor

Role of aminopeptidase N-like in the acquisition of begomoviruses by Bemisia tabaci,the whitefly vector

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Insect Science 2024年第3期31卷 707-719页

作者： Yun-Yun Fan Yao Chi Na Chen Wilmer J.Cuellar Xiao-Wei Wang Ministry of Agriculture Key lab of molecular biology of Crop Pathogens and Insects Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang ProvinceInstitute of Insect SciencesZhejiang UniversityHangzhouChina Zhejiang Tianmushan National Nature Reserve Administration HangzhouChina Institute of Plant Protection Liaoning Academy of Agricultural SciencesShenyangChina Virology laboratory Cassava ProgramInternational Center for Tropical Agriculture(CIAT)PalmiraColombia

Sri Lankan cassava mosaic virus(SLCMV)is a prominent causative agent of cassava mosaic disease in Asia and relies on the whitefly Bemisia tabaci cryptic complex for its ***,the molecular mechanisms involved in SLCMV transmission by *** have yet to be *** this study,we identified an aminopeptidase N-like protein(BtAPN)in *** Asia II 1,an efficient vector of SLCMV,which is involved in the SLCMV transmission *** the use of glutathione S-transferase pull-down assay and LC-MS/MS analysis,we demonstrated the interaction between BtAPN and the coat protein(CP)of *** interaction was further confirmed in vitro,and we observed an induction of BtAPN gene expression following SLCMV *** interfering with the function of BtAPN,the quantities of SLCMV were significantly reduced in various parts of *** Asia II 1,including the whole body,midgut,hemolymph,and primary salivary ***,we discovered that BtAPN is conserved in *** Middle East-Asia Minor 1(MEAM1)and interacts with the CP of tomato yellow leaf curl virus(TYLCV),a begomovirus known to cause severe damage to tomato *** BtAPN with antibody led to a significant reduction in the quantities of TYLCV in whitefly whole body and organs/*** results demonstrate that BtAPN plays a generic role in interacting with the CP of begomoviruses and positively regulates their acquisition by the whitefly.

关键词： BtAPN coat protein SLCMV TYLCV virus acquisition whitefly

Oriented mesoporous nanofibers show nature's wisdom

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National Science Review 2024年第6期11卷 90-91页

作者： Yonghui Deng Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Collaborative Innovation Center of Chemistry for Energy Material (iChEM) Fudan University State Key lab of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences

Electrodes assembled with conventional nanoparticulate materials in electrochemical energy devices usually have a random and torturous porous system. To meet ever-increasing demands for higher volumetric energy density at packagelevel, packing more active materials in a limited volume becomes increasingly difficult since transportation of reactants(e.g. electrolyte) and charges through high-tortuosity channels/pathways in thick electrodes meets large impedance[1].

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Versatile Organogels of Aluminum Oxide Subnanosheets for Locking Solvents and Adhesion

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Precision Chemistry 2024年第1期2卷 21-27页

作者： Wanyue Ouyang Xun Wang Key lab of Organic Optoelectronics and molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China

Herein,we present a facile strategy to prepare versatile aluminum oxide subnanometer nanosheets with oleic acid and stearic acid ligands(OA-Al SNSs and SA-Al SNSs,respectively).The size effect endows subnanosheets with abundant acting sites,remarkable intermolecular interactions,and unique polymer-like properties,including flexibility,viscoelasticity,and sol-gel transitions,which is quite different from traditional inorganic ***,subnanosheets could form freestanding organogels and OA-Al SNSs exhibit satisfying semisolidification of various solvents,making it an intriguing candidate for the safe storage and transportation of ***,SA-Al SNSs exhibit excellent adhesive properties of high strength on diverse substrates,and it is easy to erase it without any damage,demonstrating the promising prospects in practical applications.

关键词： subnanometer nanomaterials self-assembly polymer-analogue organogel adhesive

DGS1 improves rice disease resistance by elevating pathogenassociated molecular pattern-triggered immunity

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aBIOTECH 2024年第1期5卷 46-51页

作者： Yu Wang Chuan Zheng You-liang Peng Qian Chen MOA Key lab of Pest Monitoring and Green Management and Frontiers Science Center for molecular Design Breeding China Agricultural UniversityBeijing 100193China

Rice yield and disease resistance are two crucial factors in determining the suitability of a gene for agricultural *** grain size1(DGS1),encoding an RING-type E3 ligase,has been found to have a positive effect on rice yield by regulating rice grain number and 1000-grain ***,the role of DGS1 in rice blast resistance is still *** this study,we report that DGS1 enhances disease resistance by improving PTI responses,including stronger ROS burst and MAPK activation,and also increased expression of defense-related ***,DGS1 works in conjunction with ubiquitin conjugating enzyme OsUBC45 as an E2-E3 pair to facilitate the ubiquitin-dependent degradation of OsGSK3 and OsPIP2;1,thereby influencing rice yield and immunity,***,the DGS1-OsUBC45 module has the potential in facilitating rice agricultural breeding.

关键词： Rice blast PTI ERAD E2-E3 pair Ubiquitination

A weak allele of TGW5 enables greater seed propagation and efficient size-based seed sorting for hybrid rice production

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Plant Communications 2024年第4期5卷 137-140页

作者： Jiezheng Ying Yaobing Qin Fengyong Zhang Liu Duan Peng Cheng Man Yin Yifeng Wang Xiaohong Tong Jie Huang Zhiyong Li Xianjun Song Jian Zhang State Key lab of Rice biology and Breeding China National Rice Research InstituteHangzhou 311400China State Key laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhan 430062China Key laboratory of Plant molecular Physiology Institute of Botanythe Chinese Academy of SciencesBeijing 100093China These authors contributed equally to this article

Dear Editors,Heterosis utilization is an effective way to improve crop *** rice typically out-yield inbred rice varieties by 10%and show better stress resistance,and they have been widely adopted in Asian countries since the 1980s(Cheng et al.,2007).To produce rice F1 hybrid seeds(HSDs),male sterile lines(MSLs)are grown side by side with restorer lines(RLs)in order to receive the RL *** seed production system faces challenges in maintaining the seed purity of the HSDs owing to the physical proximity of MSL and RL plants in the ***,MSLs and RLs are planted in alternate rows to enable physical separation of seeds during harvesting.

关键词： planted sterile enable