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Relationships between blood chromium exposure and liver injury:Exploring the mediating role of systemic inflammation in a chromate-exposed population

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Journal of Environmental Sciences 2024年第9期143卷 224-234页

作者： Zekang Su Yali Zhang Shiyi Hong Qiaojian Zhang Jiayu Xu Guiping Hu Xiaojun Zhu Fang Yuan Shanfa Yu Tianchen Wang Guang Jia Department of Occupational and Environmental health Sciences School of Public HealthPeking UniversityBeijing 100191China School of Engineering Medicine and Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing 100191China National Center for Occupational Safety and health Beijing 102308China Department of Occupational health and Radiological health Chongqing Centers for Disease Control and PreventionChongqing 400042China Henan Institute for Occupational Medicine Zhengzhou 450052China Department of Clinical Laboratory Third Hospital of Peking UniversityBeijing 100191China

Hexavalent chromium and its compounds are prevalent pollutants,especially in the work environment,pose a significant risk for multisystem toxicity and *** it is known that chromium accumulation in the liver can cause damage,the dose-response relationship between blood chromium(Cr)and liver injury,as well as the possible potential toxic mechanisms involved,remains poorly *** address this,we conducted a follow-up study of 590 visits from 305 participants to investigate the associations of blood Cr with biomarkers for liver injury,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),and direct bilirubin(DBIL),and to evaluate the mediating effects of systemic ***(PLT)and the platelet-to-lymphocyte ratio(PLR)were utilized as biomarkers of systemic *** the linear mixed-effects analyses,each 1-unit increase in blood Cr level was associated with estimated effect percentage increases of 0.82%(0.11%,1.53%)in TBIL,1.67%(0.06%,3.28%)in DBIL,0.73%(0.04%,1.43%)in ALT and 2.08%(0.29%,3.87%)in AST,***,PLT mediated 10.04%,11.35%,and 10.77%increases in TBIL,DBIL,and ALT levels induced by chromate,*** addition,PLR mediated 8.26%and 15.58%of the association between blood Cr and TBIL or *** findings shed light on the mechanisms underlying blood Cr-induced liver injury,which is partly due to worsening systemic inflammation.

关键词： Blood chromate Liver injury Systemic inflammation Mediation analysis

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Association of preschool children behavior and emotional problems with the parenting behavior of both parents

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World Journal of Clinical Cases 2024年第6期12卷 1084-1093页

作者： Su-Mei Wang Shuang-Qin Yan Fang-Fang Xie Zhi-Ling Cai Guo-Peng Gao Ting-Ting Weng Fang-Biao Tao Department of Child health Ma’anshan Maternal and Child Health CenterMa’anshan 243011Anhui ProvinceChina Department of Maternal Child and Adolescent HealthSchool of Public HealthAnhui Medical UniversityHefei 230032Anhui ProvinceChina

BACKGROUND Parental behaviors are key in shaping children’s psychological and behavioral development,crucial for early identification and prevention of mental health issues,reducing psychological trauma in *** To investigate the relationship between parenting behaviors and behavioral and emotional issues in preschool *** From October 2017 to May 2018,7 kindergartens in Ma’anshan City were selected to conduct a parent self-filled questionnaire-health Development Survey of Preschool ***’s Strength and Difficulties Questionnaire(Parent Version)was applied to measures the children’s behavioral and emotional *** behavior was evaluated using the Parental Behavior *** logistic regression model was used to analyze the association between the detection rate of preschool children’s behavior and emotional problems and their parenting *** High level of parental support/participation was negatively correlated with conduct problems,abnormal hyperactivity,abnormal total difficulty scores and abnormal prosocial behavior *** level of maternal support/participation was negatively correlated with abnormal emotional symptoms and abnormal peer interaction in *** level of parental hostility/coercion was positively correlated with abnormal emotional symptoms,abnormal conduct problems,abnormal hyperactivity,abnormal peer interaction,and abnormal total difficulty scores in children(all P0.05),after calculating ratio of odds ratio *** Our study found that parenting behaviors are associated with behavioral and emotional issues in preschool ***,the more supportive or involved the parents are,the fewer behavioral and emotional problems the children experience;conversely,the more hostile or contro

关键词： Children Preschool age Parenting Behavioral Parenting problems

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Global,regional and national burdens of bipolar disorders in adolescents and young adults:a trend analysis from 1990 to 2019

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General Psychiatry 2024年第1期37卷 122-132页

作者： Yunxi Zhong Yifan Chen Xiaoying Su Meiqi Wang Qixiu Li Ziming Shao Long Sun Centre for health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinanShandongChina National health Commission of China(NHC)Key Laboratory of health Economics and Policy Research Shandong UniversityJinanShandongChina nstitute of health and Elderly Care Shandong UniversityJinanShandongChina

Background Bipolar disorder is identified as a cause of severe damage to the physical,psychological and social functioning of adolescents and young *** The aim of this study is to ascertain the trends in the burden of bipolar disorder among individuals aged 10-24 years at global,regional and national levels from 1990 to *** The data analysed in this study were from the Global Burden of Diseases *** numbers,rates per 100000 population,average annual percentage changes(AAPCs)of incidence,prevalence and years lived with disability(YLDs)of bipolar disorder are reported at the global,regional and national levels among individuals aged 10-24 *** trends by age,sex and Social Development Index(SDI)were further *** Globally,the incidence of bipolar disorder among adolescents and young adults increased from 79.21 per 100000 population(95%uncertainty interval(Ul):58.13 to 105.15)in 1990 to 84.97 per 100000 population(95%Ul:61.73 to 113.46)in 2019,AAPC 0.24(95%confidence interval(Cl):0.22 to 0.26).In the past three decades,there has been an increase in incidence,prevalence and YLDs in both males and *** largest increase in incidence between 1990 and 2019 was observed in those aged 20-24 years old from 51.76 per 100000 population(95%Ul:26.81 to 87.20)in 1990 to 58.37 per 100000 population(95%UI:30.39 to 98.55)in 2019;AAPC 0.42(95%Cl:0.38 to 0.47).By the SDI quintile,the largest increase in incidence was observed in the middle SDl;however,the high SDI countries had the highest ***,the largest increase in incidence was observed in southern Latin *** the national level,the most pronounced increase in the incidence was in *** The global increase in incidence among adolescents and young adults between 1990 and 2019 indicates that strategies to improve their mental health still need to be emphasised.

关键词： adolescent bipolar young

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Prevalence of Cannabis Use around the World:A Systematic Review and Meta-Analysis,2000-2024

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China CDC weekly 2024年第25期6卷 597-604,I0013,I0014页

作者： Qianning Wang Zhen Qin Xing Xing He Zhu Zhongwei Jia National Institute of health Data Science Center for Drug Abuse Prevention and ControlPeking UniversityBeijingChina School of Public health Peking UniversityBeijingChina

This study aims to perform a systematic review and meta-analysis on the global prevalence of cannabis use to inform drug prevention strategies,policy-making,and resource *** study initially screened 177,843 studies published between January 1,2000,and January 15,2024,using peer-reviewed databases including Web of Science,PubMed,Scopus,Embase,and Cochrane ***,595 studies were identified for data extraction,and 39 of these were selected as country-representative *** among the selected studies was assessed using the chi-squared test and I2 statistic,while sensitivity analysis was conducted to evaluate the robustness of the *** prevalence of cannabis use varied between 0.42%and 43.90%across 33 European countries,1.40%to 38.12%across 15 North and South American countries,0.30%to 19.10%across 16 Asian countries,and 1.30%to 48.70%across 18 Oceania and African *** pooled prevalence of cannabis use was 12.0%[95%confidence interval(CI):10.0,14.3]in countries where cannabis is legalized,compared to 5.4%(95%CI:4.3,6.9)in non-legalized *** findings indicate that the prevalence of cannabis use has disproportionately increased in most countries with the implementation of medical or recreational cannabis legalization policies and relevant geographic *** efforts are needed to monitor newly cannabis-legalized countries and prevent initial use.

关键词： prevention legal initially

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Assessing the impact of interventions on the major Omicron BA.2 outbreak in spring 2022 in Shanghai

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Infectious Disease Modelling 2024年第2期9卷 519-526页

作者： Hengcong Liu Jun Cai Jiaxin Zhou Xiangyanyu Xu Marco Ajelli Hongjie Yu School of Public health Fudan UniversityKey Laboratory of Public Health SafetyMinistry of EducationShanghaiChina Laboratory for Computational Epidemiology and Public health Department of Epidemiology and BiostatisticsIndiana University School of Public HealthBloomingtonINUSA Shanghai Institute of Infectious Disease and Biosecurity School of Public HealthFudan UniversityShanghaiChina

Background Shanghai experienced a significant surge in Omicron BA.2 infections from March to June *** addition to the standard interventions in place at that time,additional interventions were implemented in response to the ***,the impact of these interventions on BA.2 transmission remains *** We systematically collected data on the daily number of newly reported infections during this wave and utilized a Bayesian approach to estimate the daily effective reproduction *** on public health responses were retrieved from the Oxford COVID-19 Government Response Tracker and served as a proxy for the interventions implemented during this *** a log-linear regression model,we assessed the impact of these interventions on the reproduction ***,we developed a mathematical model of BA.2 *** combining the estimated effect of the interventions from the regression model and the transmission model,we estimated the number of infections and deaths averted by the implemented *** We found a negative association(−0.0069,95%CI:0.0096 to−0.0045)between the level of interventions and the number of *** interventions did not ramp up during the outbreak,we estimated that the number of infections and deaths would have increased by 22.6%(95%CI:22.4–22.8%),leading to a total of 768,576(95%CI:768,021-769,107)infections and 722(95%CI:722–723)*** no interventions were deployed during the outbreak,we estimated that the number of infections and deaths would have increased by 46.0%(95%CI:45.8–46.2%),leading to a total of 915,099(95%CI:914,639-915,518)infections and 860(95%CI:860–861)*** Our findings suggest that the interventions adopted during the Omicron BA.2 outbreak in spring 2022 in Shanghai were effective in reducing SARS-CoV-2 transmission and disease *** findings emphasize the importance of non-pharmacological interventions in controlling quick surges of cases during

关键词： impact spring finding

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Development of a Proof-of-Concept Multi-Method Computer Simulation to Support Rural healthcare Disaster Preparedness Planning

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International Journal of Disaster Risk Science 2024年第3期15卷 346-358页

作者： Thomas A.Berg Kristina W.Kintziger Julie Suzuki Crumly Scott A.Lawson Carole R.Myers Tracey T.Stansberry College of Nursing University of Tennessee Knoxville Department of Environmental Agricultural and Occupational Health University of Nebraska Medical Center Public health and healthcare Oak Ridge Associated Universities

Due to a lack of resources, rural communities often face challenges when planning catastrophic events. This project involved applying systems thinking and model-based systems engineering to develop a proof-of-concept, multi-method computer simulation and then determining whether the simulation could be used to assess the efficacy of disaster planning approaches on health outcomes in rural communities, as a function of primary healthcare. The project focus was a rural or non-urban healthcare system experiencing a natural hazard. Both system dynamics and discrete event models were incorporated to represent subsystem operations, crucial disaster responses, as well as three key response systems: public health, emergency management, and healthcare. The subsystem models included several components: policies/procedures, communications,resources, exercises/drills/training, healthcare space and staff, and the flow of affected people into and through the *** combined simulation can serve as a first step to a more comprehensive approach to helping rural communities achieve more efficient and effective healthcare planning for disaster responses.

关键词： Computer simulation Disaster preparedness Model-based systems engineering Rural healthcare System dynamics model Systems thinking

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Associations of prenatal exposure to bisphenols with BMI growth trajectories in offspring within the first two years:evidence from a birth cohort study in China

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World Journal of Pediatrics 2024年第7期20卷 701-711页

作者： Chao Xiong Kai Chen Lu-Li Xu Yi-Ming Zhang Hua Liu Meng-Lan Guo Zhi-Guo Xia Yu-Ji Wang Xiao-Feng Mu Xiao-Xuan Fan Jing-Quan Chen Yu-Ru Liu Yuan-Yuan Li Wei Xia You-Jie Wang Ai-Fen Zhou Wuhan Children’s Hospital(Wuhan Maternal and Child healthcare Hospital) Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430016China Key Laboratory of Environment and health Ministry of Education and Ministry of Environmental Protectionand State Key Laboratory of Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Maternal and Child health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Background Prenatal bisphenol exposure has been reported to be associated with lower birth weight and obesity-related indicators in early *** findings warrant an investigation of the relationship between prenatal bisphenol exposure and the dynamic growth of *** study aimed to evaluate the relationship of maternal bisphenol concentration in urine with the body mass index(BMI)growth trajectory of children aged up to two years and to identify the critical exposure *** A total of 826 mother–offspring pairs were recruited from Wuhan Children’s Hospital between November 2013 and March *** urine samples collected during the first,second,and third trimesters were analyzed for bisphenol A(BPA),bisphenol S,and bisphenol F(BPF)*** of length and weight were taken at 0,1,3,6,8,12,18,and 24 ***'s BMI was standardized using the World health Organization reference,and group-based trajectory modeling was used to identify BMI growth *** associations between prenatal bisphenol exposure and BMI growth trajectory patterns were assessed using multinomial logistic regression *** The BMI growth trajectories of the 826 children were categorized into four patterns:low-stable(n=134,16.2%),low-increasing(n=142,17.2%),moderate-stable(n=350,42.4%),and moderate-increasing(n=200,24.2%).After adjusting for potential confounders,we observed that prenatal exposure to BPA during the second trimester[odds ratio(OR)=2.20,95%confidence interval(CI)=1.09–4.43]and BPF during the third trimester(OR=3.28,95%CI=1.55–6.95)at the highest quartile concentration were associated with an increased likelihood of the low-increasing BMI ***,in the subgroup analysis by infant sex,the positive association between the highest quartile of prenatal average urinary BPF concentration during the whole pregnancy and the low-increasing BMI trajectory was found only in girls(OR=2.82,95%CI=1.04–7.68).Conclus

关键词： Birth cohort study Bisphenol A Bisphenol S Bisphenol F Body mass index trajectory Prenatal exposure

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Avian influenza and gut microbiome in poultry and humans:A“One health”perspective

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Fundamental Research 2024年第3期4卷 455-462页

作者： Ling Zhang Erkai Zhou Ce Liu Xiaoyu Tian Baode Xue Kai Zhang Bin Luo Institute of Occupational health and Environmental health School of Public HealthLanzhou UniversityLanzhouGansu 730000China Department of Environmental health Sciences School of Public HealthUniversity at AlbanyState University of New YorkRensselaerNY 12144USA Shanghai Key Laboratory of Meteorology and health Shanghai Meteorological BureauShanghai 200030China Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China

A gradual increase in avian influenza outbreaks has been found in recent *** is highly possible to trigger the next human pandemic due to the characteristics of antigenic drift and antigenic shift in avian influenza virus(AIV).Although great improvements in understanding influenza viruses and the associated diseases have been unraveled,our knowledge of how these viruses impact the gut microbiome of both poultry and humans,as well as the underlying mechanisms,is still ***“One health”approach shows better vitality in monitoring and mitigating the risk of avian influenza,which requires a multi-sectoral effort and highlights the interconnection of human health with environmental sustainability and animal ***,monitoring the gut microbiome may serve as a sentinel for protecting the common health of the environment,animals,and *** review summarizes the interactions between AIV infection and the gut microbiome of poultry and humans and their potential *** the presented suggestions,we hope to address the current major challenges in the surveillance and prevention of microbiome-related avian influenza with the“One health”approach.

关键词： Avian influenza AIV Poultry Gutmicrobiome One health Poultry-Environment-Human Interface

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Extracellular Vesicles from Mesenchymal Stromal Cells (imEVs) Improve Cold Preservation of Isolated Mitochondria

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Journal of Biosciences and Medicines 2024年第1期12卷 52-63页

作者： Xianpeng Jiang Sergey Rodin Ken Braesch-Andersen Catherine C. Baucom Karl-Henrik Grinnemo Brent Segal Elliott Mitochondrial Center Sallie Astor Burdine Breast Foundation Baton Rouge Louisiana USA Mitosense Inc. Boston Massachusetts USA Department of Surgical Sciences Division of Cardiothoracic Surgery Cardio-Thoracic Translational Medicine (CTTM) Laboratory Uppsala University Uppsala University Hospital Uppsala Sweden

Mitochondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, Parkinson’s diseases, brain and spinal cord injuries, and amyotrophic lateral sclerosis (ALS). However, one of the major challenges for widespread usage is a methodology for preservation of isolated mitochondria. Extracellular vesicles (EVs) are phospholipid bilayer-enclosed vesicles released from cells. EVs carry a cargo of proteins, nucleic acids, lipids, metabolites, and even organelles such as mitochondria. Purpose: To test if EVs enhance the stability of isolated mitochondria. Methods: We mixed isolated mitochondria of fibroblasts with EVs of mesenchymal stromal cells (imEVs) (9:1 in volume) and stored the mixture at 2°C - 6°C for different time periods. We measured morphology, mitochondrial membrane potential (MMP) and mitochondrial ATP content at 0, 2, 5 days. Key findings: After 2 days of storage, the mito-chondria without imEVs lost approximate 70% MMP (RFU: 1822 ± 68), compared to the fresh mitochondria (RFU: 5458 ± 52) (p 0.05). In agreement with MMP, mitochondria without imEVs lost significant mitochondrial ATP content (p 0.05), after 2 days of cold storage, compared to fresh mitochondria. Microscopy showed that imEVs promoted aggregation of isolated mitochondria. Summary: The preliminary data showed that imEVs enhanced the stability of isolated mitochondria in cold storage.

关键词： Mitochondria Extracellular Vesicles Mitochondrial Preservation MOT imEVs

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Trends and Distribution of Life Expectancy and health-Adjusted Life Expectancy—Asia-Pacific Region,1990-2021

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China CDC weekly 2024年第39期6卷 996-1003页

作者： Yanan Luo Panliang Zhong Yujie Huang Yihao Zhao Chenlu Hong Xiaoying Zheng Department of Global health School of Public HealthPeking UniversityBeijingChina Institute for Global health and Development Peking UniversityBeijingChina School of Population Medicine and Public health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina

What is already known about this topic?The Asia-Pacific region is the most populous and diverse globally,encompassing nations with both the longest and shortest life expectancies(LE).However,less is known about the health-adjusted life expectancy(HALE)situation in this *** is added by this report?This study found diversity in the levels and trends of HALE among countries in the Asia-Pacific region,with HALE in 2021 ranging from 49.87 years in Afghanistan to 74.96 years in *** largest HALE increase from 1990 to 2021 was observed in the Lao People’s Democratic Republic and the smallest in *** continually increased as SDI increased,but different patterns of HALE across countries varied by SDI *** are the implications for public health practice?The diversity among these countries provides a prerequisite and scientific basis for promoting the achievement of health goals in the Asia-Pacific region through multilateral and bilateral cooperation.

关键词： shortest smallest globally

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