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Genetic causes of macrozoospermia and proposal for an optimized genetic diagnosis strategy based on sperm parameters

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Journal of Genetics and genomics 2023年第7期50卷 536-540页

作者： Alicia Coudert Caroline Cazin Amir Amiri-Yekta Selima Fourati Ben Mustapha Raoudha Zouari Julien Bessonat Abdelali Zoghmar Antoine Clergeau Catherine Metzler-Guillemain Chema Triki Herve Lejeune Nathalie Sermondade Eva Pipiras Nadia Prisant Isabelle Cedrin Leila Keskes Florence Lestrade laetitia Hesters Nathalie Rives Beatrice Dorphin Agnes Guichet Catherine Patrat Emmanuel Dulioust Aur elie Feraille Franc ois Robert Eric Bieth Arthur Sorlin Jean-Pierre Siffroi Mariem Ben Khelifa Florence Boiterelle Sylvianne Hennebicq Veronique Satre Christophe Arnoult Charles Coutton Anne-laure Barbotin Nicolas Thierry-Mieg Zine-Eddine Kherraf Pierre F.Ray Genetic Epigenetic and Therapies of Infertility Team Institute for Advanced BiosciencesInserm U 1209CNRS UMR 5309Universite Grenoble Alpes38000GrenobleFrance CHU Grenoble Alpes UM GI-DPI38000GrenobleFrance CHU Grenoble Alpes UM de Genetique Chromosomique38000GrenobleFrance Department of Genetics Reproductive Biomedicine Research CenterRoyan Institute for Reproductive BiomedicineACECRTehranIran Polyclinique les Jasmins Centre d’Aide M edicale a la Procr eationCentre Urbain Nord1003TunisTunisia CHU Grenobles Alpes UF de Biologie de la Procr eation38000GrenobleFrance Reproduction Sciences and Surgery Clinique Ibn RochdConstantineAlgeria CHU Caen CECOS de CaenD epartement de BiologieUnit e de Biologie de la Reproduction14033CaenFrance APHM Hopital la-Conception P^ole Femmes-parents-enfantsCentre Clinico-biologique d’assistance M edicale a la Procr eation-CECOS13385 MarseilleFrance Aix-Marseille Univ InsermMMGU125113385 Marseille Medical Genetics13385 MarseilleFrance Clinique Hannibal Centre d’AMPLes Berges du Lac1053TunisTunisia Reproductive Medicine Department Hospices Civil de LyonLyonFrance Hopital Jean Verdier Universit e Sorbonne Paris NordParisFrance CHU de Pointe-a-Pitre/Abymes GuadeloupeFrance Service de Medecine de la Reproduction CHU Jean VerdierParisFrance Faculte de M edecine de Sfax SfaxTunisia CHR Metz-Thionville Service d’Assistance Medicale a la Procr eation57530Ars-LaquenexyFrance Unit of Reproductive Biology Antoine B ecl ere University HospitalUniversity Paris SudClamartParis-Sud UniversityLe Kremlin Bic^etreFrance Univ Rouen Normandie Inserm U1239NorDICAdrenal and Gonadal PathophysiologyReproductive Biology Laboratory-CECOSRouen University Hospital76031Rouen CedexFrance CHAL Centre Hospitalier Alpes Leman Centre AMP7474130Contamine-sur-ArveFrance CHU Angers Service de Gen etique49933AngersINSERM U1083France Service de Biologie de la Reproduction-CECOS Hopital Cochin 74014ParisFrance IRH Medicentre Clinique du Val d’Ouest39

Macrozoospermia,characterized by the presence of largeheaded spermatozoa usually carrying several flagella,is one of the most severe phenotypes of male *** in most cases,the gametes are chromosomally abnormal and cannot be used for assisted reproductive technologies(ART)(Ray et al.,2017).In 2007,subjects from consanguineous families were shown to carry the same homozygous deleterious AURKC variant(NM_001015878.2:c.144delC,later renamed c.145delC,***49TrpfsTer23),establishing AURKC as the first and main gene associated with macrozoospermia(Dieterich et al.,2007).Using flow cytometry,all spermatozoa from patients homozygous for the c.145delC variant were shown to be tetraploid,highlighting a cytokinesis blockage of the first meiotic divisions thus confirming that ART cannot be successful for these patients(Dieterich et al.,2009).

关键词： diagnosis establishing

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Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

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Protein & Cell 2022年第3期13卷 220-226页

作者： Jinghui Lei Xiaoyu Jiang Wei Li Jie Ren Datao Wang Zhejun Ji Zeming Wu Fang Cheng Yusheng Cai Zheng-Rong Yu Juan Carlos Izpisua Belmonte Chunyi Li Guang-Hui Liu Weiqi Zhang Jing Qu Si Wang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China CAS Key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Institute of Antler Science and Product Technology Changchun Sci-Tech UniversityChangchun 130000China University of Chinese Academy of Sciences Beijing 100049China National laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Department of Orthopaedics Peking University First HospitalBeijing 100034China Gene Expression laboratory Salk Institute for Biological StudiesLa JollaCAUSA

Dear Editor,Stem cell therapy holds enormous and revolutionary promise to treat various age-related diseases,such as diabetes,heart failure,and Parkinson’s ***,low retention and survival rate of delivered stem cells,partially due to immunological rejection,constitute major hurdles for the clinical implementation of stem cell therapy(Lei et al.,2021a).Since mounting evidence showed that several types of stem cells mainly exert their therapeutic effects through the secretion of paracrine effects,exosomes,which are released by stem cells and execute most paracrine functions,have begun to draw attention in the field(Tran and Damaser,2015).Exosomes are membrane-enclosed vesicles with an average diameter of∼100 nanometers secreted by the cells,containing cytokines.

关键词： Exosomes holds mount

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Involvement of the insulin signaling in DNA synthesis of silk gland cells in the silkworm, Bombyx mori

Involvement of the insulin signaling in DNA synthesis of sil...

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中国蚕学会第八届青年学术研讨会

作者： LI Yao-Feng CHEN Xiang-Yun TANG Xiao-Fang WANG la ZHANG Chun-Dong PAN Min-Hui LU Cheng State Key laboratory of Silkworm Genome Biology Southwest University Department of Biochemistry and Molecular Biology Chongqing Medical University Key laboratory for Sericulture Functional genomics and Biotechnology of Agricultural Ministry Southwest University

The insulin signal pathway plays an important role in regulating cell growth and cell proliferation. The purpose of this study was to investigate whether the insulin signal pathway is involved in endomitotic DNA replication of silk gland cells. Our results showed that the insulin activated the DNA synthesis. And the specific inhibitor of the insulin signaling pathway in vertebrates,LY294002, a phosphoinositide 3-kinase（PI3K） inhibitor, Rapamycin, a specific inhibitor of mammalian target of rapamycin（TOR）,and U0126, the mitogen-activated protein kinase（MAPK）/extracellular signal-regulated kinase（ERK） kinase（MEK） inhibitor, could inhibit the DNA synthesis of silk gland cells by time- and dose-dependent manner, indicating involvement of the PI3 K, TOR and MAPK signaling pathways. In vitro treatment, the DNA synthesis induced by insulin was blocked by either LY294002 or *** phosphorylation in the silk glands could be induced by the insulin, which was inhibited by LY294002. Phosphorylation of S6 K and 4E-BP was stimulated by insulin, and Phosphorylation of S6 K induced by insulin was inhibited by Rapamycin, indicating that insulin-stimulated the DNA synthesis is mediated by PI3 K, Akt and TOR. Moreover, PI3 K and Akt are upstream of TOR in the silk glands. Surprisingly, U0126 did not obviously inhibit the activation by the insulin, and ERK phosphorylation was not stimulated by insulin. So, PI3K/Akt/TOR signaling, which could be induced by insulin, and MAPK/ERK signaling may be two separate signaling pathways in the regulation of DNA synthesis in silk gland cells.

关键词： Bombyx mori Silk gland DNA synthesis Insulin PI3K TOR ERK

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Effects of starvation and hormones on DNA synthesis in silk gland cells of the silkworm, Bombyx mori

Effects of starvation and hormones on DNA synthesis in silk ...

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中国蚕学会第八届青年学术研讨会

作者： LI Yao-Feng CHEN Xiang-Yun ZHANG Chun-Dong TANG Xiao-Fang WANG la LIU Tai-Hang PAN Min-Hui LU Cheng State Key laboratory of Silkworm Genome Biology Southwest University Department of Biochemistry and Molecular Biology Chongqing Medical University Key laboratory for Sericulture Functional genomics and Biotechnology of Agricultural Ministry Southwest University

Silk gland cells of silkworm larvae undergo multiple endomitotic cell cycles for the synthesis of silk proteins in the spinning phase. Here we analyze the endomitotic DNA synthesis of the silk gland cells during the larval ontogeny. The endomitotic DNA synthesis exhibits a periodic fluctuation during the larval stages. In particular, the activity of the DNA synthesis is the maximum during the fifth intermolt stage. The expression levels of cyclin E, CDT1 and PCNA are consistent with the developmental change of the DNA synthesis. Moreover, the possible endomitotic cellar mechanism causing the activation of the endomitotic DNA synthesis in the intermolt stages owes to feeding with fresh mulberry and the inhibition of the DNA synthesis during the molting stages owes to the hormones is further examined. Our results indicate that the activation of the endomitotic DNA synthesis during the intermolt stages is related to feeding and the DNA synthesis is inhibited indirectly by 20-hydroxyecdysone.

关键词： Bombyx mori DNA synthesis endomitosis silk gland starvation 20-hydroxyecdysone

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High levels of psychosocial distress among Australian frontline healthcare workers during the COVID-19 pandemic: a cross- sectional survey

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General Psychiatry 2021年第5期34卷 31-41,I0006-I0025页

作者： Natasha Smallwood Leila Karimi Marie Bismark Mark Putland Douglas Johnson Shyamali Chandrika Dharmage Elizabeth Barson Nicola Atkin Claire Long Irene Ng Anne Holland Jane E Munro Irani Thevarajan Cara Moore Anthony McGillion Debra Sandford Karen Willis Department of Respiratory Medicine Alfred HospitalPrahranVictoriaAustralia Department of Allergy Immunology and Respiratory MedicineCentral Clinical SchoolAlfred HospitalMonash UniversityMelbourneVictoriaAustralia School of Psychology and Public Health La Trobe UniversityMelbourneVictoriaAustralia School of Medicine and Healthcare Management Caucasus UniversityTbilisiGeorgia Department of Psychiatry The Royal Melbourne HospitalParkvilleVictoriaAustralia Department of Public Health law Melbourne School of Population and Global HealthThe University of MelbourneParkvilleVictoriaAustralia Department of Emergency Services The Royal Melbourne HospitalParkvilleVictoriaAustralia Department of Critical Care Faculty of MedicineDentistry and Health SciencesThe University of MelbourneMelbourneVictoriaAustralia Departments of General Medicine and Infectious Diseases The Royal Melbourne HospitalParkvilleVictoriaAustralia Department of Medicine The Royal Melbourne HospitalThe University of MelbourneParkvilleVictoriaAustralia Allergy and Lung Health Unit School of Population and Global HealthThe University of MelbourneParkvilleVictoriaAustralia Department of Allied Health The Royal Melbourne HospitalParkvilleVictoriaAustralia Parkville Integrated Palliative Care Service The Royal Melbourne HospitalParkvilleVictoriaAustralia Sir Peter MacCallum Department of Oncology The University of MelbourneParkvilleVictoriaAustralia Department of Geriatric Medicine Western HealthFootscrayVictoriaAustralia Department of Anaesthesia and Pain Management The Royal Melbourne HospitalParkvilleVictoriaAustralia Centre for Integrated Critical Care Melbourne Medical SchoolThe University of MelbourneParkvilleVictoriaAustralia Department of Physiotherapy Alfred HealthMelbourneVictoriaAustralia Rheumatology Unit Royal Children's HospitalParkvilleVictoriaAustralia Arthritis and Rheumatology Murdoch Children's Research InstituteParkvilleVictoriaAustralia Department of Infectious Diseases T

Background The coronavirus disease 2019(COVID-19)pandemic has had a profound and prolonged impact on healthcare services and healthcare *** The Australian COVID-19 Frontline Healthcare Workers Study aimed to investigate the severity and prevalence of mental health issues,as well as the social,workplace and financial disruptions experienced by Australian healthcare workers during the COVID-19 *** A nationwide,voluntary,anonymous,single timepoint,online survey was conducted between 27 August and 23 October *** self-identifying as frontline healthcare workers in secondary or primary care were invited to *** were recruited through health organisations,professional associations or colleges,universities,government contacts and national ***,home and work situation,health and psychological well-being data were *** A total of 9518 survey responses were received;of the 9518 participants,7846(82.4%)participants reported complete *** regard to age,4110(52.4%)participants were younger than 40 years;6344(80.9%)participants were *** were nurses(n=3088,39.4%),doctors(n=2436,31.1%),allied health staff(n=1314,16.7%)or in other roles(n=523,6.7%).In addition,1250(15.9%)participants worked in primary *** measured mental health symptoms were common:mild to severe anxiety(n=4694,59.8%),moderate to severe burnout(n=5458,70.9%)and mild to severe depression(n=4495,57.3%).Participants were highly resilient(mean(SD)=3.2(0.66)).Predictors for worse outcomes on all scales included female gender;younger age;pre-existing psychiatric condition;experiencing relationship problems;nursing,allied health or other roles;frontline area;being worried about being blamed by colleagues and working with patients with *** The COVID-19 pandemic is associated with significant mental health symptoms in frontline healthcare *** preparedness together with policies and pra

关键词： distress nurse workers

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Cytokine and Antioxidant Regulation in the Intestine of the Gray Mouse Lemur (Microcebus murinus) During Torpor

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genomics, Proteomics & Bioinformatics 2015年第2期13卷 127-135页

作者： Shannon N.Tessier Barbara A.Katzenback Fabien Pifferi Martine Perret Kenneth B.Storey Institute of Biochemistry & Department of Biology Carleton University Department of Surgery & Center for Engineering in Medicine Massachusetts General Hospital & Harvard Medical School Department of Biology University of Waterloo UMR 7179 Centre National de la Recherche Scientifique Muse'um National d'Histoire Naturelle

During food shortages, the gray mouse lemur（Microcebus murinus） of Madagascar experiences daily torpor thereby reducing energy expenditures. The present study aimed to understand the impacts of torpor on the immune system and antioxidant response in the gut of these *** interaction may be of critical importance given the trade-off between the energetically costly immune response and the need to defend against pathogen entry during hypometabolism. The protein levels of cytokines and antioxidants were measured in the small intestine（duodenum, jejunum,and ileum） and large intestine of aroused and torpid lemurs. While there was a significant decrease of some pro-inflammatory cytokines（IL-6 and TNF-a） in the duodenum and jejunum during torpor as compared to aroused animals, there was no change in anti-inflammatory cytokines. We observed decreased levels of cytokines（IL-12p70 and M-CSF）, and several chemokines（MCP-1and MIP-2） but an increase in MIP-1a in the jejunum of the torpid animals. In addition, we evaluated antioxidant response by examining the protein levels of antioxidant enzymes and total antioxidant capacity provided by metabolites such as glutathione（and others）. Our results indicatedthat levels of antioxidant enzymes did not change between torpor and aroused states, although antioxidant capacity was significantly higher in the ileum during torpor. These data suggest a suppression of the immune response, likely as an energy conservation measure, and a limited role of antioxidant defenses in supporting torpor in lemur intestine.

关键词： Primate torpor Cytokines Chemokines Antioxidant enzymes Gut immunology

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Efficacy and safety of obinutuzumab for the first-line treatment of follicular lymphoma:a subgroup analysis of Chinese patients enrolled in the phase III GALLIUM study

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Chinese Medical Journal 2022年第4期135卷 433-440页

作者： Xiaonan Hong Yuqin Song Yuankai Shi Qingyuan Zhang Wei Guo Gang Wu Junmin Li Jifeng Feng Anastasiia Kinkolykh Andrea Knapp Tongyu Lin Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Key laboratory of Carcinogenesis and Translational research(Ministry of Education) Peking University Cancer Hospital and InstituteBeijing 100142China National Cancer Center/National Clinical research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin Medical UniversityHarbinHeilongjiang 150081China Department of Hematology The First Hospital of Jilin UniversityChangchunJilin 130015China Department of Medical Oncology Cancer CenterUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430023China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medical Oncology Jiangsu Cancer HospitalNanjing Medical University Affiliated Cancer HospitalNanjingJiangsu 210009China Consultant to F.Hoffmann-la Roche Ltd BaselSwitzerlandvia GCE Solutions-an IQVIA businessSwitzerland Product Development Oncology F.Hoffmann-La Roche LtdBaselSwitzerland Department of Medical Oncology Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South Chinaand Collaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510075China

Backgrounds:GALLIUM is a global phase Ⅲ study that demonstrated significant improvements in progression-free survival(PFS)for obinutuzumab plus chemotherapy(G-chemo)*** plus chemotherapy(R-chemo)in previously untreated patients with follicular lymphoma(FL).This study aimed to report the results of a subgroup of patients in ***:Patients were randomized to G-chemo or *** received maintenance therapy for 2 years or until disease *** primary endpoint was investigator(INV)-assessed *** endpoints included the overall response rate(ORR)and complete response rate(CRR)at the end of induction chemotherapy,overall survival(OS),and ***:Overall,58 patients with FL were randomized to the G-chemo(n=25)and R-chemo arms(n=33).The INV-assessed PFS rate at 3 years was 81.8%in the G-chemo arm,vs.70.2%in the R-chemo arm(hazard ratio 0.35;95%confidence interval:0.09-1.34;P=0.1120).The INV-assessed CRRs(without positron emission tomography[PET])in these arms were 24.0%and 21.2%,respectively,whereas the ORRs were 80.0%and 90.9%,***-assessed CRR-PET was 52.6%in the G-chemo,vs.60.9%in the *** OS was not reached in either *** 3 to 5 adverse events were more frequent in the R-chemo arm(97.0%vs.88.0%).Conclusions:The results of this subgroup analysis were consistent with those of the global population,and they suggest that G-chemo has a positive benefit-risk profile in patients from China with *** registration:***,***01332968.

关键词： Chinese Follicular lymphoma GALLIUM Obinutuzumab Rituximab

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Two homologous INDOLE-3-ACETAIVHDE (IAM) HYDROlaSE genes are required for the auxin effects of IAM in Arabidopsis

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Journal of Genetics and genomics 2020年第3期47卷 157-165页

作者： Yangbin Gao Xinhua Dai Yuki Aoi Yumiko Takebayashi Liping Yang Xiaorui Guo Qiwei Zeng Hanchuanzhi Yu Hiroyuki Kasahara Yunde Zhao Section of Cell and Developmental Biology University of California San DiegoLa JollaCA92093-0116USA RIKEN Center for Sustainable Resource Science Kanagawa230-0045Japan School of Life Sciences Jilin Normal UniversitySiping136000China Key laboratory of Plant Ecology Northeast Forestry UniversityHarbin150040China State Key laboratory of Silkworm Genome Biology Institute of Sericulture and Systems BiologySouthwest UniversityChongqing400716China Institute of Global Innovation research Tokyo University of Agriculture and TechnologyTokyo183-8509Japan Department of Bioregulation and Biointeraction Graduate School of AgricultureTokyo University of Agriculture and TechnologyFuchu183-8509Japan

Indole-3-acetamide(IAM)is the first confirmed auxin biosynthetic intermediate in some plant pathogenic *** applied IAM or production of IAM by overexpressing the bacterial iaaM gene in Arabidopsis causes auxin overproduction ***,it is still inconclusive whether plants use IAM as a key precursor for auxin ***,we reported the isolation IAM HYDROlaSE 1(IAMH1)gene in Arabidopsis from a forward genetic screen for IAM-insensitive mutants that display normal auxin ***1 has a close homolog named IAMH2 that is located right next to IAMH1on chromosomeⅣin *** generated iamh1 iamh2 double mutants using our CRISPR/Cas9gene editing *** showed that disruption of the IAMH genes rendered Arabidopsis plants resistant to IAM treatments and also suppressed the iaaM overexpression phenotypes,suggesting that IAMH1 and IAMH2 are the main enzymes responsible for converting IAM into indole-3-acetic acid(IAA)in *** iamh double mutants did not display obvious developmental defects,indicating that IAM does not play a major role in auxin biosynthesis under normal growth *** findings provide a solid foundation for clarifying the roles of IAM in auxin biosynthesis and plant development.

关键词： Auxin Auxin biosynthesis Indole-3-acetamide Arabidopsis CRISPR IAMH1 IAMH2

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Mobilizing Crop Biodiversity

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Molecular Plant 2020年第10期13卷 1341-1344页

作者： Susan McCouch Zahra Katy Navabi Michael Abberton Noelle L.Anglin Rosa Lia Barbieri Michael Baum Kirstin Bett Helen Booker Gerald L.Brown Glenn J.Bryan Luigi Cattivelli David Charest Kellye Eversole Marcelo Freitas Kioumars Ghamkhar Dario Grattipaglia Robert Henry Maria Cleria Valadares Inglis Tofazzal Islam Zakaria Kehel Paul J.Kersey Graham J.King Stephen Kresovich Emily Marden Sean Mayes Marie Noelle Ndjiondjiop Henry T.Nguyen Samuel Rezende Paiva Roberto Papa Peter W.B.Phillips Awais Rasheed Christopher Richards Mathieu Flouard Maria Jose Amstalden Sampaio Uwe Scholz Paul D.Shaw Brad Sherman S.Evan Staton Nils Stein Jan Svensson Mark Tester Jose Francisco Montenegro Valls Rajeev Varshney Stephen Visscher Eric von Wettberg Robbie Waugh Peter Wenzl Loren H.Rieseberg Plant Breeding and Genetics School of Integrated Plant SciencesCornell UniversityIthacaNY14853USA DivSeek Global Institute for Food Security110 Gymnasium PlaceUniversity of SaskatchewanSaskatoonSKS7N 0W9Canada lnternational Institute of Tropical Agriculture(IITA) PMB 5320Oyo RdIbadanNigeria International Potato Center(CIP)1895 Avenida la Molina Lima Peru 12Lima 15023Peru Embrapa Genetic Resources and Biotechnology Parque Estacjao BiologicaFinal Av W5 NorteCaixa Postal 0237270770-917-Brasilia DFBrazil International Center for Agricultural research in the Dry Areas(I CAR DA) Station Exp.INRA-Quich.Rue Hafiane Cherkaoui.Agdal.Rabat-Instituts10111RabatMorocco Department of Plant Sciences University of Saskatchewan51 Campus Dr.SaskatoonSK S7N 5A8Canada Department of Plant Agriculture University of GuelphRm 316Crop Science Bldg50 Stone Rd EGuelphON N1G 2W1Canada Genome Prairie 111 Research DriveSuite 101SaskatoonSKS7N 3R2Canada The James Hutt on Institute Errol RoadInvergowrieDundeeDD25DAUK CREA Research Centre for Genomics and Bioinformaticsvia San Protaso 302Fiorenzuola d'Arda29017Italy Genome British Columbia 400-575 West 8th AvenueVancouverBCV5Z 0C4Canada International Wheat Genome Sequencing Consortium 2841 NE Marywood CtLee's SummitMO.64086USA Forage Science Grasslands Research CentreAgResearchPalmerston North4410New Zealand Queensla nd Alliance for Agriculture and Food Inn ovation University of QueenslandBrisbaneQLD 4072Australia Institute of Biotechnology and Genetic Engineering(IBGE) Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Southern Cross University PO Box 157LismoreNSW 2480Australia Royal Botanic Gardens KewRichmondSurreyTW93AEUK Feed the Future Innovation lab for Crop Improvement 431 Weill HallCornell UniversityIthacaNY14853USA Department of Botany and Biodiversity research Centre University of British ColumbiaVancouverBC V6R 2A5Canada Crops For the Future(UK)CIC 76-80 Baddow Road ChelmsfordEs

Over the past 70 years,the world has witnessed extraordinary growth in crop productivity,enabled by a suite of technological advances,including higher yielding crop varieties,improved farm management,synthetic agrochemicals,and agricultural *** this"Green Revolution"intensified crop production,and is credited with reducing famine and malnutrition,its benefits were accompanied by several undesirable collateral effects(Pingali,2012).These include a narrowing of agricultural biodiversity,stemming from increased monoculture and greater reliance on a smaller number of crops and crop varieties for the majority of our *** reduction in diversity has created vulnerabilities to pest and disease epidemics,climate variation,and ultimately to human health(Harlan,1972).

关键词： intensified crops agricultural

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Genetic differentiation of grain, fodder and pod vegetable type cowpeas (Vigna unguiculata L.) identified through single nucleotide polymorphisms from genotyping-by-sequencing

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Molecular Horticulture 2022年第1期2卷 101-115页

作者： Xingbo Wu Andrés JCortés Matthew W.Blair Department of Agricultural and Environmental Sciences Tennessee State UniversityNashvilleTN 37209USA Tropical research and Education Center Department of Environmental HorticulturalUniversity of Florida18905 SW 280th StHomesteadFL 33031USA Corporación Colombiana de Investigación Agropecuaria AGROSAVIA C.I.La SelvaKm 7 vía Rionegro–Las PalmasRionegroColombia Universidad Nacional de Colombia–Sede Medellín Facultad de Ciencias Agrarias–Departamento de Ciencias ForestalesMedellínColombia

The species Vigna unguiculata L.(Walp),commonly known as cowpea,is a multi-purpose legume that has been selected into three subspecies that are divided into grain,fodder and pod(yardlong bean)***,genetic bases for distinctions are not well *** purpose of this study was to apply genotyping-by-sequencing(GBS)and current reference genome for *** to distinguish three subspecies and identify signatures of *** collection of 130 accessions included 128 cultivated from:1)***,fodder type;2)***,pod vegetable type;and 3)***,grain *** wilds genotypes from *** and ***,were used to anchor phylogeny.A total of 11,083 highly informative single nucleotide polymorphisms(SNPs)were *** accessions showed distinct genetic fingerprints and were separated from cultivated *** component analysis showed closer relationship between *** and *** compared to *** differentiation of cultivated subspecies(with Fixation Index,FST)indicated the existence of discrete signatures of *** work clarifies the population structure,phylogeny,and domestication of cultivated ***,significant genetic differences between grain and pod vegetable types can provide valuable information for future breeding in three cowpea groups.

关键词： Genomic landscape of divergence Relative differentiation FST GBS-derived SNP markers

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